895 research outputs found
The Self Model and the Conception of Biological Identity in Immunology
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity
Discovery of an Optical Jet in the BL Lac Object 3C 371
We have detected an optical jet in the BL Lac object 3C 371 that coincides
with the radio jet in this object in the central few kpc. The most notable
feature is a bright optical knot 3 arcsec (4 kpc) from the nucleus that occurs
at the location where the jet apparently changes its direction by ~30 degrees.
The radio, near-infrared and optical observations of this knot are consistent
with a single power-law spectrum with a radio-optical spectral index alpha =
-0.81. One possible scenario for the observed turn is that the jet is
interacting with the material in the bridge connecting 3C 371 to nearby
galaxies and the pressure gradient is deflecting the jet significantly.Comment: 11 pages, LaTeX, 4 figures (1 eps, 3 gifs), accepted for publication
in ApJ Letter
A statistical mechanics approach to autopoietic immune networks
The aim of this work is to try to bridge over theoretical immunology and
disordered statistical mechanics. Our long term hope is to contribute to the
development of a quantitative theoretical immunology from which practical
applications may stem. In order to make theoretical immunology appealing to the
statistical physicist audience we are going to work out a research article
which, from one side, may hopefully act as a benchmark for future improvements
and developments, from the other side, it is written in a very pedagogical way
both from a theoretical physics viewpoint as well as from the theoretical
immunology one.
Furthermore, we have chosen to test our model describing a wide range of
features of the adaptive immune response in only a paper: this has been
necessary in order to emphasize the benefit available when using disordered
statistical mechanics as a tool for the investigation. However, as a
consequence, each section is not at all exhaustive and would deserve deep
investigation: for the sake of completeness, we restricted details in the
analysis of each feature with the aim of introducing a self-consistent model.Comment: 22 pages, 14 figur
The Spectroscopic Orbit of the Planetary Companion Transiting HD209458
We report a spectroscopic orbit with period P = 3.52433 +/- 0.00027 days for
the planetary companion that transits the solar-type star HD209458. For the
metallicity, mass, and radius of the star we derive [Fe/H] = 0.00 +/- 0.02, M =
1.1 +/- 0.1 solar masses, and R = 1.3 +/- 0.1 solar radii. This is based on a
new analysis of the iron lines in our HIRES template spectrum, and also on the
absolute magnitude and color of the star, and uses isochrones from four
different sets of stellar evolution models. Using these values for the stellar
parameters we reanalyze the transit data and derive an orbital inclination of i
= 85.2 +/- 1.4 degrees. For the planet we derive a mass of Mp = 0.69 +/- 0.05
Jupiter masses, a radius of Rp = 1.54 +/- 0.18 Jupiter radii, and a density of
0.23 +/- 0.08 grams per cubic cm.Comment: 11 pages, 1 figure, 2 tables, LaTex, aastex, accepted for publication
by ApJ Letter
The role of the microbiome in the neurobiology of social behaviour
Microbes colonise all multicellular life, and the gut microbiome has been shown to influence a range of host physiological and behavioural phenotypes. One of the most intriguing and least understood of these influences lies in the domain of the microbiome's interactions with host social behaviour, with new evidence revealing that the gut microbiome makes important contributions to animal sociality. However, little is known about the biological processes through which the microbiome might influence host social behaviour. Here, we synthesise evidence of the gut microbiome's interactions with various aspects of host sociality, including sociability, social cognition, social stress, and autism. We discuss evidence of microbial associations with the most likely physiological mediators of animal social interaction. These include the structure and function of regions of the 'social' brain (the amygdala, the prefrontal cortex, and the hippocampus) and the regulation of 'social' signalling molecules (glucocorticoids including corticosterone and cortisol, sex hormones including testosterone, oestrogens, and progestogens, neuropeptide hormones such as oxytocin and arginine vasopressin, and monoamine neurotransmitters such as serotonin and dopamine). We also discuss microbiome-associated host genetic and epigenetic processes relevant to social behaviour. We then review research on microbial interactions with olfaction in insects and mammals, which contribute to social signalling and communication. Following these discussions, we examine evidence of microbial associations with emotion and social behaviour in humans, focussing on psychobiotic studies, microbe-depression correlations, early human development, autism, and issues of statistical power, replication, and causality. We analyse how the putative physiological mediators of the microbiome-sociality connection may be investigated, and discuss issues relating to the interpretation of results. We also suggest that other candidate molecules should be studied, insofar as they exert effects on social behaviour and are known to interact with the microbiome. Finally, we consider different models of the sequence of microbial effects on host physiological development, and how these may contribute to host social behaviour.Peer reviewe
Multifrequency Radiation of Extragalactic Large-Scale Jets
Large-scale extragalactic jets, observed to extend from a few to a few
hundred kiloparsecs from active galactic nuclei, are now studied over many
decades in frequency of electromagnetic spectrum, from radio until (possibly)
TeV gamma rays. For hundreds of known radio jets, only about 25 are observed at
optical frequencies. Most of them are relatively short and faint, with only a
few exceptions, like 3C 273 or M 87, allowing for detailed spectroscopic and
morphological studies. Somewhat surprisingly, the large-scale jets can be very
prominent in X-rays. Up to now, about 25 jets were detected within the 1 - 10
keV energy range, although the nature of this emission is still under debate.
In general, both optical and X-ray jet observations present serious problems
for standard radiation models for the considered objects. Recent TeV
observations of M 87 suggest the possibility of generating large photon fluxes
at these high energies by its extended jet.
In this paper we summarize information about multiwavelength emission of the
large-scale jets, and we point out several modifications of the standard jet
radiation models (connected with relativistic bulk velocities, jet radial
stratification and particle energization all the way along the jet), which can
possibly explain some of the mentioned puzzling observations. We also comment
on gamma-ray emission of the discussed objects.Comment: 29 pages. Modified version, accepted for publication in Chinese
Journal of Astronomy and Astrophysic
The Present State of Liver Transplantation and the Future Prospects for Intestinal Transplantation
Ancient Origins of a Modern Anthropic Cosmological Argument
Ancient origins of a modern anthropic argument against cosmologies involving
infinite series of past events are considered. It is shown that this argument -
which in modern times has been put forward by distinguished cosmologists like
Paul C. W. Davies and Frank J. Tipler - originates in pre-Socratic times and is
implicitly present in the cyclical cosmology of Empedocles. There are traces of
the same line of reasoning throughout the ancient history of ideas, and the
case of a provocative statement of Thucydides is briefly analyzed. Moreover,
the anthropic argument has been fully formulated in the epic of Lucretius,
confirming it as the summit of ancient cosmology. This is not only of
historical significance but presents an important topic for the philosophy of
cosmology provided some of the contemporary inflationary models, particularly
Linde's chaotic inflation, turn out to be correct.Comment: 11 pages, no figures; Astronomical and Astrophysical Transactions,
accepte
Direct constraint on the distance of y2 Velorum from AMBER/VLTI observations
In this work, we present the first AMBER observations, of the Wolf-Rayet and
O (WR+O) star binary system y2 Velorum. The AMBER instrument was used with the
telescopes UT2, UT3, and UT4 on baselines ranging from 46m to 85m. It delivered
spectrally dispersed visibilities, as well as differential and closure phases,
with a resolution R = 1500 in the spectral band 1.95-2.17 micron. We interpret
these data in the context of a binary system with unresolved components,
neglecting in a first approximation the wind-wind collision zone flux
contribution. We show that the AMBER observables result primarily from the
contribution of the individual components of the WR+O binary system. We discuss
several interpretations of the residuals, and speculate on the detection of an
additional continuum component, originating from the free-free emission
associated with the wind-wind collision zone (WWCZ), and contributing at most
to the observed K-band flux at the 5% level. The expected absolute separation
and position angle at the time of observations were 5.1±0.9mas and
66±15° respectively. However, we infer a separation of
3.62+0.11-0.30 mas and a position angle of 73+9-11°. Our analysis thus
implies that the binary system lies at a distance of 368+38-13 pc, in agreement
with recent spectrophotometric estimates, but significantly larger than the
Hipparcos value of 258+41-31 pc
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