A Decade of Editing the European Economic Review

This story describes the circumstances that led to all five of us starting as editors at the same time, the unexpected things we have found, the unanticipated reactions we have encountered, how we worked as an editorial team, the central role of the editorial office manager, how we managed to work with five different publishers in ten years, the various initiatives we have developed to involve associate editors and referees, the early electronic editing system, and the creation of the essential database of potential referees. We will also describe the difficulties we have encountered in reaching one of our early goals to reduce the median time of first response to less than four months. Along the way, we will share a few anecdotes to illustrate the work of an academic journal editor.journal, editing, economics

Budget Processes: Theory and Experimental Evidence

This paper studies budget processes, both theoretically and experimentally. We compare the outcomes of bottom-up and top-down budget processes. It is often presumed that a top-down budget process leads to a smaller overall budget than a bottom-up budget process. Ferejohn and Krehbiel (1987) showed theoretically that this need not be the case. We test experimentally the theoretical predictions of their work. The evidence from these experiments lends strong support to their theory, both at the aggregate and the individual subject level

Molecular characterisation of congenital myasthenic syndromes in Southern Brazil

Objective To perform genetic testing of patients with congenital myasthenic syndromes (CMS) from the Southern Brazilian state of Parana. Patients and methods Twenty-five CMS patients from 18 independent families were included in the study. Known CMS genes were sequenced and restriction digest for the mutation RAPSN p.N88K was performed in all patients. Results We identified recessive mutations of CHRNE in ten families, mutations in DOK7 in three families and mutations in COLQ, CHRNA1 and CHRNB1 in one family each. The mutation CHRNE c. 70insG was found in six families. We have repeatedly identified this mutation in patients from Spain and Portugal and haplotype studies indicate that CHRNE c. 70insG derives from a common ancestor. Conclusions Recessive mutations in CHRNE are the major cause of CMS in Southern Brazil with a common mutation introduced by Hispanic settlers. The second most common cause is mutations in DOK7. The minimum prevalence of CMS in Parana is 0.18/100 000

Molecular characterisation of congenital myasthenic syndromes in Southern Brazil

Objective To perform genetic testing of patients with congenital myasthenic syndromes (CMS) from the Southern Brazilian state of Parana. Patients and methods Twenty-five CMS patients from 18 independent families were included in the study. Known CMS genes were sequenced and restriction digest for the mutation RAPSN p.N88K was performed in all patients. Results We identified recessive mutations of CHRNE in ten families, mutations in DOK7 in three families and mutations in COLQ, CHRNA1 and CHRNB1 in one family each. The mutation CHRNE c. 70insG was found in six families. We have repeatedly identified this mutation in patients from Spain and Portugal and haplotype studies indicate that CHRNE c. 70insG derives from a common ancestor. Conclusions Recessive mutations in CHRNE are the major cause of CMS in Southern Brazil with a common mutation introduced by Hispanic settlers. The second most common cause is mutations in DOK7. The minimum prevalence of CMS in Parana is 0.18/100 000

Neuro-Muscular Differentiation of Adult Porcine Skin Derived Stem Cell-Like Cells

BACKGROUND: Due to the genetic relationship to humans, porcine stem cells are a very important model system to investigate cell differentiation, associated cell signaling pathways, and cell fate. Porcine skin derived stem cells have been isolated from mid-gestation porcine fetus recently. To our knowledge, stem cells from the skin of the adult porcine organism have not been isolated until now. Hence, to our knowledge, we here describe the isolation, expansion, characterization and differentiation of multipotent porcine skin derived stem cell-like cells (pSSCs) from the adult porcine organism for the first time. METHODOLOGY/PRINCIPAL FINDINGS: pSSCs had a spindle shaped morphology similar to mesenchymal stem cells (MSCs). They could be maintained proliferatively active in vitro for more than 120 days and were able to form colonies from single cells. pSSCs expressed Sox2 and Oct3/4, both transcription factors essential to the pluripotent and self-renewing phenotypes of embryonic stem cells, which recently gained attention due to their function in inducing pluripotent stem cells. Furthermore, the expression of the progenitor marker nestin, the somatic stem cell markers Bcrp1/ABCG2, Bmi1, and Stat3 was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in undifferentiated pSSCs. Flow cytometry revealed the expression of the MSC related proteins CD9, CD29, CD44 and CD105, but not CD90. After neuronal differentiation cells with a characteristic morphology of neuronal and smooth muscle-like cells were present in the cultures. Subsequent immunochemistry and flow cytometry revealed the down-regulation of nestin and the up-regulation of the neuron specific protein beta-III-tubulin and the astrocyte marker GFAP. Also, alpha-SMA expressing cells increased during differentiation suggesting the neuro-muscular differentiation of these skin derived cells. pSSCs could also be induced to differentiate into adipocyte-like cells when cultured under specific conditions. CONCLUSIONS/SIGNIFICANCE: Adult porcine skin harbors a population of stem cell-like cells (pSSCs) that can be isolated via enzymatic digestion. These pSSCs show characteristic features of MSCs originated in other tissues and express the embryonic stem cell marker Oct3/4, Sox2, and Stat3. Furthermore, pSSCs have the potential to differentiate into cells from two different germ lines, the ectoderm (neurons, astrocytes) and the mesoderm (smooth muscle cells, adipocytes)

Intact priors for gaze direction in adults with high-functioning autism spectrum conditions

This research was supported by the UK Medical Research Council under project code MC-A060-5PQ50 (Andrew J. Calder). IM was supported by a Leverhulme Trust Project Grant. CC was supported by an Australian Research Council Future Fellowship. SBC was supported by the MRC, the Wellcome Trust and the Autism Research Trust during the period of this work. The research was also supported by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care East of England at Cambridgeshire and Peterborough NHS Foundation Trust

The 0.1-200 keV spectrum of the blazar PKS 2005-489 during an active state

The bright BL Lac object PKS 2005-489 was observed by BeppoSAX on November 1-2, 1998, following an active X-ray state detected by RossiXTE. The source, detected between 0.1 and 200 keV, was in a very high state with a continuum well fitted by a steepening spectrum due to synchrotron emission only. Our X-ray spectrum is the flattest ever observed for this source. The different X-ray spectral slopes and fluxes, as measured by various satellites, are consistent with relatively little changes of the peak frequency of the synchrotron emission, always located below 10^{17} Hz. We discuss these results in the framework of synchrotron self-Compton models. We found that for the BeppoSAX observation, the synchrotron peak frequency is between 10^{15} and 2.5x10^{16} Hz, depending on the model assumptions.Comment: 7 pages, 4 figures, accepted for publication in A&

Knowledge-driven perceptual organization reshapes information sampling via eye movements

Humans constantly move their eyes to explore the environment. However, how image-computable features and object representations contribute to eye-movement control is an ongoing debate. Recent developments in object perception indicate a complex relationship between features and object representations, where image-independent object knowledge generates objecthood by reconfiguring how feature space is carved up. Here, we adopt this emerging perspective, asking whether object-oriented eye movements result from gaze being guided by image-computable features, or by the fact that these features are bound into an object representation. We recorded eye movements in response to stimuli that initially appear as meaningless patches but are experienced as coherent objects once relevant object knowledge has been acquired. We demonstrate that fixations on identical images are more object-centered, less dispersed, and more consistent across observers once these images are organized into objects. Gaze guidance also showed a shift from exploratory information sampling to exploitation of object-related image areas. These effects were evident from the first fixations onwards. Importantly, eye movements were not fully determined by knowledge-dependent object representations but were best explained by the integration of these representations with image-computable features. Overall, the results show how information sampling via eye movements is guided by a dynamic interaction between image-computable features and knowledge-driven perceptual organization

Topological Sectors of Spin 1 Theories} in 2+1 Dimensions}

It is shown that the Topological Massive and ``Self-dual'' theories, which are known to provide locally equivalent descriptions of spin 1 theories in 2+1 dimensions, have different global properties when formulated over topologically non-trivial regions of space-time. The partition function of these theories, when constructed on an arbitrary Riemannian manifold, differ by a topological factor, which is equal to the partition function of the pure Chern-Simons theory. This factor is related to the space of solutions of the field equations of the Topological Massive Theory for which the connection is asymptotically flat but not gauge equivalent to zero. A new covariant, first order, gauge action,which generalize the ``Self-dual'' action, is then proposed. It is obtained by sewing local self-dual theories. Its global equivalence to the Topological Massive gauge theory is shown.Comment: 11 page