A Simulation Model Articulation of the REA Ontology

This paper demonstrates how the REA enterprise ontology can be used to construct simulation models for business processes, value chains and collaboration spaces in supply chains. These models support various high-level and operational management simulation applications, e.g. the analysis of enterprise sustainability and day-to-day planning. First, the basic constructs of the REA ontology and the ExSpect modelling language for simulation are introduced. Second, collaboration space, value chain and business process models and their conceptual dependencies are shown, using the ExSpect language. Third, an exhibit demonstrates the use of value chain models in predicting the financial performance of an enterprise

BPR best practices for the healthcare domain

Healthcare providers are under pressure to work more efficiently and in a more patient-focused way. One possible way to achieve this is to launch Business Process Redesign (BPR) initiatives, which focus on changing the structure of the involved processes and using IT as an enabler for such changes. In this paper, we argue that a list of historically successful improvement tactics, the BPR best practices, are a highly suitable ingredient for such efforts in the healthcare domain. Our assessment is based on the analysis of 14 case studies. The insights obtained by the analysis also led to an extension of the original set of best practices

Mutual facilitation between foundation species Mytilus edulis and Lanice conchilega promotes habitat heterogeneity on tidal flats

Foundation species that modify their habitat can facilitate other species, including other foundation species. Most studies focus solely on a single foundation species, overlooking such facilitation cascades. In this study, we investigated the interactions between the two coastal foundation species Mytilus edulis (blue mussel) and Lanice conchilega (sand mason worm). We investigated whether these species engage in facilitative interactions or if their association simply reflects a shared ecological niche on the soft-sediment intertidal flats of the Dutch Wadden Sea. To do so, we performed species distribution modeling, manipulative field experiments, and field surveys. We found a positive association between both foundation species, with a 2.45 times higher occurrence of both species compared to a random distribution. In addition, these species partially occupied the same ecological niche. We demonstrated that L. conchilega provided settlement substrate for M. edulis spat, increasing densities by 400 times compared to bare plots. Furthermore, M. edulis reefs facilitated L. conchilega occurrence in the wake of the reef. Biogenic reef development revealed that this interspecific facilitation resulted in spatial habitat heterogeneity. Therefore, we conclude that interspecific facilitation can significantly enhance the occurrence of these two important intertidal foundation species. Acknowledgment of such complex facilitation interactions has an untapped potential for improving the success of restoration and conservation programs.</p

The Effect of Modularity Representation and Presentation Medium on the Understandability of Business Process Models in BPMN

Many factors influence the creation of understandable business process models for an appropriate audience. Understandability of process models becomes critical particularly when a process is complex and its model is large in structure. Using modularization to represent such models hierarchically (e.g. using sub-processes) is considered to contribute to the understandability of these models. To investigate this assumption, we conducted an experiment that involved 2 large-scale real-life business process models that were modeled using BPMN v2.0 (Business Process Model and Notation). Each process was modeled in 3 modularity forms: fully-flattened, flattened where activities are clustered using BPMN groups, and modularized using separately viewed BPMN sub-processes. The objective is to investigate if and how different forms of modularity representation in BPMN collaboration diagrams influence the understandability of process models. In addition to the forms of modularity representation, we also looked into the presentation medium (paper vs. computer) as a factor that potentially influences model comprehension. Sixty business practitioners from a large organization participated in the experiment. The results of our experiment indicate that for business practitioners, to optimally understand a BPMN model in the form of a collaboration diagram, it is best to present the model in a ‘fully-flattened’ fashion (without using collapsed sub-processes in BPMN) in the ‘paper’ format

Blockchain and Government Transformation

In today’s digital age, transactions are made increasingly in the virtual universe. Some do all financial transactions online, but some do not even want to think about this possibility since the consideration is unreliable. To make online financial transactions more reliable, many technologies have already been tested. Since passwords, tokens, physical code generation accessories, there have been many attempts, being the most elaborate, the blockchain. Governments, especially in developed countries, often find it difficult to gain the trust of their citizens, especially when it comes to evidence of service provision and improvement of existing services. In developing countries, blockchain requests from governments would be useful in eliminating some important problems, such as corruption, while ensuring more effective deployment and distribution of resources. The adoption of such technologies can also help to facilitate better use of resources. In this paper, we will analyze the impact of the application of blockchain technology on e-government.2020-2

Adaptive Workflow Design Based on Blockchain

Increasingly, organizational processes have become more complex. There is a need for the design of workflows to focus on how organizations adapt to emergent processes while balancing the need for decentralization and centralization goal. The advancement in new technologies especially blockchain provides organizations with the opportunity to achieve the goal. Using blockchain technology (i.e. smart contract and blocks of specified consensus for deferred action), we leverage the theory of deferred action and a coordination framework to conceptually design a workflow management system that addresses organizational emergence (e-WfMS). Our artifact helps managers to predict and store the impact of deferred actions. We evaluated the effectiveness of our system against a complex adaptive system for utility assessment

Change Patterns in Use: A Critical Evaluation

Process model quality has been an area of considerable research efforts. In this context, the correctness-by-construction principle of change patterns provides promising perspectives. However, using change patterns for model creation imposes a more structured way of modeling. While the process of process modeling (PPM) based on change primitives has been investigated, little is known about this process based on change patterns. To obtain a better understanding of the PPM when using change patterns, the arising challenges, and the subjective perceptions of process designers, we conduct an exploratory study. The results indicate that process designers face little problems as long as control-flow is simple, but have considerable problems with the usage of change patterns when complex, nested models have to be created. Finally, we outline how effective tool support for change patterns should be realized.This research is supported by Austrian Science Fund (FWF): P23699-N23.Weber, B.; Pinggera, J.; Torres Bosch, MV.; Reichert, M. (2013). Change Patterns in Use: A Critical Evaluation. En Enterprise, Business-Process and Information Systems Modeling, BPMDS 2013. Springer Verlag. 261-276. https://doi.org/11007/978-3-642-38484-4_19S26127

Baseline natural killer and T cell populations correlation with virologic outcome after regimen simplification to atazanavir/ritonavir alone (ACTG 5201)

Objectives: Simplified maintenance therapy with ritonavir-boosted atazanavir (ATV/r) provides an alternative treatment option for HIV-1 infection that spares nucleoside analogs (NRTI) for future use and decreased toxicity. We hypothesized that the level of immune activation (IA) and recovery of lymphocyte populations could influence virologic outcomes after regimen simplification. Methods: Thirty-four participants with virologic suppression ≥48 weeks on antiretroviral therapy (2 NRTI plus protease inhibitor) were switched to ATV/r alone in the context of the ACTG 5201 clinical trial. Flow cytometric analyses were performed on PBMC isolated from 25 patients with available samples, of which 24 had lymphocyte recovery sufficient for this study. Assessments included enumeration of T-cells (CD4/CD8), natural killer (NK) (CD3+CD56 +CD16+) cells and cell-associated markers (HLA-DR, CD's 38/69/94/95/158/279). Results: Eight of the 24 patients had at least one plasma HIV-1 RNA level (VL) <50 copies/mL during the study. NK cell levels below the group median of 7.1% at study entry were associated with development of VL <50 copies/mL following simplification by regression and survival analyses (p = 0.043 and 0.023), with an odds ratio of 10.3 (95% CI: 1.92-55.3). Simplification was associated with transient increases in naïve and CD25+ CD4+ T-cells, and had no impact on IA levels. Conclusions: Lower NK cell levels prior to regimen simplification were predictive of virologic rebound after discontinuation of nucleoside analogs. Regimen simplification did not have a sustained impact on markers of IA or T lymphocyte populations in 48 weeks of clinical monitoring. Trial Registration: ClinicalTrials.gov NCT00084019