Modelling uncertainties in phase-space boundary integral models of ray propagation

A recently proposed phase-space boundary integral model for the stochastic propagation of ray densities is presented and, for the first time, explicit connections between this model and parametric uncertainties arising in the underlying physical model are derived. In particular, an asymptotic analysis for a weak noise perturbation of the propagation speed is used to derive expressions for the probability distribution of the phase-space boundary coordinates after transport along uncertain, and in general curved, ray trajectories. Furthermore, models are presented for incorporating geometric uncertainties in terms of both the location of an edge within a polygonal domain, as well as small scale geometric fluctuations giving rise to rough boundary reflections. Uncertain source terms are also considered in the form of stochastically distributed point sources and uncertain boundary data. A series of numerical experiments is then performed to illustrate these uncertainty models in two-dimensional convex polygonal domains

Structure of human RNA polymerase III

In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across eukaryotes. Upregulation of Pol III transcription is observed in cancer and causative Pol III mutations have been described in neurodevelopmental disorders and hypersensitivity to viral infection. Here, we report a cryo-EM reconstruction at 4.0 Å of human Pol III, allowing mapping and rationalization of reported genetic mutations. Mutations causing neurodevelopmental defects cluster in hotspots affecting Pol III stability and/or biogenesis, whereas mutations affecting viral sensing are located in proximity to DNA binding regions, suggesting an impairment of Pol III cytosolic viral DNA-sensing. Integrating x-ray crystallography and SAXS, we also describe the structure of the higher eukaryote specific RPC5 C-terminal extension. Surprisingly, experiments in living cells highlight a role for this module in the assembly and stability of human Pol III

Felsefe tarihi, ikinci kısım: yeni zamanda Kant'a kadar felsefe

Eserin Baş Tarafındaki İlave Sayfalarda Mütercimin "İlk Söz"Ü İle Eserin "Fihrist"İ Vardır. Eserin Sonunda "Mezahib Ve Alam Cedeveli" (261-271 S.) Vardır. Eserin Sonundaki İlave Sayfalarda Latin Harfleri İle "Yanlışlar Cetveli" Vardır. Eserin İç Kapağında Yayınevi (İstanbul Darülfünunu Edebiyat Fakültesi) Amblemi Vardır

Auralization: fundamentals of acoustics, modelling, simulation, algorithms and acoustic virtual reality

"Auralization" is the technique of creation and reproduction of sound on the basis of computer data. With this tool is it possible to predict the character of sound signals which are generated at the source and modified by reinforcement, propagation and transmission in systems such as rooms, buildings, vehicles or other technical devices. This book is organized as a comprehensive collection of the basics of sound and vibration, acoustic modelling, simulation, signal processing and audio reproduction. Implementations of the auralization technique are described using examples drawn from various fields in acoustic’s research and engineering, architecture, sound design and virtual reality

Felsefe tarihi, birinci kısım: medeniyet-i kâdime ve kurûn-ı vustada felsefe

Eserin Baş Tarafındaki İlave Sayfada "Mütercimin Diğer Neşriyatı" Listesi Vardır. Eserin "Fihrist"İ (S. 3) Vardır. Eserin Sonunda "Mezahib Ve Alam Cedveli" (350-63 S.) Vardır. Eserde "İstanbul Eğitim Enstitüsü Kitaplığı" Ve "İstanbul Kız Muallim Mektebi Müdürlüğü" Mühürleri Vardır. Eserin İç Kapağında Yayınevi (İstanbul Darülfünunu Edebiyat Fakültesi) Amblemi Vardır

Felsefe tarihi, ikinci kısım: yeni zamanda Kant'a kadar felsefe

Eserin Baş Tarafındaki İlave Sayfalarda Mütercimin "İlk Söz"Ü İle Eserin "Fihrist"İ Vardır. Eserin Sonunda "Mezahib Ve Alam Cedeveli" (261-271 S.) Vardır. Eserin Sonundaki İlave Sayfalarda Latin Harfleri İle "Yanlışlar Cetveli" Vardır. Eserde "İstanbul Eğitim Enstitüsü Kitaplığı" Ve "İstanbul Kız Muallim Mektebi Müdürlüğü" Mühürleri Vardır. Eserin İç Kapağında Yayınevi (İstanbul Darülfünunu Edebiyat Fakültesi) Amblemi Vardır