Understanding peace through the world news

Peace is a principal dimension of well-being and is the way out of inequity and violence. Thus, its measurement has drawn the attention of researchers, policymakers, and peacekeepers. During the last years, novel digital data streams have drastically changed the research in this field. The current study exploits information extracted from a new digital database called Global Data on Events, Location, and Tone (GDELT) to capture peace through the Global Peace Index (GPI). Applying predictive machine learning models, we demonstrate that news media attention from GDELT can be used as a proxy for measuring GPI at a monthly level. Additionally, we use explainable AI techniques to obtain the most important variables that drive the predictions. This analysis highlights each country’s profile and provides explanations for the predictions, and particularly for the errors and the events that drive these errors. We believe that digital data exploited by researchers, policymakers, and peacekeepers, with data science tools as powerful as machine learning, could contribute to maximizing the societal benefits and minimizing the risks to peace.Peace is a principal dimension of well-being and is the way out of inequity and violence. Thus, its measurement has drawn the attention of researchers, policymakers, and peacekeepers. During the last years, novel digital data streams have drastically changed the research in this field. The current study exploits information extracted from a new digital database called Global Data on Events, Location, and Tone (GDELT) to capture peace through the Global Peace Index (GPI). Applying predictive machine learning models, we demonstrate that news media attention from GDELT can be used as a proxy for measuring GPI at a monthly level. Additionally, we use explainable AI techniques to obtain the most important variables that drive the predictions. This analysis highlights each country’s profile and provides explanations for the predictions, and particularly for the errors and the events that drive these errors. We believe that digital data exploited by researchers, policymakers, and peacekeepers, with data science tools as powerful as machine learning, could contribute to maximizing the societal benefits and minimizing the risks to peace

Measuring objective and subjective well-being: dimensions and data sources

Well-being is an important value for people’s lives, and it could be considered as an index of societal progress. Researchers have suggested two main approaches for the overall measurement of well-being, the objective and the subjective well-being. Both approaches, as well as their relevant dimensions, have been traditionally captured with surveys. During the last decades, new data sources have been suggested as an alternative or complement to traditional data. This paper aims to present the theoretical background of well-being, by distinguishing between objective and subjective approaches, their relevant dimensions, the new data sources used for their measurement and relevant studies. We also intend to shed light on still barely unexplored dimensions and data sources that could potentially contribute as a key for public policing and social development

The expression of Omental 11β-HSD1 is not increased in severely obese women with metabolic syndrome

Objective: Plasma cortisol in obese subjects does not differ from that in normoweight subjects. Extra-adrenal cortisol production by 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1) can result in local hypercortisolemia. The aim of the present study was to examine the role of visceral hypercortisolemia in the development of metabolic syndrome in severe obesity. Methods: Eight lean women during hysterectomy (controls) and 19 severely obese women during bariatric surgery were studied, 8 without metabolic syndrome (OM- group) and 11 with it (OM+ group). Biopsies of omental and subcutaneous fat were performed in the severely obese women during surgery, but only omental biopsies in the controls. Expression of 11β-HSD1, glucocorticoid receptor α (GRα) and glucocorticoid receptor β (GRβ) was evaluated using real-time PCR.Results: Omental 11β-HSD1 expression was different between groups (one-way ANOVA, p < 0.01). Post-hoc analysis revealed that mean omental 11β-HSD1 mRNA levels were higher in the OM- group compared to controls, whereas they were similar when comparing the OM+ group with lean controls. Expression of 11β-HSD1 in subcutaneous fat was not different between OM+ and OM- groups. GRα expression in omental fat did not differ among groups or between omental and subcutaneous fat in severely obese patients. An expression of GRβ was not detected.Conclusion: Contrary to our original hypothesis, omental 11β-HSD1 expression is not increased in the OM+ group. Copyright © 2012 S. Karger GmbH, Freiburg

Conceptual design of the main Ancillary Systems of the ITER Water Cooled Lithium Lead Test Blanket System

The Water Cooled Lithium Lead Test Blanket System (WCLL TBS) is one of the EU Test Blanket Systems candidate for being installed and operated in ITER. In view of its Conceptual Design Review by F4E and ITER Organization (IO), planned for mid-September 2020, several technical activities have been performed in the areas of WCLL TBS Ancillary Systems design. In this article the outcomes of the conceptual design phase of the four main Ancillary Systems of WCLL TBS, namely the Water Cooling System (WCS), the Coolant Purification System (CPS), the PbLi loop and the Tritium Extraction System (TES), are reported and critically discussed. In particular, for each Ancillary System hereafter are reported: i) a short design description, including the conceptual design of their main components together with their operative conditions under the so-called Normal Operational State (NOS), ii) the ESP-ESPN classification for their main components, and iii) their arrangement and integration in the assigned ITER areas (PC#16, Vertical Shaft, TCWS Vault, Galleries and Tritium Process Room)

Salts of Clopidogrel: Investigation to Ensure Clinical Equivalence: A 12-Month Randomized Clinical Trial

Background: In the present clinical trial, we compared the efficacy and safety of the generic clopidogrel besylate (CB) with the innovator clopidogrel hydrogen sulfate (CHS) salt in patients eligible to receive clopidogrel. Methods: A prospective 2-arm, multicenter, open-label, phase 4 clinical trial. Consecutive patients (n = 1864) were screened and 1800 were enrolled in the trial and randomized to CHS or CB. Primary efficacy end point was the composite of myocardial infarction, stroke, or death from vascular causes, and primary safety end point was rate of bleeding events as defined by Bleeding Academic Research Consortium criteria. Results: At 12-month follow-up, no differences were observed between CB (n = 759) and CHS (n = 798) in primary efficacy and safety end points (age, sex, history of percutaneous coronary intervention adjusted odds ratio [OR], 0.70; 95% confidence interval [CI], 0.41-1.21 and OR, 0.81; 95% CI, 0.51-1.29, respectively) between CHS and CB. Analyses of efficacy and safety in subgroups that were defined according to the qualifying diagnosis revealed that there was no difference between CHS and CB. Conclusion: The efficacy and safety of CB administered for 12 months for the secondary prevention of atherothrombotic events are similar to that of CHS

Generic Clopidogrel Besylate in the Secondary Prevention of Atherothrombotic Events: A 6-month Follow-up of a Randomised Clinical Trial

Background: The aim of the present interim analysis was to compare the clinical efficacy and safety of the generic clopidogrel besylate (CB) with the innovator clopidogrel hydrogen sulphate (CHS) salt in patient groups eligible to receive clopidogrel. Methods: A 2-arm, multicenter, open-label, phase IV clinical trial. Consecutive patients (n=1,864) were screened and 1,800 were enrolled in the trial and randomized to CHS (n=759) or CB (n=798). Primary efficacy end point was the composite of myocardial infarction, stroke or death from vascular causes. Primary safety end point was the rate of bleeding events as defined by Bleeding Academic Research Consortium (BARC) criteria. Results: At 6-months follow-up no differences were observed between CB and CHS in primary efficacy end point (OR, 0.80; 95% CI, 0.37 to 1.71; p=0.57). Rates of BARC-1,-2,-3a and -5b bleeding were similar between the two study groups whereas no bleeding events according to BARC-3b, -3c, -4 and -5a were observed in either CHS or CB group. Conclusion: The clinical efficacy and safety of the generic CB were similar to those of the innovator CHS salt, thus this generic clopidogrel formulation can be routinely used in the secondary prevention of atherothrombotic events for a period of at least 6 months. (Salts of Clopidogrel: Investigation to ENsure Clinical Equivalence, SCIENCE study Clinical Trials.gov Identifier: NCT02126982)

Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana

The plant Arabidopsis thaliana (Arabidopsis) has become an important model species for the study of many aspects of plant biology(1). The relatively small size of the nuclear genome and the availability of extensive physical maps of the five chromosomes(2-4) provide a feasible basis for initiating sequencing of the five chromosomes. The YAC (yeast artificial chromosome)-based physical map of chromosome 4 was used to construct a sequence-ready map of cosmid and BAC (bacterial artificial chromosome) clones covering a 1,9-megabase (Mb) contiguous region(5), and the sequence of this region is reported here. Analysis of the sequence revealed an average gene density of one gene every 4.8 kilobases (kb), and 54% of the predicted genes had significant similarity to known genes. Other interesting features were found, such as the sequence of a disease-resistance gene locus, the distribution of retroelements, the frequent occurrence of clustered gene families, and the sequence of several classes of genes not previously encountered in plants