William Arbuthnot Lane (1856-1943): Surgical Innovator and His Theory of Autointoxication.

William Arbuthnot Lane contributed to the advancement of many fields of orthopedics, otolaryngology, and general surgery. He is credited for his no-touch technique and the invention of long-handled instruments, some of which are still in use today, to minimize tissue handling. He is most well known for his hypothesis that slowing of gastric contents could cause a variety of ailments and this became known as Lane\u27s disease. Although his surgical treatment of Lane\u27s disease is now defunct, it advanced the surgical technique in colorectal surgery. It seems likely that some of Lane\u27s autointoxication patients would be classified today as patients with colonic inertia, diverticulitis, colonic volvulus, and megacolon or, which are all treated with colectomy. Lane was a pioneer in multiple fields and a true general surgeon. He advanced colorectal surgery immensely and propelled the field of surgery into a new era

Intelligence-Led Policing and Forces of Organizational Change in the United States

The intent of this study is to explore organisational factors that, both conceptually and operationally, facilitate or inhibit a police agency from adopting intelligence-led policing (ILP). Research to date is yet to explore organisational factors related to ILP among American law enforcement agencies. Drawing from original survey data of national law enforcement agencies as part of a 2009 US Department of Justice, National Institute of Justice-funded project, the present study incorporates force field analysis to explore factors of ILP adoption in the USA. Findings suggest state and local agencies' familiarity with the intelligence-led concept and utilisation of open source and received information appear to be driving adoption. Conversely, formal policies, lack of sufficient personnel, training and a lack of intelligence-led decision-making appear to be inhibiting change towards the ILP paradigm. It appears agency size has minimal influence on an agency's shift towards ILP. Access to necessary resources and training appear to pose a significant challenge to law enforcement. Limited resources to develop an intelligence-led approach may result in the capability going underdeveloped or taking the form of other policing practices related to available resources – such as homeland security preparedness. This research is one of the first empirical explorations of ILP adoption, especially with a national sample of state and local agencies. Further conceptual clarity of the ILP paradigm is provided and organisational factors are discussed

Magnetic back-to-back locator

A back-to-back locator instrument includes a first portion with an array of two or more magnetic sensors, and an indicator arrangement. A second portion of the instrument includes an array of correspondingly located magnets. Each of the first and second portions includes a marking arrangement, which either allows marking of the underlying surface, or viewing of a mark on the surface for properly locating the instrument portion thereon. When the two portions are congruent or registered, the indicator arrangement gives a maximum indication of corresponding locations. In a particular use, corresponding locations on the inside and outside of a tank are identified. The indicator arrangement may include a separate indicator for each magnetic sensor. A flux concentrator may be associated with each magnetic sensor

SWAT raids are more about symbolism than reducing crime in the long term.

SWAT raids are among the most dramatic display of the power of law enforcement to deal with crime and disorder. But are SWAT raids actually effective at reducing crime? In new research which studies 39 SWAT raids in Buffalo, New York, Dae-Young Kim, Scott W. Phillips and Andrew P. Wheeler find that the raids did lead to fewer street crimes involving property – though only for a short time, and that they had no deterrent effect on violent crimes in private places, drug arrests, or calls for service

Implementing Intelligence-Led Policing: An Application of Loose-Coupling Theory

Author's manuscript made available in accordance with the publisher's policy.Purpose: This research is intended to inform a knowledge gap in the literature and present the first national findings related to intelligence-led policing adoption among state and local agencies. Specific practices are identified to inform scholars and practitioners regarding intelligence-led policing behaviors. Methods: Original survey research from a federally-funded project is gleaned to explore intelligence-led policing adoption through a loose-coupling theoretical perspective. Negative binomial and logistic regression models are employed to identify predictive relationships. Results: Agencies nationwide appear to be closely following the National Criminal Intelligence Sharing Plan recommendations to enhance information sharing. Consistent with the Department of Homeland Security’s Target Capabilities List is also observed. Agency size appears to have a significant effect on key organizational information sharing behaviors. The findings are tempered due to limitations in the research design. Conclusions: Local agencies appear to be tightly-coupled with the recommendations put forth in the National Criminal Intelligence Sharing Plan in their efforts to adopt intelligence-led policing. Agency size appears to enhance adoption across most dependent metrics. This research progresses the limited evidence base and progress regarding this emerging policing philosophy

Modeling Soil Water Contents and Their Effects on Stream Flow in Kentucky

Soil water contents of eight important soil series in Kentucky were measured periodically during the summer growing season for four years, 1977 through 1980. The soils divided into three groups according to their behavior. The first group (Maury and Crider) is well-drained and never showed excess water above field capacity at any time during the four seasons. The second group (Zanesville, Lowell, Calloway, Grenada and Shelbyville) showed perched water tables at times, especially during the early part of the growing season. The third group was represented by the Huntington soil which has a permanent water table. The in-situ field capacity or upper limits was determined on numerous samples of the Maury, Crider and Shelbyville soil series. Variation within series was rather low, indicating that samples taken at one site are representative of the soil in general. A model for estimating the soil water in each 15 cm layer was developed and proved to work very well with both Maury and Crider soils. Lowell soil was predicted poorly by the model, with other soils being intermediate. A variation of the model which assumed that the lowest layer of the Huntington was always at the upper limit due to a permanent water table also worked well. The water calculated from the model as deep drainage was used as a measure of increase in streamflow and compared to measured streamflow on three watersheds and four soils in 1978 and 1979. The R2 values ranged from 0.41 to 0.95 and the slope, which ideally should be 1.0, ranged from 0.54 to 1.36. The quantitative measure of streamflow was not satisfactory but the prediction of events was quite good. Modifications in the model that seem to be required include provisions for evaporation from foliage with small rains, higher evapotranspiration at lower soil water contents, less deep drainage with small rains and an aquifer storage factor

Seismic Imaging Of The Velocity Structure And The Location Of A Hydrofrac In A Geothermal Reservoir

The Los Alamos Hot Dry Rock Reservoir is an experimental geothermal project in north-central New Mexico. A fractured zone was created within otherwise impermeable igneous and metamorphic rock by injecting water into a borehole under high pressure, at about 3.5 km depth. During the injection process, the seismic waves created by the fracturing events were recorded by seismometers located in four nearby boreholes. A subset of the arrival times from these microearthquakes is iteratively inverted for the three-dimensional P-wave and S-wave velocity structures and the hypocenter parameters, using the separation of parameters technique. The inversion results indicate that the P-wave and S-wave velocities decrease by at least 20% within the fractured zone. Also, the hypocenters are rotated into a more compact distribution, elative to the initiallocations found using a homogeneous velocity model, suggesting that the hypocenter locations are significantly improved.United States. Dept. of Energy (Grant DE-FG02-86ER136360)Massachusetts Institute of Technology. Full Waveform Acoustic Logging ConsortiumPhillips Petroleum Fellowshi

The Direct Medical Costs of Undiagnosed Chronic Obstructive Pulmonary Disease

AbstractObjectiveTo estimate the costs of undiagnosed chronic obstructive pulmonary disease (COPD) by describing inpatient, outpatient, and pharmacy utilization in the years before and after the diagnosis.MethodsA total of 6864 patients who were enrolled in the Lovelace Health Plan for at least 12 months during the study period (January 1, 1999 through December 31, 2004) were identified. The first date that utilization was attributed to COPD was considered the first date of diagnosis. Each COPD case was matched to up to three age- and sex-matched controls. All utilization and direct medical costs during the study period were compiled monthly and compared based on the time before and after the initial diagnosis.ResultsTotal costs were higher by an average of $1182 per patient in the 2 years before the initial COPD diagnosis, and$2489 in the 12 months just before the initial diagnosis, compared to matched controls. Most of the higher cost for undiagnosed COPD was attributable to hospitalizations. Inpatient costs did not increase after the diagnosis was made, but approximately one-third of admissions after the diagnosis were attributed to respiratory disease. Outpatient and pharmacy costs did not differ substantially between cases and matched controls until just a few months before the initial diagnosis, but remained 50% to 100% higher than for controls in the 2 years after diagnosis.ConclusionsUndiagnosed COPD has a substantial impact on health-care costs and utilization in this integrated managed care system, particularly for hospitalizations

Neural responses to facial and vocal expressions of fear and disgust

Neuropsychological studies report more impaired responses to facial expressions of fear than disgust in people with amygdala lesions, and vice versa in people with Huntington's disease. Experiments using functional magnetic resonance imaging (fMRI) have confirmed the role of the amygdala in the response to fearful faces and have implicated the anterior insula in the response to facial expressions of disgust. We used fMRI to extend these studies to the perception of fear and disgust from both facial and vocal expressions. Consistent with neuropsychological findings, both types of fearful stimuli activated the amygdala. Facial expressions of disgust activated the anterior insula and the caudate-putamen; vocal expressions of disgust did not significantly activate either of these regions. All four types of stimuli activated the superior temporal gyrus. Our findings therefore (i) support the differential localization of the neural substrates of fear and disgust; (ii) confirm the involvement of the amygdala in the emotion of fear, whether evoked by facial or vocal expressions; (iii) confirm the involvement of the anterior insula and the striatum in reactions to facial expressions of disgust; and (iv) suggest a possible general role for the perception of emotional expressions for the superior temporal gyrus

Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise

<p>Abstract</p> <p>Background</p> <p>The thermogenic and metabolic properties of capsinoids appear to mimic those of the more pungent sister compound capsaicin. However, few data exist on how capsinoid ingestion affects energy expenditure in humans and no data exist on its interaction with exercise. We aimed to determine how ingestion of capsinoids affected energy expenditure, lipid oxidation and blood metabolites at rest and during moderate intensity exercise.</p> <p>Methods</p> <p>Twelve healthy young men (age = 24.3 ± 3 yr, BMI = 25.5 ± 1.7 kg·m^-2) were studied on two occasions in a double-blind design following ingestion of either placebo or 10 mg of purified capsinoids at rest, after 90 min of cycling at 55% VO₂peak, and for 30 min into recovery. Subjects ingested the capsules 30 min prior to exercise.</p> <p>Results</p> <p>At rest, following ingestion of capsinoids, we observed increases in VO₂and plasma norepinephrine levels, and decreases in concentrations of serum free fatty acids, plasma glycerol and the respiratory exchange ratio (all P < 0.05). At exercise onset, we observed a blunted accumulation of blood lactate with capsinoid ingestion vs. placebo (P < 0.05). There were no other significant differences between the conditions during or post-exercise.</p> <p>Conclusion</p> <p>The ingestion of 10 mg of capsinoids increased adrenergic activity, energy expenditure, and resulted in a shift in substrate utilization toward lipid at rest but had little effect during exercise or recovery. The changes we observed confirm previous data on the thermogenic and metabolic effects of capsinoids at rest and further promote its potential role as an adjunct weight loss aid, in addition to diet and exercise.</p