Assessing the Distraction Potential of Changeable Highway Message Signs

Two experiments were conducted to assess how changeable message signs (CMS) within the right-of-way affect driver behavior and attention. Experiment 1 evaluated whether repeated exposure to irrelevant messages would cause drivers to fail to respond to a safety critical message. Experiment 2 evaluated whether the presence of a driving irrelevant message designed to attract attention would cause drivers to fail to respond to a hazard in the roadway. In both experiments, drivers completed a lengthy (about 50 min) driving simulation in a freeway scenario with CMS every 0.8 km (0.5 mi). Dependent measures were gaze location, response to safety critical message (Exp. 1), and response to spilled load in roadway (Exp. 2). It was found that (1) when headways were short, drivers tend to focus on the roadway and not on a CMS; (2) repeated exposure to irrelevant messages did not cause drivers to miss safety critical messages; (3) salient CMS images (changing faces) did not cause failures to detect a roadway hazard, and (4) the frequency and duration of looks to salient images and travel time messages were similar

L\'evy Distribution of Single Molecule Line Shape Cumulants in Low Temperature Glass

We investigate the distribution of single molecule line shape cumulants, $\kappa_1,\kappa_2,...$, in low temperature glasses based on the sudden jump, standard tunneling model. We find that the cumulants are described by L\'evy stable laws, thus generalized central limit theorem is applicable for this problem.Comment: 5 pages, 3 figure

Physical characteristics underpinning repetitive lunging in fencing

Given the repetitive demand to execute lunging and changes in direction within fencing, the ability to sustain these at maximal capacity is fundamental to performance. The aim of this study was threefold. Firstly to provide normative values for this variable referred to as repeat lunge ability (RLA) and secondly to identify the physical characteristics that underpin it. Thirdly, was to establish if a cause and effect relationship existed by training the associated characteristics. Assessment of lower body power, reactive strength, speed, change of direction speed (CODS) and a sport specific RLA were conducted on senior and junior elite male fencers (n = 36). Fencers were on average (± SD) 18.9 ± 3.2 years of age, 174.35 ± 10.42 cm tall, 70.67 ± 7.35 kg in mass, and 8.5 ± 4.2 years fencing experience. The RLA test had average work times of 16.03 s ± 1.40 and demonstrated "large" to "very large" associations with all tested variables, but in particular CODS (r = .70) and standing broad jump (SBJ; r = -68). Through linear regression analysis, these also provided a two-predictor model accounting for 61% of the common variance associated with RLA. A cause and effect relationship with SBJ and CODS was confirmed by the training group, where RLA performance in these fencers improved from 15.80 ± 1.07 s to 14.90 ± 0.86 s, with the magnitude of change reported as "moderate" (ES = 0.93). Concurrent improvements were also noted in both SBJ (216.86 cm ± 17.15 vs. 221.71 ± 17.59 cm) and CODS (4.44 ± 0.29 s s. 4.31 ± 0.09 s) and while differences were only significant in SBJ, magnitudes of change were classed as "small" (ES = 0.28) and "moderate" (ES = 0.61)respectively. In conclusion, to improve RLA strength and conditioning coaches should focus on improving lower-body power and reactive strength, noting that jump training and plyometrics designed to enhance horizontal propulsion may be most effective, and translate to improvement in CODS also

Selecting stimuli parameters for video quality studies based on perceptual similarity distances

This work presents a methodology to optimize the selection of multiple parameter levels of an image acquisition, degradation, or post-processing process applied to stimuli intended to be used in a subjective image or video quality assessment (QA) study. It is known that processing parameters (e.g. compression bit-rate) or technical quality measures (e.g. peak signal-to-noise ratio, PSNR) are often non-linearly related to human quality judgment, and the model of either relationship may not be known in advance. Using these approaches to select parameter levels may lead to an inaccurate estimate of the relationship between the parameter and subjective quality judgments – the system’s quality model. To overcome this, we propose a method for modeling the relationship between parameter levels and perceived quality distances using a paired comparison parameter selection procedure in which subjects judge the perceived similarity in quality. Our goal is to enable the selection of evenly sampled parameter levels within the considered quality range for use in a subjective QA study. This approach is tested on two applications: (1) selection of compression levels for laparoscopic surgery video QA study, and (2) selection of dose levels for an interventional X-ray QA study. Subjective scores, obtained from the follow-up single stimulus QA experiments conducted with expert subjects who evaluated the selected bit-rates and dose levels, were roughly equidistant in the perceptual quality space - as intended. These results suggest that a similarity judgment task can help select parameter values corresponding to desired subjective quality levels

The PROP1 2-Base Pair Deletion Is a Common Cause of Combined Pituitary Hormone Deficiency

Combined pituitary hormone deficiency (CPHD) has an incidence of approximately 1 in 8000 births. Although the proportion of familial CPHD cases is unknown, about 10% have an affected first degree relative. We have recently reported three mutations in the PROP1 gene that cause CPHD in human subjects. We report here the frequency of one of these mutations, a 301–302delAG deletion in exon 2 of PROP1, in 10 independently ascertained CPHD kindreds and 21 sporadic cases of CPHD from 8 different countries. Our results show that 55% (11 of 20) of PROP1 alleles have the 301–302delAG deletion in familial CPHD cases. Interestingly, although only 12% (5 of 42) of the PROP1 alleles of our 21 sporadic cases were 301–302delAG, the frequency of this allele (in 20 of 21 of the sporadic subjects given TRH stimulation tests) was 50% (3 of 6) and 0% (0 of 34) in the CPHD cases with pituitary and hypothalamic defects, respectively. Using whole genome radiation hybrid analysis, we localized the PROP1 gene to the distal end of chromosome 5q and identified a tightly linked polymorphic marker, D5S408, which can be used in segregation studies. Analysis of this marker in affected subjects with the 301–302delAG deletion suggests that rather than being inherited from a common founder, the 301–302delAG may be a recurring mutation

Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver

Developmental changes in the liver can significantly impact drug disposition. Due to the emergence of microRNAs (miRNAs) as important regulators of drug disposition gene expression, we studied age-dependent changes in miRNA expression. Expression of 533 miRNAs was measured in 90 human liver tissues (fetal, pediatric [1-17 years], and adult [28-80 years]; n = 30 each). In all, 114 miRNAs were upregulated and 72 were downregulated from fetal to pediatric, and 2 and 3, respectively, from pediatric to adult. Among the developmentally changing miRNAs, 99 miRNA-mRNA interactions were predicted or experimentally validated (e.g., hsa-miR-125b-5p-CYP1A1; hsa-miR-34a-5p-HNF4A). In human liver samples (n = 10 each), analyzed by RNA-sequencing, significant negative correlations were observed between the expression of >1,000 miRNAs and mRNAs of drug disposition and regulatory genes. Our data suggest a mechanism for the marked changes in hepatic gene expression between the fetal and pediatric developmental periods, and support a role for these age-dependent miRNAs in regulating drug disposition

Photofission of heavy nuclei at energies up to 4 GeV

Total photofission cross sections for 238U, 235U, 233U, 237Np, 232Th, and natPb have been measured simultaneously, using tagged photons in the energy range Egamma=0.17-3.84 GeV. This was the first experiment performed using the Photon Tagging Facility in Hall B at Jefferson Lab. Our results show that the photofission cross section for 238U relative to that for 237Np is about 80%, implying the presence of important processes that compete with fission. We also observe that the relative photofission cross sections do not depend strongly on the incident photon energy over this entire energy range. If we assume that for 237Np the photofission probability is equal to unity, we observe a significant shadowing effect starting below 1.5 GeV.Comment: 4 pages of RevTex, 6 postscript figures, Submitted to Phys. Rev. Let