2,874 research outputs found
Triple correlation for detection of damage-related nonlinearities in composite structures
Nonlinear effects in vibration responses are investigated for the undamaged composite plate and the composite plate with a delamination. The analysis is focused on higher harmonic generation in vibration responses for various excitation amplitude levels. This effect is investigated using the triple correlation technique. The dynamics of composite plate was modelled using two-dimensional finite elements and the classical lamination theory. The doubled-node approach was used to model delamination area. Mode shapes and natural frequencies were estimated based on numerical models. Next, the delamination divergence analysis was used to obtain relative displacements for delaminated plies. Experimental modal analysis test was carried out to verify the numerical models. The two strongest vibration modes as well as two vibration modes with the smallest and largest motion level of delaminated plies were selected for nonlinear vibration test. The Fisher criterion was employed to verify the effectiveness and confidence level of the proposed technique. The results show that the method can be used not only to reveal nonlinearities, but also to reliably detect impact damage in composites. These results are confirmed using the statistical analysis
Damage detection by using FBGs and strain field pattern recognition techniques
A novel methodology for damage detection and location in structures is proposed. The methodology is based on strain measurements and consists in the development of strain field pattern recognition techniques. The aforementioned are based on PCA (principal component analysis) and damage indices (T 2 and Q). We propose the use of fiber Bragg gratings (FBGs) as strain sensor
Analysis of elastic nonlinearity for impact damage detection in composite laminates
This paper concerns the experimental analysis of nonlinear response features of a
composite laminate plate for impact damage detection. The measurement procedure is based on
the Scaling Subtraction Method (SSM) and consists in exciting the damaged specimen with two
sinusoidal signals at different amplitude. The linearly rescaled response signal at low amplitude
excitation is subtracted from the response at large amplitude excitation to extract the nonlinear
signatures. The latter are analysed in the time domain to infer the presence of damage. Results
are compared with frequency domain analyses using the nonlinear vibro-acoustic modulation
technique (NWMS). Changes in amplitude and phase as well as modulation effects of the
acquired responses are also monitored. Surface-bonded, low profile piezoceramic transducers
are used for excitation and sensing. Both measurements techniques are applied to detect barely
visible impact damage in laminate composite plate. Non-destructive penetrant-enhanced X-ray
inspections are carried out to characterize the extent of internal damage. The behavior of the
nonlinear features and the sensitivity of each technique are also investigated in the paper
VIBROTHERMOGRAPHY FOR IMPACT DAMAGE DETECTION IN COMPOSITES STRUCTURES
The paper investigates modelling aspects related to application of vibrothermography for detection of barely visible impact damage in composite structures. Low-velocity impact tests were performed to introduce multiple delaminations into carbon/epoxy composite plate. Damage severity was revealed using well-established non-destructive evaluation techniques. Vibrothermography was used subsequently to show good agreement with classical damage detection techniques. Following these experimental investigations, numerical simulations were performed to assess feasibility and sensitivity of vibrothermography for impact damage detection. Numerical results were validated using experimental data showing very good qualitative and encouraging quantitative agreement. The study demonstrates that virtual impact damage detection using vibrothermography can be performed as part of structural design to assess sensitivity of the method in real engineering applications. Copyright © 2012 John Wiley & Sons, Ltd
Rescaled Local Interaction Simulation Approach for Shear Wave Propagation Modelling in Magnetic Resonance Elastography
Properties of soft biological tissues are increasingly used in medical diagnosis to detect various abnormalities, for example, in liver fibrosis or breast tumors. It is well known that mechanical stiffness of human organs can be obtained from organ responses to shear stress waves through Magnetic Resonance Elastography. The Local Interaction Simulation Approach is proposed for effective modelling of shear wave propagation in soft tissues. The results are validated using experimental data from Magnetic Resonance Elastography. These results show the potential of the method for shear wave propagation modelling in soft tissues. The major advantage of the proposed approach is a significant reduction of computational effort
Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation
Therapeutic DNA vaccine induces broad T cell responses in the gut and sustained protection from viral rebound and AIDS in SIV-infected rhesus macaques.
Immunotherapies that induce durable immune control of chronic HIV infection may eliminate the need for life-long dependence on drugs. We investigated a DNA vaccine formulated with a novel genetic adjuvant that stimulates immune responses in the blood and gut for the ability to improve therapy in rhesus macaques chronically infected with SIV. Using the SIV-macaque model for AIDS, we show that epidermal co-delivery of plasmids expressing SIV Gag, RT, Nef and Env, and the mucosal adjuvant, heat-labile E. coli enterotoxin (LT), during antiretroviral therapy (ART) induced a substantial 2-4-log fold reduction in mean virus burden in both the gut and blood when compared to unvaccinated controls and provided durable protection from viral rebound and disease progression after the drug was discontinued. This effect was associated with significant increases in IFN-γ T cell responses in both the blood and gut and SIV-specific CD8+ T cells with dual TNF-α and cytolytic effector functions in the blood. Importantly, a broader specificity in the T cell response seen in the gut, but not the blood, significantly correlated with a reduction in virus production in mucosal tissues and a lower virus burden in plasma. We conclude that immunizing with vaccines that induce immune responses in mucosal gut tissue could reduce residual viral reservoirs during drug therapy and improve long-term treatment of HIV infection in humans
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