138 research outputs found
Nonlinear dielectric effect of dipolar fluids
The nonlinear dielectric effect for dipolar fluids is studied within the
framework of the mean spherical approximation (MSA) of hard core dipolar Yukawa
fluids. Based on earlier results for the electric field dependence of the
polarization our analytical results show so-called normal saturation effects
which are in good agreement with corresponding NVT ensemble Monte Carlo
simulation data. The linear and the nonlinear dielectric permittivities
obtained from MC simulations are determined from the fluctuations of the total
dipole moment of the system in the absence of an applied electric field. We
compare the MSA based theoretical results with the corresponding Langevin and
Debye-Weiss behaviors.Comment: 10 pages including 4 figure
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
Oral estrogen administration attenuates the metabolic action of growth hormone (GH) in humans. To investigate the mechanism involved, we studied the effects of estrogen on GH signaling through Janus kinase (JAK)2 and the signal transducers and activators of transcription (STATs) in HEK293 cells stably expressing the GH receptor (293GHR), HuH7 (hepatoma) and T-47D (breast cancer) cells. 293GHR cells were transiently transfected with an estrogen receptor-α expression plasmid and luciferase reporters with binding elements for STAT3 and STAT5 or the β-casein promoter. GH stimulated the reporter activities by four- to sixfold. Cotreatment with 17β-estradiol (E2) resulted in a dose-dependent reduction in the response of all three reporters to GH to a maximum of 49-66% of control at 100 nM (P < 0.05). No reduction was seen when E2 was added 1-2 h after GH treatment. Similar inhibitory effects were observed in HuH7 and T-47D cells. E2 suppressed GH-induced JAK2 phosphorylation, an effect attenuated by actinomycin D, suggesting a requirement for gene expression. Next, we investigated the role of the suppressors of cytokine signaling (SOCS) in E2 inhibition. E2 increased the mRNA abundance of SOCS-2 but not SOCS-1 and SOCS-3 in HEK293 cells. The inhibitory effect of E2 was absent in cells lacking SOCS-2 but not in those lacking SOCS-1 and SOCS-3. In conclusion, estrogen inhibits GH signaling, an action mediated by SOCS-2. This paper provides evidence for regulatory interaction between a sex steroid and the GH/JAK/STAT pathway, in which SOCS-2 plays a central mechanistic role
Nucleon to Delta Weak Excitation Amplitudes in the Non-relativistic Quark Model
We investigate the nucleon to Delta(1232) vector and axial vector amplitudes
in the non-relativistic quark model of the Isgur-Karl variety. A particular
interest is to investigate the SU(6) symmetry breaking, due to color hyperfine
interaction. We compare the theoretical estimates to recent experimental
investigation of the Adler amplitudes by neutrino scattering.Comment: \documentstyle[aps]{revtex}, 21pages; 11 postscript figures. Accepted
for publication by Phys. Rev.
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