2,721 research outputs found
Capability of Cherenkov Telescopes to Observe Ultra-fast Optical Flares
The large optical reflector (~ 100 m^2) of a H.E.S.S. Cherenkov telescope was
used to search for very fast optical transients of astrophysical origin. 43
hours of observations targeting stellar-mass black holes and neutron stars were
obtained using a dedicated photometer with microsecond time resolution. The
photometer consists of seven photomultiplier tube pixels: a central one to
monitor the target and a surrounding ring of six pixels to veto background
events. The light curves of all pixels were recorded continuously and were
searched offline with a matched-filtering technique for flares with a duration
of 2 us to 100 ms. As expected, many unresolved (500 us)
background events originating in the earth's atmosphere were detected. In the
time range 3 to 500 us the measurement is essentially background-free, with
only eight events detected in 43 h; five from lightning and three presumably
from a piece of space debris. The detection of flashes of brightness ~ 0.1 Jy
and only 20 us duration from the space debris shows the potential of this setup
to find rare optical flares on timescales of tens of microseconds. This
timescale corresponds to the light crossing time of stellar-mass black holes
and neutron stars.Comment: Accepted for publication in Astroparticle Physics, 8 pages, 9
figures, 1 tabl
Updates of the ATLAS Tracking Event Data Model (Release 13)
In a previous document we have presented the ATLAS tracking Event Data Model (EDM) that has been developed during the recent restructuring of the ATLAS offline track reconstruction. The tracking EDM has become a cornerstone of the new modular track reconstruction algorithms of both tracking devices of the ATLAS detector, the Inner Detector and the Muon System. Recently, some components have undergone yet another design evolution targeted at completing missing modules and at establishing anticipated functionality for the startup of the ATLAS experiment. One particular aspect of the EDM is that is does not only have to fulfill the requirements of today's algorithmic modules, but has to provide the flexibility for future developments. This document is based on ATLAS software release 13.0.0
Self-Reported Memory Complaints: Implications from a Longitudinal Cohort with Autopsies
OBJECTIVE: We assessed salience of subjective memory complaints (SMCs) by older individuals as a predictor of subsequent cognitive impairment while accounting for risk factors and eventual neuropathologies.
METHODS: Subjects (n = 531) enrolled while cognitively intact at the University of Kentucky were asked annually if they perceived changes in memory since their last visit. A multistate model estimated when transition to impairment occurred while adjusting for intervening death. Risk factors affecting the timing and probability of an impairment were identified. The association between SMCs and Alzheimer-type neuropathology was assessed from autopsies (n = 243).
RESULTS: SMCs were reported by more than half (55.7%) of the cohort, and were associated with increased risk of impairment (unadjusted odds ratio = 2.8, p \u3c 0.0001). Mild cognitive impairment (dementia) occurred 9.2 (12.1) years after SMC. Multistate modeling showed that SMC reporters with an APOE ε4 allele had double the odds of impairment (adjusted odds ratio = 2.2, p = 0.036). SMC smokers took less time to transition to mild cognitive impairment, while SMC hormone-replaced women took longer to transition directly to dementia. Among participants (n = 176) who died without a diagnosed clinical impairment, SMCs were associated with elevated neuritic amyloid plaques in the neocortex and medial temporal lobe.
CONCLUSION: SMC reporters are at a higher risk of future cognitive impairment and have higher levels of Alzheimer-type brain pathology even when impairment does not occur. As potential harbingers of future cognitive decline, physicians should query and monitor SMCs from their older patients
Mild Cognitive Impairment: Statistical Models of Transition Using Longitudinal Clinical Data
Mild cognitive impairment (MCI) refers to the clinical state between normal cognition and probable Alzheimer's disease (AD), but persons diagnosed with MCI may progress to non-AD forms of dementia, remain MCI until death, or recover to normal cognition. Risk factors for these various clinical changes, which we term “transitions,” may provide targets for therapeutic interventions. Therefore, it is useful to develop new approaches to assess risk factors for these transitions. Markov models have been used to investigate the transient nature of MCI represented by amnestic single-domain and mixed MCI states, where mixed MCI comprised all other MCI subtypes based on cognitive assessments. The purpose of this study is to expand this risk model by including a clinically determined MCI state as an outcome. Analyses show that several common risk factors play different roles in affecting transitions to MCI and dementia. Notably, APOE-4 increases the risk of transition to clinical MCI but does not affect the risk for a final transition to dementia, and baseline hypertension decreases the risk of transition to dementia from clinical MCI
Hippocampal Sclerosis of Aging, a Prevalent and High-Morbidity Brain Disease
Hippocampal sclerosis of aging (HS-Aging) is a causative factor in a large proportion of elderly dementia cases. The current definition of HS-Aging rests on pathologic criteria: neuronal loss and gliosis in the hippocampal formation that is out of proportion to AD-type pathology. HS-Aging is also strongly associated with TDP-43 pathology. HS-Aging pathology appears to be most prevalent in the oldest-old: autopsy series indicate that 5-30 % of nonagenarians have HS-Aging pathology. Among prior studies, differences in study design have contributed to the study-to-study variability in reported disease prevalence. The presence of HS-Aging pathology correlates with significant cognitive impairment which is often misdiagnosed as AD clinically. The antemortem diagnosis is further confounded by other diseases linked to hippocampal atrophy including frontotemporal lobar degeneration and cerebrovascular pathologies. Recent advances characterizing the neurocognitive profile of HS-Aging patients have begun to provide clues that may help identify living individuals with HS-Aging pathology. Structural brain imaging studies of research subjects followed to autopsy reveal hippocampal atrophy that is substantially greater in people with eventual HS-Aging pathology, compared to those with AD pathology alone. Data are presented from individuals who were followed with neurocognitive and neuroradiologic measurements, followed by neuropathologic evaluation at the University of Kentucky. Finally, we discuss factors that are hypothesized to cause or modify the disease. We conclude that the published literature on HS-Aging provides strong evidence of an important and under-appreciated brain disease of aging. Unfortunately, there is no therapy or preventive strategy currently available
Self-Reported Head Injury and Risk of Late-Life Impairment and AD Pathology in an AD Center Cohort
Aims: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer\u27s disease (AD)-type pathological changes. Methods: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. Results: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. Conclusions: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes
Fitting the Gamma-Ray Spectrum from Dark Matter with DMFIT: GLAST and the Galactic Center Region
We study the potential of GLAST to unveil particle dark matter properties
with gamma-ray observations of the Galactic center region. We present full
GLAST simulations including all gamma-ray sources known to date in a region of
4 degrees around the Galactic center, in addition to the diffuse gamma-ray
background and to the dark matter signal. We introduce DMFIT, a tool that
allows one to fit gamma-ray emission from pair-annihilation of generic particle
dark matter models and to extract information on the mass, normalization and
annihilation branching ratios into Standard Model final states. We assess the
impact and systematic effects of background modeling and theoretical priors on
the reconstruction of dark matter particle properties. Our detailed simulations
demonstrate that for some well motivated supersymmetric dark matter setups with
one year of GLAST data it will be possible not only to significantly detect a
dark matter signal over background, but also to estimate the dark matter mass
and its dominant pair-annihilation mode.Comment: 37 pages, 16 figures, submitted to JCA
First detection of a VHE gamma-ray spectral maximum from a Cosmic source: H.E.S.S. discovery of the Vela X nebula
The Vela supernova remnant (SNR) is a complex region containing a number of
sources of non-thermal radiation. The inner section of this SNR, within 2
degrees of the pulsar PSR B0833-45, has been observed by the H.E.S.S. gamma-ray
atmospheric Cherenkov detector in 2004 and 2005. A strong signal is seen from
an extended region to the south of the pulsar, within an integration region of
radius 0.8 deg. around the position (RA = 08h 35m 00s, dec = -45 deg. 36'
J2000.0). The excess coincides with a region of hard X-ray emission seen by the
ROSAT and ASCA satellites. The observed energy spectrum of the source between
550 GeV and 65 TeV is well fit by a power law function with photon index = 1.45
+/- 0.09(stat) +/- 0.2(sys) and an exponential cutoff at an energy of 13.8 +/-
2.3(stat) +/- 4.1(sys) TeV. The integral flux above 1 TeV is (1.28 +/- 0.17
(stat) +/- 0.38(sys)) x 10^{-11} cm^{-2} s^{-1}. This result is the first clear
measurement of a peak in the spectral energy distribution from a VHE gamma-ray
source, likely related to inverse Compton emission. A fit of an Inverse Compton
model to the H.E.S.S. spectral energy distribution gives a total energy in
non-thermal electrons of ~2 x 10^{45} erg between 5 TeV and 100 TeV, assuming a
distance of 290 parsec to the pulsar. The best fit electron power law index is
2.0, with a spectral break at 67 TeV.Comment: 5 pages, 4 figures, accepted for publication in Astronomy and
Astrophysics letter
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