601 research outputs found
Brønsted Acid Catalyzed Asymmetric S<sub>N</sub>2-Type O-Alkylations
Bridging the gap: Brønsted acids catalyze an intramolecular SN2-type alkylation of alcohols with ethers by bridging a pentacoordinate transition state, thus simultaneously activating both the leaving group and nucleophile (see scheme). Density functional calculations provide detailed insight into the course of the reaction and the transition-state structure
A non-symmetric Yang-Baxter Algebra for the Quantum Nonlinear Schr\"odinger Model
We study certain non-symmetric wavefunctions associated to the quantum
nonlinear Schr\"odinger model, introduced by Komori and Hikami using Gutkin's
propagation operator, which involves representations of the degenerate affine
Hecke algebra. We highlight how these functions can be generated using a
vertex-type operator formalism similar to the recursion defining the symmetric
(Bethe) wavefunction in the quantum inverse scattering method. Furthermore,
some of the commutation relations encoded in the Yang-Baxter equation for the
relevant monodromy matrix are generalized to the non-symmetric case.Comment: 31 pages; added some references; minor corrections throughou
On the role of dauer in the adaptation of nematodes to a parasitic lifestyle
Abstract Nematodes are presumably the most abundant Metazoa on Earth, and can even be found in some of the most hostile environments of our planet. Various types of hypobiosis evolved to adapt their life cycles to such harsh environmental conditions. The five most distal major clades of the phylum Nematoda (Clades 8–12), formerly referred to as the Secernentea, contain many economically relevant parasitic nematodes. In this group, a special type of hypobiosis, dauer, has evolved. The dauer signalling pathway, which culminates in the biosynthesis of dafachronic acid (DA), is intensively studied in the free-living nematode Caenorhabditis elegans, and it has been hypothesized that the dauer stage may have been a prerequisite for the evolution of a wide range of parasitic lifestyles among other nematode species. Biosynthesis of DA is not specific for hypobiosis, but if it results in exit of the hypobiotic state, it is one of the main criteria to define certain behaviour as dauer. Within Clades 9 and 10, the involvement of DA has been validated experimentally, and dauer is therefore generally accepted to occur in those clades. However, for other clades, such as Clade 12, this has hardly been explored. In this review, we provide clarity on the nomenclature associated with hypobiosis and dauer across different nematological subfields. We discuss evidence for dauer-like stages in Clades 8 to 12 and support this with a meta-analysis of available genomic data. Furthermore, we discuss indications for a simplified dauer signalling pathway in parasitic nematodes. Finally, we zoom in on the host cues that induce exit from the hypobiotic stage and introduce two hypotheses on how these signals might feed into the dauer signalling pathway for plant-parasitic nematodes. With this work, we contribute to the deeper understanding of the molecular mechanisms underlying hypobiosis in parasitic nematodes. Based on this, novel strategies for the control of parasitic nematodes can be developed
Дослідження підходів до оцінки стану конкурентоспроможності підприємств
Мета статті – наведення підходів до оцінки стану конкурентоспроможності підприємств
Early intravenous unfractionated heparin and outcome in acute lung injury and acute respiratory distress syndrome: a retrospective propensity matched cohort study.
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are.BACKGROUND: Acute lung injury (ALI) is characterized by a pro-coagulant state. Heparin is an anticoagulant with anti-inflammatory properties. Unfractionated heparin has been found to be protective in experimental models of ALI. We hypothesized that an intravenous therapeutic dose of unfractionated heparin would favorably influence outcome of critically ill patients diagnosed with ALI. METHODS: Patients admitted to the Intensive Care Unit (ICU) of a tertiary referral center in the Netherlands between November 2004 and October 2007 were screened. Patients who developed ALI (consensus definition) were included. In this cohort, the impact of heparin use on mortality was assessed by logistic regression analysis in a propensity matched case-control design. RESULTS: Of 5,561 admitted patients, 2,138 patients had a length of stay > 48 hours, of whom 723 were diagnosed with ALI (34%), of whom 164 received intravenous heparin. In a propensity score adjusted logistic regression analysis, heparin use did not influence 28-day mortality (odds ratio 1.23 [confidence interval 95% 0.80-1.89], nor did it affect ICU length of stay. CONCLUSIONS: Administration of therapeutic doses of intravenous unfractionated heparin was not associated with reduced mortality in critically ill patients diagnosed with ALI. Heparin treatment did not increase transfusion requirements. These results may help in the design of prospective trials evaluating the use of heparin as adjunctive treatment for ALI
Quasitriangular coideal subalgebras of Uq(g) in terms of generalized Satake diagrams
© 2020 The Authors. Bulletin of the London Mathematical Society is copyright © London Mathematical Society. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.Let (Formula presented.) be a finite-dimensional semisimple complex Lie algebra and (Formula presented.) an involutive automorphism of (Formula presented.). According to Letzter, Kolb and Balagović the fixed-point subalgebra (Formula presented.) has a quantum counterpart (Formula presented.), a coideal subalgebra of the Drinfeld–Jimbo quantum group (Formula presented.) possessing a universal (Formula presented.) -matrix (Formula presented.). The objects (Formula presented.), (Formula presented.), (Formula presented.) and (Formula presented.) can all be described in terms of Satake diagrams. In the present work, we extend this construction to generalized Satake diagrams, combinatorial data first considered by Heck. A generalized Satake diagram naturally defines a semisimple automorphism (Formula presented.) of (Formula presented.) restricting to the standard Cartan subalgebra (Formula presented.) as an involution. It also defines a subalgebra (Formula presented.) satisfying (Formula presented.), but not necessarily a fixed-point subalgebra. The subalgebra (Formula presented.) can be quantized to a coideal subalgebra of (Formula presented.) endowed with a universal (Formula presented.) -matrix in the sense of Kolb and Balagović. We conjecture that all such coideal subalgebras of (Formula presented.) arise from generalized Satake diagrams in this way.Peer reviewe
Mechanical Ventilation and the Titer of Antibodies as Risk Factors for the Development of Transfusion-Related Lung Injury
Purpose. Onset of transfusion-related acute lung injury (TRALI) is suggested to be a threshold-event. Data is lacking on the relation between titer of antibodies infused and onset of TRALI. We determined whether onset of TRALI is dependent on the titer of MHC-I antibodies infused in a combined model of ventilator-induced lung injury and antibody-induced TRALl. Methods. BALB/c mice were ventilated for five hours with low (7.5 ml/kg) or high (15 ml/kg) tidal volume. After three hours of MV, TRALI was induced by infusion of 0.5 mg/kg, 2.0 mg/kg or 4.5 mg/kg MHC-I antibodies. Control animals received vehicle. After five hours of MV, animals were sacrificed. Results. MV with high tidal volumes resulted in increased levels of all markers of lung injury compared to animals ventilated with low tidal MV. In ventilator-induced lung injury, infusion of 4.5 mg/kg of antibodies further increased pulmonary wet-to-dry ratio, pulmonary neutrophil influx and pulmonary KC levels, whereas infusion of lower dose of antibodies did not augment lung injury. In contrast, mice ventilated with low tidal volumes did not develop lung injury, irrespective of the dose of antibody used. Conclusions. In the presence of injurious MV, onset of TRALI depends on the titer of antibodies infused
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