Series voltage regulator for radial DC-microgrid

The concept of a novel series voltage regulator (SVR) for controlling the dc-bus voltage of a radial dc microgrid is presented in this paper. The proposed SVR uses a dual-active-bridge dc-dc converter followed by a full-bridge dc-dc converter. It injects dynamic voltage in series with the dc grid to compensate resistive drop over the network. As a result, the voltage level at the different points of the grid becomes independent of load variation and stays within the specified limit. Note that the required power rating of the SVR is very low (say 2.7%) compared to the load demand considering 5% voltage regulation. In this paper, the voltage regulator is connected at the midpoint of the grid, but it may be connected in some other locations to get optimal rating of the same. The proposed configuration is simulated in MATLAB/SIMULINK at a 380-V level to check the dynamic performance under various operating conditions. A scaled-down version (at 30-V level) of the proposed system is developed in the laboratory to experimentally validate the concept. The results show the effectiveness of such a voltage regulator for the radial dc microgrid, especially under critical load condition

An efficient chaotic salp swarm optimization approach based on ensemble algorithm for class imbalance problems

Class imbalance problems have attracted the research community, but a few works have focused on feature selection with imbalanced datasets. To handle class imbalance problems, we developed a novel fitness function for feature selection using the chaotic salp swarm optimization algorithm, an efficient meta-heuristic optimization algorithm that has been successfully used in a wide range of optimization problems. This paper proposes an AdaBoost algorithm with chaotic salp swarm optimization. The most discriminating features are selected using salp swarm optimization, and AdaBoost classifiers are thereafter trained on the features selected. Experiments show the ability of the proposed technique to find the optimal features with performance maximization of AdaBoost

Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses

A novel nucleoside analogue, 1-[(2S,4S-2-(hydroxymethyl)-1,3-dioxolan-4-yl]5-vinylpyrimidine-2,4(1H,3H)-dione, or HDVD, was evaluated against a wide variety of herpesviruses and was found to be a highly selective inhibitor of replication of the gammaherpesviruses Kaposi's sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). HDVD had also a pronounced inhibitory activity against murine herpesvirus 68 (MHV-68) and herpes simplex virus 1 (HSV-1). In contrast, replication of herpesvirus saimiri (HVS), HSV-2, and varicella-zoster virus (VZV) was weakly inhibited by the compound, and no antiviral activity was determined against human cytomegalovirus (HCMV) and rhesus rhadinovirus (RRV). The HDVD-resistant virus phenotype contained point mutations in the viral thymidine kinase (TK) of HSV-1, MHV-68, and HVS isolates. These mutations conferred cross-resistance to other TK-dependent drugs, with the exception of an MHV-68 mutant (E358D) that exhibited resistance only to HDVD. HSV-1 and HVS TK-mutants isolated under selective pressure with bromovinyldeoxyuridine (BVDU) also showed reduced sensitivity to HDVD. Oral treatment with HDVD and BVDU was assessed in an intranasal model of MHV-68 infection in BALB/c mice. In contrast to BVDU treatment, HDVD-treated animals showed a reduction in viral DNA loads and diminished viral gene expression during acute viral replication in the lungs in comparison to levels in untreated controls. The valyl ester prodrug of HDVD (USS-02-71-44) suppressed the latent infection in the spleen to a greater extent than HDVD. In the present study, HDVD emerged as a highly potent antiviral with a unique spectrum of activity against herpesviruses, in particular, gammaherpesviruses, and may be of interest in the treatment of virus-associated diseases.status: publishe