259 research outputs found
Hydrogen atom moving across a strong magnetic field: analytical approximations
Analytical approximations are constructed for binding energies,
quantum-mechanical sizes and oscillator strengths of main radiative transitions
of hydrogen atoms arbitrarily moving in magnetic fields 10^{12}-10^{13} G.
Examples of using the obtained approximations for determination of maximum
transverse velocity of an atom and for evaluation of absorption spectra in
magnetic neutron star atmospheres are presented.Comment: 17 pages, 3 figures, 5 tables, LaTeX with IOP style files (included).
In v.2, Fig.1 and Table 5 have been corrected. In v.3, a misprint in the fit
for oscillator strengths, Eq.(21), has been correcte
THE CNGS FACILITY: PERFORMANCE AND OPERATIONAL EXPERIENCE
The CNGS facility (CERN Neutrinos to Gran Sasso) aims at directly detecting muon to tau neutrino oscillations. An intense muon-neutrino beam (1E17 muon neutrinos/day) is generated at CERN and directed over 732 km towards the Gran Sasso National Laboratory, LNGS, in Italy, where two large and complex detectors, OPERA and ICARUS, are located. CNGS is the first long-baseline neutrino facility in which the measurement of the oscillation parameters is performed by observation of tau-neutrino appearance. In this paper, an overview of the CNGS facility is presented. The experience gained in operating this 500 kW neutrino beam facility is described. Major events since the commissioning of the facility in 2006 are summarized. Highlights on CNGS beam performance since the start of physics run in 2008 are given
First Year Physics at CNGS, presented at PAC09, Vancouver, Canada, 4-8 May 2009
The CNGS facility (CERN Neutrinos to Gran Sasso) aims at directly detecting νμ→ντ neutrino oscillations [1]. An intense νμ beam (1017 νμ per day) is generated at CERN and directed over 732 km towards the Gran Sasso National Laboratory, LNGS, in Italy, where two large and complex detectors, OPERA and ICARUS, are located. Having resolved successfully some initial issues that occurred since its commissioning in 2006, that will be briefly summarized here, the facility had its first complete year of physics with 1.78×10^19 protons extracted towards CNGS. The experiences gained in operating this 500 kW neutrino beam facility along with highlights of the beamperformance in 2008 are discussed
First Year of Physics at CNGS
The CNGS facility (CERN Neutrinos to Gran Sasso) aims at directly detecting νμ→ντ neutrino oscillations [1]. An intense νμ beam (1017 νμ per day) is generated at CERN and directed over 732 km towards the Gran Sasso National Laboratory, LNGS, in Italy, where two large and complex detectors, OPERA and ICARUS, are located. Having resolved successfully some initial issues that occurred since its commissioning in 2006, that will be briefly summarized here, the facility had its first complete year of physics with 1.78×1019 protons extracted towards CNGS. The experiences gained in operating this 500 kW neutrino beam facility along with highlights of the beam performance in 2008 are discussed
Spectrum of Neutral Helium in Strong Magnetic Fields
We present extensive and accurate calculations for the excited state spectrum
of spin-polarized neutral helium in a range of magnetic field strengths up to
G. Of considerable interest to models of magnetic white dwarf stellar
atmospheres, we also present results for the dipole strengths of the low lying
transitions among these states. Our methods rely on a systematically saturated
basis set approach to solving the Hartree--Fock self-consistent field
equations, combined with an ``exact'' stochastic method to estimate the
residual basis set truncation error and electron correlation effects. We also
discuss the applicability of the adiabatic approximation to strongly magnetized
multi-electron atoms.Comment: 19 pages, 7 figures, 10 table
Phage Display in the Quest for New Selective Recognition Elements for Biosensors
Phages are bacterial viruses that have gained a significant role in biotechnology owing to their widely studied biology and many advantageous characteristics. Perhaps the best-known application of phages is phage display that refers to the expression of foreign peptides or proteins outside the phage virion as a fusion with one of the phage coat proteins. In 2018, one half of the Nobel prize in chemistry was awarded jointly to George P. Smith and Sir Gregory P. Winter "for the phage display of peptides and antibodies." The outstanding technology has evolved and developed considerably since its first description in 1985, and today phage display is commonly used in a wide variety of disciplines, including drug discovery, enzyme optimization, biomolecular interaction studies, as well as biosensor development. A cornerstone of all biosensors, regardless of the sensor platform or transduction scheme used, is a sensitive and selective bioreceptor, or a recognition element, that can provide specific binding to the target analyte. Many environmentally or pharmacologically interesting target analytes might not have naturally appropriate binding partners for biosensor development, but phage display can facilitate the production of novel receptors beyond known biomolecular interactions, or against toxic or nonimmunogenic targets, making the technology a valuable tool in the quest of new recognition elements for biosensor development.This study was supported by the Ministry of Economy and Competitiveness (Ministerio de Ciencia, Innovación y Universidades RTI2018-096410-B-C21). R.P. acknowledges UCM for a predoctoral grant and R.B. the PI17CIII/00045 grant from the AES-ISCIII program.S
Isotope shift in the electron affinity of chlorine
The specific mass shift in the electron affinity between ^{35}Cl and ^{37}Cl
has been determined by tunable laser photodetachment spectroscopy to be
-0.51(14) GHz. The isotope shift was observed as a difference in the onset of
the photodetachment process for the two isotopes. In addition, the electron
affinity of Cl was found to be 29138.59(22) cm^{-1}, giving a factor of 2
improvement in the accuracy over earlier measurements. Many-body calculations
including lowest-order correlation effects demonstrates the sensitivity of the
specific mass shift and show that the inclusion of higher-order correlation
effects would be necessary for a quantitative description.Comment: 16 pages, 6 figures, LaTeX2e, amsmat
The LBNO long-baseline oscillation sensitivities with two conventional neutrino beams at different baselines
The proposed Long Baseline Neutrino Observatory (LBNO) initially consists of
kton liquid double phase TPC complemented by a magnetised iron
calorimeter, to be installed at the Pyh\"asalmi mine, at a distance of 2300 km
from CERN. The conventional neutrino beam is produced by 400 GeV protons
accelerated at the SPS accelerator delivering 700 kW of power. The long
baseline provides a unique opportunity to study neutrino flavour oscillations
over their 1st and 2nd oscillation maxima exploring the behaviour, and
distinguishing effects arising from and matter. In this paper we
show how this comprehensive physics case can be further enhanced and
complemented if a neutrino beam produced at the Protvino IHEP accelerator
complex, at a distance of 1160 km, and with modest power of 450 kW is aimed
towards the same far detectors. We show that the coupling of two independent
sub-MW conventional neutrino and antineutrino beams at different baselines from
CERN and Protvino will allow to measure CP violation in the leptonic sector at
a confidence level of at least for 50\% of the true values of
with a 20 kton detector. With a far detector of 70 kton, the
combination allows a sensitivity for 75\% of the true values of
after 10 years of running. Running two independent neutrino
beams, each at a power below 1 MW, is more within today's state of the art than
the long-term operation of a new single high-energy multi-MW facility, which
has several technical challenges and will likely require a learning curve.Comment: 21 pages, 12 figure
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model
Single domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because of their restricted blood–brain barrier (BBB) penetration. Here, we propose a gene transfer strategy based on BBB-crossing adeno-associated virus (AAV)-based vectors to deliver VHH directly into the CNS. As a proof-of-concept, we explored the potential of AAV-delivered VHH to inhibit BACE1, a well-characterized target in Alzheimer’s disease. First, we generated a panel of VHHs targeting BACE1, one of which, VHH-B9, shows high selectivity for BACE1 and efficacy in lowering BACE1 activity in vitro. We further demonstrate that a single systemic dose of AAV-VHH-B9 produces positive long-term (12 months plus) effects on amyloid load, neuroinflammation, synaptic function, and cognitive performance, in the AppNL-G-F Alzheimer’s mouse model. These results constitute a novel therapeutic approach for neurodegenerative diseases, which is applicable to a range of CNS disease targets
- …