ABCB subfamily in GtoPdb v.2023.1

The ABCB subfamily is composed of four full transporters and two half transporters. This is the only human subfamily to have both half and full types of transporters. ABCB1 was discovered as a protein overexpressed in certain drug resistant tumor cells. It is expressed primarily in the blood brain barrier and liver and is thought to be involved in protecting cells from toxins. Cells that overexpress this protein exhibit multi-drug resistance [8, 1]

ABCA subfamily in GtoPdb v.2023.1

To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment [1, 2]

ABCC subfamily in GtoPdb v.2023.1

Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions. They are known to be involved in ion transport, toxin secretion, and signal transduction [7, 2]

ABCA subfamily (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment [1]

ABCC subfamily in GtoPdb v.2021.3

Subfamily ABCC contains thirteen members and nine of these transporters are referred to as the Multidrug Resistance Proteins (MRPs). The MRP proteins are found throughout nature and they mediate many important functions. They are known to be involved in ion transport, toxin secretion, and signal transduction [7, 2]

“No end of a lesson” : observations from the first high-intensity drone war

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Physical Therapist Faculty Transition To Academic Leadership

The Commission on Accreditation in Physical Therapy Education (CAPTE) has elevated the accreditation standards for physical therapy (PT) faculty and program directors. These increased standards along with the proliferation of new physical therapy education programs and retirements of current program directors has created a nationwide program director shortage. The purpose of this quantitative descriptive study identified factors that influence PT faculty in pursuing the position of program director as well as their perceptions of the responsibilities of program director. Qualified PT faculty (n=51) from accredited physical therapy education programs in the Middle Atlantic and New England regions of the United States completed an on-line survey. The survey consisted of Likert scale questions asking the likelihood respondents would apply for a program director position based on job responsibilities identified by CAPTE. The respondents were also asked to rank the program director responsibilities from most to least essential. Frequencies, t-test and Fisher’s exact test were completed to analyze the data. Respondents rated ‘facilitate change’, ‘represent the department at college/university-level meetings’ and ‘oversee the curriculum content, design and evaluation’ as factors that would influence their likelihood to apply for a program director position. Respondents’ ranking of program director responsibilities identified ‘maintain accreditation’ as the most essential responsibility followed by ‘faculty advocate to higher administration’ and ‘develop strategic plans’. In contrast, respondents rated ‘maintain accreditation’ as a factor to unlikely apply for a program director position. Results indicated females (p=0.01) were more likely to consider applying for a program director position than males and there was an association between gender and ‘maintain program accreditation’ (p=0.04) and ‘develop strategic plans’ (p=0.02). Findings from this study may be beneficial for current program directors and higher education administrators when recruiting for physical therapy program directors as well as determining succession of current program directors. The implementation of professional development plans could include informal and formal support of program director responsibilities that influenced PT faculty to pursue a program director position as well as addressing barriers to applying for the position

Attitudes and perceptions of high school career and technical education in California\u27s Central Valley

The purpose of this study was to investigate and analyze the attitudes and perceptions of community college leadership, union officials and high school school-to-career counselors regarding high school vocational education in the California\u27s Central San Joaquin Valley, and to identify characteristics deemed most necessary in the design of a high school vocational education program. This researcher investigated this problem using the following questions as guides: 1. What are the attitudes/perceptions of community college leaders, union officials and high school school-to-career counselors, regarding high school vocational education in California\u27s Central San Joaquin Valley? 2. How do the attitudes/perceptions of community college leaders, union officials and high school school-to-career counselors, with and without prior work related experience, compare regarding high school vocational education in California\u27s Central San Joaquin Valley? 3. What characteristics do community college leaders, union officials and high school school-to-career counselors deem most important in the design of a high school vocational education program in California\u27s Central San Joaquin Valley? The design of this study was descriptive in nature and survey in methodology. Specifically, this study utilized 2 written questionairres with rating scales. One questionnaire evaluates attitudes/perceptions regarding vocational education in the Central San Joaquin Valley of California. The other questionnaire evaluates the importance of vocational education program design characteristics. The first survey, the IVE, contained 28 questions. The second survey contained 21 close-ended statements. Both surveys were rated on a 5 point Likert scale. Study findings suggest that community college leaders, union officials and high school counselors collectively view vocational education in California\u27s Central San Joaquin Valley in a positive light. Respondents in all 3 subgroups identified access to further education and training, employer involvement and curriculum alignment with local labor market to be the characteristics most needed in the design of a program to serve students of California\u27s Central San Joaquin Valley

GEOPHYSICAL INVESTIGATIONS OF THREE SITES WITHIN THE KNIFE RIVER INDIAN VILLAGES NATIONAL HISTORIC SITE, MERCER COUNTY, NORTH DAKOTA

The National Park Service’s Midwest Archeological Center staff and instructors and participants of the 2010 NPS archeological prospection workshop, along with students from the University of North Dakota’s 2010 fieldschool conducted geophysical investigations at three sites within Knife River Indian Villages National Historic Site in Mercer County, North Dakota. The geophysical investigations were conducted between May 10 and May 29, 2010. The investigations at the Elbee site, 32ME408, and Site 32ME2377 were requested by the KNRI superintendent as part of the compliance activities related to the erosion of the Knife River bank in the vicinity of the two sites. The geophysical investigations at the Taylor Bluff site, 32ME366, were conducted as part of the field exercises associated with the twentieth annual NPS archeological prospection workshop. The geophysical survey at the Elbee site included a resistance survey with a resistance meter and twin-probe array, a limited magnetic survey with a dual fluxgate gradiometer, and the re-analysis of the 2002 and 2006 magnetic data from the site. The geophysical survey at Site 32ME2377 included a resistance survey with a resistance meter and twin probe array and a magnetic survey with a single fluxgate gradiometer. Primary data collected at the Taylor Bluff site during the workshop included a ground- penetrating radar survey with a 400 mHz antenna and a magnetic survey with a dual fluxgate gradiometer. The geophysical surveys were conducted in order to identify buried archeological remains in the vicinity of the Knife River bank at the Elbee site and Site 32ME2377. The survey results provide a baseline of archeological geophysical data for a data recovery project by the University of North Dakota’s archeological fieldschool. The survey data from Sites 32ME366, 32ME407, and 32ME2377 provide subsurface information for future park planning activities. The geophysical data also provide information on the potential damage to the archeological resources from the continued erosion of the Knife River bank. The geophysical surveys identified numerous buried archeological remains associated with the prehistoric human occupation of the Elbee site, the historic Native American occupation of the Taylor Bluff site, and more recent historic farming and modern NPS activities at all three sites. The combined total area investigated by the geophysical survey in the three KNRI geophysical project areas was 17,086 m2 or 4.22 acres. The Elbee site and the Taylor Bluff site were recommended as eligible for listing on the National Register of Historic Places while Site 32ME2377 was recommended as not eligible