227 research outputs found
Description and performance of the Langley differential maneuvering simulator
The differential maneuvering simulator for simulating two aircraft or spacecraft operating in a differential mode is described. Tests made to verify that the system could provide the required simulated aircraft motions are given. The mathematical model which converts computed aircraft motions into the required motions of the various projector gimbals is described
Rapid Cooling of the Neutron Star in Cassiopeia A Triggered by Neutron Superfluidity in Dense Matter
We propose that the observed cooling of the neutron star in Cassiopeia A is
due to enhanced neutrino emission from the recent onset of the breaking and
formation of neutron Cooper pairs in the 3P2 channel. We find that the critical
temperature for this superfluid transition is ~0.5x10^9 K. The observed
rapidity of the cooling implies that protons were already in a superconducting
state with a larger critical temperature. Our prediction that this cooling will
continue for several decades at the present rate can be tested by continuous
monitoring of this neutron star.Comment: Revised version, to be published in Phys. Rev. Let
On the Cooling of the Neutron Star in Cassiopeia A
We demonstrate that the high-quality cooling data observed for the young
neutron star in the supernova remnant Cassiopeia A over the past 10 years--as
well as all other reliably known temperature data of neutron stars--can be
comfortably explained within the "nuclear medium cooling" scenario. The cooling
rates of this scenario account for medium-modified one-pion exchange in dense
matter and polarization effects in the pair-breaking formations of superfluid
neutrons and protons. Crucial for the successful description of the observed
data is a substantial reduction of the thermal conductivity, resulting from a
suppression of both the electron and nucleon contributions to it by medium
effects. We also find that possibly in as little as about ten years of
continued observation, the data may tell whether or not fast cooling processes
are active in this neutron star.Comment: 4 pages, 3 figure
Infrared Properties of Cataclysmic Variables from 2MASS: Results from the 2nd Incremental Data Release
Because accretion-generated luminosity dominates the radiated energy of most
cataclysmic variables, they have been ``traditionally'' observed primarily at
short wavelengths. Infrared observations of cataclysmic variables contribute to
the understanding of key system components that are expected to radiate at
these wavelengths, such as the cool outer disk, accretion stream, and secondary
star. We have compiled the J, H, and Ks photometry of all cataclysmic variables
located in the sky coverage of the 2 Micron All Sky Survey (2MASS) 2nd
Incremental Data Release. This data comprises 251 systems with reliably
identified near-IR counterparts and S/N > 10 photometry in one or more of the
three near-IR bands.Comment: 2 pages, including 1 figure. To appear in the proceedings of The
Physics of Cataclysmic Variables and Related Objects, Goettingen, Germany.
For our followup ApJ paper (in press), also see
http://www.ctio.noao.edu/~hoard/research/2mass/index.htm
Next-generation sequencing
Next-generation sequencing (also known as massively parallel sequencing) technologies are revolutionising our ability to characterise cancers at the genomic, transcriptomic and epigenetic levels. Cataloguing all mutations, copy number aberrations and somatic rearrangements in an entire cancer genome at base pair resolution can now be performed in a matter of weeks. Furthermore, massively parallel sequencing can be used as a means for unbiased transcriptomic analysis of mRNAs, small RNAs and noncoding RNAs, genome-wide methylation assays and high-throughput chromatin immunoprecipitation assays. Here, I discuss the potential impact of this technology on breast cancer research and the challenges that come with this technological breakthrough
Genetic Association for Renal Traits among Participants of African Ancestry Reveals New Loci for Renal Function
Chronic kidney disease (CKD) is an increasing global public health concern, particularly among populations of African ancestry. We performed an interrogation of known renal loci, genome-wide association (GWA), and IBC candidate-gene SNP association analyses in African Americans from the CARe Renal Consortium. In up to 8,110 participants, we performed meta-analyses of GWA and IBC array data for estimated glomerular filtration rate (eGFR), CKD (eGFR <60 mL/min/1.73 m2), urinary albumin-to-creatinine ratio (UACR), and microalbuminuria (UACR >30 mg/g) and interrogated the 250 kb flanking region around 24 SNPs previously identified in European Ancestry renal GWAS analyses. Findings were replicated in up to 4,358 African Americans. To assess function, individually identified genes were knocked down in zebrafish embryos by morpholino antisense oligonucleotides. Expression of kidney-specific genes was assessed by in situ hybridization, and glomerular filtration was evaluated by dextran clearance. Overall, 23 of 24 previously identified SNPs had direction-consistent associations with eGFR in African Americans, 2 of which achieved nominal significance (UMOD, PIP5K1B). Interrogation of the flanking regions uncovered 24 new index SNPs in African Americans, 12 of which were replicated (UMOD, ANXA9, GCKR, TFDP2, DAB2, VEGFA, ATXN2, GATM, SLC22A2, TMEM60, SLC6A13, and BCAS3). In addition, we identified 3 suggestive loci at DOK6 (p-value = 5.3×10−7) and FNDC1 (p-value = 3.0×10−7) for UACR, and KCNQ1 with eGFR (p = 3.6×10−6). Morpholino knockdown of kcnq1 in the zebrafish resulted in abnormal kidney development and filtration capacity. We identified several SNPs in association with eGFR in African Ancestry individuals, as well as 3 suggestive loci for UACR and eGFR. Functional genetic studies support a role for kcnq1 in glomerular development in zebrafish
INCITE: A randomised trial comparing constraint induced movement therapy and bimanual training in children with congenital hemiplegia
Background: Congenital hemiplegia is the most common form of cerebral palsy (CP) accounting for 1 in 1300 live births. These children have limitations in capacity to use the impaired upper limb and bimanual coordination deficits which impact on daily activities and participation in home, school and community life. There are currently two diverse intensive therapy approaches. Traditional therapy has adopted a bimanual approach (BIM training) and recently, constraint induced movement therapy (CIMT) has emerged as a promising unimanual approach. Uncertainty remains about the efficacy of these interventions and characteristics of best responders. This study aims to compare the efficacy of CIMT to BIM training to improve outcomes across the ICF for school children with congenital hemiplegia
SOSORT consensus paper: school screening for scoliosis. Where are we today?
This report is the SOSORT Consensus Paper on School Screening for Scoliosis discussed at the 4th International Conference on Conservative Management of Spinal Deformities, presented by SOSORT, on May 2007. The objectives were numerous, 1) the inclusion of the existing information on the issue, 2) the analysis and discussion of the responses by the meeting attendees to the twenty six questions of the questionnaire, 3) the impact of screening on frequency of surgical treatment and of its discontinuation, 4) the reasons why these programs must be continued, 5) the evolving aim of School Screening for Scoliosis and 6) recommendations for improvement of the procedure
Constitutive modelling of skin ageing
The objective of this chapter is to review the main biomechanical and structural aspects associated with both intrinsic and extrinsic skin ageing, and to present potential research avenues to account for these effects in mathematical and computational models of the skin. This will be illustrated through recent work of the authors which provides a basis to those interested in developing mechanistic constitutive models capturing the mechanobiology of skin across the life course
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