Management of expatriate medical assistance in Mozambique

This paper discusses how Mozambique coped with the health system needs in terms of specialized doctors since independence, in a troubled context of war, lack of financial resources and modifying settings of foreign aid. The Ministry of Health (MOH) managed to make up for its severe scarcity of specialist MDs especially through contracting expatriate technical assistance. Different scenarios, partnerships and contract schemes that have evolved since independence are briefly described, as well as self-reliance option possibility and implications. Lessons learned about donor initiatives aimed at contracting specialists from other developing countries are singled out. The issue of obtaining expertise and knowledge in the global market as cheap as possible is stressed, and realistic figures of cost planning are highlighted, as determined by the overall health system necessities and budget limitations

QPOs: Einstein's gravity non-linear resonances

There is strong evidence that the observed kHz Quasi Periodic Oscillations (QPOs) in the X-ray flux of neutron star and black hole sources in LMXRBs are linked to Einstein's General Relativity. Abramowicz&Klu\'zniak (2001) suggested a non-linear resonance model to explain the QPOs origin: here we summarize their idea and the development of a mathematical toy-model which begins to throw light on the nature of Einstein's gravity non-linear oscillations.Comment: Proceeding of the Einstein's Legacy, Munich 200

Filter design for the detection of compact sources based on the Neyman-Pearson detector

This paper considers the problem of compact source detection on a Gaussian background in 1D. Two aspects of this problem are considered: the design of the detector and the filtering of the data. Our detection scheme is based on local maxima and it takes into account not only the amplitude but also the curvature of the maxima. A Neyman-Pearson test is used to define the region of acceptance, that is given by a sufficient linear detector that is independent on the amplitude distribution of the sources. We study how detection can be enhanced by means of linear filters with a scaling parameter and compare some of them (the Mexican Hat wavelet, the matched and the scale-adaptive filters). We introduce a new filter, that depends on two free parameters (biparametric scale-adaptive filter). The value of these two parameters can be determined, given the a priori pdf of the amplitudes of the sources, such that the filter optimizes the performance of the detector in the sense that it gives the maximum number of real detections once fixed the number density of spurious sources. The combination of a detection scheme that includes information on the curvature and a flexible filter that incorporates two free parameters (one of them a scaling) improves significantly the number of detections in some interesting cases. In particular, for the case of weak sources embedded in white noise the improvement with respect to the standard matched filter is of the order of 40%. Finally, an estimation of the amplitude of the source is introduced and it is proven that such an estimator is unbiased and it has maximum efficiency. We perform numerical simulations to test these theoretical ideas and conclude that the results of the simulations agree with the analytical ones.Comment: 15 pages, 13 figures, version accepted for publication in MNRAS. Corrected typos in Tab.

Velocity Field Statistics in Star-Forming Regions. I. Centroid Velocity Observations

The probability density functions (pdfs) of molecular line centroid velocity fluctuations and fluctuation differences at different spatial lags are estimated for several nearby molecular clouds with active internal star formation. The data consist of over 75,000 $^{13}$CO line profiles divided among twelve spatially and/or kinematically distinct regions. Although three regions (all in Mon R2) appear nearly Gaussian, the others show strong evidence for non-Gaussian, often nearly exponential, centroid velocity pdfs, possibly with power law contributions in the far tails. Evidence for nearly exponential centroid pdfs in the neutral HI component of the ISM is also presented, based on older optical and radio observations. These results are in contrast to pdfs found in isotropic incompressible turbulence experiments and simulations. Furthermore, no evidence is found for the scaling of difference pdf kurtosis with Reynolds number which is seen in incompressible turbulence, and the spatial distribution of high-amplitude velocity differences shows little indication of the filamentary appearance predicted by decay simulations dominated by vortical interactions. The variation with lag of the difference pdf moments is presented as a constraint on future simulations.Comment: LaTeX, 23 pages, with 15 Figures included separately as gif image files. Refereed/revised version accepted to the Astrophysical Journal. A complete (but much larger) postscript version is available from http://ktaadn.gsfc.nasa.gov/~miesc

Measuring the Three-Dimensional Structure of Galaxy Clusters. II. Are clusters of galaxies oblate or prolate?

The intrinsic shape of galaxy clusters can be obtained through a combination of X-ray and Sunyaev-Zeldovich effect observations once cosmological parameters are assumed to be known. In this paper we discuss the feasibility of modelling galaxy clusters as either prolate or oblate ellipsoids. We analyze the intra-cluster medium distribution for a sample of 25 X-ray selected clusters, with measured Sunyaev-Zeldovich temperature decrements. A mixed population of prolate and oblate ellipsoids of revolution fits the data well, with prolate shapes preferred on a 60-76% basis. We observe an excess of clusters nearly aligned along the line of sight, with respect to what is expected from a randomly oriented cluster population, which might imply the presence of a selection bias in our sample. We also find signs that a more general triaxial morphology might better describe the morphology of galaxy clusters. Additional constraints from gravitational lensing could disentangle the degeneracy between an ellipsoidal and a triaxial morphology, and could also allow an unbiased determination of the Hubble constant.Comment: 9 pages, 8 figures, accepted for publication in Astrophys.

The Apparent and Intrinsic Shape of the APM Galaxy Clusters

We estimate the distribution of intrinsic shapes of APM galaxy clusters from the distribution of their apparent shapes. We measure the projected cluster ellipticities using two alternative methods. The first method is based on moments of the discrete galaxy distribution while the second is based on moments of the smoothed galaxy distribution. We study the performance of both methods using Monte Carlo cluster simulations covering the range of APM cluster distances and including a random distribution of background galaxies. We find that the first method suffers from severe systematic biases, whereas the second is more reliable. After excluding clusters dominated by substructure and quantifying the systematic biases in our estimated shape parameters, we recover a corrected distribution of projected ellipticities. We use the non-parametric kernel method to estimate the smooth apparent ellipticity distribution, and numerically invert a set of integral equations to recover the corresponding distribution of intrinsic ellipticities under the assumption that the clusters are either oblate or prolate spheroids. The prolate spheroidal model fits the APM cluster data best.Comment: 8 pages, including 7 figures, accepted for publication in MNRA

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance

AbstractMetabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has limited the development of therapeutic strategies. We induced a MetS-like condition by exposing mice to fructose feeding for 7weeks. There was a dramatic deterioration in the capacity of the hippocampus to sustain synaptic plasticity in the forms of long-term potentiation (LTP) and long-term depression (LTD). Mice exposed to fructose showed a reduction in the number of contact zones and the size of postsynaptic densities (PSDs) in the hippocampus, as well as a decrease in hippocampal neurogenesis. There was an increase in lipid peroxidation likely associated with a deficiency in plasma membrane excitability. Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. Most of the pathological sequel of MetS in the brain was reversed three month after discontinue fructose feeding. These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. The overall information raises concerns about the risk imposed by excessive fructose consumption on the pathology of neurological disorders

Porcine Lawsonia intracellularis Ileitis in Italy and Its Association with Porcine Circovirus Type 2 (PCV2) Infection

The objective of this study was to employ a diagnostic algorithm, which involves detecting positive farms by stool PCR followed by PCR and histology/immunohistochemistry on ileum samples, for diagnosing Lawsonia intracellularis proliferative enteritis in Northern Italy. The primary aim was to examine the relationship between the gold standard of L. intracellularis diagnostics, namely histology and immunohistochemistry, and PCR in acute and chronic cases of L. intracellularis enteritides. An additional goal was to investigate the coinfection of L. intracellularis with porcine circovirus type 2 (PCV2). Twenty-eight ileum samples, including four from acute cases and 24 from chronic cases, were collected. PCR yielded positive results in 19 cases (four acute and 15 chronic cases). In comparison, immunohistochemistry was positive in 16 cases (four acute and 12 chronic cases), with an observed agreement of 89%. The findings suggest that performing the two tests in series can increase the specificity of the causal diagnosis. PCR may be used as a screening tool to identify the presence of the microorganism, and only positive cases will be examined by histology and immunohistochemistry to confirm the causative role of L. intracellularis. Co-infection with PCV2 was demonstrate in two out of four acute cases and in two out of 24 chronic cases, providing further evidence to support the hypothesis that when the infection starts with ubiquitous pathogens such as L. intracellularis, it may boost the possibility of PCV2 replication, especially in acute cases. As a result, this may trigger a transition from subclinical to clinical forms of PCV2 disease