Clinical trials in systemic lupus erythematosus: the dilemma—Why have phase III trials failed to confirm the promising results of phase II trials?

Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease of unknown aetiology, characterised by the production of auto-antibodies and formation of immune complexes against self-antigens and complement activation. This inflammatory response can lead to tissue infiltration and eventually, to organ damage.Patients with SLE invariably have periods of relapse and remission. Flares can occur even when the patient is on seemingly adequate treatment, which suggests that more effective therapies are necessary for the management of SLE. Thus, trials with many drugs against different targets, such as CD22, IL-12 and IL-23 or tyrosine kinases, have been carried out in recent years.A frustrating feature of some of the biologic drugs used to treat SLE has been the reporting of successful phase II trials followed by failures of the phase III trials.In this review, we will focus on phase II and III trials carried out with epratuzumab (anti CD22), baricitinib (Janus kinases inhibitor), rigerimod (P140 peptide) and ustekinumab (IL-12 and IL-23 inhibitor) and consider the reasons for their ultimate failure to 'make the grade'. Likewise, we will try to explain the possible reasons that can influence why good results may be obtained in phase II trials and lead to undue optimism

Sensor electroquímico de lactato basado en el nanocomposite Ppy/AuNPs/LDH/NAD+ para el análisis de vinos

El lactato es un compuesto clave en el metabolismo humano, cuya detección es de gran utilidad en diagnóstico clínico, medicina deportiva e industria alimentaria. Los biosensores electroquímicos surgen ante las desventajas de los métodos de medida tradicionales: costosos y requieren un pretratamiento de las muestras. En este trabajo, se explica la preparación de un biosensor amperométrico mediante la electrodeposición de un composite de polipirrol y nanopartículas de oro (Ppy/AuNPs) modificado con la enzima lactato deshidrogenasa L-LDH. Esta enzima se inmoviliza junto a la coenzima NAD+ mediante entrecruzamiento con glutaraldehído. Se ha evaluado el comportamiento del electrodo en términos del límite de detección, sensibilidad e interacción entre el analito y la enzima. Para su optimización, se ha probado con distintas condiciones de preparación del electrodo y concentraciones de la enzima. Por último, se ha estudiado la selectividad del biosensor y comprobado su funcionamiento en la medición de muestras reales de vinoDepartamento de Química Física y Química InorgánicaGrado en Ingeniería Químic

A Deep Learning-Based Multimodal Architecture to predict Signs of Dementia

This paper proposes a multimodal deep learning architecture combining text and audio information to predict dementia, a disease which affects around 55 million people all over the world and makes them in some cases dependent people. The system was evaluated on the DementiaBank Pitt Corpus dataset, which includes audio recordings as well as their transcriptions for healthy people and people with dementia. Different models have been used and tested, including Convolutional Neural Networks (CNN) for audio classification, Transformers for text classification, and a combination of both in a multimodal ensemble. These models have been evaluated on a test set, obtaining the best results by using the text modality, achieving 90.36% accuracy on the task of detecting dementia. Additionally, an analysis of the corpus has been conducted for the sake of explainability, aiming to obtain more information about how the models generate their predictions and identify patterns in the data.We would like to thank “A way of making Europe” European Regional Development Fund (ERDF) and MCIN/AEI/10.13039/501100011033 for supporting this work under the MoDeaAS project (grant PID2019-104818RB-I00) and AICARE project (grant SPID202200X139779IV0). Furthermore, we would like to thank Nvidia for their generous hardware donation that made these experiments possible

Automated Generation of Clinical Reports Using Sensing Technologies with Deep Learning Techniques

This study presents a pioneering approach that leverages advanced sensing technologies and data processing techniques to enhance the process of clinical documentation generation during medical consultations. By employing sophisticated sensors to capture and interpret various cues such as speech patterns, intonations, or pauses, the system aims to accurately perceive and understand patient–doctor interactions in real time. This sensing capability allows for the automation of transcription and summarization tasks, facilitating the creation of concise and informative clinical documents. Through the integration of automatic speech recognition sensors, spoken dialogue is seamlessly converted into text, enabling efficient data capture. Additionally, deep models such as Transformer models are utilized to extract and analyze crucial information from the dialogue, ensuring that the generated summaries encapsulate the essence of the consultations accurately. Despite encountering challenges during development, experimentation with these sensing technologies has yielded promising results. The system achieved a maximum ROUGE-1 metric score of 0.57, demonstrating its effectiveness in summarizing complex medical discussions. This sensor-based approach aims to alleviate the administrative burden on healthcare professionals by automating documentation tasks and safeguarding important patient information. Ultimately, by enhancing the efficiency and reliability of clinical documentation, this innovative method contributes to improving overall healthcare outcomes.We would like to thank “A way of making Europe” European Regional Development Fund (ERDF) and MCIN/AEI/10.13039/501100011033 for supporting this work under the “CHAN-TWIN” project (grant TED2021-130890B-C21. HORIZON-MSCA-2021-SE-0 action number: 101086387, REMARKABLE, Rural Environmental Monitoring via ultra wide-ARea networKs And distriButed federated Learning; CIAICO/2022/132 Consolidated group project “AI4Health” funded by the Valencian government and International Center for Aging Research ICAR funded project “IASISTEM.” This work has also been supported by a Valencian government grant for PhD studies, CIACIF/2022/175 and a research initiation grant from the University of Alicante, AII23-12

Evaluación de las redes socioproductivas del sector rural como herramienta de desarrollo de las localidades

Dentro del sector productivo de un país las redes representan instrumentos vitales para el fortalecimiento de iniciativas socioproductivas. En el medio rural, este tipo de iniciativas nacen debido a que las comunidades y los integrantes de las organizaciones rurales se organizan, y establecen alianzas con el fi n de resolver sus necesidades y por hacer frente a los problemas sociales y de producción de los rubros agrícolas. El objetivo de este estudio fue evaluar las redes socioproductivas del sector rural como herramienta de desarrollo de sus localidades. Se trata de una investigación descriptiva cuya población bajo estudio estuvo conformada por integrantes y productores de organizaciones rurales de los estados Lara, Zulia, Mérida y Guárico. Se utilizó la encuesta como instrumento de recolección de datos, conformada por seis ítems que consolidaron los indicadores y características de las redes, además, se utilizaron entrevistas y mesas de trabajo donde participaron los integrantes de estas organizaciones. Se determinó la disposición al trabajo de cada uno de ellos y el interés por mejorar la calidad de vida propia y de la comunidad a través del trabajo mancomunado. Como conclusión se evidenció que las redes estudiadas no corresponden con los lineamientos de una red socioproductiva, donde el trabajo particular se encadena al objetivocomún, sin embargo, existe la disposición general de establecer acuerdos con criterios de intercambio y formas propias de asociatividad tomando en cuenta su idiosincrasia cultural, conducentes a formar verdaderas cadenas de comercialización de los productos para el aprovechamiento económico y social de todos los miembros integrantes de la futura red. Palabras clave: redes socioproductivas, sector rural, agrícol

Imagen de arte fija didáctica y lengua inglesa

Esta investigación tiene como propósito analizar las posibilidades que ofrece la lectura de imágenes de arte fija de la obra de artistas colombianos en el fortalecimiento de la habilidad comunicativa oral en lengua inglesa, en una población de 34 estudiantes de grado undécimo de la Institución Educativa Agustín Nieto Caballero del municipio de Dosquebradas (Risaralda, Colombia). Su enfoque investigativo es descriptivo, interdisciplinar y cualitativo, en donde la experiencia referencial docente y la fundamentación teórica en el estudio de la imagen visual en el contexto educativo y sus cualidades estéticas, así como las competencias comunicativas en lengua inglesa y su método de enseñanza inductivo, confluyen en el desarrollo de una unidad didáctica que oficia como un instrumento de investigación. Se prioriza el trabajo cooperativo y se generan productos audiovisuales, plásticos y digitales, además de categorías de análisis originadas en la aplicación de las técnicas, recursos o instrumentos investigativos, en donde destacan las entrevistas semiestructuradas, las guías de observación, el diario de campo y el test de Likert. Se logra constatar la espontaneidad como un valioso aliado para la comunicación oral en lengua inglesa, el crecimiento en la fluidez de los estudiantes a partir del reconocimiento de la obra de artistas nacionales como agente motivador, la apropiación de nuevos espacios de aprendizaje como los museos, la importancia del trabajo en equipo para reducir el miedo a la equivocación y el valor de la Unidad Didáctica para la estructuración de la complejidad del aprendizajeThe purpose of this research project is to analyze the possibilities offered by reading fixed art images of the work of Colombian artists in strengthening oral communicative ability in English, in a population of 34 eleventh grade students from the Agustín Nieto Caballero Educational Institution from the municipality of Dosquebradas (Risaralda, Colombia). Its investigative approach is descriptive, interdisciplinary and qualitative, where the referential teaching experience and the theoretical foundation in the study of the visual image in the educational context and its aesthetic qualities, as well as the communicative skills in English and its inductive teaching method, converge in the development of a didactic unit that acts as a research instrument. Cooperative work is prioritized and audiovisual, plastic and digital products are generated, in addition to categories of analysis originated in the application of investigative techniques, resources or instruments such as semi-structured interviews, observation guides, field diary and the Likert test. It is possible to verify spontaneity as a valuable ally for oral communication in English, the growth in the fluency of students from the recognition of the work of national artists as a motivating agent, the appropriation of new learning spaces such as museums, the importance of teamwork to reduce the fear of making a mistake and the value of the didactic unit for structuring the complexity of learning.MaestríaMagíster en Educación y ArteTABLA DE CONTENIDO Pág RESUMEN……………………………………………………………………..…. 6 ABSTRACT……………………………………………………………………….. 7 INTRODUCCIÓN………………………………………………………………… 8 CAPÍTULO 1- CONTEXTUALIZACIÓN DEL PROYECTO…………………...... 14 1.1 PLANTEAMIENTO DEL PROBLEMA EN TÉRMINOS DE JUSTIFICACIÓN. 14 1.2 FORMULACIÓN DEL PROBLEMA……………………………………………. 21 1.3 OBJETIVOS………..……………………………………………………………… 22 1.3.1 General……………………………………………………………………. 22 1.3.2 Específicos………………………………………………………….…….. 23 CAPÍTULO 2- MARCO REFERENCIAL……..……………………………….…… 23 2.1 Antecedentes y Estado del Arte …………………………………………………… 23 2.2 Marco Teórico y Conceptual……………………………………………………… 31 2.2.1 Imagen de arte fija………………………………………………………... 31 2.2.2 Enseñanza del Inglés como Segunda Lengua (L2)………………………. 45 2.2.3 Acto Educativo…………………………………………………………… 57 2.3 Marco Geográfico y Contextualización Histórica…………………………….….. 69 CAPÍTULO 3- LOS MÉTODOS…………………………..…………………………. 71 3.1 Tipo de Proyecto………………………………………………………………..….. 71 3.2 Estudio de la Unidad de Análisis………………………………………………….. 75 3.3 Descripción de la Población Abordada……………………………………………. 77 3.4 Técnicas y recursos empleados Para la Recolección de Datos…...………..…....… 79 3.5 Producto resultante………………………………………………………………… 96 3.6 Secuencia de desarrollo de la investigación……………………………………….. 97 CAPÍTULO 4- ANÁLISIS, CONCLUSIONES Y RECOMENDACIONES…..…… 100 4.1 Análisis de resultados……………………………………………………………… 100 4.1.1 Análisis de resultados a la luz de las categorías…...……………………… 101 4.1.2 Análisis de resultados a la luz de la pregunta de investigación…………… 105 4.1.3 Análisis de resultados a la luz de las teorías………………………………. 108 Imagen de Arte Fija, Didáctica y Lengua Inglesa 4 4.2 Conclusiones y recomendaciones…………………………………………………. 117 BIBLIOGRAFÍA…………………………………………………………………..….. 12

Triggers of change in sexual behavior among people with HIV: The Swiss U = U statement and Covid-19 compared.

We assessed changes in sexual behaviour among people with HIV (PWH) over 20 years. Condom use with stable partners steadily declined from over 90% to 29% since the Swiss U = U statement with similar trajectories between men who have sex with men (MSM) and heterosexuals. Occasional partnership remained higher among MSM compared to heterosexuals even during COVID-19 social distancing

Prognosis of patients with malignant mesothelioma by expression of programmed cell death 1 ligand 1 and mesothelin in a contemporary cohort in Finland

ObjectivesWe aimed to describe mesothelin (MSLN) and programmed cell death 1 ligand 1 (PD-L1) tumour overexpression amongst patients with malignant mesothelioma (MM), and their associations with survival, amongst a cohort of patients with MM in Finland.MethodsBetween 2004 and 2017, 91 adults with histologically confirmed MM were identified from the Auria Biobank in Finland and followed-up using linked data from electronic health records and national statistics. Biomarker content in tumour cell membranes was determined using automated Immunohistochemistry on histological sections. Stained tumour sections were scored for MSLN and PD-L1 intensity. Adjusted associations between MSLN/PD-L1 co-expression and mortality were evaluated by estimating hazard ratios (HRs) with 95% confidence intervals (CIs) using Cox regression.ResultsBiomarker overexpression occurred in 52 patients for MSLN and 34 patients for PD-L1 and was associated with tumour histology and certain comorbidities. Fifteen per cent of patients had a tumour that overexpressed both biomarkers; r =-0.244, p-value: 0.02. Compared with MSLN+/PD-L1+ patients, HRs (95% CIs) for death were 4.18 (1.71–10.23) for MSLN-/PD-L1+ patients, 3.03 (1.35–6.77) for MSLN-/PD-L1- patients, and 2.13 (0.97–4.67) for MSLN+/PD-L1- patients.ConclusionsBoth MSLN and PD-L1 markers were independent prognostic indicators in patients with MM. Overexpression of MSLN was associated with longer survival; yet their combined expression gave a better indication of survival. The risk of death was four times higher amongst MSLN-/PD-L1+ patients than in MSLN+/PD-L1+ patients.</p

Triggers of change in sexual behavior among people with HIV: The Swiss U = U statement and Covid-19 compared

We assessed changes in sexual behaviour among people with HIV (PWH) over 20 years. Condom use with stable partners steadily declined from over 90% to 29% since the Swiss U = U statement with similar trajectories between men who have sex with men (MSM) and heterosexuals. Occasional partnership remained higher among MSM compared to heterosexuals even during COVID-19 social distancing

Sexual Behaviour and STI Incidence in Sexually Active MSM Living With HIV in Times of COVID-19

Despite decreased numbers of sexual partners, the COVID-19 pandemic had limited impact on the prevalence of attending private sex parties, traveling for sex within Switzerland, and practicing chemsex in men with HIV who have sex with men. COVID-19 risk perception was low, and STI-diagnosis incidence rates remained stable over time