141 research outputs found

    Between consonance and dissonance

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    This document and accompanying portfolio trace the philosophical and technical evolution of my work in composition from 2012 to 2015. It shows how my work - originally influenced largely by Morton Feldman and John Cage - developed as a result of my interest in just intonation and microtonality and through the influences of James Tenney, Alvin Lucier, La Monte Young, and painters Jackson Pollock and Gerhard Richter. The first section provides background and places my work within the compositional/artistic canon while the second section discusses the work in more technical detail. At the end of the document there is a more detailed examination of four works: ’Harmonic Catalogue’, ‘Some Perfect Chords’, ‘Some Imperfect Chords’, and ’Landscape with Train Whistle’, which are the culmination of the attitudes at University College Cork

    Transcriptional regulation of the urokinase receptor (u-PAR) - A central molecule of invasion and metastasis

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    The phenomenon of tumor-associated proteolysis has been acknowledged as a decisive step in the progression of cancer. This short review focuses on the urokinase receptor (u-PAR), a central molecule involved in tumor-associated invasion and metastasis, and summarizes the transcriptional regulation of u-PAR. The urokinase receptor (u-PAR) is a heavily glycosylated cell surface protein and binds the serine protease urokinase specifically and with high affinity. It consists of three similar cysteine-rich repeats and is anchored to the cell membrane via a GPI-anchor. The u-PAR gene comprises 7 exons and is located on chromosome 19q13. Transcriptional activation of the u-PAR promoter region can be induced by binding of transcription factors (Sp1, AP-1, AP-2, NF-kappaB). One current study gives an example for transcriptional downregulation of u-PAR through a PEA3/ets transcriptional silencing element. Knowledge of the molecular regulation of this molecule in tumor cells could be very important for diagnosis and therapy in the near future

    A POLARIMETER FOR PROTONS BETWEEN 100 AND 800 MeV

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    A carbon polarimeter has been built and used for protons with energies between 100 and 800 MeV. The polarimeter accepts scatters in the carbon analyzer up to 30~ab, with negligible instrumental asymmetries. Drift chambers 60 cm square were used with a system for resolving the left-right ambiguity inherent in drift chambers. A hardware system for rejecting small angle scatters is described. The polarimeter is routinely used to measure spin transfer parameters with a typical precision of ±0.03 in about eight hours of low-duty LAMPF beam

    Transverse-spin dependence of the p-p total cross section ΔσT from 0.8 to 2.5 GeV/c

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    The difference ΔσT=σ(↓↑)-σ(↑↑) between the proton-proton total cross sections for protons in pure transverse-spin states, was measured at incident momenta 0.8 to 2.5 GeV/c in experiments performed at the Los Alamos Clinton P. Anderson Meson Physics Facility and the Argonne Zero Gradient Synchrotron. In agreement with other data, peaks were observed at center-of-mass energies of 2.14 and 2.43 GeV/c2, where 1D2 and 1G4 dibaryon resonances have been proposed

    Neutron-Proton Analyzing Power Measurements from 375 to 775 Mev

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    Journals published by the American Physical Society can be found at http://publish.aps.org

    Zero-Crossing Angle in the Np Analyzing Power at Medium Energies and its Relation to Charge Symmetry

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    Journals published by the American Physical Society can be found at http://publish.aps.org

    Produtos de hidratação em argamassas geopoliméricas à base de argila da Tunísia para reparação de estruturas de concreto

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    A reparação de estruturas degradadas de concreto representa uma oportunidade para a indústria da construção mas também um desafio para a comunidade científica. O desenvolvimento de novas argamassas de reparação constitui por isso uma importante área de investigação. Os geopolímeros são ligantes inovadores alternativos ao cimento Portland pelo que as argamassas à base destes materiais, geopolíméricas, apresentam algumas potencialidades no campo da reparação das estruturas de concreto. O presente artigo apresenta resultados de uma investigação sobre o desenvolvimento de argamassas geopoliméricas à base de uma argila da Tunísia sujeita a tratamento térmico. É incluída uma análise da argila e também dos produtos de hidratação da argamassa os quais apresentam fases geopoliméricas típicas
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