4,992 research outputs found
AutoAD II: The Sequel - who, when, and what in movie audio description
Audio Description (AD) is the task of generating descriptions of visual content, at suitable time intervals, for the benefit of visually impaired audiences. For movies, this presents notable challenges -- AD must occur only during existing pauses in dialogue, should refer to characters by name, and ought to aid understanding of the storyline as a whole. To this end, we develop a new model for automatically generating movie AD, given CLIP visual features of the frames, the cast list, and the temporal locations of the speech; addressing all three of the `who', `when', and `what' questions: (i) who -- we introduce a character bank consisting of the character's name, the actor that played the part, and a CLIP feature of their face, for the principal cast of each movie, and demonstrate how this can be used to improve naming in the generated AD; (ii) when -- we investigate several models for determining whether an AD should be generated for a time interval or not, based on the visual content of the interval and its neighbours; and (iii) what -- we implement a new vision-language model for this task, that can ingest the proposals from the character bank, whilst conditioning on the visual features using cross-attention, and demonstrate how this improves over previous architectures for AD text generation in an apples-to-apples comparison
Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels
Filariases are diseases caused by arthropod-borne filaria nematodes. The related pathologies depend on the location of the infective larvae when their migration, the asymptomatic and least studied phase of the disease, comes to an end. To determine factors assisting in filariae dissemination, we image Litomosoides sigmodontis infective larvae during their escape from the skin. Burrowing through the dermis filariae exclusively enter pre-collecting lymphatics by mechanical disruption of their wall. Once inside collectors, their rapid and unidirectional movement towards the lymph node is supported by the morphology of lymphatic valves. In a microfluidic maze mimicking lymphatic vessels, filariae follow the direction of the flow, the first biomechanical factor capable of helminth guidance within the host. Finally, non-infective nematodes that rely on universal morpho-physiological cues alone also migrate through the dermis, and break in lymphatics, indicating that the ability to spread by the lymphatic route is an ancestral trait rather than acquired parasitic adaptation
Effect of magnetic state on the transition in iron: First-principle calculations of the Bain transformation path
Energetics of the fcc () - bcc () lattice transformation by
the Bain tetragonal deformation is calculated for both magnetically ordered and
paramagnetic (disordered local moment) states of iron. The first-principle
computational results manifest a relevance of the magnetic order in a scenario
of the - transition and reveal a special role of the Curie
temperature of -Fe, , where a character of the transformation is
changed. At a cooling down to the temperatures one can expect that
the transformation is developed as a lattice instability whereas for
it follows a standard mechanism of creation and growth of an embryo of the new
phase. It explains a closeness of to the temperature of start of the
martensitic transformation, .Comment: 4 pages, 3 figures, submitted in Phys. Rev. Letter
Tumor site immune markers associated with risk for subsequent basal cell carcinomas.
BackgroundBasal cell carcinoma (BCC) tumors are the most common skin cancer and are highly immunogenic.ObjectiveThe goal of this study was to assess how immune-cell related gene expression in an initial BCC tumor biopsy was related to the appearance of subsequent BCC tumors.Materials and methodsLevels of mRNA for CD3Δ (a T-cell receptor marker), CD25 (the alpha chain of the interleukin (IL)-2 receptor expressed on activated T-cells and B-cells), CD68 (a marker for monocytes/macrophages), the cell surface glycoprotein intercellular adhesion molecule-1 (ICAM-1), the cytokine interferon-Îł (IFN-Îł) and the anti-inflammatory cytokine IL-10 were measured in BCC tumor biopsies from 138 patients using real-time PCR.ResultsThe median follow-up was 26.6 months, and 61% of subjects were free of new BCCs two years post-initial biopsy. Patients with low CD3Δ CD25, CD68, and ICAM-1 mRNA levels had significantly shorter times before new tumors were detected (pâ=â0.03, pâ=â0.02, pâ=â0.003, and pâ=â0.08, respectively). Furthermore, older age diminished the association of mRNA levels with the appearance of subsequent tumors.ConclusionsOur results show that levels of CD3Δ, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new BCC tumors
Lattice dynamics and structural stability of ordered Fe3Ni, Fe3Pd and Fe3Pt alloys
We investigate the binding surface along the Bain path and phonon dispersion
relations for the cubic phase of the ferromagnetic binary alloys Fe3X (X = Ni,
Pd, Pt) for L12 and DO22 ordered phases from first principles by means of
density functional theory. The phonon dispersion relations exhibit a softening
of the transverse acoustic mode at the M-point in the L12-phase in accordance
with experiments for ordered Fe3Pt. This instability can be associated with a
rotational movement of the Fe-atoms around the Ni-group element in the
neighboring layers and is accompanied by an extensive reconstruction of the
Fermi surface. In addition, we find an incomplete softening in [111] direction
which is strongest for Fe3 Ni. We conclude that besides the valence electron
density also the specific Fe-content and the masses of the alloying partners
should be considered as parameters for the design of Fe-based functional
magnetic materials.Comment: Revised version, accepted for publication in Physical Review
A Note on D-brane - Anti-D-brane Interactions in Plane Wave Backgrounds
We study aspects of the interaction between a D-brane and an anti-D-brane in
the maximally supersymmetric plane wave background of type IIB superstring
theory, which is equipped with a mass parameter mu. An early such study in flat
spacetime (mu=0) served to sharpen intuition about D-brane interactions,
showing in particular the key role of the ``stringy halo'' that surrounds a
D-brane. The halo marks the edge of the region within which tachyon
condensation occurs, opening a gateway to new non-trivial vacua of the theory.
It seems pertinent to study the fate of the halo for non--zero mu. We focus on
the simplest cases of a Lorentzian brane with p=1 and an Euclidean brane with
p=-1, the D--instanton. For the Lorentzian brane, we observe that the halo is
unaffected by the presence of non--zero mu. This most likely extends to other
(Lorentzian) p. For the Euclidean brane, we find that the halo is affected by
non-zero mu. As this is related to subtleties in defining the exchange
amplitude between Euclidean branes in the open string sector, we expect this to
extend to all Euclidean branes in this background.Comment: 14 pages, LaTeX, 2 eps figures. v2: a reference and some clarifying
remarks added; v3: Considerably revised version; halo unaffected by plane
wave background for Lorentzian branes, but Euclidean branes' halo is modifie
A population Monte Carlo scheme with transformed weights and its application to stochastic kinetic models
This paper addresses the problem of Monte Carlo approximation of posterior
probability distributions. In particular, we have considered a recently
proposed technique known as population Monte Carlo (PMC), which is based on an
iterative importance sampling approach. An important drawback of this
methodology is the degeneracy of the importance weights when the dimension of
either the observations or the variables of interest is high. To alleviate this
difficulty, we propose a novel method that performs a nonlinear transformation
on the importance weights. This operation reduces the weight variation, hence
it avoids their degeneracy and increases the efficiency of the importance
sampling scheme, specially when drawing from a proposal functions which are
poorly adapted to the true posterior.
For the sake of illustration, we have applied the proposed algorithm to the
estimation of the parameters of a Gaussian mixture model. This is a very simple
problem that enables us to clearly show and discuss the main features of the
proposed technique. As a practical application, we have also considered the
popular (and challenging) problem of estimating the rate parameters of
stochastic kinetic models (SKM). SKMs are highly multivariate systems that
model molecular interactions in biological and chemical problems. We introduce
a particularization of the proposed algorithm to SKMs and present numerical
results.Comment: 35 pages, 8 figure
The structure of causal sets
More often than not, recently popular structuralist interpretations of
physical theories leave the central concept of a structure insufficiently
precisified. The incipient causal sets approach to quantum gravity offers a
paradigmatic case of a physical theory predestined to be interpreted in
structuralist terms. It is shown how employing structuralism lends itself to a
natural interpretation of the physical meaning of causal sets theory.
Conversely, the conceptually exceptionally clear case of causal sets is used as
a foil to illustrate how a mathematically informed rigorous conceptualization
of structure serves to identify structures in physical theories. Furthermore, a
number of technical issues infesting structuralist interpretations of physical
theories such as difficulties with grounding the identity of the places of
highly symmetrical physical structures in their relational profile and what may
resolve these difficulties can be vividly illustrated with causal sets.Comment: 19 pages, 4 figure
On d=4,5,6 Vacua with 8 Supercharges
We show how all known N=2, d=4,5,6 maximally supersymmetric vacua (Hpp-waves
and aDSxS solutions) are related through dimensional reduction/oxidation
preserving all the unbroken supersymmetries. In particular we show how the N=2,
d=5 family of vacua (which are the near-horizon geometry of supersymmetric
rotating black holes) interpolates between aDS_2xS^3 and aDS_3xS^2 in parameter
space and how it can be dimensionally reduced to an N=2, d=4 dyonic
Robinson-Bertotti solution with geometry aDS_2xS^2 and oxidized to an N=2, d=6
solution with aDS_3xS^3 geometry (which is the near-horizon of the self-dual
string).Comment: Latex2e, 19 pages, 1 figure. v2: typos corrected, refs. added. v3:
very minor corrections, more refs. added, version to be published in
Classical and Quantum Gravit
Effect of 17 Days of Bed Rest on Peak Isometric Force and Unloaded Shortening Velocity of Human Soleus Fibers
The purpose of this study was to examine the effect of prolonged bed rest (BR) on the peak isometric force (Po) and unloaded shortening velocity (Vo) of single Ca2+-activated muscle fibers. Soleus muscle biopsies were obtained from eight adult males before and after 17 days of 6° head-down BR. Chemically permeabilized single fiber segments were mounted between a force transducer and position motor, activated with saturating levels of Ca2+, and subjected to slack length steps. Vo was determined by plotting the time for force redevelopment vs. the slack step distance. Gel electrophoresis revealed that 96% of the pre- and 87% of the post-BR fibers studied expressed only the slow type I myosin heavy chain isoform. Fibers with diameter \u3e100 ÎŒm made up only 14% of this post-BR type I population compared with 33% of the pre-BR type I population. Consequently, the post-BR type I fibers (n = 147) were, on average, 5% smaller in diameter than the pre-BR type I fibers (n = 218) and produced 13% less absolute Po. BR had no overall effect on Po per fiber cross-sectional area (Po/CSA), even though half of the subjects displayed a decline of 9â12% in Po/CSA after BR. Type I fiber Vo increased by an average of 34% with BR. Although the ratio of myosin light chain 3 to myosin light chain 2 also rose with BR, there was no correlation between this ratio and Vo for either the pre- or post-BR fibers. In separate fibers obtained from the original biopsies, quantitative electron microscopy revealed a 20â24% decrease in thin filament density, with no change in thick filament density. These results raise the possibility that alterations in the geometric relationships between thin and thick filaments may be at least partially responsible for the elevated Vo of the post-BR type I fibers
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