489 research outputs found
Delivering through Diversity
Companies with diverse members in leadership positions are more than 20 percent likely to outperform on profitability and have superior value creation. Delivering through Diversity from McKinsey & Company discusses the relationship between diversity and business success and describes the inclusion and diversity (I&D) initiatives that seem to accelerate business performance. This report draws on public annual reports and websites of more than 1,000 companies worldwide and financial data from the Corporate Performance Analytics database of McKinsey and S&P Global. The authors also highlight the I&D efforts of 17 companies across multiple industries. Results show that companies in the top-quartile for gender diversity and ethnic/cultural diversity in their executive teams have better than predicted return on investments, outperform on profitability and are more likely to have superior value creation. Companies in the top-quartile for ethnic/cultural diversity in their executive teams, for example, were 33 percent more likely to lead industry profitability. Additionally, the report reveals that bottom-quartile companies are lagging in comparison to their competitors. The authors suggest that all levels of leadership commit to I&D goals, that managers connect I&D initiatives to growth strategies and company culture, and that I&D strategies should be tailored to local conditions to maximize their impact
Morbidity costs associated with ambient air pollution exposure in Sao Paulo, Brazil
AbstractIn 2007 we conducted a contingent valuation survey in Sao Paulo, Brazil, to estimate the population's willingness–to–pay (WTP) to avoid one hospital admission (HA) and one emergency–room visit (ER) due to respiratory diseases in adults and children younger than 5 years old; and cardiovascular diseases in adults only; both associated with atmospheric air pollution. Our annual mean WTP estimates are €81.82 (adult) and €137.92 (child) for HA; €48.40 (adult) and €90.66 (child) for ER due to respiratory diseases; €53.57 (ER) and €90.08 (HA) for cardiovascular diseases. Our results suggest altruism towards children, and a strong income effect on WTP. Results will help analysts evaluating the health benefits of specific policies with potential air pollution impacts in Sao Paulo, Brazil
Usability evaluation of an interactive leg press training robot for children with neuromuscular impairments.
BACKGROUND
The use of robotic technology for neurorehabilitative applications has become increasingly important for adults and children with different motor impairments.
OBJECTIVE
The aim of this study was to evaluate the technical feasibility and usability of a new interactive leg-press training robot that was developed to train leg muscle strength and control, suitable for children with neuromuscular impairments.
METHODS
An interactive robotic training system was designed and constructed with various control strategies, actuators and force/position sensors to enable the performance of different training modes (passive, active resistance, and exergames). Five paediatric patients, aged between 7 and 16 years (one girl, age 13.0 ± 3.7 years, [mean ± SD]), with different neuromuscular impairments were recruited to participate in this study. Patients evaluated the device based on a user satisfaction questionnaire and Visual Analog Scale (VAS) scores, and therapists evaluated the device with the modified System Usability Scale (SUS).
RESULTS
One patient could not perform the training session because of his small knee range of motion. Visual Analog Scale scores were given by the 4 patients who performed the training sessions. All the patients adjudged the training with the interactive device as satisfactory. The average SUS score given by the therapists was 61.2 ± 18.4.
CONCLUSION
This study proposed an interactive lower limb training device for children with different neuromuscular impairments. The device is deemed feasible for paediatric rehabilitation applications, both in terms of technical feasibility and usability acceptance. Both patients and therapists provided positive feedback regarding the training with the device
Impact of the government's restrictions and guidance in relation to “social distancing” on the lives of ethnic minority populations:A mixed methods study
Background and Aims: The impacts of the COVID-19 pandemic have not been equal, with a disproportionate impact among ethnic minority communities. Structural inequalities in social determinants of health such as housing and employment have contributed to COVID-19's impact on deprived communities, including many ethnic minority communities. To compare (1) how the UK government's “social distancing” restrictions and guidance were perceived and implemented by ethnic minority populations compared to white populations, (2) the impact of restrictions and guidance upon these groups. Methods: An explanatory sequential mixed methods study incorporated a quantitative survey and qualitative semi-structured interviews to explore individual perceptions and experiences of COVID-19 and the national restrictions. Survey participants (n = 1587) were recruited from North West England; 60 (4%) participants were from ethnic minority communities. Forty-nine interviews were conducted; 19 (39%) participants were from ethnic minority communities. Interviews were transcribed verbatim and analysed using a thematic approach. Data collection was between April and August 2020. Results: Significant differences in demographics and household overcrowding were observed between white vs ethnic minority survey respondents, who were also significantly less confident in their knowledge of COVID-19, less likely to be high-risk drinkers, and marginally more likely to have experienced job loss and/or reduced household income. There were no group differences in wellbeing, perceptions, or nonfinancial impacts. Two inter-related themes included: (1) government guidance, incorporating people's knowledge and understanding of the guidance and their confusion/frustration over messaging; (2) the impacts of restrictions on keyworkers, home-schooling, working from home and changes in lifestyle/wellbeing. Conclusions: Further research is needed on the long-term impacts of COVID-19 on ethnic minority communities. If policy responses to COVID-19 are to benefit ethnic minority communities, there is a need for future studies to consider fundamental societal issues, such as the role of housing and economic disadvantage.</p
Impact of the government's restrictions and guidance in relation to "social distancing" on the lives of ethnic minority populations:A mixed methods study
Background and Aims: The impacts of the COVID-19 pandemic have not been equal, with a disproportionate impact among ethnic minority communities. Structural inequalities in social determinants of health such as housing and employment have contributed to COVID-19's impact on deprived communities, including many ethnic minority communities. To compare (1) how the UK government's “social distancing” restrictions and guidance were perceived and implemented by ethnic minority populations compared to white populations, (2) the impact of restrictions and guidance upon these groups. Methods: An explanatory sequential mixed methods study incorporated a quantitative survey and qualitative semi-structured interviews to explore individual perceptions and experiences of COVID-19 and the national restrictions. Survey participants (n = 1587) were recruited from North West England; 60 (4%) participants were from ethnic minority communities. Forty-nine interviews were conducted; 19 (39%) participants were from ethnic minority communities. Interviews were transcribed verbatim and analysed using a thematic approach. Data collection was between April and August 2020. Results: Significant differences in demographics and household overcrowding were observed between white vs ethnic minority survey respondents, who were also significantly less confident in their knowledge of COVID-19, less likely to be high-risk drinkers, and marginally more likely to have experienced job loss and/or reduced household income. There were no group differences in wellbeing, perceptions, or nonfinancial impacts. Two inter-related themes included: (1) government guidance, incorporating people's knowledge and understanding of the guidance and their confusion/frustration over messaging; (2) the impacts of restrictions on keyworkers, home-schooling, working from home and changes in lifestyle/wellbeing. Conclusions: Further research is needed on the long-term impacts of COVID-19 on ethnic minority communities. If policy responses to COVID-19 are to benefit ethnic minority communities, there is a need for future studies to consider fundamental societal issues, such as the role of housing and economic disadvantage.</p
V1647 Orionis: Reinvigorated Accretion and the Re-Appearance of McNeil's Nebula
In late 2003, the young eruptive variable star V1647 Orionis optically
brightened by over 5 magnitudes, stayed bright for around 26 months, and then
decline to its pre-outburst level. In August 2008 the star was reported to have
unexpectedly brightened yet again and we herein present the first detailed
observations of this new outburst. Photometrically, the star is now as bright
as it ever was following the 2003 eruption. Spectroscopically, a pronounced P
Cygni profile is again seen in Halpha with an absorption trough extending to
-700 km/s. In the near-infrared, the spectrum now possesses very weak CO
overtone bandhead absorption in contrast to the strong bandhead emission seen
soon after the 2003 event. Water vapor absorption is also much stronger than
previously seen. We discuss the current outburst below and relate it to the
earlier event.Comment: 6 pages, 3 figure
A population of luminous accreting black holes with hidden mergers
Major galaxy mergers are thought to play an important part in fuelling the
growth of supermassive black holes. However, observational support for this
hypothesis is mixed, with some studies showing a correlation between merging
galaxies and luminous quasars and others showing no such association. Recent
observations have shown that a black hole is likely to become heavily obscured
behind merger-driven gas and dust, even in the early stages of the merger, when
the galaxies are well separated (5 to 40 kiloparsecs). Merger simulations
further suggest that such obscuration and black-hole accretion peaks in the
final merger stage, when the two galactic nuclei are closely separated (less
than 3 kiloparsecs). Resolving this final stage requires a combination of
high-spatial-resolution infrared imaging and high-sensitivity hard-X-ray
observations to detect highly obscured sources. However, large numbers of
obscured luminous accreting supermassive black holes have been recently
detected nearby (distances below 250 megaparsecs) in X-ray observations. Here
we report high-resolution infrared observations of hard-X-ray-selected black
holes and the discovery of obscured nuclear mergers, the parent populations of
supermassive-black-hole mergers. We find that obscured luminous black holes
(bolometric luminosity higher than 2x10^44 ergs per second) show a significant
(P<0.001) excess of late-stage nuclear mergers (17.6 per cent) compared to a
sample of inactive galaxies with matching stellar masses and star formation
rates (1.1 per cent), in agreement with theoretical predictions. Using
hydrodynamic simulations, we confirm that the excess of nuclear mergers is
indeed strongest for gas-rich major-merger hosts of obscured luminous black
holes in this final stage.Comment: To appear in the 8 November 2018 issue of Nature. This is the
authors' version of the wor
A Randomized Controlled Trial of Team-Based Care: Impact of Physician-Pharmacist Collaboration on Uncontrolled Hypertension
Educated mother-tongue South African English: A corpus approach
South Africa is anecdotally known for its complex system of speech varieties correlating with variables such as ethnicity, first language, class and education. These intuitions (e.g. Lass 1990) require further investigation, especially in the context of a changing South Africa where language variety plays a key role in identifying social, economic and ethnic group membership. Thus, in this research, the extent to which these variables play a role in variety is explored using a corpus approach (the nature of class and race in the corpus is discussed more fully later in the article). The corpus project, focusing primarily on accent, has been undertaken by members of the Department of English Language and Linguistics at Rhodes University in South Africa, collaborating with staff from the Department of Electrical and Electronic Engineering from Stellenbosch University, South Africa. A corpus (the first of its kind) is being compiled, comprising the speech of educated, white, mother-tongue speakers of South African English (as distinct from Afrikaans English, Indian English, and the second language (L2) varieties of English used by speakers of indigenous African languages), and data collection is well under way. This short article aims to describe the aims of the project, and the methodological approach which underpins it, as well as to highlight some of the more problematic aspects of the research
Inferring predominant pathways in cellular models of breast cancer using limited sample proteomic profiling
<p>Abstract</p> <p>Background</p> <p>Molecularly targeted drugs inhibit aberrant signaling within oncogenic pathways. Identifying the predominant pathways at work within a tumor is a key step towards tailoring therapies to the patient. Clinical samples pose significant challenges for proteomic profiling, an attractive approach for identifying predominant pathways. The objective of this study was to determine if information obtained from a limited sample (i.e., a single gel replicate) can provide insight into the predominant pathways in two well-characterized breast cancer models.</p> <p>Methods</p> <p>A comparative proteomic analysis of total cell lysates was obtained from two cellular models of breast cancer, BT474 (HER2+/ER+) and SKBR3 (HER2+/ER-), using two-dimensional electrophoresis and MALDI-TOF mass spectrometry. Protein interaction networks and canonical pathways were extracted from the Ingenuity Pathway Knowledgebase (IPK) based on association with the observed pattern of differentially expressed proteins.</p> <p>Results</p> <p>Of the 304 spots that were picked, 167 protein spots were identified. A threshold of 1.5-fold was used to select 62 proteins used in the analysis. IPK analysis suggested that metabolic pathways were highly associated with protein expression in SKBR3 cells while cell motility pathways were highly associated with BT474 cells. Inferred protein networks were confirmed by observing an up-regulation of IGF-1R and profilin in BT474 and up-regulation of Ras and enolase in SKBR3 using western blot.</p> <p>Conclusion</p> <p>When interpreted in the context of prior information, our results suggest that the overall patterns of differential protein expression obtained from limited samples can still aid in clinical decision making by providing an estimate of the predominant pathways that underpin cellular phenotype.</p
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