Delocalization of states in two component superlattices with correlated disorder

Electron and phonon states in two different models of intentionally disordered superlattices are studied analytically as well as numerically. The localization length is calculated exactly and we found that it diverges for particular energies or frequencies, suggesting the existence of delocalized states for both electrons and phonons. Numerical calculations for the transmission coefficient support the existence of these delocalized states.Comment: RevTeX, 12 pages, 2 PS figures adde

Trial-by-Trial Changes in a Priori Informational Value of External Cues and Subjective Expectancies in Human Auditory Attention

Background: Preparatory activity based on a priori probabilities generated in previous trials and subjective expectancies would produce an attentional bias. However, preparation can be correct (valid) or incorrect (invalid) depending on the actual target stimulus. The alternation effect refers to the subjective expectancy that a target will not be repeated in the same position, causing RTs to increase if the target location is repeated. The present experiment, using the Posner’s central cue paradigm, tries to demonstrate that not only the credibility of the cue, but also the expectancy about the next position of the target are changedin a trial by trial basis. Sequences of trials were analyzed. Results: The results indicated an increase in RT benefits when sequences of two and three valid trials occurred. The analysis of errors indicated an increase in anticipatory behavior which grows as the number of valid trials is increased. On the other hand, there was also an RT benefit when a trial was preceded by trials in which the position of the target changed with respect to the current trial (alternation effect). Sequences of two alternations or two repetitions were faster than sequences of trials in which a pattern of repetition or alternation is broken. Conclusions: Taken together, these results suggest that in Posner’s central cue paradigm, and with regard to the anticipatory activity, the credibility of the external cue and of the endogenously anticipated patterns of target location are constantly updated. The results suggest that Bayesian rules are operating in the generation of anticipatory activity as

Internal dynamics of the radio-halo cluster A2744

We present a detailed dynamical analysis of the rich galaxy cluster A2744, containing a powerful diffuse radio halo.Our analysis is based on redshift data for 102 galaxies, part of them recovered from unexplored spectra in the ESO archive. We combine galaxy velocity and position information to select the cluster members and determine global dynamical properties of the cluster. We use a variety of statistical tests to detect possible substructures. We find that A2744 appears as a well isolated peak in the redshift space at =0.306, which includes 85 galaxies recognized as cluster members. We compute the line-of-sight (LOS) velocity dispersion of galaxies (~1750 km/sec), which is significantly larger than what is expected in the case of a relaxed cluster with an observed X-ray temperature of 8 keV. We find evidence that this cluster is far from dynamical equilibrium, as shown by the non-Gaussian nature of the velocity distribution, the presence of a velocity gradient and a significant substructure. In particular, our results suggest a merging scenario of two clumps with a mass ratio of 3:1 and a LOS impact velocity (rest frame) of ~3000 km/sec, likely observed just after the core passage. The merging is occuring roughly in the NS direction with the axis close to the LOS. This scenario agrees with that proposed on the basis of recent Chandra results in its general lines, although suggesting a somewhat more advanced merging phase.Comment: 14 pages. Paper in press on Astronomy & Astrophysic

Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure.

Background & aims: Patients with acute-on-chronic liver failure (ACLF) present a systemic hyperinflammatory response associated with increased circulating levels of small-molecule metabolites. To investigate whether these alterations reflect inadequate cell energy output, we assessed mitochondrial morphology and central metabolic pathways with emphasis on the tricarboxylic acid (TCA) cycle in peripheral leukocytes from patients with acutely decompensated (AD) cirrhosis, with and without ACLF. Methods: The study included samples from patients with AD cirrhosis (108 without and 128 with ACLF) and 41 healthy individuals. Leukocyte mitochondrial ultrastructure was visualized by transmission electron microscopy and cytosolic and mitochondrial metabolic fluxes were determined by assessing NADH/FADH2 production from various substrates. Plasma GDF15 and FGF21 were determined by Luminex and acylcarnitines by LC-MS/MS. Gene expression was analyzed by RNA-sequencing and PCR-based glucose metabolism profiler array. Results: Mitochondrial ultrastructure in patients with advanced cirrhosis was distinguished by cristae rarefication and swelling. The number of mitochondria per leukocyte was higher in patients, accompanied by a reduction in their size. Increased FGF21 and C6:0- and C8:0-carnitine predicted mortality whereas GDF15 strongly correlated with a gene set signature related to leukocyte activation. Metabolic flux analyses revealed increased energy production in mononuclear leukocytes from patients with preferential involvement of extra-mitochondrial pathways, supported by upregulated expression of genes encoding enzymes of the glycolytic and pentose phosphate pathways. In patients with ACLF, mitochondrial function analysis uncovered break-points in the TCA cycle at the isocitrate dehydrogenase and succinate dehydrogenase level, which were bridged by anaplerotic reactions involving glutaminolysis and nucleoside metabolism. Conclusions: Our findings provide evidence at the cellular, organelle and biochemical levels that severe mitochondrial dysfunction governs immunometabolism in leukocytes from patients with AD cirrhosis and ACLF. Lay summary: Patients at advanced stages of liver disease have dismal prognosis due to vital organ failures and the lack of treatment options. In this study, we report that the functioning of mitochondria, which are known as the cell powerhouse, is severely impaired in leukocytes of these patients, probably as a consequence of intense inflammation. Mitochondrial dysfunction is therefore a hallmark of advanced liver disease

Direct Detection of Dark Matter in the MSSM with Non-Universal Higgs Masses

We calculate dark matter scattering rates in the minimal supersymmetric extension of the Standard Model (MSSM), allowing the soft supersymmetry-breaking masses of the Higgs multiplets, m_{1,2}, to be non-universal (NUHM). Compared with the constrained MSSM (CMSSM) in which m_{1,2} are required to be equal to the soft supersymmetry-breaking masses m_0 of the squark and slepton masses, we find that the elastic scattering cross sections may be up to two orders of magnitude larger than values in the CMSSM for similar LSP masses. We find the following preferred ranges for the spin-independent cross section: 10^{-6} pb \ga \sigma_{SI} \ga 10^{-10} pb, and for the spin-dependent cross section: 10^{-3} pb \ga \sigma_{SD}, with the lower bound on \sigma_{SI} dependent on using the putative constraint from the muon anomalous magnetic moment. We stress the importance of incorporating accelerator and dark matter constraints in restricting the NUHM parameter space, and also of requiring that no undesirable vacuum appear below the GUT scale. In particular, values of the spin-independent cross section another order of magnitude larger would appear to be allowed, for small \tan \beta, if the GUT vacuum stability requirement were relaxed, and much lower cross-section values would be permitted if the muon anomalous magnetic moment constraint were dropped.Comment: 30 pages LaTeX, 40 eps figure