High Metallicity Mg II Absorbers in the z < 1 Lyman alpha Forest of PKS 0454+039: Giant LSB Galaxies?

We report the discovery of two iron-group enhanced high-metallicity Mg II absorbers in a search through 28 Lyman Alpha forest clouds along the PKS 0454+039 sight line. Based upon our survey and the measured redshift number densities of W_r(MgII) <= 0.3 A absorbers and Lyman Alpha absorbers at z ~ 1, we suggest that roughly 5% of Lyman Alpha absorbers at z < 1 will exhibit "weak" Mg II absorption to a 5-sigma W_r(2796) detection limit of 0.02 A. The two discovered absorbers, at redshifts z = 0.6248 and z = 0.9315, have W_r(Lya) = 0.33 and 0.15 A, respectively. Based upon photoionization modeling, the H I column densities are inferred to be in the range 15.8 <= log N(HI) <= 16.8 cm^-2. For the z = 0.6428 absorber, if the abundance pattern is solar, then the cloud has [Fe/H] > -1; if its gas-phase abundance follows that of depleted clouds in our Galaxy, then [Fe/H] > 0 is inferred. For the z = 0.9315 absorber, the metallicity is [Fe/H] > 0, whether the abundance pattern is solar or suffers depletion. Imaging and spectroscopic studies of the PKS 0454+039 field reveal no candidate luminous objects at these redshifts. We discuss the possibility that these Mg II absorbers may arise in the class of "giant" low surface brightness galaxies, which have [Fe/H] >= -1, and even [Fe/H] >= 0, in their extended disks. We tentatively suggest that a substantial fraction of these "weak" Mg II absorbers may select low surface brightness galaxies out to z ~ 1.Comment: Accepted The Astrophysical Journal; 25 pages; 6 encapsulated figure

Classical and MgII-selected Damped Lyman-alpha Absorbers: impact on Omega_HI at z<1.7

The Damped Lyman-alpha systems (DLAs), seen in absorption in the spectrum of quasars, are believed to contain a large fraction of the neutral gas in the Universe. Paradoxically, these systems are more difficult to observe at z_abs<1.7, since they are rare and their HI feature then falls in UV spectra. Rao & Turnshek (2000) pioneered a method based on MgII-selected DLAs, that is absorbers discovered thanks to our knowledge of their MgII feature in optical spectra. We use new observations undertaken at the TNG as well as a careful literature & archival search to build samples of low redshift absorbers classified according to the technique used for their discovery. We successfully recover N(HI) and equivalent widths of FeII 2600, MgII 2796, MgII 2803 and MgII 2852 for a sample of 36 absorbers, 21 of which are MgII-selected. We find that the MgII-selected sample contains a marginally larger fraction of absorbers with log N(HI)>21.0 than seen otherwise at low redshift. If confirmed, this property will in turn affect estimates of Omega_HI which is dominated by the highest HI column densities. We find that log N(HI) does not correlate significantly with metal equivalent widths. Similarly, we find no evidence that gravitational lensing, the fraction of associated systems or redshift evolution affect the absorber samples in a different way. We conclude that the hint of discrepancies in N(HI) distributions most likely arises from small number statistics. Therefore, further observations are required to better clarify the impact of this discrepancy on estimates of Omega_HI at low redshift.Comment: 13 pages, 8 figures. Accepted for publication in MNRA

Small scale structure in diffuse molecular gas from repeated FUSE and visible spectra of HD 34078

We present preliminary results from an ongoing program devoted to a study of small scale structure in the spatial distribution of molecular gas. Our work is based on multi-epoch FUSE and visible observations of HD34078. A detailed comparison of H2, CH and CH+ absorption lines is performed. No short term variations are seen (except for highly excited H2) but long-term changes in N(CH) are clearly detected when comparing our data to spectra taken about 10 years ago.Comment: 4 pages, 2 figures, To appear in the Proceedings of the XVII IAP Colloquium "Gaseous Matter in Galaxies and Intergalactic Space

Management of trypanosomiasis and leishmaniasis

&lt;p&gt;Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress. For HAT the only advances in treatment over the past two decades have been the introduction of an eflornithine/nifurtimox co-administration and a shorter regime of the old standard melarsoprol.&lt;/p&gt; &lt;p&gt;Sources of data: PubMed.&lt;/p&gt; &lt;p&gt;Areas of Agreement: There is a need for new safe, oral drugs for cost-effective treatment of patients and use in control programmes for all the trypanosomatid diseases.&lt;/p&gt; &lt;p&gt;Areas of controversy: Cutaneous leishmaniasis is not on the agenda and treatments are lagging behind.&lt;/p&gt; &lt;p&gt;Growing points: There are three compounds in development for the treatment of the CNS stage of HAT: fexinidazole, currently due to entry into phase II clinical studies, a benzoxaborole (SCYX-7158) in phase I trials and a diamidine derivative (CPD-0802), in advanced pre-clinical development. For Chagas disease, two anti-fungal triazoles are now in clinical trial. In addition, clinical studies with benznidazole, a drug previously recommended only for acute stage treatment, are close to completion to determine the effectiveness in the treatment of early chronic and indeterminate Chagas disease. For visceral leishmaniasis new formulations, therapeutic switching, in particular AmBisome, and the potential for combinations of established drugs have significantly improved the opportunities for the treatment in the Indian subcontinent, but not in East Africa.&lt;/p&gt; &lt;p&gt;Areas timely for developing research: Improved diagnostic tools are needed to support treatment, for test of cure in clinical trials and for monitoring/surveillance of populations in control programmes.&lt;/p&gt

Coordinate Transcriptomic and Metabolomic Effects of the Insulin Sensitizer Rosiglitazone on Fundamental Metabolic Pathways in Liver, Soleus Muscle, and Adipose Tissue in Diabetic db/db Mice

Rosiglitazone (RSG), developed for the treatment of type 2 diabetes mellitus, is known to have potent effects on carbohydrate and lipid metabolism leading to the improvement of insulin sensitivity in target tissues. To further assess the capacity of RSG to normalize gene expression in insulin-sensitive tissues, we compared groups of 18-day-treated db/db mice with increasing oral doses of RSG (10, 30, and 100 mg/kg/d) with untreated non-diabetic littermates (db/+). For this aim, transcriptional changes were measured in liver, inguinal adipose tissue (IAT) and soleus muscle using microarrays and real-time PCR. In parallel, targeted metabolomic assessment of lipids (triglycerides (TGs) and free fatty acids (FFAs)) in plasma and tissues was performed by UPLC-MS methods. Multivariate analyses revealed a relationship between the differential gene expressions in liver and liver trioleate content and between blood glucose levels and a combination of differentially expressed genes measured in liver, IAT, and muscle. In summary, we have integrated gene expression and targeted metabolomic data to present a comprehensive overview of RSG-induced changes in a diabetes mouse model and improved the molecular understanding of how RSG ameliorates diabetes through its effect on the major insulin-sensitive tissues

The zCOSMOS 10k-Bright Spectroscopic Sample

We present spectroscopic redshifts of a large sample of galaxies with I_(AB) < 22.5 in the COSMOS field, measured from spectra of 10,644 objects that have been obtained in the first two years of observations in the zCOSMOS-bright redshift survey. These include a statistically complete subset of 10,109 objects. The average accuracy of individual redshifts is 110 km s^(–1), independent of redshift. The reliability of individual redshifts is described by a Confidence Class that has been empirically calibrated through repeat spectroscopic observations of over 600 galaxies. There is very good agreement between spectroscopic and photometric redshifts for the most secure Confidence Classes. For the less secure Confidence Classes, there is a good correspondence between the fraction of objects with a consistent photometric redshift and the spectroscopic repeatability, suggesting that the photometric redshifts can be used to indicate which of the less secure spectroscopic redshifts are likely right and which are probably wrong, and to give an indication of the nature of objects for which we failed to determine a redshift. Using this approach, we can construct a spectroscopic sample that is 99% reliable and which is 88% complete in the sample as a whole, and 95% complete in the redshift range 0.5 < z < 0.8. The luminosity and mass completeness levels of the zCOSMOS-bright sample of galaxies is also discussed

Unveiling Cosmic Dawn: the synergetic role of space and ground-based telescopes

Large scale structure and cosmolog