Radial velocity variations of the pulsating subdwarf B star PG 1605+072

We present an analysis of high-speed spectroscopy of the pulsating subdwarf B star PG 1605+072. Periodic radial motions are detected at frequencies similar to those reported for photometric variations in the star, with amplitudes of up to 6 km/s. Differences between relative strengths for given frequency peaks for our velocity data and previously measured photometry are probably a result of shifting of power between modes over time. Small differences in the detected frequencies may also indicate mode-shifting. We report the detection of line-shape variations using the moments of the cross correlation function profiles. It may be possible to use the moments to identify the star's pulsation modes.Comment: 5 pages, 6 figure

A Once-Weekly R207910-containing Regimen Exceeds Activity of the Standard Daily Regimen in Murine Tuberculosis

Rationale: R207910 (TMC207 or J) is a member of the diarylquinolines, a new family of antituberculous drugs with high bactericidal activity when given daily in the murine model of tuberculosis. R207910 exhibits a long half-life and thus is a good candidate for once-weekly therapy of tuberculosis. Objectives: To study the activity of once-weekly R207910 monotherapy and combinations of R207910 with other antituberculous agents (isoniazid, rifapentine, moxifloxacin, and pyrazinamide). Methods: The established infection model of murine tuberculosis was used. Colony counts were determined in the lungs. Measurements and Main Results: Eight weeksofmonotherapy reduced the bacillary load by 3 to 4 log10 for rifapentine and by 5 to 6 log10 for R207910 (P , 0.05). The addition of rifapentine and isoniazid or moxifloxacin did not improve the bactericidal activity of R207910 monotherapy. In contrast, the triple combination of R207910 plus rifapentine plus pyrazinamide given once weekly for 2 months (i.e., a total of only eight administrations), was significantly (P , 0.05) more active than R207910 monotherapy or other R207910 combinations, and led to lung culture negativity in 9 of 10 mice, whereas all lungs were culture positive in the groups treated with other drug combinations. Moreover, R207910 plus rifapentine plus pyrazinamide given once weekly was more active than the current standard regimen of rifampin plus isoniazid plus pyrazinamide given five times per week. Conclusions: The unprecedented activity of the triple combination of R207910 plus rifapentine plus pyrazinamide suggests that it may be feasible to develop a fully intermittent once-weekly regimen

Pickering stabilization of thymol through green emulsification using soluble fraction of almond gum : whey protein isolate nano-complexes

In this study, the soluble fraction of almond gum (SFAG) as a sustainable biopolymer source and whey protein isolate (WPI) were used for self-assembly preparation of SFAG-WPI nano-complexes through electrostatic interaction. The SFAG was characterized using H-1 and C-13 NMR. The influence of total biopolymer concentration (0.2-0.4 %w/v) and ratios (1:3-3:1) as well as of the pH (2-6) on the formation of complexes was established by visual, light scattering, surface charge, and spectrometric observations. The outcomes proved the formation of negatively charged soluble complexes in the range of pH 4-5 and insoluble complexes at pH values 3 to 4. The soluble coacervate particles at pH 4.5 and total concentration of 0.4 %w/v were selected to induce Pickering stabilization of thymol. The static light scattering with microscopy studies (CLSM and Cryo-SEM) showed the formation of thymol oil-in-water emulsions by adsorption of nano-complexes on the surface of the droplets. Thymol emulsions stabilized using complexes had no size variation under storage (40 days) with an opaque and homogenous appearance. On the other hand, the emulsions containing solely WPI at pH 4.5 showed a substantial droplet size increase with severe creaming. Droplet size analysis together with coalescence and flocculation indices presented that coalescence was mainly responsible for droplet size coarsening of the emulsions stabilized by native WPI at pH 4.5. Overall, our outcomes indicated the improvement of WPI in the stabilization of emulsions through complexation

Exploring the integration of business and CSR perspectives in smallholder sourcing: black soybean in Indonesia and tomato in India

Purpose – The purpose of this paper is to assess the impact of smallholder supply chains on sustainable sourcing to answer the question how food and agribusiness multinationals can best include smallholders in their sourcing strategies and take social responsibility for large-scale sustainable and more equitable supply. A sustainable smallholder sourcing model with a list of critical success factors (CSFs) has been applied on two best-practise cases. In this model, business and corporate social responsibility perspectives are integrated. Design/methodology/approach – The primary data of the value chain analyses of the two smallholder supply chains of a food and agribusiness multinational have been applied. Both cases were of a join research program commissioned by the multinational and a non-governmental organization using the same methods and research tools. Similarities, differences and interference between the cases have been determined and assessed in order to confirm, fine tune or adjust the CSFs. Findings – Both cases could be conceptualized through the smallholder sourcing model. Most CSFs could be found in both cases, but differences were also found, which led to fine tuning of some CSFs: building of a partnership and effective producers organization, providing farm financing and the use of cross-functional teams in smallholder supplier development programs. It was also concluded that the smallholder sourcing model is applicable in different geographical areas. Research limitations/implications – The findings of this study are based on just two cases. More best-practise cases are recommended in order to confirm or to adjust the developed sourcing model and the CSFs. Originality/value – This paper/research fills the need in sustainable supply chain management literature to study supply chains that comply with the triple bottom line concept, rather than supply chains that are just more “green.” Keywords Small- to medium-sized enterprises, Food products, Supply chain management, Developing countries, Business development, Food industry, Commodity markets Paper type Research pap

Reproducibility of lymphovascular space invasion (LVSI) assessment in endometrial cancer

Aims Lymphovascular space invasion (LVSI) in endometrial cancer (EC) is an important prognostic variable impacting on a patient's individual recurrence risk and adjuvant treatment recommendations. Recent work has shown that grading the extent of LVSI further improves its prognostic strength in patients with stage I endometrioid EC. Despite this, there is little information on the reproducibility of LVSI assessment in EC. Therefore, we designed a study to evaluate interobserver agreement in discriminating true LVSI from LVSI mimics (Phase I) and reproducibility of grading extent of LVSI (Phase II). Methods and results Scanned haematoxylin and eosin (H&E) slides of endometrioid EC (EEC) with a predefined possible LVSI focus were hosted on a website and assessed by a panel of six European gynaecological pathologists. In Phase I, 48 H&E slides were included for LVSI assessment and in Phase II, 42 H&E slides for LVSI grading. Each observer was instructed to apply the criteria for LVSI used in daily practice. The degree of agreement was measured using the two-way absolute agreement average-measures intraclass correlation coefficient (ICC). Reproducibility of LVSI assessment (ICC = 0.64, P < 0.001) and LVSI grading (ICC = 0.62, P < 0.001) in EEC was substantial among the observers. Conclusions Given the good reproducibility of LVSI, this study further supports the important role of LVSI in decision algorithms for adjuvant treatment

Archeologisch onderzoek te Aalst - Sint-Jozefscollege (prov. Oost-Vlaanderen) 2009-2010

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