Thomas W. Burke, MD, Oral History Interview, March 11, 2014

Major Topics Covered: Personal and educational background Military service A portrait of a clinician with an “entrepreneurial spirit” Research: combination therapies for gynecologic cancershttps://openworks.mdanderson.org/mchv_interviewsessions/1218/thumbnail.jp

Thomas W. Burke, MD, Oral History Interview, March 18, 2014

Major Topics Covered: Gynecologic Oncology at MD Anderson and multi-disciplinary care Development of multi-disciplinary care at MD Anderson Roles as Physician-in-Chief Developing MD Anderson support serviceshttps://openworks.mdanderson.org/mchv_interviewsessions/1219/thumbnail.jp

Thomas W. Burke, MD, Oral History Interview, April 29, 2014

Major Topics Covered: Developing networks to serve MD Anderson MD Anderson culture: changes and continuities amid growth MD Anderson’s financial challenges and strategies to navigate themhttps://openworks.mdanderson.org/mchv_interviewsessions/1220/thumbnail.jp

Soil improvement with bauxite residues

The sandy soils of the Peel-Harvey catchment hold water and nutrients very poorly. The Gavin ridges dry out quickly during rainless periods and this severely limits pasture growth. These ridges and the lower lying Joel and Coolup sands also lose a large proportion of the phosphorus, sulfer and potash fertilisers applied to them. Normally the sands lack clay materials to bind and hold the nutrients so rainfall leaches them out. The Peel-Harvey Study Group, CSIRO, Alcoa and Murdock University have studied the use of a residue from bauxite mining to help overcome these problems. The treated residue has a texture similar to loam and helps to hold more water and nutrients. When the residue is incorporated into these sandy soils, little phosphorus is leached out and productive pastures can be grown on otherwise poor country

Decreased Aerobic Exercise Capacity After Long-Term Remission From Cushing Syndrome: Exploration of Mechanisms.

BACKGROUND: Although major improvements are achieved after cure of Cushing syndrome (CS), fatigue and decreased quality of life persist. This is the first study to measure aerobic exercise capacity in patients in remission of CS for more than 4 years in comparison with matched controls, and to investigate whether the reduction in exercise capacity is related to alterations in muscle tissue. METHODS: Seventeen patients were included. A control individual, matched for sex, estrogen status, age, body mass index, smoking, ethnicity, and physical activity level was recruited for each patient. Maximal aerobic capacity (VO2peak) was assessed during incremental bicycle exercise to exhaustion. In 8 individually matched patients and controls, a percutaneous muscle biopsy was obtained and measures were made of cross-sectional areas, capillarization, and oxphos complex IV (COXIV) protein content as an indicator of mitochondrial content. Furthermore, protein content of endothelial nitric oxide synthase (eNOS) and eNOS phosphorylated on serine1177 and of the NAD(P)H-oxidase subunits NOX2, p47phox, and p67phox were measured in the microvascular endothelial layer. FINDINGS: Patients showed a lower mean VO2peak (SD) (28.0 [7.0] vs 34.8 [7.9] ml O2/kg bw/min, P < .01), maximal workload (SD) (176 [49] vs 212 [67] watt, P = .01), and oxygen pulse (SD) (12.0 [3.7] vs 14.8 [4.2] ml/beat, P < .01) at VO2peak. No differences were seen in muscle fiber type-specific cross-sectional area, capillarization measures, mitochondrial content, and protein content of eNOS, eNOS-P-ser1177, NOX2, p47phox, and p67phox. INTERPRETATION: Because differences in muscle fiber and microvascular outcome measures are not statistically significant, we hypothesize that cardiac dysfunction, seen in active CS, persists during remission and limits blood supply to muscles

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Chapter 02: Developing A Surgical Perspective and Style, Passing it on Through Mentoring

Dr. Burke begins by describing the unique qualities of the operating room environment where, he notes, a surgeon’s interactive style may be more important than his technical skills He explains his philosophy of “de-stressing” the surgery environment to in order that a patient is not put at risk. Dr. Burke talks about his surgery training. He observes that the environment that a surgeon created in the operating rooms influences how they were able to attract people to their specialties, a fact he has integrated into his own surgical practice and environment. Dr. Burke tells a story of acquiring a cadaver during his clinical fellowship to redo anatomy from the perspective of surgeons. Dr. Burke explains what he learned from this and how the experience has helped him in his work at MD Anderson.https://openworks.mdanderson.org/mchv_interviewchapters/1915/thumbnail.jp