Sistem Aplikasi Monitoring Ruangan Berbasis Webcam

Software design and hardware application system monitoring room webcam based aims to add value to the webcam to be used as part of the security system, implementing the work process of hardware and software monitoring system formed using delphi 7, analyzing the performance o f a stepper motor as the driving platform webcam and documenting object images and sounds in the room activities into a file format AVI (Audio Video Interleave). Webcams are used in this design is equipped with a standard webcam lighting lamps LED (Light Emitting Diode) with a USB data line, while the driver controls the webcam in the design o f this platform using unipolar type stepper motor controlled by a microcontroller, motor drivers and line interface RS232 to USB (Universal Serial Bus) converter. The installation o f the webcam to webcam platform play will lead to the right, left, stop rotating right and or to the left automatically. From the test results it can be concluded that the monitoring system and webcam based indoor stepper motor consists o f webcam applications and motor control applications platform which is separately because both applications use the USB and COM communication channels are opened simultaneously. As for the results o f the motion setting webcam platform proved to have a consistent degree of deviation for the wine and left turn kenanan but still require a series o f additional gears for smooth movement o f the platform and to reduce the effects o f shadow on motion pictures

Penyelesaian Perselisihan Tenaga Kerja melalui Konsiliasi Berdasarkan Undang-undang Nomor 2 Tahun 2004 Tentang Penyelesaian Perselisihan Hubungan Industrial pada PT. Jarsindo Karya Utama di Kabupaten Siak

Kabupaten Siak banyak menyerap tenaga kerja dan konsekwensinya juga banyak terjadi permasalahan ketenagakerjaan atau yang sering disebut dengan perselisihan hubungan industrial. Salah satu yang terjadi di Kabupaten Siak adalah kasus perselisihan pemutusan hubungan kerja secara sepihak yang dialami seorang karyawan yaitu Poster Sijintak. Permasalahannya, Poster Sijintak dipecat sebagai pengawas lapangan pengangkutan kayu oleh PT. Jarsindo Karya Utama, karena pekerja dinilai oleh pengusaha tidak mampu menunjukkan kinerja/prestasi yang baik, disamping itu atas pertimbangan Perusahaan tidak secara kontinu mendapatkan/order kerja pengangkutan kayu dari pengusaha pemberi/penyedia kerja PT.IKKP Perawang. Penyelesaian kasus tersebut di tempauh melalui jalur konsilidasi. Tujuan penulisan skripsi ini untuk mengetahui penyelesaian perselisihan tenaga kerja melalui konsiliasi Pada PT. Jarsindo Karya Utama di Kabupaten Siak dan untuk mengetahui hambatan yang dihadapi dalam penyelesaian perselisihan tenaga kerja melalui konsiliasi pada PT. Jarsindo Karya Utama di Kabupaten Siak. Jenis penelitian ini adalah yuridis sosiologis karena dalam penelitian ini penulis langsung mengadakan penelitian pada lokasi atau tempat yang diteliti guna memperoleh gambaran secara lengkap tentang masalah yang diteliti. Penelitian ini dilakukan di Kabupaten Siak, tepatnya pada Kantor Dinas Sosial dan Tenaga Kerja Kabupaten Siak. Populasi pada penelitian ini adalah seluruh pihak yang terkait dengan penyelesaian tenaga kerja melalui konsiliasi pada PT. Jarsindo Karya Utama di Kabupaten Siak, yakni konsiliator, serta pekerja dan para pengusaha yang menyelesaikan perselisihan hubungan industrial melalui perantaraan Konsiliator di Kabupaten Siak dengan teknik penarikan sampel secara sensus. Sumber data yang digunakan data primer, data sekunder, dan data tersier teknik pengumpulan data dalam penelitian ini adalah wawancara dan dokumentasi. Dari hasil penelitian dapat disimpulkan, penyelesaian Perselisihan Tenaga Kerja Melalui Konsiliasi Pada PT. Jarsindo Karya Utama di Kabupaten Siak telah dilaksanakan dengan baik sesuai dengan Undang-Undang Nomor 2 Tahun 2004 Tentang Tentang Penyelesaian dan sudah diterapkan secara baik oleh konsiliator. Hambatan yang dihadapi dalam penyelesaian perselisihan tenaga kerja melalui konsiliasi pada PT. Jarsindo Karya Utama di Kabupaten Siak yaitu belum ditetapkannya keputusan menteri mengenai besarnya biaya transportasi dan akomodasi saksi-saksi, belum adanya petugas khusus untuk mengirimkan surat panggilan kepada para pihak, belum ditetapkannya keputusan direktur jenderal mengenai bentuk dan isi risalah, laporan, serta tata cara pelaporan, sarana prasarana tidak memadai dan pihak yang berselisih kurang responsif yaitu tidak menghadiri panggilan sidang konsiliasi

The Effect of Algorithms on Copy Number Variant Detection

BACKGROUND: The detection of copy number variants (CNVs) and the results of CNV-disease association studies rely on how CNVs are defined, and because array-based technologies can only infer CNVs, CNV-calling algorithms can produce vastly different findings. Several authors have noted the large-scale variability between CNV-detection methods, as well as the substantial false positive and false negative rates associated with those methods. In this study, we use variations of four common algorithms for CNV detection (PennCNV, QuantiSNP, HMMSeg, and cnvPartition) and two definitions of overlap (any overlap and an overlap of at least 40% of the smaller CNV) to illustrate the effects of varying algorithms and definitions of overlap on CNV discovery. METHODOLOGY AND PRINCIPAL FINDINGS: We used a 56 K Illumina genotyping array enriched for CNV regions to generate hybridization intensities and allele frequencies for 48 Caucasian schizophrenia cases and 48 age-, ethnicity-, and gender-matched control subjects. No algorithm found a difference in CNV burden between the two groups. However, the total number of CNVs called ranged from 102 to 3,765 across algorithms. The mean CNV size ranged from 46 kb to 787 kb, and the average number of CNVs per subject ranged from 1 to 39. The number of novel CNVs not previously reported in normal subjects ranged from 0 to 212. CONCLUSIONS AND SIGNIFICANCE: Motivated by the availability of multiple publicly available genome-wide SNP arrays, investigators are conducting numerous analyses to identify putative additional CNVs in complex genetic disorders. However, the number of CNVs identified in array-based studies, and whether these CNVs are novel or valid, will depend on the algorithm(s) used. Thus, given the variety of methods used, there will be many false positives and false negatives. Both guidelines for the identification of CNVs inferred from high-density arrays and the establishment of a gold standard for validation of CNVs are needed

Measurement of overall quality of life in nursing homes through self-report: the role of cognitive impairment

Measuring quality of life is a necessity for adequate interventions. This paper concerns the usefulness of six self-report measures for overall quality of life for nursing home residents with various levels of cognitive impairment. It was investigated which proportion of residents from four cognition groups could complete a scale, and internal consistency and construct validity of the scales were studied. Data collection took place in ten Dutch nursing homes (N = 227). The proportion of residents that could complete each scale varied. The Depression List could be administered most often to the cognitively most impaired group (43%; Mini Mental State Examination-scores 0–4). In the three cognition groups with MMSE-score >5, internal consistency of the Depression List, Geriatric Depression Scale and Negative Affect Scale was adequate in all three groups (alpha ≥.68). Intercorrelation was highest for the Philadelphia Geriatric Center Morale Scale, the Depression List, and the Geriatric Depression Scale (rho ≥.65). Nonetheless, self-report scales were not strongly correlated with two observational scales for depression, especially in cognitively severely impaired residents (rho ≤.30). In conclusion, it may not be possible to measure overall quality of life through self-report, and possibly also through observation, in many nursing home residents

Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence

There are 91 known capsular serotypes of Streptococcus pneumoniae. The nasopharyngeal carriage prevalence of particular serotypes is relatively stable worldwide, but the host and bacterial factors that maintain these patterns are poorly understood. Given the possibility of serotype replacement following vaccination against seven clinically important serotypes, it is increasingly important to understand these factors. We hypothesized that the biochemical structure of the capsular polysaccharides could influence the degree of encapsulation of different serotypes, their susceptibility to killing by neutrophils, and ultimately their success during nasopharyngeal carriage. We sought to measure biological differences among capsular serotypes that may account for epidemiological patterns. Using an in vitro assay with both isogenic capsule-switch variants and clinical carriage isolates, we found an association between increased carriage prevalence and resistance to non-opsonic neutrophil-mediated killing, and serotypes that were resistant to neutrophil-mediated killing tended to be more heavily encapsulated, as determined by FITC-dextran exclusion. Next, we identified a link between polysaccharide structure and carriage prevalence. Significantly, non-vaccine serotypes that have become common in vaccinated populations tend to be those with fewer carbons per repeat unit and low energy expended per repeat unit, suggesting a novel biological principle to explain patterns of serotype replacement. More prevalent serotypes are more heavily encapsulated and more resistant to neutrophil-mediated killing, and these phenotypes are associated with the structure of the capsular polysaccharide, suggesting a direct relationship between polysaccharide biochemistry and the success of a serotype during nasopharyngeal carriage and potentially providing a method for predicting serotype replacement

F-Spondin/spon1b Expression Patterns in Developing and Adult Zebrafish

F-spondin, an extracellular matrix protein, is an important player in embryonic morphogenesis and CNS development, but its presence and role later in life remains largely unknown. We generated a transgenic zebrafish in which GFP is expressed under the control of the F-spondin (spon1b) promoter, and used it in combination with complementary techniques to undertake a detailed characterization of the expression patterns of F-spondin in developing and adult brain and periphery. We found that F-spondin is often associated with structures forming long neuronal tracts, including retinal ganglion cells, the olfactory bulb, the habenula, and the nucleus of the medial longitudinal fasciculus (nMLF). F-spondin expression coincides with zones of adult neurogenesis and is abundant in CSF-contacting secretory neurons, especially those in the hypothalamus. Use of this new transgenic model also revealed F-spondin expression patterns in the peripheral CNS, notably in enteric neurons, and in peripheral tissues involved in active patterning or proliferation in adults, including the endoskeleton of zebrafish fins and the continuously regenerating pharyngeal teeth. Moreover, patterning of the regenerating caudal fin following fin amputation in adult zebrafish was associated with F-spondin expression in the blastema, a proliferative region critical for tissue reconstitution. Together, these findings suggest major roles for F-spondin in the CNS and periphery of the developing and adult vertebrate

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR, and SPINK1 variants were associated with pancreatitis risk. We now report two significant genome-wide associations identified and replicated at PRSS1-PRSS2 (1×10-12) and x-linked CLDN2 (p < 1×10-21) through a two-stage genome-wide study (Stage 1, 676 cases and 4507 controls; Stage 2, 910 cases and 4170 controls). The PRSS1 variant affects susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous male) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men – male hemizygous frequency is 0.26, female homozygote is 0.07

Detectable A Disintegrin and Metalloproteinase With Thrombospondin Motifs-1 in Serum Is Associated With Adverse Outcome in Pediatric Sepsis.

ImportanceA Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 is hypothesized to play a role in the pathogenesis of invasive infection, but studies in sepsis are lacking.ObjectivesTo study A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 protein level in pediatric sepsis and to study the association with outcome.DesignData from two prospective cohort studies.Setting and participantsCohort 1 is from a single-center study involving children admitted to PICU with meningococcal sepsis (samples obtained at three time points). Cohort 2 includes patients from a multicenter study involving children admitted to the hospital with invasive bacterial infections of differing etiologies (samples obtained within 48 hr after hospital admission).Main outcomes and measuresPrimary outcome measure was mortality. Secondary outcome measures were PICU-free days at day 28 and hospital length of stay.ResultsIn cohort 1 (n = 59), nonsurvivors more frequently had A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels above the detection limit than survivors at admission to PICU (8/11 [73%] and 6/23 [26%], respectively; p = 0.02) and at t = 24 hours (2/3 [67%] and 3/37 [8%], respectively; p = 0.04). In cohort 2 (n = 240), A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels in patients within 48 hours after hospital admission were more frequently above the detection limit than in healthy controls (110/240 [46%] and 14/64 [22%], respectively; p = 0.001). Nonsurvivors more often had detectable A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 levels than survivors (16/21 [76%] and 94/219 [43%], respectively; p = 0.003), which was mostly attributable to patients with Neisseria meningitidis.Conclusions and relevanceIn children with bacterial infection, detection of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 within 48 hours after hospital admission is associated with death, particularly in meningococcal sepsis. Future studies should confirm the prognostic value of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-1 and should study pathophysiologic mechanisms