Distorted cyclotron line profile in Cep X-4 as observed by NuSTAR

We present spectral analysis of NuSTAR and Swift observations of Cep X-4 during its outburst in 2014. We observed the source once during the peak of the outburst and once during the decay, finding good agreement in the spectral shape between the observations. We describe the continuum using a powerlaw with a Fermi-Dirac cutoff at high energies. Cep X-4 has a very strong cyclotron resonant scattering feature (CRSF) around 30 keV. A simple absorption-like line with a Gaussian optical depth or a pseudo-Lorentzian profile both fail to describe the shape of the CRSF accurately, leaving significant deviations at the red side of the line. We characterize this asymmetry with a second absorption feature around 19 keV. The line energy of the CRSF, which is not influenced by the addition of this feature, shows a small but significant positive luminosity dependence. With luminosities between (1-6)e36 erg/s, Cep X-4 is below the theoretical limit where such a correlation is expected. This behavior is similar to Vela X-1 and we discuss parallels between the two systems.Comment: 6 pages, 4 figure, accepted for publication in ApJ letter

Possible Detection of an Emission Cyclotron Resonance Scattering Feature from the Accretion-powered Pulsar 4U 1626-67

We present analysis of 4U 1626-67, a 7.7 s pulsar in a low-mass X-ray binary system, observed with the hard X-ray detector of the Japanese X-ray satellite Suzaku in March 2006 for a net exposure of \sim88 ks. The source was detected at an average 10-60 keV flux of \sim4 x10^-10 erg cm^-2 s^-1. The phase-averaged spectrum is reproduced well by combining a negative and positive power-law times exponential cutoff (NPEX) model modified at \sim 37 keV by a cyclotron resonance scattering feature (CRSF). The phase-resolved analysis shows that the spectra at the bright phases are well fit by the NPEX with CRSF model. On the other hand, the spectrum in the dim phase lacks the NPEX high-energy cutoff component, and the CRSF can be reproduced by either an emission or an absorption profile. When fitting the dim phase spectrum with the NPEX plus Gaussian model, we find that the feature is better described in terms of an emission rather than an absorption profile. The statistical significance of this result, evaluated by means of an F-test, is between 2.91 x 10^-3 and 1.53 x 10^-5, taking into account the systematic errors in the background evaluation of HXD-PIN. We find that, the emission profile is more feasible than the absorption one for comparing the physical parameters in other phases. Therefore, we have possibly detected an emission line at the cyclotron resonance energy in the dim phase.Comment: Accepted for publication in ApJ on March 16, 2012. 12 pages, 14 figure

Bedside Sublingual Video Imaging of Microcirculation in Assessing Bacterial Infection in Cirrhosis

Bacterial infections are common in cirrhosis and can lead to life-threatening complications. Sidestream dark-field (SDF) imaging has recently emerged as a noninvasive tool for capturing real-time video images of sublingual microcirculation in critically ill patients with sepsis. The objective of this study was to assess the utility of SDF in determining underlying infection in patients with cirrhosis. Sublingual microcirculation was compared among patients with compensated cirrhosis (Group A, n = 13), cirrhosis without sepsis (Group B, n = 18), cirrhosis with sepsis (Group C, n = 14), and sepsis only (Group D, n = 10). The blood flow was semi-quantitatively evaluated in four equal quadrants in small (10–25 mm); medium (26–50 mm); and large (51–100 mm) sublingual capillaries. The blood flow was described as no flow (0), intermittent flow (1), sluggish flow (2), and continuous flow (3). The overall flow score or microvascular flow index (MFI) was measured for quantitative assessment of microcirculation and predicting power for concurrent infection in cirrhosis. Marked impairment was observed at all levels of microvasculature in Groups B and C when compared with Group A. This effect was restricted to small vessels only when Group B was compared with Group C. MFI < 1.5 was found to have highest sensitivity (100%) and specificity (100%) for infection in decompensated cirrhosis. SDF imaging of sublingual microcirculation can be a useful bedside diagnostic tool to assess bacterial infection in cirrhosis

Molecular Prognostic Prediction for Locally Advanced Nasopharyngeal Carcinoma by Support Vector Machine Integrated Approach

BACKGROUND:Accurate prognostication of locally advanced nasopharyngeal carcinoma (NPC) will benefit patients for tailored therapy. Here, we addressed this issue by developing a mathematical algorithm based on support vector machine (SVM) through integrating the expression levels of multi-biomarkers. METHODOLOGY/PRINCIPAL FINDINGS:Ninety-seven locally advanced NPC patients in a randomized controlled trial (RCT), consisting of 48 cases serving as training set and 49 cases as testing set of SVM models, with 5-year follow-up were studied. We designed SVM models by selecting the variables from 38 tissue molecular biomarkers, which represent 6 tumorigenesis signaling pathways, and 3 EBV-related serological biomarkers. We designed 3 SVM models to refine prognosis of NPC with 5-year follow-up. The SVM1 displayed highly predictive sensitivity (sensitivity, specificity were 88.0% and 81.9%, respectively) by integrating the expression of 7 molecular biomarkers. The SVM2 model showed highly predictive specificity (sensitivity, specificity were 84.0% and 94.5%, respectively) by grouping the expression level of 12 molecular biomarkers and 3 EBV-related serological biomarkers. The SVM3 model, constructed by combination SVM1 with SVM2, displayed a high predictive capacity (sensitivity, specificity were 88.0% and 90.3%, respectively). We found that 3 SVM models had strong power in classification of prognosis. Moreover, Cox multivariate regression analysis confirmed these 3 SVM models were all the significant independent prognostic model for overall survival in testing set and overall patients. CONCLUSIONS/SIGNIFICANCE:Our SVM prognostic models designed in the RCT displayed strong power in refining patient prognosis for locally advanced NPC, potentially directing future target therapy against the related signaling pathways

Polarization constraints on the X-ray corona in Seyfert Galaxies: MCG-05-23-16

We report on the first observation of a radio-quiet Active Galactic Nucleus (AGN) using polarized X-rays: the Seyfert 1.9 galaxy MCG-05-23-16. This source was pointed with the Imaging X-ray Polarimetry Explorer (IXPE) starting on May 14, 2022 for a net observing time of 486 ks, simultaneously with XMM-Newton (58 ks) and NuSTAR (83 ks). A polarization degree smaller than $\Pi<4.7\%$ (at the 99% c.l.) is derived in the 2-8 keV energy range, where emission is dominated by the primary component ascribed to the hot corona. The broad-band spectrum, inferred from a simultaneous fit to the IXPE, NuSTAR, and XMM-Newton data, is well reproduced by a power law with photon index $\Gamma=1.85\pm0.01$ and a high-energy cutoff $E_{\rm C}=120\pm15$ keV. A comparison with Monte Carlo simulations shows that a lamp-post and a conical geometry of the corona are consistent with the observed upper limit, a slab geometry is allowed only if the inclination angle of the system is less than 50$^{\circ}$.Comment: 7 pages, 3 figures, 1 table. Submitted to MNRAS Letter

Induction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human b cells; relevance to cellular transformation.

Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by physiological stimulation with CD40L plus IL-4. One important difference is that infection leads to the establishment of permanently growing lymphoblastoid cell lines, whereas CD40L/IL-4 blasts have finite proliferation lifespans. To identify early events which might later determine why EBV infected blasts go on to establish transformed cell lines, we performed global transcriptome analyses on resting B cells and on EBV and CD40L/IL-4 blasts after 7 days culture. As anticipated there was considerable overlap in the transcriptomes of the two types of lymphoblasts when compared to the original resting B cells, reflecting common changes associated with lymphocyte activation and proliferation. Of interest to us was a subset of 255 genes that were differentially expressed between EBV and CD40L/IL-4 blasts. Genes which were more highly expressed in EBV blasts were substantially and significantly enriched for a set of interferon-stimulated genes which on further in silico analyses were found to be repressed by IL-4 in other cell contexts and to be up-regulated in micro-dissected malignant cells from Hodgkin's lymphoma biopsies when compared to their normal germinal center cell counterparts. We hypothesized that EBV and IL-4 were targeting and discordantly regulating a common set of genes. This was supported experimentally in our B cell model where IL-4 stimulation partially reversed transcriptional changes which follow EBV infection and it impaired the efficiency of EBV-induced B cell transformation. Taken together, these data suggest that the discordant regulation of interferon and IL-4 pathway genes by EBV that occurs early following infection of B cells has relevance to the development or maintenance of an EBV-associated malignancy

Accretion geometry of the neutron star low mass X-ray binary Cyg X-2 from X-ray polarization measurements

We report spectro-polarimetric results of an observational campaign of the bright neutron star low-mass X-ray binary Cyg X-2 simultaneously observed by IXPE, NICER and INTEGRAL. Consistently with previous results, the broad-band spectrum is characterized by a lower-energy component, attributed to the accretion disc with $kT_{\rm in} \approx$ 1 keV, plus unsaturated Comptonization in thermal plasma with temperature $kT_{\rm e} = 3$ keV and optical depth $\tau \approx 4$, assuming a slab geometry. We measure the polarization degree in the 2-8 keV band $P=1.8 \pm 0.3$ per cent and polarization angle $\phi = 140^{\circ} \pm 4^{\circ}$, consistent with the previous X-ray polarimetric measurements by OSO-8 as well as with the direction of the radio jet which was earlier observed from the source. While polarization of the disc spectral component is poorly constrained with the IXPE data, the Comptonized emission has a polarization degree $P =4.0 \pm 0.7$ per cent and a polarization angle aligned with the radio jet. Our results strongly favour a spreading layer at the neutron star surface as the main source of the polarization signal. However, we cannot exclude a significant contribution from reflection off the accretion disc, as indicated by the presence of the iron fluorescence line.Comment: 10 pages, 7 figures, accepted for publication in MNRA

X-Ray Polarization of BL Lacertae in Outburst

We report the first &gt;99% confidence detection of X-ray polarization in BL Lacertae. During a recent X-ray/γ-ray outburst, a 287 ks observation (2022 November 27-30) was taken using the Imaging X-ray Polarimetry Explorer (IXPE), together with contemporaneous multiwavelength observations from the Neil Gehrels Swift observatory and XMM-Newton in soft X-rays (0.3-10 keV), NuSTAR in hard X-rays (3-70 keV), and optical polarization from the Calar Alto and Perkins Telescope observatories. Our contemporaneous X-ray data suggest that the IXPE energy band is at the crossover between the low- and high-frequency blazar emission humps. The source displays significant variability during the observation, and we measure polarization in three separate time bins. Contemporaneous X-ray spectra allow us to determine the relative contribution from each emission hump. We find &gt;99% confidence X-ray polarization Π 2 - 4 keV = 21.7 − 7.9 + 5.6 % and electric vector polarization angle ψ 2-4keV = −28.°7 ± 8.°7 in the time bin with highest estimated synchrotron flux contribution. We discuss possible implications of our observations, including previous IXPE BL Lacertae pointings, tentatively concluding that synchrotron self-Compton emission dominates over hadronic emission processes during the observed epochs