Eco-labels voor visserij en viskweek : benchmark aan de hand van FAO-richtlijnen

In deze nota wordt de vraag beantwoord in hoeverre de volgende eco-labels: Marine Stewardship Council (MSC), Friend of the Sea (FOS), KRAV, Naturland, SKAL en Milieukeur voldoen aan de richtlijnen van de FAO

Performance Centered Maintenance as a Core Policy in Strategic Maintenance Control

Rolling stock maintenance in the Netherlands traditionally is performed on several levels of complexity and therefore on levels of non-availability and cost. The challenge in optimizing performance and cost of rolling stock maintenance is to integrate the policy on maintenance concepts, maintenance locations and maintenance intervals (what, when & where). NedTrain as a subsidiary of the Netherlands Railways is developing and implementing this improved concept of maintenance. On one hand maintenance concepts are being improved based on the philosophy of Risk Based Maintenance, with customer demands on risks regarding safety, reliability, availability and cost as a basis for maintenance renewal. On the other hand - during analysis of current maintenance concepts and risk based improvements – modularization of maintenance tasks is taken into account leading to possibilities to perform these tasks on a lower complexity level, during natural non-availability moments of train sets (off-peak hours in daytime or at night) in local depots instead of larger workshops. With this maintenance policy “Performance Centered Maintenance”, performance improvements and cost reduction are being achieved. New strategies arise for investments in depots, train equipment (e.g. Real Time Monitoring) and training of mechanics.In this document a general overview and first results will be given of the approach

Kleine deeltjes, grote kwesties: Een issueanalyse van de maatschappelijke dialoog nanotechnologie

Dit artikel beantwoordt de vraag welke kwesties aan bod zijn gekomen in de Maatschappelijke Dialoog Nanotechnologie en in hoeverre deze dialoog heeft bijgedragen aan verbreding van het debat. Is het gelukt naast een technologisch ook een maatschappelijk perspectief neer te zetten? Naast de issueanalyse is ook onderzocht welke organisaties hierbij betrokken zijn geweest en de mogelijkheden die zij boden voor publieksinbren

República: Año III Número 346 - (10/08/33)

BACKGROUND: Biomedical knowledge graphs have become important tools to computationally analyse the comprehensive body of biomedical knowledge. They represent knowledge as subject-predicate-object triples, in which the predicate indicates the relationship between subject and object. A triple can also contain provenance information, which consists of references to the sources of the triple (e.g. scientific publications or database entries). Knowledge graphs have been used to classify drug-disease pairs for drug efficacy screening, but existing computational methods have often ignored predicate and provenance information. Using this information, we aimed to develop a supervised machine learning classifier and determine the added value of predicate and provenance information for drug efficacy screening. To ensure the biological plausibility of our method we performed our research on the protein level, where drugs are represented by their drug target proteins, and diseases by their disease proteins. RESULTS: Using random forests with repeated 10-fold cross-validation, our method achieved an area under the ROC curve (AUC) of 78.1% and 74.3% for two reference sets. We benchmarked against a state-of-the-art knowledge-graph technique that does not use predicate and provenance information, obtaining AUCs of 65.6% and 64.6%, respectively. Classifiers that only used predicate information performed superior to classifiers that only used provenance information, but using both performed best. CONCLUSION: We conclude that both predicate and provenance information provide added value for drug efficacy screening

Automated detection of wedge-shaped defects in polarimetric images of the retinal nerve fibre layer

Purpose: Automated glaucoma detection in images obtained by scanning laser polarimetry is currently insensitive to local abnormalities, impairing its performance. The purpose of this investigation was to tes

The Effect of Various Spinal Neurostimulation Paradigms on the Supraspinal Somatosensory Evoked Response:A Systematic Review

Introduction: Spinal neurostimulation is a therapy for otherwise intractable chronic pain. Spinal neurostimulation includes stimulation of the spinal cord (SCS), dorsal root ganglion (DRGS), and dorsal root entry zone (DREZS). New paresthesia-free neurostimulation paradigms may rely on different mechanisms of action from those of conventional tonic neurostimulation. The aim of this systematic review is to assess the existing knowledge on the effect of spinal neurostimulation on somatosensory processing in patients with chronic pain. We therefore reviewed the existing literature on the effect of various spinal neurostimulation paradigms on the supraspinal somatosensory evoked response (SER). Materials and Methods: Multiple scientific data bases were searched for studies that assessed the effect of spinal neurostimulation on the supraspinal SER, evoked by painful or nonpainful peripheral stimuli in patients with chronic pain. We found 205 studies, of which 24 were included. Demographic data, study design, and study outcome were extracted. Results: Of the 24 included studies, 23 used electroencephalography to assess the SER; one study used magnetoencephalography. Fifteen studies evaluated tonic SCS; six studies (also) evaluated paresthesia-free paradigms; three studies evaluated the effect of tonic DRGS or DREZS. Sixteen studies used nonpainful stimuli to elicit the SER, 14 observed a decreased SER amplitude. Ten studies used painful stimuli to elicit the SER, yielding mixed results. Discussion: The included studies suggest that both paresthesia-based and paresthesia-free spinal neurostimulation paradigms can decrease (part of) the SER elicited by a nonpainful peripheral stimulus. The observed SER amplitude reduction likely is the effect of various spinal and supraspinal mechanisms of spinal neurostimulation that also contribute to pain relief. Conclusions: Spinal neurostimulation modulates the processing of a peripherally applied nonpainful stimulus. For painful stimuli, the results are not conclusive. It is not yet clear whether paresthesia-free neurostimulation affects the SER differently from paresthesia-based neurostimulation.</p

Huishoudelijke arbeid in de schaduw van Achterhuis

Reactie op het hoofdstuk over de geschiedenis van de huishoudelijke arbeid uit: "arbeid een eigenaardig medicijn" van Hans Achterhui