In vitro activity of a new 'higher-lactam' antibacterial agent LY 193239

In vitro activity ofthe new bicyclic pyrazolidinone LY 193239 (Eli Lilly) was evaluated against 52 clinical isolates of Haemophilus influenzae (4 were β-lactamase producers), 32 Enterococcus faecalis, 14 Neisseria gonorrhoeae (1 β-lactamasepositive) and 19 Neisseria meningitidis. Activity was best against Neisseria spp. and H. influenzae, including penicillinase- producing strains. Results of the time-kill study against a non-enzyme-mediated penicillin resistant strain of N. meningitidis indicate that exposure to an antibacterial concentration four times the minimal inhibitory concentration was bactericidal. E. faecalis was insensitive

A clinical and molecular investigation of two South African families with Simpson-Golabi-Behmel syndrome

Background. Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked recessive overgrowth syndrome manifesting primarily in boys and characterised by macrosomia, distinctive facial features and multiple congenital abnormalities. Although this rare condition is thought to be underdiagnosed, making a diagnosis is important as affected boys have a 7.5% risk of developing visceral tumours and surveillance is warranted. Mutations in GPC3 are found in up to 70% of boys affected with SGBS.Objectives. A clinical and molecular investigation of two boys with SGBS, probands B and S, and their mothers. Documentation of the clinical phenotype could assist with diagnosis in affected boys and will lead to early initiation of tumour surveillance.Methods. Hospital folders were reviewed and clinical consultations arranged for both probands and their mothers. Molecular investigations initially searched for whole-exon deletions in GPC3 followed by gene sequencing.Results. The clinical phenotype of both probands was consistent with that previously reported in the literature. The main features pointing towards the diagnosis were macrosomia, coarse facial features and macroglossia with a midline groove in the tongue. Proband B developed a Wilms tumour. He was found to have a novel mutation causing a premature stop codon.Conclusions. This research represents the first published report of SGBS in South Africa. Early recognition and confirmation of this condition is important in order to institute tumour surveillance and assist families with accurate recurrence risks

Unidentified Galactic High-Energy Sources as Ancient Pulsar Wind Nebulae in the light of new high energy observations and the new code

In a Pulsar Wind Nebula (PWN), the lifetime of inverse Compton (IC) emitting electrons exceeds the lifetime of its progenitor pulsar (as well as its shell-type remnant), but it also exceeds the age of those that emit via synchrotron radiation. Therefore, during its evolution, the PWN can remain bright in IC so that its GeV-TeV gamma-ray flux remains high for timescales much larger (for 10^5 - 10^6 yrs) than the pulsar lifetime and the X-ray PWN lifetime. In this scenario, the magnetic field in the cavity induced by the wind of the progenitor star plays a crucial role. This scenario is in line with the discovery of several unidentified or "dark" sources in the TeV gamma-ray band without X-ray counterparts; and it is also finding confirmation in the recent discoveries at GeV gamma rays. Moreover, these consequences could be also important for reinterpreting the detection of starburst galaxies in the TeV gamma-ray band when considering a leptonic origin of the gamma-ray signal. Both theoretical aspects and their observational proofs will be discussed, as well as the first results of our new modeling code.Comment: Proceedings of the 5th International Symposium on High-Energy Gamma-Ray Astronomy (Gamma2012

Institutionalizing diversity and inclusion engaged marketing (DIEM) for multicultural marketplace wellbeing

Within an institutional theory framework, this paper identifies three interconnected fields of the marketing institution – research, education, and practice – that contribute to advancing the diversity and inclusion discourse in promoting multicultural marketplace wellbeing. Conducting three studies, one in each field and across contexts in three continents, we identify barriers that inhibit effective implementation of diversity and inclusion initiatives in today’s multicultural marketplaces. These barriers exist within and across fields and pertain to cultural-cognitive (shared meanings), normative (normative factors), and regulatory (rules and systems) pillars supporting the existence or transformation of institutions. From our research findings, we provide specific guidance for institutional work within marketing’s fields and policy developments needed to advance diversity and inclusion engaged marketing (DIEM) for enhancing multicultural marketplace wellbeing

Brokering intercultural relations in the rainbow nation: introducing intercultural marketing

This paper considers the role of marketing in building intercultural relations in superdiverse, post-colonial societies, using post-apartheid South Africa as a case study. Drawing on neo-institutional theory, we analyze South African advertising campaigns to determine how marketing brokers intercultural relations by legitimizing social meanings conveyed through nation-building ideologies and consumers’ lived experiences. We examine whether marketing outputs align with stages of Rainbow Nation-building strategies and types of consumers’ lived experiences of South Africa’s superdiversity. We then derive a conceptualization of intercultural marketing, which we characterize as an approach focused on brokering meanings of convivial intercultural engagement and collective development of societal welfare goals. We contribute to macromarketing theory, directing attention to the important brokering role marketing has, in bridging conceptions of reconciliatory social development held by public policy makers and by societies’ populations. By conceptualizing intercultural marketing, its goals and tools, we contribute to multiculturally-sensitive marketing research and practice advancement

Why a contextual approach to professional development?

One of the peculiarities of the literature on academic professional development with regard to teaching is its a-political nature. It pays insufficient attention to issues of equity, and to how privilege, geographical location, class and ethnicity influence the way that staff in higher education learn to teach. This is surprising, or paradoxical, given the strong world-wide concern for widening participation and student success in higher education. The approaches towards professional academic development have been dominated by literature from the global North, which does not take into account conditions in resource-constrained environments. We contend that literature from these Southern environments enrich the international body of literature. Thus there is a need for scholarly writing on learning to teach in higher education, which takes a specifically social, contextual and relational approach and which considers these within resource-rich as well as resource-constrained environments

Spatially resolved XMM-Newton analysis and a model of the nonthermal emission of MSH 15-52

We present an X-ray analysis and a model of the nonthermal emission of the pulsar wind nebula (PWN) MSH15-52. We analyzed XMM-Newton data to obtain the spatially resolved spectral parameters around the pulsar PSRB1509-58. A steepening of the fitted power-law spectra and decrease in the surface brightness is observed with increasing distance from the pulsar. In the second part of this paper, we introduce a model for the nonthermal emission, based on assuming the ideal magnetohydrodynamic limit. This model is used to constrain the parameters of the termination shock and the bulk velocity of the leptons in the PWN. Our model is able to reproduce the spatial variation of the X-ray spectra. The parameter ranges that we found agree well with the parameter estimates found by other authors with different approaches. In the last part of this paper, we calculate the inverse Compton emission from our model and compare it to the emission detected with the H.E.S.S. telescope system. Our model is able to reproduce the flux level observed with H.E.S.S., but not the spectral shape of the observed TeV {\gamma}-ray emission.Comment: Accepted for publication in A&A, 9 pages, 15 figure

Impact of urbanisation on Serum lipid profiles -the thusa survey

Objective. To examine the impact of urbanisation on lipid profiles of black South Africans, stratified for HIV status.Design. Cross-sectional population-based survey.Setting. North West province of South Africa.Subjects. A representative sample of 1854 apparently healthy volunteers aged ≥ 15 years, was recruited from 37 randomly selected sites throughout the province. Subjects were stratified into five urbanisation strata (S): Sl rural villages, S2 farms, S3 informal housing or 'squatter camps', S4 urban townships, and S5 surburban housing.Outcome measures. Demographic, physical activity and dietary intake information was collected using validated and culture-sensitive questionnaires. Anthropometric measurements and lipid analyses were determined using standardised methodology.Results. The results revealed significantly lower mean(95% confidence interval) total serum cholesterol (TC) levels in HIV-negative men in Sl -S4 compared with S5 (S1 3.91 (3.77- 4.05) v. S5 4.79 (4.54- 5.04) mmol/1). In HIV-negative women, TC levels were significantly lower in Sl - S3 than in S4 and S5 (S1 4.05 (3.94- 4.17) v. S5 4.79 (4.59- 5.00) mmol/1). The same trends were seen for serum low-density lipoprotein cholesterol (LDLC) and triglycerides and in HIV-positive subjects. Binary logistical analysis indicated that the main factor responsible for the increased TC levels seemed to be increased body mass index (BMI) due to decreased physical activity. Conclusions. Serum lipid levels increased with urbanisation although they remained within levels recommended for ther populations. This may, however, become an important health problem in future if preventive strategies are not implemented. Culturally sensitive physical activity programmes to decrease BMI, targeted at professional me and women, and women in urban townships, seem to constitute the most appropriate intervention