10 research outputs found
Prevalence and Clinical Significance of Helicobacter Pylori-negative Chronic Gastritis in Children
OBJECTIVES: The clinical significance of Helicobacter pylori-negative chronic gastritis (HPNCG) in children is unclear. We examined this issue in patients who had undergone esophagogastroduodenoscopy with systematic gastric sampling. METHODS: Data of 1178 consecutive children who underwent diagnostic esophagogastroduodenoscopy were collected. Baseline characteristics and long-term outcomes were compared between children with active and inactive HPNCG and those with normal gastric histology. Follow-up data were available for up to 13âyears. RESULTS: Altogether 24 (2.0%) children had active and 235 (19.9%) inactive HPNCG, 27 (2.3%) were Hpylori-positive, 46 (3.9%) had other gastric pathology, and 846 (71.8%) normal histology. Diarrhea (31.3% vs 25.1%, Pâ =â0.033), poor growth (23.6% vs 14.7%, Pâ <â0.001), bloody stools (13.9% vs 7.2%, Pâ<â0.001), anemia (46.5% vs 23.4%, Pâ<â0.001), hypersedimentation (39.7% vs 21.4%, Pâ<â0.001), hypoalbuminemia (40.4% vs 16.2%, Pâ<â0.001), and elevated fecal calprotectin (62.4% vs 31.5%, Pâ<â0.001) were more common and heartburn (13.9% vs 22.9%, Pâ=â0.002) less common in the HPNCG group than in the controls. Both active (OR 3.64,95% CI 1.35-9.82) andinactive (2.98, 2.18-4.08) HPNCG predicted a diagnosis in the initial investigations. Crohn disease (41.7%) was the most common diagnosis in active HPNCG and celiac disease (37.4%) in inactive HPNCG. During follow-up, 7 (9.9%) of the 71 initially nondiagnosed HPNCG children received a diagnosis. CONCLUSIONS: HPNCG is a frequent finding in children undergoing EGD, the active form being associated especially with Crohn disease and the inactive with celiac disease. The long-term prognosis of patients with HPNCG who do not receive an initial diagnosis is good.acceptedVersionPeer reviewe
Translation, cross-cultural adaptation, and validation of the sino-nasal outcome test (snot)-22 for Finnish patients
Purpose The Sino-Nasal Outcome Test-22 (SNOT-22) is the most commonly used disease-specific quality of life questionnaire in rhinology. The purpose of this prospective study was to translate and validate SNOT-22 into Finnish. Methods The validation process followed the guidelines proposed for cross-cultural adaptation of health-related measures of quality of life. The study consisted of three groups: rhinologic out-patients (N = 96), FESS patients (N = 49) and healthy controls (N = 79). Out-patient and FESS groups completed the questionnaire twice (answers A and B), out-patients after two weeks and FESS patients after 3 months. Validity, reliability and responsiveness were evaluated. Results The mean SNOT-22 sum score of the out-patient questionnaires were 35.3 points (answer A) and 32.4 points (answer B). ICC in out-patient group was 0.879. For the FESS patients, the mean pre- and postoperative (answer A and B) SNOT-22 sum scores were 46.8 and 21.9 points, respectively (p <0.0001). The mean SNOT-22 of healthy controls was 8.9 points. The out-patients (answer A) and healthy controls had statistically significant difference in SNOT-22 scores (p <0.0001). Conclusions The results of our study show that the validated Finnish version of the SNOT-22 questionnaire demonstrates good validity, reliability and responsiveness.Peer reviewe
Factors Affecting the Control of Chronic Rhinosinusitis With Nasal Polyps : A Comparison in Patients With or Without NERD
Objectives: The aim was to compare the control of chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS), in patients with/without nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). Study Desing: A retrospective hospital-based sample of CRSwNP patients with/without NERD with follow-up. Setting: Tertiary rhinology centers. Methods: Electronic patient record data from 116 CRSwNP patients (46 with NERD and 70 without NERD) undergoing ESS during 2001-17 were studied. Mean follow-up time was 9.9 years (range 1.1-15.3). Endpoints reflecting uncontrolled CRSwNP were revision ESS, and need for rescue/advanced therapy (e.g. antibiotics, oral corticosteroids and/or biological therapy) during follow-up. NERD was variable of interest and gender, age, asthma, allergic rhinitis (AR), smoking, Lund-Mackay (LM) score of sinus computed tomography scans previous ESS and baseline total ethmoidectomy were used as covariates. Results: Twenty-one (49.7%) NERD patients and 18 (25.7%) non-NERD patients underwent revision ESS within a mean +/- SD of 4.3 +/- 2.8 and 3.7 +/- 2.6 years, respectively (p = .013, by Logrank test). In Cox ' s regression models, NERD, female gender, young age, asthma, AR, previous ESS, and lack of total ethmoidectomy were associated with revision-ESS. In adjusted model, only the total ethmoidectomy predicted revision-free survival. In adjusted logistic regression model, there was an insignificant trend that NERD and LM score were associated with the need for rescue/advanced therapy in the follow-up. Conclusions: Patients with NERD had higher risk of uncontrolled CRSwNP than patient group without NERD, as measured by revision ESS and/or need for rescue/advanced therapy in the follow-up. In addition, baseline total ethmoidectomy was associated with revision-free survival.Peer reviewe
Translation, cross-cultural adaptation, and validation of the sino-nasal outcome test (snot)-22 for Finnish patients
Purpose The Sino-Nasal Outcome Test-22 (SNOT-22) is the most commonly used disease-specific quality of life questionnaire in rhinology. The purpose of this prospective study was to translate and validate SNOT-22 into Finnish. Methods The validation process followed the guidelines proposed for cross-cultural adaptation of health-related measures of quality of life. The study consisted of three groups: rhinologic out-patients (N = 96), FESS patients (N = 49) and healthy controls (N = 79). Out-patient and FESS groups completed the questionnaire twice (answers A and B), out-patients after two weeks and FESS patients after 3 months. Validity, reliability and responsiveness were evaluated. Results The mean SNOT-22 sum score of the out-patient questionnaires were 35.3 points (answer A) and 32.4 points (answer B). ICC in out-patient group was 0.879. For the FESS patients, the mean pre- and postoperative (answer A and B) SNOT-22 sum scores were 46.8 and 21.9 points, respectively (p p Conclusions The results of our study show that the validated Finnish version of the SNOT-22 questionnaire demonstrates good validity, reliability and responsiveness.</p
Mikroyritysten tuotteisiin ja palveluihin uutta nostetta yhdessĂ€ kehittĂ€mĂ€llĂ€ : Made in Maaseutu â markkinointi- ja designosaamista maaseutuyrityksille -hankkeen loppujulkaisu
Made in Maaseutu â markkinointi- ja designosaamista maaseutuyrityksille -hankkeessa (Euroopan maaseuturahasto) jĂ€rjestettiin kahdeksan yhteiskehittĂ€miseen pohjautuvaa työpajaa, joihin osallistui mikroyrityksiĂ€, korkeakouluopiskelijoita ja toisen asteen opiskelijoita. Työpajojen teemalliset sisĂ€llöt liittyivĂ€t asiakaskokemukseen, sisĂ€llöntuotantoon ja visuaaliseen suunnitteluun ja niiden tavoitteena oli saada yrityksille asiakaslĂ€htöistĂ€ nĂ€kökulmaa ja uusia ideoita toiminnan kehittĂ€miseen. Opiskelijoille työpajat antoivat todellista työelĂ€mĂ€lĂ€htöistĂ€ kokemusta ja mahdollisuuden kĂ€yttÀÀ työpajan tuotosta referenssinÀÀn. Hankkeen tavoitteena oli kehittÀÀ työpajan rakennetta vastaamaan mikroyritysten ja opiskelijoiden tarpeita sekĂ€ edistÀÀ yritys-oppilaitosyhteistyötĂ€. MerkittĂ€vĂ€ osa työpajoista jĂ€rjestettiin hybriditapahtumina tai kokonaan verkossa
Photochemical Aging Induces Changes in the Effective Densities, Morphologies, and Optical Properties of Combustion Aerosol Particles
Effective density (Ïeff) is an important
property
describing particle transportation in the atmosphere and in the human
respiratory tract. In this study, the particle size dependency of
Ïeff was determined for fresh and photochemically
aged particles from residential combustion of wood logs and brown
coal, as well as from an aerosol standard (CAST) burner. Ïeff increased considerably due to photochemical aging, especially
for soot agglomerates larger than 100 nm in mobility diameter. The
increase depends on the presence of condensable vapors and agglomerate
size and can be explained by collapsing of chain-like agglomerates
and filling of their voids and formation of secondary coating. The
measured and modeled particle optical properties suggest that while
light absorption, scattering, and the single-scattering albedo of
soot particle increase during photochemical processing, their radiative
forcing remains positive until the amount of nonabsorbing coating
exceeds approximately 90% of the particle mass
Photochemical Aging Induces Changes in the Effective Densities, Morphologies, and Optical Properties of Combustion Aerosol Particles
Effective density (Ïeff) is an important
property
describing particle transportation in the atmosphere and in the human
respiratory tract. In this study, the particle size dependency of
Ïeff was determined for fresh and photochemically
aged particles from residential combustion of wood logs and brown
coal, as well as from an aerosol standard (CAST) burner. Ïeff increased considerably due to photochemical aging, especially
for soot agglomerates larger than 100 nm in mobility diameter. The
increase depends on the presence of condensable vapors and agglomerate
size and can be explained by collapsing of chain-like agglomerates
and filling of their voids and formation of secondary coating. The
measured and modeled particle optical properties suggest that while
light absorption, scattering, and the single-scattering albedo of
soot particle increase during photochemical processing, their radiative
forcing remains positive until the amount of nonabsorbing coating
exceeds approximately 90% of the particle mass