Comparative Study on Speaking Assessment Rubrics in Trinity and Cambridge Language Certificates: Adaptation to the Common European Framework Guidelines

[Abstract] The European Council has been instrumental in the standardization of language competence levels and certifications with the guidelines provided in the Common European Framework of Reference for Languages (CEFR) published in 2001 and later reviewed in 2020 with the Companion Volume with New Descriptors (CEFRCV). Cambridge Assessment English and Trinity College are two of the highest regarded institutions at the international level that grant their language certificates following the language competence levels provided by the CEFR. For this reason, the current study is grounded on the conviction that those certificates should meet certain principles of the Framework as a form of guarantee that they are assessing the CEFR level correctly. In particular, this paper focuses on the speaking skill and the rubrics of assessment used by the two afore-mentioned institutions. The rubrics of Trinity and Cambridge for the assessment of the oral production at the B2 CEFR level were considered for the purposes of this study – in particular, the rubrics that assess the oral production in the Integrated Skills in English (ISE-II) exam and in the First Certificate in English (B2 First). With a qualitative document research approach, this study analyses these rubrics in order to determine to what extent they respect the criteria established by the CEFR

Tunable lenses: Dynamic characterization and fine-tuned control for high-speed applications

Tunable lenses are becoming ubiquitous, in applications including microscopy, optical coherence tomography, computer vision, quality control, and presbyopic corrections. Many applications require an accurate control of the optical power of the lens in response to a time-dependent input waveform. We present a fast focimeter (3.8 KHz) to characterize the dynamic response of tunable lenses, which was demonstrated on different lens models. We found that the temporal response is repetitive and linear, which allowed the development of a robust compensation strategy based on the optimization of the input wave, using a linear time-invariant model. To our knowledge, this work presents the first procedure for a direct characterization of the transient response of tunable lenses and for compensation of their temporal distortions, and broadens the potential of tunable lenses also in high-speed applicationsVA and EL acknowledge financial support from Comunidad de Madrid and Marie Curie Action of the European Union FP7/2007-2013 COFUND 291820; XB from Comunidad de Madrid Doctorado Industrial IND2017/BMD-7670; EL from Spanish Government Ramon y Cajal Program RyC-2016-21125; EG from Spanish Government Torres-Quevedo Program PTQ-15-07432; LS from EU H2020 SME Innovation Associate GA-739882; EG from EIT Health; SM from ERC Grant Agreement ERC-2011-AdC 294099 and Spanish Government Grants FIS2014-56643-R; SM and CD from Spanish Government Grant FIS2017-84753-R; and CD from DTS16-0012

The C Allele of ATM rs11212617 Associates With Higher Pathological Complete Remission Rate in Breast Cancer Patients Treated With Neoadjuvant Metformin

Background: The minor allele (C) of the single-nucleotide polymorphism (SNP) rs11212617, located near the ataxia telangiectasia mutated (ATM) gene, has been associated with an increased likelihood of treatment success with metformin in type 2 diabetes. We herein investigated whether the same SNP would predict clinical response to neoadjuvant metformin in women with early breast cancer (BC). Methods: DNA was collected from 79 patients included in the intention-to-treat population of the METTEN study, a phase 2 clinical trial of HER2-positive BC patients randomized to receive either metformin combined with anthracycline/taxane-based chemotherapy and trastuzumab or equivalent regimen without metformin, before surgery. SNP rs11212617 genotyping was assessed using allelic discrimination by quantitative polymerase chain reaction. Results: Logistic regression analyses revealed a significant relationship between the rs11212617 genotype and the ability of treatment arms to achieve a pathological complete response (pCR) in patients (odds ratio [OR](genotypexarm) = 10.33, 95% confidence interval [CI]: 1.29-82.89, p = 0.028). In the metformin-containing arm, patients bearing the rs11212617 C allele had a significantly higher probability of pCR (ORA/C,C/C = 7.94, 95% CI: 1.60-39.42, p = 0.011). Conversely, no association was found between rs11212617 and clinical response in the reference arm (ORA/C,C/C = 0.77, 95% CI: 0.20-2.92, p = 0.700). After controlling for tumor size and hormone receptor status, the rs11212617 C allele remained a significant predictor of pCR solely in the metformin-containing arm. Conclusions: If reproducible, the rs11212617 C allele might warrant consideration as a predictive clinical biomarker to inform the personalized use of metformin in BC patients

Multinational evaluation of genetic diversity indicators for the Kunming‐Montreal Global Biodiversity Framework

Under the recently adopted Kunming‐Montreal Global Biodiversity Framework, 196 Parties committed to reporting the status of genetic diversity for all species. To facilitate reporting, three genetic diversity indicators were developed, two of which focus on processes contributing to genetic diversity conservation: maintaining genetically distinct populations and ensuring populations are large enough to maintain genetic diversity. The major advantage of these indicators is that they can be estimated with or without DNA‐based data. However, demonstrating their feasibility requires addressing the methodological challenges of using data gathered from diverse sources, across diverse taxonomic groups, and for countries of varying socio‐economic status and biodiversity levels. Here, we assess the genetic indicators for 919 taxa, representing 5271 populations across nine countries, including megadiverse countries and developing economies. Eighty‐three percent of the taxa assessed had data available to calculate at least one indicator. Our results show that although the majority of species maintain most populations, 58% of species have populations too small to maintain genetic diversity. Moreover, genetic indicator values suggest that IUCN Red List status and other initiatives fail to assess genetic status, highlighting the critical importance of genetic indicators

Table_1_Somatic embryogenesis and plant regeneration from transverse thin cell layers of adult peach palm (Bactris gasipaes) lateral offshoots.XLSX

In this work, we report a successful protocol to obtain in vitro peach palm (Bactris gasipaes Kunth) “Diamantes 10” plants through somatic embryogenesis from transverse thin cell layer (TCL) explants, dissected from three sections (basal, medial, and apical) of lateral offshoots of adult plants cultured on different concentrations of 4-amino-3,5,6-trichloropicolonic acid (picloram). After swelling and development of primary callus in all treatments, without any strong effect of explant origin or picloram concentration, it was possible to observe the formation of embryogenic structures and the exact point from where they developed. Browning was also observed and correlated to the induction treatments, although it was not an impairment for the production of embryogenic structures. Subsequent maturation and conversion of somatic embryos into plantlets allowed their acclimatization 17 months after culture initiation (ACI), which was quicker than previous reports with juvenile tissues (from embryos or seed-germinated plantlets). To the best of our knowledge, this is the first report on peach palm regeneration through somatic embryogenesis from TCL explants from adult plants and could constitute, after fine-tuning the acclimatization stage, a tool for mass clonal propagation of elite genotypes of this open-pollinated crop, as well as for the establishment of conservation strategies of in situ gene bank plant accessions endangered due to aging and other threats.</p

Pilot Assessment of Status and Trends of Persistent Chemicals in Marine Mammals

Polychlorinated biphenyls (PCBs) are present in marine mammals living in all five OSPAR Regions. Toothed-cetaceans and some subpopulations of pinnipeds present moderate to high ranges of PCB concentrations, often surpassing the estimated toxicity thresholds for the onset of reproductive incapacity. The ranges of PCB concentrations of baleen whales are always below the estimated toxicity thresholds.14. Life below wate

Monitoring status and trends in genetic diversity for the Convention on Biological Diversity: An ongoing assessment of genetic indicators in nine countries

Abstract Recent scientific evidence shows that genetic diversity must be maintained, managed, and monitored to protect biodiversity and nature's contributions to people. Three genetic diversity indicators, two of which do not require DNA‐based assessment, have been proposed for reporting to the Convention on Biological Diversity and other conservation and policy initiatives. These indicators allow an approximation of the status and trends of genetic diversity to inform policy, using existing demographic and geographic information. Application of these indicators has been initiated and here we describe ongoing efforts in calculating these indicators with examples. We specifically describe a project underway to apply these indicators in nine countries, provide example calculations, address concerns of policy makers and implementation challenges, and describe a roadmap for further development and deployment, incorporating feedback from the broader community. We also present guidance documents and data collection tools for calculating indicators. We demonstrate that Parties can successfully and cost‐effectively report these genetic diversity indicators with existing biodiversity observation data, and, in doing so, better conserve the Earth's biodiversity

El conde de Floridablanca y su época

El 30 de diciembre de 1808 moría José Moñino Redondo, conde de Floridablanca, titular que fue de la primera Secretaría de Estado de la monarquía hispánica (1777-1792) y, a la sazón, presidente de la Junta Central Suprema. Su actividad política se desarrolló durante los años considerados como de plenitud del reformismo ilustrado en España en los que procuró desplegar un programa de modernización del país que lo pusiera en sintonía con la Europa del momento. Su caída en desgracia y su posterior recuperación para la política hacen de él un personaje enormemente atractivo, aunque su trayectoria ofrece aún espacios velados. Los artículos que conforman este dossier aportan nuevos datos, reflexión e interpretación con el ánimo de contribuir a una mejor caracterización del político que, sin duda, marcó con su gestión un período clave de la historia de España. Le 30 décembre 1808 décédait José Moñino Redondo, comte de Floridablanca, ancien membre du premier Secrétariat d'État de la monarchie hispanique (1777-1792) et à sa mort, président de la Junta Central Suprema. Son activité politique a coïncidé avec les années de plénitude du réformisme éclairé en Espagne qui virent se développer un programme de modernisation destiné à élever le pays au niveau de l'Europe du moment. Sa chute en disgrâce et son retour en politique font de lui un personnage très attrayant, même si sa trajectoire comprend encore nombre d'inconnues. Les articles qui composent ce dossier apportent de nouveaux faits, une réflexion et une interprétation inédites qui permettent de mieux cerner l'homme politique qui, sans aucun doute, marqua par sa gestion une période clé de l'histoire de l'Espagne