BIBLE INSPIRATION IN WOLFHART PANNENBERG’ THEOLOGY: AN EXAMINATION

Wolfhart Pannenberg was a theologian from German. He was a Lutheran theologian. His concept of revelation and inspiration was widely debated among Protestant and Catholic theologians. This article attempts to examine Wolfhart Pannenberg’s theology of Biblical Inspiration. A biblical examination of the inspirations in Pannenberg’s theology shows contrasting things. His idea of revelation is not direct communication between the Divine and man but rather as history, contrary to the biblical notion. Pannenberg rejected Divine intervention in biblical inspiration. This led him to focus on the role of man in Inspiration. For him, the authors played an active role, in cognitive processes. According to the Bible, writers have a passive role, because they are led and directed by the Holy Spirit. Therefore, Pannenberg's idea of the Bible as a human document is not in harmony with the teachings of the Bible Key words: revelation, inspiration, biblical.   Bibliography Bloesch, Donald G.  Holy Scripture: Revelation, Inspiration and Interpretation.  Downers Grove, IL: IVP Academic, 2005. Canale, Fernando L.  “Revelation and Inspiration: The Classical Model.” Andrews University Seminary Studies 32 (1994): 22-30. ________.  “Revelation and Inspiration,” Understanding Scripture: An Adventist Approach, ed., by, George W. Reid.  Hagerstown, MD: Review & Herald, 2005. Carson, D. A. and Douglass J. Moo.  An Introduction to the New Testament.  Grand Rapids, MI: Zondervan, 2009. Dederen, Raoul.  “Revelation-Inspiration Phenomenon According to the Bible Writers,” in, Adventist Theological Society Occasional Papers, ed., by, Frank Holbrook dan Leo Van Dolson. Berrien Springs, MI: Adventist Theological Society Publications, 1992. Grudem, Wayne.  Systematic Theology: Introduction to Biblical Doctrines.  Downers Grove, IL: IVP Academic, 2004. Gulley, Norman R.  Systematic Theology I: Prolegomena.  Berrien Springs, MI: Andrews University Press, 2003. Hagner, Donald A. The New Testament: Historical and Theological Introduction.  Grand Rapids, MI: Baker Academic, 2013. Hasel, Frank M. “The Scripture in the Theologies of W. Pannenberg and D. G. Bloesch: An Investigation and Assessment of Its Origin, Nature and Use.” (Ph.D Dissertation, Andrews University, 1994. McKenzie, David. Wolfhart Pannenberg and Religious Philosophy.  Lanham, MD: University of America, 1980). Ministerial Association of General Conference of SDA, Seventh-day Adventist Believe: A Biblical Exposition of 28 Fundamental Doctrines.  Nampa, ID: Pacific Press, 2005. Pannenberg, Wolfhart.  Systematic Theology, 3 vols., trans., by, Geoffrey Bromiley. London: T & T Clark International, 2004. ________.  Introduction to Systematic Theology.  Grand Rapids, MI: Eerdmans, 1991. ________.  Revelation as History.  New York: The Macmillan Company, 1968. ________.  What is Man?: Contemporary Anthropology in Theological Perspective. Philadelphia: Fortress Press, 1970. White, Ellen G. Steps to Christ.  Washington, DC: Review & Herald, 1915

Mechanical ventilation modulates Toll-like receptor-3-induced lung inflammation via a MyD88-dependent, TLR4-independent pathway: a controlled animal study

<p>Abstract</p> <p>Background</p> <p>Mechanical ventilation augments lung inflammation resulting from exposure to microbial products. The objective of this study was to test the hypothesis that ventilator-associated immune modulation requires MyD88-dependent signaling. Because MyD88 is a critical adapter protein utilized for pro-inflammatory signaling by all Toll-like receptors (TLRs), with the exception of TLR3, as well as by the IL-1 and IL-18 receptors, MyD88 dependence would implicate generation of an endogenous soluble ligand recognized by one or more of these receptors during mechanical ventilation and would provide an opportunity for a potential future therapeutic intervention.</p> <p>Methods</p> <p>We compared the effect of mechanical ventilation on lung inflammation and permeability between poly(I:C) exposed mice with or without expression of MyD88. Poly(I:C) is a synthetic ligand for TLR3, the only MyD88-independent TLR, allowing isolation of the effect of MyD88 deletion on ventilator-augmentation of lung inflammation. Lung inflammation was assessed by cytokine concentration in lung tissue homogenate and polymorphonuclear cell (PMN) number in bronchoalveolar lavage fluid (BALF). Lung permeability was assessed by total protein, IgM, and intravenously injected FITC-dextran concentrations in BALF.</p> <p>Results</p> <p>We found that MyD88 was required for mechanical ventilation augmentation of TLR3-induced lung inflammation and permeability. Because TLR4 is the most commonly reported receptor for endogenous ligands generated during tissue injury, we performed a second experiment comparing wildtype and TLR4-/- mice. We found that mechanical ventilation increased TLR3-mediated inflammation and permeability independent of TLR4.</p> <p>Conclusion</p> <p>These data support the hypothesis that mechanical ventilation with moderate tidal volumes generates an endogenous ligand(s) recognized by MyD88-dependent receptor(s) other than TLR4, and that this mechanism can contribute to the development of ventilator-associated lung inflammation and injury. Identification of these ligands and/or receptors could lead to new pharmacological treatments for ARDS.</p

A perpetual switching system in pulmonary capillaries

Of the 300 billion capillaries in the human lung, a small fraction meet normal oxygen requirements at rest, with the remainder forming a large reserve. The maximum oxygen demands of the acute stress response require that the reserve capillaries are rapidly recruited. To remain primed for emergencies, the normal cardiac output must be parceled throughout the capillary bed to maintain low opening pressures. The flow-distributing system requires complex switching. Because the pulmonary microcirculation contains contractile machinery, one hypothesis posits an active switching system. The opposing hypothesis is based on passive switching that requires no regulation. Both hypotheses were tested ex vivo in canine lung lobes. The lobes were perfused first with autologous blood, and capillary switching patterns were recorded by videomicroscopy. Next, the vasculature of the lobes was saline flushed, fixed by glutaraldehyde perfusion, flushed again, and then reperfused with the original, unfixed blood. Flow patterns through the same capillaries were recorded again. The 16-min-long videos were divided into 4-s increments. Each capillary segment was recorded as being perfused if at least one red blood cell crossed the entire segment. Otherwise it was recorded as unperfused. These binary measurements were made manually for each segment during every 4 s throughout the 16-min recordings of the fresh and fixed capillaries (>60,000 measurements). Unexpectedly, the switching patterns did not change after fixation. We conclude that the pulmonary capillaries can remain primed for emergencies without requiring regulation: no detectors, no feedback loops, and no effectors-a rare system in biology. NEW & NOTEWORTHY The fluctuating flow patterns of red blood cells within the pulmonary capillary networks have been assumed to be actively controlled within the pulmonary microcirculation. Here we show that the capillary flow switching patterns in the same network are the same whether the lungs are fresh or fixed. This unexpected observation can be successfully explained by a new model of pulmonary capillary flow based on chaos theory and fractal mathematics

Landscape, Memory, and the Shifting Regional Geographies of Northwest Bosnia-Herzegovina

Writing and arguing with older discourses that have informed the subdiscipline of regional geography and setting them against new ways of conceiving of the region, this article considers the northwest of Bosnia-Herzegovina as a site that calls for a newly animated form of regional study. Of particular concern here is the role that memory and commemorative practices play in such a spatial schema. The monumental landscapes of the Tito regime and its collective commemoration of World War II sit alongside and are troubled by the more recent traumas and spaces of unmarked death associated with the ethnic war in Bosnia during the early 1990s. Read together, northwest Bosnia-Herzegovina functions as a vivid exemplar for understanding traumatic historical mourning as a phenomenological process that is inseparable from the wider geopolitical landscape

Branch Mode Selection during Early Lung Development

Many organs of higher organisms, such as the vascular system, lung, kidney, pancreas, liver and glands, are heavily branched structures. The branching process during lung development has been studied in great detail and is remarkably stereotyped. The branched tree is generated by the sequential, non-random use of three geometrically simple modes of branching (domain branching, planar and orthogonal bifurcation). While many regulatory components and local interactions have been defined an integrated understanding of the regulatory network that controls the branching process is lacking. We have developed a deterministic, spatio-temporal differential-equation based model of the core signaling network that governs lung branching morphogenesis. The model focuses on the two key signaling factors that have been identified in experiments, fibroblast growth factor (FGF10) and sonic hedgehog (SHH) as well as the SHH receptor patched (Ptc). We show that the reported biochemical interactions give rise to a Schnakenberg-type Turing patterning mechanisms that allows us to reproduce experimental observations in wildtype and mutant mice. The kinetic parameters as well as the domain shape are based on experimental data where available. The developed model is robust to small absolute and large relative changes in the parameter values. At the same time there is a strong regulatory potential in that the switching between branching modes can be achieved by targeted changes in the parameter values. We note that the sequence of different branching events may also be the result of different growth speeds: fast growth triggers lateral branching while slow growth favours bifurcations in our model. We conclude that the FGF10-SHH-Ptc1 module is sufficient to generate pattern that correspond to the observed branching modesComment: Initially published at PLoS Comput Bio

The interpretation of systematic reviews with meta-analyses: an objective or subjective process?

<p>Abstract</p> <p>Background</p> <p>Discrepancies between the conclusions of different meta-analyses (quantitative syntheses of systematic reviews) are often ascribed to methodological differences. The objective of this study was to determine the discordance in interpretations when meta-analysts are presented with identical data.</p> <p>Methods</p> <p>We searched the literature for all randomized clinical trials (RCT) and review articles on the efficacy of intravenous magnesium in the early post-myocardial infarction period. We organized the articles chronologically and grouped them in packages. The first package included the first RCT, and a summary of the review articles published prior to first RCT. The second package contained the second and third RCT, a meta-analysis based on the data, and a summary of all review articles published prior to the third RCT. Similar packages were created for the 5^thRCT, 10^thRCT, 20^thRCT and 23^rdRCT (all articles). We presented the packages one at a time to eight different reviewers and asked them to answer three clinical questions after each package based solely on the information provided. The clinical questions included whether 1) they believed magnesium is now proven beneficial, 2) they believed magnesium will eventually be proven to be beneficial, and 3) they would recommend its use at this time.</p> <p>Results</p> <p>There was considerable disagreement among the reviewers for each package, and for each question. The discrepancies increased when the heterogeneity of the data increased. In addition, some reviewers became more sceptical of the effectiveness of magnesium over time, and some reviewers became less sceptical.</p> <p>Conclusion</p> <p>The interpretation of the results of systematic reviews with meta-analyses includes a subjective component that can lead to discordant conclusions that are independent of the methodology used to obtain or analyse the data.</p

Communications and Transport: The mobility of information, people and commodities

In a context where the study of communications tends to focus only on the mobility of information, to the neglect of that of people and commodities, this article explores the potential for a closer integration between the fields of communications and transport studies. Against the presumption that the emergence of virtuality means that material geographies are no longer of consequence, the role of mediated ‘technologies of distance’ is considered here in the broader contexts of the construction (and regulation) of a variety of physical forms of mobility and the changing modes of articulation of the virtual and material worlds