Publication Incentives Undermine the Utility of Science: Ecological Research in Mexico

Governmental spending on science is usually justified by claims that the resulting research will yield benefits for the sponsoring nation. I present policy-analytic and ethnographic research—based on 30 hour-long interviews—of the Mexican ecological research community to explore the structural influence of publication incentives on research content and its relevance to national needs. During a financial crisis in the 1980s, Mexico created a national publication incentive system, the Sistema Nacional de Investigadores, to identify and reward scientists producing the most and the most-cited research as defined by dominant international scientific norms at the time. The system has increased productivity but in the process has undermined that country’s ability to benefit from its ecological research by surrendering priority setting to the editorial preferences of journals that are linguistically and financially unavailable to potential domestic users. The Mexican experience has implications for institutions worldwide that utilize quantitative productivity measures in researcher evaluation

El efecto Peirce. Sugestiones para una teoría de la comunicación

From a personal reading of Peirce’s work, especially his semiotics, the author has chosen some ideas that can be developed in the context of a Communication Theory. Particularly he proposes semiosis to be considered as social circulation of meaning. Discussion about object and feelings in the field of communication studies is also introduced. Finally, the connection of Peirce’s theories with others that equally adopt the interpretative perspective, such as hermeneutics, deconstruction and discourse analysis, is pointed out

El efecto Peirce. Sugestiones para una teoría de la comunicación

From a personal reading of Peirce’s work, especially his semiotics, the author has chosen some ideas that can be developed in the context of a Communication Theory. Particularly he proposes semiosis to be considered as social circulation of meaning. Discussion about object and feelings in the field of communication studies is also introduced. Finally, the connection of Peirce’s theories with others that equally adopt the interpretative perspective, such as hermeneutics, deconstruction and discourse analysis, is pointed out

Activin-Like Kinase 5 (ALK5) Mediates Abnormal Proliferation of Vascular Smooth Muscle Cells from Patients with Familial Pulmonary Arterial Hypertension and Is Involved in the Progression of Experimental Pulmonary Arterial Hypertension Induced by Monocrotaline

Mutations in the gene for the transforming growth factor (TGF)-β superfamily receptor, bone morphogenetic protein receptor II, underlie heritable forms of pulmonary arterial hypertension (PAH). Aberrant signaling via TGF-β receptor I/activin receptor-like kinase 5 may be important for both the development and progression of PAH. We investigated the therapeutic potential of a well-characterized and potent activin receptor-like kinase 5 inhibitor, SB525334 [6-(2-tert-butyl-5-{6-methyl-pyridin-2-yl}-1H-imidazol-4-yl)-quinoxaline] for the treatment of PAH. In this study, we demonstrate that pulmonary artery smooth muscle cells from patients with familial forms of idiopathic PAH exhibit heightened sensitivity to TGF-β1 in vitro, which can be attenuated after the administration of SB525334. We further demonstrate that SB525334 significantly reverses pulmonary arterial pressure and inhibits right ventricular hypertrophy in a rat model of PAH. Immunohistochemical studies confirmed a significant reduction in pulmonary arteriole muscularization induced by monocrotaline (used experimentally to induce PAH) after treatment of rats with SB525334. Collectively, these data are consistent with a role for the activin receptor-like kinase 5 in the progression of idiopathic PAH and imply that strategies to inhibit activin receptor-like kinase 5 signaling may have therapeutic benefit