Two distinct aetiologies of cardia cancer, evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status

Background: Non-cardia gastric adenocarcinoma is positively associated with Helicobacter pylori infection and atrophic gastritis. The role of H pylori infection and atrophic gastritis in cardia cancer is unclear. Aim: To compare cardia versus non-cardia cancer with respect to the premorbid state of the stomach. Methods: Nested case–control study. To each of 129 non-cardia and 44 cardia cancers, three controls were matched. Serum collected a median of 11.9 years before the diagnosis of cancer was tested for anti-H pylori antibodies, pepsinogen I:II and gastrin. Results: Non-cardia cancer was positively associated with H pylori (OR 4.75, 95% CI 2.56 to 8.81) and gastric atrophy (pepsinogen I:II ,2.5; OR 4.47, 95% CI 2.71 to 7.37). The diffuse and intestinal histological subtypes of non-cardia cancer were of similar proportions and both showed a positive association with H pylori and atrophy. Cardia cancer was negatively associated with H pylori (OR 0.27, 95% CI 0.12 to 0.59), but H pylori-positive cardia cancer showed an association with gastric atrophy (OR 3.33, 95% CI 1.06 to 10.5). The predominant histological subtype of cardia cancer was intestinal and was not associated with gastric atrophy compared with the diffuse subtype ((OR 0.72, 95% CI 0.19 to 2.79) vs (OR 3.46, 95% CI 0.32 to 37.5)). Cardia cancer in patients with atrophy had an intestinal: diffuse ratio (1:1) similar to non-cardia cancer (1.9:1), whereas cardia cancers in patients without atrophy were predominantly intestinal (7:1). Conclusion: These findings indicate two aetiologies of cardia cancer, one associated with H pylori atrophic gastritis, resembling non-cardia cancer, and the other associated with non-atrophic gastric mucosa, resembling oesophageal adenocarcinoma. Serological markers of gastric atrophy may provide the key to determining gastric versus oesophageal origin of cardia cancer

Interplay of individual interactions and turbidity affects the functional response of three-spined sticklebacks \u3ci\u3eGasterosteus aculeatus\u3c/i\u3e

The effects of turbidity, size and the presence of conspecifics on the functional response, feeding latency and activity in the three-spined stickleback Gasterosteus aculeatus were examined. A significant interaction between standard length and presence of conspecifics demonstrated an increase in attack rates of larger individuals in the presence of conspecifics. Attack rate was also higher in turbid water. Feeding latency decreased with prey concentration and presence of conspecifics, but was not affected by turbidity. Activity level did not change with prey levels, but increased with turbidity. These results can help to better understand how individual flexibility in the functional response can affect prey mortality according to environmental perturbation and social interaction at the level of the predator

Delayed maturity does not offset negative impact afflicted by ectoparasitism in salmon

The negative effects of parasitism on host population dynamics may be mediated by plastic compensatory life-history changes in hosts. Theory predicts that hosts should shift their life-history towards early reproduction in response to virulent pathogens to maximize reproduction before death. However, for sublethal infections that affect growth, hosts whose fecundity is correlated with body size are predicted to shift towards delayed reproduction associated with larger body size and higher fecundity. This has been observed in Atlantic salmon and parasitic sea lice, via mark-recapture studies that recover mature fish from paired groups of control and parasiticide-treated smolts. We investigated whether such louse-induced changes to age at maturity can offset some of the negative effect of mortality on population growth rate in salmon using a structured population matrix model. Model results show that delayed maturity can partially compensate for reduced survival. However, this only occurs when marine survival is moderate to poor and growth conditions at sea are good. Also, the impact of delayed maturity on population growth when parameterizing the model with empirical data is negligible compared with effects of direct mortality. Our model thus suggests that management that works on minimizing the effect of sea lice from fish farms on wild salmon should focus mainly on correctly quantifying the effect of parasite-induced mortality during the smolt stage if the goal is to maximize population growth rate.publishedVersio

Interplay of individual interactions and turbidity affects the functional response of three-spined sticklebacks \u3ci\u3eGasterosteus aculeatus\u3c/i\u3e

The effects of turbidity, size and the presence of conspecifics on the functional response, feeding latency and activity in the three-spined stickleback Gasterosteus aculeatus were examined. A significant interaction between standard length and presence of conspecifics demonstrated an increase in attack rates of larger individuals in the presence of conspecifics. Attack rate was also higher in turbid water. Feeding latency decreased with prey concentration and presence of conspecifics, but was not affected by turbidity. Activity level did not change with prey levels, but increased with turbidity. These results can help to better understand how individual flexibility in the functional response can affect prey mortality according to environmental perturbation and social interaction at the level of the predator

Making the best of lousy circumstances: The impact of salmon louse Lepeophtheirus salmonis on depth preference of sea trout Salmo trutta

Sea trout are known for seeking out sources of freshwater to rid themselves of salmon lice. However, the effect of natural haloclines in fjords on parasite dynamics is not well understood. We tagged 48 naturally infested wild sea trout with acoustic depth sensors. The fish were kept inside a small net-pen (4 × 4 × 5 m), 12 at a time, in western Norway during 4 separate time periods in spring 2017. The sea trout were relatively highly infested with sea lice (prevalence: 100%, mean ± SD: 68 ± 58 lice fish-1), and a relatively large proportion of the individuals did not survive the trials (25% mortality). The results show that temperature and light were the 2 most important factors explaining the vertical behaviour of the surviving trout. Mobile lice also had a significant effect on depth distribution, where fish with higher abundances of lice were observed at shallower depths. During the 7 d periods in the net-pen, total sea louse abundance decreased from a mean of 68 to 35 fish-1. Surface salinity explained this reduction better than the experienced salinity of the individual fish, suggesting that short-time exposure to very low salinities, rather than long-term exposure to moderate salinities, is the driving force behind the effect of haloclines on reduction in sea lice numbers.publishedVersio

Predation by Eurasian otters on adult Atlantic salmon

The return of the Eurasian otter to western Norway has sparked human-predator conflicts as otters prey on vulnerable Atlantic salmon populations. Although predation may not be the direct cause of salmon population declines, otters that kill salmon in rivers before they spawn may impact the salmon spawning stock, with potential consequences for stock recruitment. Concerns of local people and stakeholders suggest that otter predation inhibits recovery of salmon populations. However, there is limited information on mortality caused by otter predation on adult salmon. To gain insight into impacts of otter predation on salmon populations, I quantified the predation by otters on adult salmon in two rivers in Western Norway using a novel combination of radiotelemetry and temperature loggers. I tagged 45 salmon in Aureelva and 30 salmon in Søre Vartdalselva and tracked the salmon until they died or left the river. This method identified the fates of 95 % of tagged salmon. Otters killed 9 tagged salmon in Aureelva and 20 tagged salmon in Søre Vartdalselva. I found no evidence that otters selectively killed salmon based on sex, length, health status or activity level, which suggests that predation mortality on pre-spawners was additive. Otter predation contributed in reducing both salmon populations below their spawning targets, and without otter predation both populations would have been closer to reaching their spawning targets. However, the magnitude of predation differed greatly between rivers. Salmon in Søre Vartdalselva had greater predation risk compared to salmon in Aureelva, possibly due to differences in the number of holding pools between the two rivers. The findings from this study emphasise that management decisions should be guided by river-specific evaluations of impacts of otter predation on salmon, for which the combination of radiotelemetry and temperature loggers can provide a valuable tool.Predation by Eurasian otters on adult Atlantic salmonpublishedVersio

Assessing the occurrence of egg stranding for trout and salmon in a regulated river

A key challenge in many regulated rivers is to define adequate flow levels to protect aquatic organisms. Provisioning of suitable flow can be pivotal bottlenecks for fishes such as salmon and trout that use the riverbed as an incubation habitat. Additionally, the locations where females spawn will define the probability that embryos will be dewatered during the incubation period in a regulated flow regime. We investigated the water flow, dewatering, and incubation mortality in Atlantic salmon and brown trout in natural nests over 19 years in the regulated Bjoreio River in western Norway. During the study period, different flow strategies were applied to mitigate the dewatering of incubating salmon and trout embryos. Average survival in nests sampled in late winter ranged from 54% to 92% among years and was significantly correlated with the minimum water flow occurring during the incubation period. Mortality was significantly higher in nests in shallow areas, reflecting nests exposed to dewatering. The results demonstrate a strong link between incubation mortality and managed flow regimes for river spawning salmonids. Using detailed information on the nest location and incubation mortality, we estimate minimum flow requirements for this river and demonstrate an approach to effectively mitigate the impact of river regulations on embryo survival in Atlantic salmon and brown trout.publishedVersio

Design and evaluation of crash tolerant protocols for mobile ad-hoc networks

Mobile ad-hoc networks are wireless networks operating without any form of supporting infrastructure such as base-stations, and thus require the participating nodes to co-operate by forwarding each other's messages. Ad-hoc networks can be deployed when installing network infrastructure is considered too expensive, too cumbersome or simply too slow, for example in domains such as battlefields, search-and-rescue or space exploration. Tolerating node crashes and transient network partitions is likely to be important in such domains. However, developing applications which do so is a difficult task, a task which can be made easier by the availability of fault-tolerant protocols and middleware. This dissertation studies two core fault-tolerant primitives, reliable dissemination and consensus, and presents two families of protocols which implement these primitives in a wide range of mobile ad-hoc networks. The performance of the protocols is studied through simulation indicating that they are able to provide their guarantees in a bandwidth efficient manner. This is achieved by taking advantage of the broadcast nature and variable message delivery latencies inherent in ad-hoc networks. To illustrate the usefulness of these two primitives, a design for a distributed, fault-tolerant tuple space suitable to implement on mobile ad-hoc networks is presented. This design, if implemented, would provide a simple, yet powerful abstraction to the developer of fault-tolerant applications in mobile ad-hoc networks.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

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Masteroppgave i pedagogikkPED395MAPS-PE