Intrusion Detection Systems Using Adaptive Regression Splines

Past few years have witnessed a growing recognition of intelligent techniques for the construction of efficient and reliable intrusion detection systems. Due to increasing incidents of cyber attacks, building effective intrusion detection systems (IDS) are essential for protecting information systems security, and yet it remains an elusive goal and a great challenge. In this paper, we report a performance analysis between Multivariate Adaptive Regression Splines (MARS), neural networks and support vector machines. The MARS procedure builds flexible regression models by fitting separate splines to distinct intervals of the predictor variables. A brief comparison of different neural network learning algorithms is also given

Characterisation of Portuguese RC precast industrial building stock

The construction of a vulnerability model requires reliable information on the features of the buildings in the study. The purpose of this work is the characterisation of the precast industrial buildings in Portuguese industrial park, based on the survey of 73 design projects of existing buildings. The collected data are based on a previous study on the features that influence the seismic response of this type of buildings. The parameters collected are associated with the global geometry and specific elements characteristics (e.g., column dimensions, reinforcement ratios, and connections details), to the mechanical properties of the materials and other parameters that can give some important information in the characterisation of the buildings (e.g., construction year and localization). In the end, a comparison with other available databases, namely, from Italy and Turkey, is done in order to conclude about the similarity. This information is important to define representative experimental specimens and numerical simulation to conduce seismic risk analysis.publishe

Influence of olive anthracnose and olive fruit fly on bioactive compounds of Cobrançosa olive oils

Phenolic compounds are the most important bioactive compounds in olives and since 2012 a health claim can be declared for the olive oil if it contains more than 5 mg of hydroxytyrosol (Hyt) and its derivatives per 20 g of oil1. In turn, β-carotene is a precursor of vitamin A that essentially functions in many biological processes including vision. However, the presence of bioactive compounds in olive oils depends on cultivar, agro-ecological conditions, harvest time, post-harvest, extraction technology and storage.This study was funded by the FCT, Portugal (research project PTDC/ASP-PLA/28547/2017).info:eu-repo/semantics/publishedVersio

Matrisomal components involved in regenerative wound healing in axolotl and acomys: implications for biomaterial development

Achieving regeneration in humans has been a long-standing goal of many researchers. Whereas amphibians like the axolotl (Ambystoma mexicanum) are capable of regenerating whole organs and even limbs, most mammals heal their wounds via fibrotic scarring. Recently, the African spiny mouse (Acomys sp.) has been shown to be injury resistant and capable of regenerating several tissue types. A major focal point of research with Acomys has been the identification of drivers of regeneration. In this search, the matrisome components related to the extracellular matrix (ECM) are often overlooked. In this review, we compare Acomys and axolotl skin wound healing and blastema-mediated regeneration by examining their wound healing responses and comparing the expression pattern of matrisome genes, including glycosaminoglycan (GAG) related genes. The goal of this review is to identify matrisome genes that are upregulated during regeneration and could be potential candidates for inclusion in pro-regenerative biomaterials. Research papers describing transcriptomic or proteomic coverage of either skin regeneration or blastema formation in Acomys and axolotl were selected. Matrisome and GAG related genes were extracted from each dataset and the resulting lists of genes were compared. In our analysis, we found several genes that were consistently upregulated, suggesting possible involvement in regenerative processes. Most of the components have been implicated in regulation of cell behavior, extracellular matrix remodeling and wound healing. Incorporation of such pro-regenerative factors into biomaterials may help to shift pro-fibrotic processes to regenerative responses in treated wounds.European Union’s Horizon 2020 ;Grant Agreement No. 955722info:eu-repo/semantics/publishedVersio

Resveratrol Reverses Endothelial Colony-Forming Cell Dysfunction in Adulthood in a Rat Model of Intrauterine Growth Restriction.

Individuals born after intrauterine growth restriction (IUGR) are at risk of developing cardiovascular diseases (CVDs). Endothelial dysfunction plays a role in the pathogenesis of CVDs; and endothelial colony-forming cells (ECFCs) have been identified as key factors in endothelial repair. In a rat model of IUGR induced by a maternal low-protein diet, we observed an altered functionality of ECFCs in 6-month-old males, which was associated with arterial hypertension related to oxidative stress and stress-induced premature senescence (SIPS). Resveratrol (R), a polyphenol compound, was found to improve cardiovascular function. In this study, we investigated whether resveratrol could reverse ECFC dysfunctions in the IUGR group. ECFCs were isolated from IUGR and control (CTRL) males and were treated with R (1 μM) or dimethylsulfoxide (DMSO) for 48 h. In the IUGR-ECFCs, R increased proliferation (5'-bromo-2'-deoxyuridine (BrdU) incorporation, p < 0.001) and improved capillary-like outgrowth sprout formation (in Matrigel), nitric oxide (NO) production (fluorescent dye, p < 0.01), and endothelial nitric oxide synthase (eNOS) expression (immunofluorescence, p < 0.001). In addition, R decreased oxidative stress with reduced superoxide anion production (fluorescent dye, p < 0.001); increased Cu/Zn superoxide dismutase expression (Western blot, p < 0.05); and reversed SIPS with decreased beta-galactosidase activity (p < 0.001), and decreased p16 <sup>ink4a</sup> (p < 0.05) and increased Sirtuin-1 (p < 0.05) expressions (Western blot). No effects of R were observed in the CTRL-ECFCs. These results suggest that R reverses long-term ECFC dysfunctions related to IUGR

Disclosing Hypoalbuminemia: A Lupus Protein-Losing Enteropathy (Lupple) Report

A enteropatia perdedora de proteínas (EPP) caracteriza-se pela presença de edema generalizado e hipoalbuminemia grave, secundários à perda proteica através do trato gastrointestinal. Os autores reportam um caso de enteropatia perdedora de proteínas secundária a lupus eritematoso sistémico (LES), como a manifestação inicial desta doença. A doente relatava um quadro pautado por 4 meses de diarreia aquosa, não sanguinolenta, (com um máximo de 10 dejeções diárias), e perda ponderal significativa. Posteriormente desenvolveu marcado edema periférico e rash cutâneo malar e maculopapular ao nível do tórax e membros. Analiticamente apresentava anemia, hipoalbuminemia grave, hipocaliémia e hipomagnesémia. No decurso da investigação foram excluídas proteinúria e outras causas de hipoalbuminemia. Após resultados como a pesquisa de anticorpos anti-nucleares e anti-ribonucleoproteinas positiva foi assumido o diagnóstico de EPP secundária ao LES. A doente foi tratada com pulsos de Metilprednisolona 1000 mg/dia durante 3 dias, seguido de prednisolona 1 mg/kg/dia, com boa resposta clínica. Após 20 dias, foi adicionada Azatioprina e iniciado o desmame de corticoides. O presente caso clínico destaca uma EPP como forma de apresentação do LES, cujo diagnóstico pode passar despercebido, tendo em conta a sua raridade, e acarretar um aumento da morbilidade e mortalidade.info:eu-repo/semantics/publishedVersio

A visual chaotic system simulation in Arduino platform controlled by Android app

The application of computer and electronic technologies has grown extensively in recent years being a useful tool for teaching in various fields of knowledge. The use of these technologies aims at bridging the gap between theory and practice, improving learning outcomes. This work demonstrates the project of didactic prototype based on the Arduino platform to study and teach nonlinear dynamical systems. The teaching platform presented here aims at providing visual effects and better understanding of basic concepts of nonlinear dynamical systems, such as chaos. It is also demonstrated when the data loses the precision, also in a visual setup. Additionally, input data may be configured by wireless communication, which makes it very attractive for young students

Three-Dimensional Simulations of Jets from Keplerian Disks: Self--Regulatory Stability

We present the extension of previous two-dimensional simulations of the time-dependent evolution of non-relativistic outflows from the surface of Keplerian accretion disks, to three dimensions. The accretion disk itself is taken to provide a set of fixed boundary conditions for the problem. The 3-D results are consistent with the theory of steady, axisymmetric, centrifugally driven disk winds up to the Alfv\'en surface of the outflow. Beyond the Alfv\'en surface however, the jet in 3-D becomes unstable to non-axisymmetric, Kelvin-Helmholtz instabilities. We show that jets maintain their long-term stability through a self-limiting process wherein the average Alfv\'enic Mach number within the jet is maintained to order unity. This is accomplished in at least two ways. First, poloidal magnetic field is concentrated along the central axis of the jet forming a ``backbone'' in which the Alfv\'en speed is sufficiently high to reduce the average jet Alfv\'enic Mach number to unity. Second, the onset of higher order Kelvin-Helmholtz ``flute'' modes (m \ge 2) reduce the efficiency with which the jet material is accelerated, and transfer kinetic energy of the outflow into the stretched, poloidal field lines of the distorted jet. This too has the effect of increasing the Alfv\'en speed, and thus reducing the Alfv\'enic Mach number. The jet is able to survive the onset of the more destructive m=1 mode in this way. Our simulations also show that jets can acquire corkscrew, or wobbling types of geometries in this relatively stable end-state, depending on the nature of the perturbations upon them. Finally, we suggest that jets go into alternating periods of low and high activity as the disappearance of unstable modes in the sub-Alfv\'enic regime enables another cycle of acceleration to super-Alfv\'enic speeds.Comment: 57 pages, 22 figures, submitted to Ap