167 research outputs found
Isoquinoline and quinazoline urea analogues as antagonists for the Human Adenosine A3 receptor
To swim or not to swim: an interpretation of farmed mink's motivation for a water bath
How an animal’s behavioural (ethological) needs can be met is a pivotal issue in the assessment of welfare for captive animals. The value of swimming water for farmed mink is an example how scientific and societal questions relating to animal welfare can be answered. A number of studies have addressed the issue of the indispensability of swimming water for mink; however, so far with inconclusive evidence. In this paper, the results of these studies and related literature are reviewed.
First, the biological definition of need is discussed. Subsequently, attention is paid to the effects of the presence, absence and the removal of swimming water on behavioural and physiological correlates of well-being including stereotypic and anticipatory behaviour and urinary cortisol. Thereafter we discuss individual differences in the use of swimming water, the price animals pay for access to a water bath, and the effect of access to swimming water on juvenile play.
The main conclusions of the literature review are that 1) the use of a water bath for mink is most likely related to foraging behaviour (foraging areas: land and water); 2) absence of swimming water, without prior experience, does not lead to consistent changes in level of stereotypic behaviour, or anticipatory responses; 3) removal of a previously experienced water bath may induce short-term stress as indicated by behavioural parameters and elevated cortisol responses; 4) mink work hard for access to a swimming bath and running wheel in consumer demand studies. Other cage modifications such as tunnels and biting objects, may also provide environmental enrichment, if they are added to otherwise impoverished conditions; 5) There are individual differences in the use of swimming water: these are related in part to variation in prior experience of aquatic resources.; 6) As prior experience is important both with respect to individual use of swimming water and the response to deprivation, swimming water can not be described as biological need in the sense of a fixed requirement for survival. As swimming water appears to act as an incentive that induces its own motivation a more accurate term may be an “incentive induced or environmentally facilitated need”. Given the available evidence, it is not possible to conclude whether mink that have never experienced swimming water, suffer as a consequence of its absence. However, it is possible to predict that mink with access to water have improved quality of life, due to increased behavioural opportunities, in comparison to farmed mink without access to swimming water. In practical terms, it is still open to debate whether mink should be provided with swimming water, or if alternative, less valued, but easier to install and maintain forms of environmental enrichment, should be provided in mink housing.
To clarify these issues a number of future studies would be valuable. These include; 1) whether specific environmental cues affect motivation to swim, such as the form of drinking water delivery systems ; 2) whether prior experience of swimming water affects its incentive value; in other words “can you miss what you never experienced?”; 3) do behavioural parameters such as stereotypic behaviour; rebound effects and vacuum activity have any general utility in assessing the value of absent resources; 4) what are preferences for and the value of alternative resources which may act as substitutes for swimming water. In addition we would recommend further work investigating: relationship between access to swimming water and positive indicators of welfare such as play and/or anticipatory behaviour; the effects of preventing the performance of rewarding behaviours and deprivation of a previous experienced resource; and health and hygeine issues related to provision of a water bath. In future work, it would be desirable to present be the actual percentages of animals using a water bath during the experiment and the use of power analyses, to aid their interpretation
Effects of resocialization on post-weaning social isolation-induced abnormal aggression and social deficits in rats
As previously shown, rats isolated from weaning develop abnormal
social and aggressive behavior characterized by biting attacks targeting vulnera-
ble body parts of opponents, reduced attack signaling, and increased defensive
behavior despite increased attack counts. Here we studied whether this form of
violent aggression could be reversed by resocialization in adulthood. During the
first weak of resocialization, isolation-reared rats showed multiple social deficits
including increased defensiveness and decreased huddling during sleep. Deficits
were markedly attenuated in the second and third weeks. Despite improved social
functioning in groups, isolated rats readily showed abnormal features of aggres-
sion in a resident-intruder test performed after the 3-week-long resocialization.
Thus, post-weaning social isolation-induced deficits in prosocial behavior were
eliminated by resocialization during adulthood, but abnormal aggression was
resilient to this treatment. Findings are compared to those obtained in humans
who suffered early social maltreatment, and who also show social deficits
and dysfunctional aggression in adulthood
Announced reward counteracts the effects of chronic social stress on anticipatory behavior and hippocampal synaptic plasticity in rats
Putative role of the adenosine A3 receptor in the antiproliferative action of N6-(2-isopentenyl)adenosine
We tested a panel of naturally occurring nucleosides for their affinity towards adenosine receptors. Both N6-(2-isopentenyl)adenosine (IPA) and racemic zeatin riboside were shown to be selective human adenosine A3 receptor (hA3R) ligands with affinities in the high nanomolar range (Ki values of 159 and 649 nM, respectively). These values were comparable to the observed Ki value of adenosine on hA3R, which was 847 nM in the same radioligand binding assay. IPA also bound with micromolar affinity to the rat A3R. In a functional assay in Chinese hamster ovary cells transfected with hA3R, IPA and zeatin riboside inhibited forskolin-induced cAMP formation at micromolar potencies. The effect of IPA could be blocked by the A3R antagonist VUF5574. Both IPA and reference A3R agonist 2-chloro-N6-(3-iodobenzyl)adenosine-5′-N-methylcarboxamide (Cl-IB-MECA) have known antitumor effects. We demonstrated strong and highly similar antiproliferative effects of IPA and Cl-IB-MECA on human and rat tumor cell lines LNCaP and N1S1. Importantly, the antiproliferative effect of low concentrations of IPA on LNCaP cells could be fully blocked by the selective A3R antagonist MRS1523. At higher concentrations, IPA appeared to inhibit cell growth by an A3R-independent mechanism, as was previously reported for other A3R agonists. We used HPLC to investigate the presence of endogenous IPA in rat muscle tissue, but we could not detect the compound. In conclusion, the antiproliferative effects of the naturally occurring nucleoside IPA are at least in part mediated by the A3R
Bas Kromhout, De voorman. Henk Feldmeijer en de Nederlandse SS; Perry Pierik, Friedrich Knolle. Bekentenissen van een SD-officier; Tessel Pollmann, Mussert & Co. De NSB-leider en zijn vertrouwelingen
Preocupacions nacionals i col·laboració internacional. Els holandesos i la germanització en l’ocupació nazi de l’Europa de l’Est
Durant la Segona Guerra Mundial, el lideratge nazi utilitzarà els serveis “estrangers” dels països que van ocupar per dur a terme la seva ambició expansionista. En la mesura que se’ls van proporcionar aquests serveis voluntàriament, hi ha grans interrogants sobre el grau en què aquests participants locals, situats en un nivell de base, van compartir la mateixa visió imperialista alemanya; i com els objectius ideològics de major transcendència del règim nazi van ser adoptats, aplicats i es van reconfigurar a nivell local. Aquest article explora la contribució holandesa
a la política nazi de germanització en la seva ocupació de l’Europa de l’Est. Així mateix, analitza els motius, experiències i expectatives que es van donar entre els voluntaris holandesos i els supervisors d’aquestes tasques. Encara que la majoria dels col·laboradors locals van ser favorables a la creació d’una Gran Reich germànic, també van perseguir clarament metes nacionals; és a dir, es plantejava que el seu treball ajudaria també a restaurar la grandesa holandesa mitjançant l’adquisició
de mercats i territoris addicionals. Aquest article mostra que aquests dos objectius van ser essencialment incompatibles, de manera que van complicar seriosament la col·laboració entre les autoritats alemanyes i holandeses
Bart van der Boom, De politiek van het kleinste kwaad: een geschiedenis van de Joodse Raad voor Amsterdam 1941-1943, en Laurien Vastenhout, Between Community and Collaboration: ‘Jewish Councils’ in Western Europe under Nazi Occupation
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