GANCANG ARON: Public Service Innovation as an Effort to Improve Health Services in Blambangan Regional General Hospital.

Blambangan Regional General Hospital had created an innovation to improve their health services called Gancang Aron. Gancang Aron is launched by the Local Government collaborated with private sector, GO-JEK. With this program, the patients only stay at home and the drug will be delivered by Go-jek drivers who have been specially trained for safe drug delivery. Therefore, they do not have to wait and go to Blambangan Regional General Hospital, because the drug will be delivered. The objectives of this study were to describe the utilization of public service innovation in Banyuwangi Regency, called Gancang Aron. This study is a descriptive qualitative research using primary data in the form of interviews with informants in the field, collection of related organizational documents and supported by the use of literature data. The innovation of Gancang Aron is not a single innovation that only occurs in the service department, it means there is involvement between actors in certain areas that contribute to the emergence of these innovative practices

Penerapan Sapta Pesona di Objek Wisata Benteng Fort De Kock Bukittinggi

This study aimed to describe the adoption of Sapta Pesona Attraction in Fort Fort De Kock Bukittinggi which includes seven indicators Sapta Pesona namely: safe, orderly, clean, cool, beautiful, friendly, and memories. This type of research is quantitative descriptive. This study population is the average monthly number is 8231 people. The number of samples in this study are numbered 99 people were taken by using the formula Riduwan. The sampling technique in this research is non probability sampling (purposive sampling). Data collection techniques using a questionnaire based on the Likert scale that has been tested for validity and reliability. The results showed that the overall application of stepping in attraction Fort Fort de Kock Bukittinggi classified in the category quite well with the average value score of 176.99 in the range of 160 - <200 with the interpretation of the percentage of 46.47%, while under each each indicator are: for safe, orderly, clean, friendly and reasonably good memories of the category and to cool and beautiful in both categories

Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates

An important question in memory development is understanding the differences between effector CD8 T cells that die versus effector cells that survive and give rise to memory cells. In this study, we provide a comprehensive phenotypic, functional, and genomic profiling of terminal effectors and memory precursors. Using killer cell lectin-like receptor G1 as a marker to distinguish these effector subsets, we found that despite their diverse cell fates, both subsets possessed remarkably similar gene expression profiles and functioned as equally potent killer cells. However, only the memory precursors were capable of making interleukin (IL) 2, thus defining a novel effector cell that was cytotoxic, expressed granzyme B, and produced inflammatory cytokines in addition to IL-2. This effector population then differentiated into long-lived protective memory T cells capable of self-renewal and rapid recall responses. Experiments to understand the signals that regulate the generation of terminal effectors versus memory precursors showed that cells that continued to receive antigenic stimulation during the later stages of infection were more likely to become terminal effectors. Importantly, curtailing antigenic stimulation toward the tail end of the acute infection enhanced the generation of memory cells. These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation

Sum of Lyapunov exponents of the Hodge bundle with respect to the Teichmuller geodesic flow

We compute the sum of the positive Lyapunov exponents of the Hodge bundle with respect to the Teichmuller geodesic flow. The computation is based on the analytic Riemann-Roch Theorem and uses a comparison of determinants of flat and hyperbolic Laplacians when the underlying Riemann surface degenerates.Comment: Minor corrections. To appear in Publications mathematiques de l'IHE

Biogenesis of Influenza A Virus Hemagglutinin Cross-Protective Stem Epitopes

Antigenic variation in the globular domain of influenza A virus (IAV) hemagglutinin (HA) precludes effective immunity to this major human pathogen. Although the HA stem is highly conserved between influenza virus strains, HA stem-reactive antibodies (StRAbs) were long considered biologically inert. It is now clear, however, that StRAbs reduce viral replication in animal models and protect against pathogenicity and death, supporting the potential of HA stem-based immunogens as drift-resistant vaccines. Optimally designing StRAb-inducing immunogens and understanding StRAb effector functions require thorough comprehension of HA stem structure and antigenicity. Here, we study the biogenesis of HA stem epitopes recognized in cells infected with various drifted IAV H1N1 strains using mouse and human StRAbs. Using a novel immunofluorescence (IF)-based assay, we find that human StRAbs bind monomeric HA in the endoplasmic reticulum (ER) and trimerized HA in the Golgi complex (GC) with similar high avidity, potentially good news for producing effective monomeric HA stem immunogens. Though HA stem epitopes are nestled among several N-linked oligosaccharides, glycosylation is not required for full antigenicity. Rather, as N-linked glycans increase in size during intracellular transport of HA through the GC, StRAb binding becomes temperature-sensitive, binding poorly to HA at 4°C and well at 37°C. A de novo designed, 65-residue protein binds the mature HA stem independently of temperature, consistent with a lack of N-linked oligosaccharide steric hindrance due to its small size. Likewise, StRAbs bind recombinant HA carrying simple N-linked glycans in a temperature-independent manner. Chemical cross-linking experiments show that N-linked oligosaccharides likely influence StRAb binding by direct local effects rather than by globally modifying the conformational flexibility of HA. Our findings indicate that StRAb binding to HA is precarious, raising the possibility that sufficient immune pressure on the HA stem region could select for viral escape mutants with increased steric hindrance from N-linked glycans.</p

Impact of low-carbon technologies on the power distribution network

Over recent decades, there has been a growing concern about how modern technologies would impact on an electrical grid. Whilst the UK is set to meet the target of 15% energy demand from renewable sources by 2020 to ensure energy security and decarbonisation objectives, there has been a greater concern over how the increasing deployment of low carbon technologies (LCTs) would affect an electrical grid, in particular the residential low voltage distribution network. While LCTs can provide clean energy and decreases the dependence on oil and natural gas stocks, their impact on distribution networks is unknown and the operators are visibly blind as they use a ‘fit and forget’ approach. Consumers’ connections are uncertain and stochastic and the LCT uptake poses a potential threat for distribution network operators. A review is presented in this paper, illustrating the potential impacts the LCTs have on a local electrical grid such as voltage regulation, thermal limits, power quality and harmonics. Potential solutions, such as Deregulation, Soft Open Points, On Load Tap Changer, and Active Power Filter currently available for Distribution Network Operators and power system planners before costly network reinforcement work is undertaken