UAS Regulation in Foreign Countries: Alternatives to UAS Operations in the United States

Wide range interest in Unmanned Aerial Systems (UAS) across the globe Rapid growth has been stymied in the U.S. due to slow progression of integration and privacy concerns U.S. may lose competitive advantage Other countries provide opportunities for potential research and collaboratio

AI for People with Visual Impairments: Exploring Designing for Interdependence

With this thesis I aim to understand what the concept of interdependence offers to the design of novel AI Assistive Technology (AT) for people with visual impairments. The interdependence framework, proposed by Cynthia Bennett and colleagues in ASSETS 2018, emphasises the collective work done by people with disabilities and others to achieve access and independence. In this framework assistive technology is seen as a further way to extend the relations between one another, focusing on how actors are made more or less able through other actors and with technology. Current work in AI assistive technology has neglected this kind of collaboration, opening up opportunities to think differently about the design and role of AI in the future. Using the sighted guiding partnership as a specific case study, I re-frame the role of AI navigational aid technology, resisting current AI trends which treat blind navigation as an individual activity in need of a technological solution. In opposition to this solution-driven approach, I question how we can use interdependence as the basis for designing AI assistive technologies for people with visual impairments. Answering this research question was approached in three stages: 1. A systematic and empirical study, investigating how people with visual impairments and their guides accomplish navigation together. I show examples of interdependence in action, where people use multimodal resources to co-constitute a common space to move through together, and I draw important design implications. 2. Approaching a design space at the intersection of AI and interdependence. Focusing on the context of physical disengagement in sighted guiding, I unpack bodily movement language, and I introduce an AI prototype to sighted guiding companions. I discover the skepticism, and challenges in engaging people in thinking about future AI assistive technology. 3. Informed by the previous study, I reconsider the design process and introduce an accessible design methods that invites participants to creatively think about how AI might strengthen the sighted guiding partnership. I show how companions engage in this process, and how the method invites people to reflect, and extend ideas around future AI assistive technology. The main contributions of this thesis are: (i) a detailed understanding of the theoretical concept of interdependence in the sighted guiding partnership; (ii) extending current design method at the intersection of workbooks and cultural probes; (iii) a methodological contribution in reframing the design space to attend to interdependence and AI. While this research represents an initial attempt to disrupt social norms and established thinking in HCI research, future work would need to investigate the interdependence frame in different settings, and how the design process can be shaped to accommodate the complexity of AI and people with mixed abilities. New tools and methods are essential to inspire people making alternative AI’s designs, which will empower people with disabilities in social life

Polymers in linear shear flow: a numerical study

We study the dynamics of a single polymer subject to thermal fluctuations in a linear shear flow. The polymer is modeled as a finitely extendable nonlinear elastic FENE dumbbell. Both orientation and elongation dynamics are investigated numerically as a function of the shear strength, by means of a new efficient integration algorithm. The results are in agreement with recent experiments.Comment: 7 pages, see also the preceding paper (http://arxiv.org/nlin.CD/0503028

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?

Background: The immune response in melanoma patients is locally affected by presence of tumor-infiltrating lymphocytes (TILs), generally divided into brisk, nonbrisk, and absent. Several studies have shown that a greater presence of TILs, especially brisk, in primary melanoma is associated with a better prognosis and higher survival rate. Patients and Methods: We investigated by enzyme-linked immunosorbent assay (ELISA) the correlation between PD-1 levels in plasma and the presence/absence of TILs in 28 patients with metastatic melanoma. Results: Low plasma PD-1 levels were correlated with brisk TILs in primary melanoma, whereas intermediate values correlated with the nonbrisk TILs, and high PD-1 levels with absent TILs. Although the low number of samples did not allow us to obtain a statistically significant correlation between the plasma PD-1 levels and the patients' overall survival depending on the absence/presence of TILs, the median survival of patients having brisk type TILs was 5 months higher than that of patients with absent and nonbrisk TILs. Conclusions: This work highlights the ability of measuring the plasma PD-1 levels in order to predict the prognosis of patients with untreated metastatic melanoma without a BRAF mutation at the time of diagnosis

Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis

Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metastases (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status.Background: Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metastases (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status. Materials and methods: Data from all published studies reporting survival outcomes (RFS and/or OS) of CRC patients who received resection of CLM, stratified by KRAS and/or BRAF mutation status were collected, according to the PRISMA guidelines. Pooled HRs were calculated for both the OS and/or RFS. Results: Seven eligible trials (1403 patients) were included. Pooled analysis showed that KRAS mutations predicted a significantly worse both RFS (HR: 1.65; 95% CI: 1.23-2.21) and OS (HR: 1.86; 95% CI: 1.51-2.30) in patients who underwent surgical resection of CLM. BRAF mutations were also associated with a significantly worse OS (HR: 3.90; 95% CI: 1.96-7.73) in this subgroup of patients. Conclusions: This meta-analysis suggests both KRAS and BRAF mutations as poor, prognostic biomarkers, associated with worse survival outcomes, in patients undergoing hepatic resection of CLM

Gemcitabine-based doublets versus single-agent therapy for elderly patients with advanced nonsmall cell lung cancer: a Literature-based Meta-analysis.

Although platinum-based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single-agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third-generation agents (gemcitabine [G], vinorel- bine, docetaxel, and paclitaxel) have been tested, yielding contradictory results. The authors of this report performed a literature-based meta-analysis to assess the efficacy and tolerability of G-based doublets compared with single-agent chemotherapy for elderly patients with NSCLC. METHODS: Data from all published, randomized, phase 3 trials that compared a G-based doublet with a third-generation single agent in elderly patients were collected from electronic databases (Medline and the Cochrane Central Register of Controlled Trials), relevant reference lists, and abstract books. Pooled odds ratios (ORs) were calculated for the 1-year survival rate, the overall response rate (ORR), and grade 3 and 4 toxicities. RESULTS: Four eligible trials (1436 patients) were selected from 442 studies that initially were identified. A significant difference in ORR favoring G-based doublets over single agents was observed (OR, 0.65; 95% confidence interval [95% CI], 0.51-0.82 [P<.001]), whereas the trend toward an improved 1-year survival rate was not significant (OR, 0.78; 95% CI, 0.57-1.06 [P¼.169]). Grade 3 and 4 toxicities did not differ significantly except for thrombocytopenia (OR, 1.76; 95% CI, 1.12-2.76 [P¼.014]). CONCLUSIONS: G-based doublets appeared to be effective and feasible compared with single agents in the treatment of elderly patients with advanced NSCLC who were not suitable for full-dose, platinum-based chemotherapy. Further prospective, elderly specific, phase 3 trials will be necessary

Anticancer activity of "Trigno M", extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models

Abstract In 2018 there were over 1.8 million new cases worldwide of colorectal cancer and relapses after clinical treatments. Many studies ascribe the risk of the appearance of this cancer to the Western life style : a sedentary life, obesity, and low -fiber, high -fat diets can promote the onset of disease. Several studies have shown supplement phytochemicals to have an inhibiting effect on the growth of various cancers through the activation of apoptosis. Our goal was to prove the effectiveness of a natural compound in the combined therapy of colorectal cancer. Trigno M supplement was an optimal candidate as anticancer product for its high concentrations of phenolic acids, flavonoids and anthocyanins. Our work showed the antitumor activity of Trigno M, extract of Prunus spinosa drupes combined with the nutraceutical activator complex (NAC), in 2D, 3D and in vivo colorectal cancer models. The cellular model we used both in vitro and in vivo was the HCT116 cell line, particularly suitable for engraftment after inoculation in mice. Trigno M inhibited the growth and colony formation of HCT116 cells (35%) as compared to the chemotherapy treatment with 5-fluorouracil (80%) used in clinical therapy. The reduction of the morphological dimensions in the spheroid cells after Trigno M, was compared with 5-fluorouracil demonstrating the efficacy of the Trigno M compound also in 3D models. Flow cytometric analysis on 3D cells showed a significant increase in the apoptotic cell fraction after Trigno M treatment (44.8%) and a low level of necrotic fraction (6.7%) as compared with control cells. Trigno M and 5-fluorouracil induced the apoptosis in a comparable percentage. Monotherapy with Trigno M in severely immunodeficient mice, carrying colon rectal cancer xenografts, significantly reduced tumor growth. The histopatological analysis of the ectopic tumors showed a lower level of necrosis after Trigno M treatment compared with the control. We conclude that Trigno M is well tolerated by mice, delays colorectal cancer growth in these animals and should be weighed up for integration of the current multi-drug protocols in the treatment of colon carcinoma

Type Ia Supernova cosmology combining data from the EuclidEuclid mission and the Vera C. Rubin Observatory

The $Euclid$ mission will provide first-of-its-kind coverage in the near-infrared over deep (three fields, $\sim$10-20 square degrees each) and wide ($\sim$10000 square degrees) fields. While the survey is not designed to discover transients, the deep fields will have repeated observations over a two-week span, followed by a gap of roughly six months. In this analysis, we explore how useful the deep field observations will be for measuring properties of Type Ia supernovae (SNe Ia). Using simulations that include $Euclid$'s planned depth, area and cadence in the deep fields, we calculate that more than 3700 SNe between $0.0<z<1.5$ will have at least five $Euclid$ detections around peak with signal-to-noise ratio larger than 3. While on their own, $Euclid$ light curves are not good enough to directly constrain distances, when combined with LSST deep field observations, we find that uncertainties on SN distances are reduced by 20-30% for $z0.8$. Furthermore, we predict how well additional $Euclid$ mock data can be used to constrain a key systematic in SN Ia studies - the size of the luminosity 'step' found between SNe hosted in high mass ($>10^{10} M_{\odot}$) and low mass ($>10^{10} M_{\odot}$) galaxies. This measurement has unique information in the rest-frame NIR. We predict that if the step is caused by dust, we will be able to measure its reduction in the NIR compared to optical at the 4$\sigma$ level. We highlight that the LSST and $Euclid$ observing strategies used in this work are still provisional and some level of joint processing is required. Still, these first results are promising, and assuming $Euclid$ begins observations well before the Nancy Roman Space Telescope (Roman), we expect this dataset to be extremely helpful for preparation for Roman itself