Acute complete heart block in dogs

A study has been conducted immediately and up to 18 days after the surgical production of complete heart block in dogs. Immediately after surgery cardiac output, coronary flow, and mean arterial pressure were reduced in rough proportion to the degree of bradycardia. In time, these measures began to return toward preoperative levels. Paralleling the diminished left ventricular work was a diminished left ventricular oxygen consumption with little consequent change in myocardial efficiency. Small rises were detected in central venous pressure. At autopsy, the only unequivocal abnormality was myocardial hypertrophy which became measurable between 2 and 18 days after operation

John Y. Templeton III: Pioneer of modern cardiothoracic surgery.

John Young Templeton III was born in 1917 in Portsmouth, Virginia, and graduated from Jefferson Medical College in 1941. He completed his residency training under Dr. John H. Gibbon, Jr., and was the first resident who worked on Gibbon\u27s heart-lung machine. After his training, he remained at Jefferson as an American Cancer Society fellow and Damon Runyon fellow and went on to become the fourth Samuel D. Gross Professor and Chair of the Department of Surgery in 1967. Dr. Templeton was the recipient of numerous grants and published over 80 papers in the field of cardiothoracic surgery. As a teacher and mentor, he was a beloved figure who placed great faith in his residents. He participated in over 60 professional societies, serving as president to many such as the Philadelphia Academy of Surgery and the Pennsylvania Association of Thoracic Surgery. He was also recognized through his many awards, in particular the John Y. Templeton III lectureship established in 1980 at Jefferson of whom Denton Cooley was the first lecturer. Dr. Templeton retired from practice in 1987. He is forever remembered as an important model of a modern surgeon evident in numerous academic achievements, the admiration and affection of his trainees, and the lives of patients that he had touched

Dimers on two-dimensional lattices

We consider close-packed dimers, or perfect matchings, on two-dimensional regular lattices. We review known results and derive new expressions for the free energy, entropy, and the molecular freedom of dimers for a number of lattices including the simple-quartic (4^4), honeycomb (6^3), triangular (3^6), kagome (3.6.3.6), 3-12 (3.12^2) and its dual [3.12^2], and 4-8 (4.8^2) and its dual Union Jack [4.8^2] Archimedean tilings. The occurrence and nature of phase transitions are also analyzed and discussed.Comment: Typos corrections in Eqs. (28), (32) and (43

ViTac: Feature Sharing between Vision and Tactile Sensing for Cloth Texture Recognition

Vision and touch are two of the important sensing modalities for humans and they offer complementary information for sensing the environment. Robots could also benefit from such multi-modal sensing ability. In this paper, addressing for the first time (to the best of our knowledge) texture recognition from tactile images and vision, we propose a new fusion method named Deep Maximum Covariance Analysis (DMCA) to learn a joint latent space for sharing features through vision and tactile sensing. The features of camera images and tactile data acquired from a GelSight sensor are learned by deep neural networks. But the learned features are of a high dimensionality and are redundant due to the differences between the two sensing modalities, which deteriorates the perception performance. To address this, the learned features are paired using maximum covariance analysis. Results of the algorithm on a newly collected dataset of paired visual and tactile data relating to cloth textures show that a good recognition performance of greater than 90% can be achieved by using the proposed DMCA framework. In addition, we find that the perception performance of either vision or tactile sensing can be improved by employing the shared representation space, compared to learning from unimodal data

Temperature Effects on Threshold Counterion Concentration to Induce Aggregation of fd Virus

We seek to determine the mechanism of like-charge attraction by measuring the temperature dependence of critical divalent counterion concentration ($\rm{C_{c}}$) for the aggregation of fd viruses. We find that an increase in temperature causes $\rm{C_c}$ to decrease, primarily due to a decrease in the dielectric constant ($\epsilon$) of the solvent. At a constant $\epsilon$, $\rm{C_c}$ is found to increase as the temperature increases. The effects of $T$ and $\epsilon$ on $\rm {C_{c}}$ can be combined to that of one parameter: Bjerrum length ($l_{B}$). $\rm{C_{c}}$ decreases exponentially as $l_{B}$ increases, suggesting that entropic effect of counterions plays an important role at the onset of bundle formation.Comment: 12 pages, 3 figure

Faint X-ray Sources in the Globular Cluster Terzan 5

We report our analysis of a Chandra X-ray observation of the rich globular cluster Terzan 5, in which we detect 50 sources to a limiting 1.0-6 keV X-ray luminosity of 3*10^{31} ergs/s within the half-mass radius of the cluster. Thirty-three of these have L_X>10^{32} ergs/s, the largest number yet seen in any globular cluster. In addition to the quiescent low-mass X-ray binary (LMXB, identified by Wijnands et al.), another 12 relatively soft sources may be quiescent LMXBs. We compare the X-ray colors of the harder sources in Terzan 5 to the Galactic Center sources studied by Muno and collaborators, and find the Galactic Center sources to have harder X-ray colors, indicating a possible difference in the populations. We cannot clearly identify a metallicity dependence in the production of low-luminosity X-ray binaries in Galactic globular clusters, but a metallicity dependence of the form suggested by Jordan et al. for extragalactic LMXBs is consistent with our data.Comment: 15 pages, 10 figures (3 color). Resubmitted to ApJ after incorporating referee comments. v2: Added references to introductio

Submillimeter satellite radiometer Final engineering report

All solid-state superheterodyne Dicke radiometer for submillimeter wavelength

Cabozantinib in hepatocellular carcinoma: results of a phase 2 placebo-controlled randomized discontinuation study.

BackgroundCabozantinib, an orally bioavailable inhibitor of tyrosine kinases including MET, AXL, and VEGF receptors, was assessed in patients with hepatocellular carcinoma (HCC) as part of a phase 2 randomized discontinuation trial with nine tumor-type cohorts.Patients and methodsEligible patients had Child-Pugh A liver function and ≤1 prior systemic anticancer regimen, completed ≥4 weeks before study entry. The cabozantinib starting dose was 100 mg daily. After an initial 12-week cabozantinib treatment period, patients with stable disease (SD) per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.0 were randomized to cabozantinib or placebo. The primary endpoint of the lead-in stage was objective response rate (ORR) at week 12, and the primary endpoint of the randomized stage was progression-free survival (PFS).ResultsAmong the 41 HCC patients enrolled, the week 12 ORR was 5%, with 2 patients achieving a confirmed partial response (PR). The week 12 disease control rate (PR or SD) was 66% (Asian subgroup: 73%). Of patients with ≥1 post-baseline scan, 78% had tumor regression, with no apparent relationship to prior sorafenib therapy. Alpha-fetoprotein (AFP) response (>50% reduction from baseline) occurred in 9 of the 26 (35%) patients with elevated baseline AFP and ≥1 post-baseline measurement. Twenty-two patients with SD at week 12 were randomized. Median PFS after randomization was 2.5 months with cabozantinib and 1.4 months with placebo, although this difference was not statistically significant. Median PFS and overall survival from Day 1 in all patients were 5.2 and 11.5 months, respectively. The most common grade 3/4 adverse events, regardless of attribution, were diarrhea (20%), hand-foot syndrome (15%), and thrombocytopenia (15%). Dose reductions were utilized in 59% of patients.ConclusionsCabozantinib has clinical activity in HCC patients, including objective tumor responses, disease stabilization, and reductions in AFP. Adverse events were managed with dose reductions.Trial registration numberNCT00940225

Hole Localization in Underdoped Superconducting Cuprates Near 1/8th Doping

Measurements of thermal conductivity versus temperature over a broad range of doping in YBa$_2$Cu$_3$O$_{6+x}$ and HgBa$_2$Ca$_{n-1}$Cu$_n$O$_{2n+2+\delta}$ ($n$=1,2,3) suggest that small domains of localized holes develop for hole concentrations near $p$=1/8. The data imply a mechanism for localization that is intrinsic to the CuO$_2$-planes and is enhanced via pinning associated with oxygen-vacancy clusters.Comment: 4 pages, 4 eps fig.'s, to be published, Phys. Rev.