1,338 research outputs found
Millimeter wave satellite concepts. Volume 1: Executive summary
The objectives of the program were: (1) development of methodology based on the technical requirements of potential services that might be assigned to millimeter wave bands for identifying the viable and appropriate technologies for future NASA millimeter research and development programs, and (2) testing of this methodology with user applications and services. The scope of the program included the entire communications network, both ground and space subsystems. The reports include: (1) cost, weight, and performance models for the subsystems, (2) conceptual design for point-to-point and broadcast communications satellites, (3) analytic relationships between subsystem parameters and an overall link performance, (4) baseline conceptual systems, (5) sensitivity studies, (6) model adjustment analyses, (7) identification of critical technologies and their risks, (8) brief R&D program scenarios for the technologies judged to be moderate or extensive risks
Calculation of coercivity of magnetic nanostructures at finite temperatures
We report a finite temperature micromagnetic method (FTM) that allows for the
calculation of the coercive field of arbitrary shaped magnetic nanostructures
at time scales of nanoseconds to years. Instead of directly solving the
Landau-Lifshitz-Gilbert equation, the coercive field is obtained without any
free parameter by solving a non linear equation, which arises from the
transition state theory. The method is applicable to magnetic structures where
coercivity is determined by one thermally activated reversal or nucleation
process. The method shows excellent agreement with experimentally obtained
coercive fields of magnetic nanostructures and provides a deeper understanding
of the mechanism of coercivity.Comment: submitted to Phys. Rev.
An X-ray Mini-survey of Nearby Edge-on Starburst Galaxies II. The Question of Metal Abundance
(abbreviated) We have undertaken an X-ray survey of a far-infrared flux
limited sample of seven nearby edge-on starburst galaxies. Here, we examine the
two X-ray-brightest sample members NGC 253 and M 82 in a self-consistent
manner, taking account of the spatial distribution of the X-ray emission in
choosing our spectral models. There is significant X-ray absorption in the disk
of NGC 253. When this is accounted for we find that multi-temperature thermal
plasma models with significant underlying soft X-ray absorption are more
consistent with the imaging data than single-temperature models with highly
subsolar abundances or models with minimal absorption and non-equilibrium
thermal ionization conditions. Our models do not require absolute abundances
that are inconsistent with solar values or unusually supersolar ratios of the
alpha-burning elements with respect to Fe (as claimed previously). We conclude
that with current data, the technique of measuring abundances in starburst
galaxies via X-ray spectral modeling is highly uncertain.
Based on the point-like nature of much of the X-ray emission in the PSPC
hard-band image of NGC 253, we suggest that a significant fraction of the
``extended'' X-ray emission in the 3-10 keV band seen along the disk of the
galaxy with ASCA and BeppoSAX (Cappi et al.) is comprised of discrete sources
in the disk, as opposed to purely diffuse, hot gas. This could explain the low
Fe abundances of ~1/4 solar derived for pure thermal models.Comment: (accepted for publication in the Astrophysical Journal
Uncovering trophic interactions in arthropod predators through DNA shotgun-sequencing of gut contents
Characterizing trophic networks is fundamental to many questions in ecology, but this typically requires painstaking efforts, especially to identify the diet of small generalist predators. Several attempts have been devoted to develop suitable molecular tools to determine predatory trophic interactions through gut content analysis, and the challenge has been to achieve simultaneously high taxonomic breadth and resolution. General and practical methods are still needed, preferably independent of PCR amplification of barcodes, to recover a broader range of interactions. Here we applied shotgun-sequencing of the DNA from arthropod predator gut contents, extracted from four common coccinellid and dermapteran predators co-occurring in an agroecosystem in Brazil. By matching unassembled reads against six DNA reference databases obtained from public databases and newly assembled mitogenomes, and filtering for high overlap length and identity, we identified prey and other foreign DNA in the predator guts. Good taxonomic breadth and resolution was achieved (93% of prey identified to species or genus), but with low recovery of matching reads. Two to nine trophic interactions were found for these predators, some of which were only inferred by the presence of parasitoids and components of the microbiome known to be associated with aphid prey. Intraguild predation was also found, including among closely related ladybird species. Uncertainty arises from the lack of comprehensive reference databases and reliance on low numbers of matching reads accentuating the risk of false positives. We discuss caveats and some future prospects that could improve the use of direct DNA shotgun-sequencing to characterize arthropod trophic networks
Delivery of sTRAIL variants by MSCs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects
Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related apoptosis-inducing ligand (TRAIL), which is a potent inducer of apoptosis in tumor cells, and tested these MSCs, termed MSC.sTRAIL, in combination with conventional chemotherapeutic drug treatment in colon cancer models. When we pretreated human colorectal cancer HCT116 cells with low doses of 5-fluorouracil (5-FU) and added MSC.sTRAIL, we found significantly increased apoptosis as compared with single-agent treatment. Moreover, HCT116 xenografts, which were cotreated with 5-FU and systemically delivered MSC.sTRAIL, went into remission. Noteworthy, this effect was protein 53 (p53) independent and was mediated by TRAIL-receptor 2 (TRAIL-R2) upregulation, demonstrating the applicability of this approach in p53-defective tumors. Consequently, when we generated MSCs that secreted TRAIL-R2-specific variants of soluble TRAIL (sTRAIL), we found that such engineered MSCs, labeled MSC.sTRAIL DR5, had enhanced antitumor activity in combination with 5-FU when compared with MSC.sTRAIL. In contrast, TRAIL-resistant pancreatic carcinoma PancTu1 cells responded better to MSC.sTRAIL DR4 when the antiapoptotic protein XIAP (X-linked inhibitor of apoptosis protein) was silenced concomitantly. Taken together, our results demonstrate that TRAIL-receptor selective variants can potentially enhance the therapeutic efficacy of MSC-delivered TRAIL as part of individualized and tumor-specific combination treatments. © 2013 Macmillan Publishers Limited All rights reserved
The BeppoSAX view of the X-ray active nucleus of NGC4258
BeppoSAX observed NGC4258 on December 1998, when its 2-10 keV luminosity was
\~1E41 erg/s. 100% variability is observed in the 3-10 keV band on timescales
of a half a day while 20% variability is observed on timescales of one hour.
The nuclear component is visible above 2 keV only, being obscured by a column
density of (9.5+/-1.2)E22 cm-2; this component is detected up to 70 keV with
S/N>=3 and with the steep power law energy index of 1.11+/-0.14. Bremsstrahlung
emission for the 2-70 keV X-ray luminosity, as expected in ADAF models with
strong winds, is ruled out by the data. The ratio between the nuclear radio and
the X-ray luminosities is <=1E-5, similar to that of radio quiet AGN. X-ray
variability and spectral shape, radio to X-ray and NIR to X-ray luminosity
ratios suggest that the nucleus of NGC4258 could be a scaled-down version of a
Seyfert nucleus. The soft (E<=2keV) X-ray emission is complex. There are at
least two thermal-like components, with T1=0.6+/-0.1 keV and T2>=1.3 keV. The
cooler (L(0.1-2.4keV)=1E40 erg/s) component is probably associated with the
jet, resolved in X-rays by the ROSAT HRI. The second component, which can be
modeled equally well by an unobscured power law model, has L(0.1-2.4keV)~7E39
erg/s, consistent with that expected from discrete X-ray sources in the host
galaxy. NGC4258 and other maser AGNs show strong nuclear X-ray absorption. We
propose that this large column of gas might be responsible for shielding the
regions of maser emission from X-ray illumination. So a large column density
gas may be a necessary property of masing AGNs.Comment: ApJ in pres
XMM-Newton observations of ultraluminous X-ray sources in nearby galaxies
An XMM-Newton study of ultraluminous X-ray sources (ULX) has been performed
in a sample of 10 nearby Seyfert galaxies. Eighteen ULX have been found with
positional uncertainty of about 4". The large collecting area of XMM-Newton
makes the statistics sufficient to perform spectral fitting with simple models
in 8 cases. The main results of the present minisurvey strengthen the theory
that the ULX could be accreting black holes in hard or soft state. In some
cases, the contribution of the ULX to the overall X-ray flux appears to be
dominant with respect to that of the active nucleus. In addition, 6 ULX present
probable counterparts at other wavelengths (optical/infrared, radio). A
multiwavelength observing strategy is required to better assess the nature of
these sources.Comment: 10 pages, 11 figures. Accepted for publication by Astronomy and
Astrophysics. If you want figures at full resolution, please send an email to
Foschin
ROSAT Blank Field Sources I: Sample Selection and Archival Data
We have identified a population of blank field sources (or `blanks') among
the ROSAT bright unidentified X-ray sources with faint optical counterparts.
The extreme X-ray over optical flux ratio of blanks is not compatible with the
main classes of X-ray emitters except for extreme BL Lacertae objects. From the
analysis of ROSAT archival data we found no indication of variability and
evidence for only three sources, out of 16, needing absorption in excess of the
Galactic value. We also found evidence for an extended nature for only one of
the 5 blanks with a serendipitous HRI detection; this source (1WGAJ1226.9+3332)
was confirmed as a z=0.89 cluster of galaxies. Palomar images reveal the
presence of a red (O-E~2) counterpart in the X-ray error circle for 6 blanks.
The identification process brought to the discovery of another high z cluster
of galaxies, one (possibly extreme) BL Lac, two ultraluminous X-ray sources in
nearby galaxies and two apparently normal type1 AGNs. These AGNs, together with
4 more AGN-like objects seem to form a well defined group: they present
unabsorbed X-ray spectra but red Palomar counterparts. We discuss the possible
explanations for the discrepancy between the X-ray and optical data, among
which: a suppressed big blue bump emission, an extreme dust to gas (~40-60 the
Galactic ratio), a high redshift (z>3.5) QSO nature, an atypical dust grain
size distribution and a dusty warm absorber. These AGN-like blanks seem to be
the bright (and easier to study) analogs of the sources which are found in deep
Chandra observations. Three more blanks have a still unknown nature.Comment: 23 pages, 8 figures, accepted by ApJ main journa
FACT -- The G-APD revolution in Cherenkov astronomy
Since two years, the FACT telescope is operating on the Canary Island of La
Palma. Apart from its purpose to serve as a monitoring facility for the
brightest TeV blazars, it was built as a major step to establish solid state
photon counters as detectors in Cherenkov astronomy. The camera of the First
G-APD Cherenkov Telesope comprises 1440 Geiger-mode avalanche photo diodes
(G-APD), equipped with solid light guides to increase the effective light
collection area of each sensor. Since no sense-line is available, a special
challenge is to keep the applied voltage stable although the current drawn by
the G-APD depends on the flux of night-sky background photons significantly
varying with ambient light conditions. Methods have been developed to keep the
temperature and voltage dependent response of the G-APDs stable during
operation. As a cross-check, dark count spectra with high statistics have been
taken under different environmental conditions. In this presentation, the
project, the developed methods and the experience from two years of operation
of the first G-APD based camera in Cherenkov astronomy under changing
environmental conditions will be presented.Comment: Proceedings of the Nuclear Science Symposium and Medical Imaging
Conference (IEEE-NSS/MIC), 201
FACT -- the First Cherenkov Telescope using a G-APD Camera for TeV Gamma-ray Astronomy (HEAD 2010)
Geiger-mode Avalanche Photodiodes (G-APD) bear the potential to significantly
improve the sensitivity of Imaging Air Cherenkov Telescopes (IACT). We are
currently building the First G-APD Cherenkov Telescope (FACT) by refurbishing
an old IACT with a mirror area of 9.5 square meters and construct a new, fine
pixelized camera using novel G-APDs. The main goal is to evaluate the
performance of a complete system by observing very high energy gamma-rays from
the Crab Nebula. This is an important field test to check the feasibility of
G-APD-based cameras to replace at some time the PMT-based cameras of planned
future IACTs like AGIS and CTA. In this article, we present the basic design of
such a camera as well as some important details to be taken into account.Comment: Poster shown at HEAD 2010, Big Island, Hawaii, March 1-4, 201
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