7 research outputs found
Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study
- Author
- Ababneh Hazim
- Abbas Kinan
- Abdalah Haidar M.
- Abdelsalam Wafaa
- Abdullaev Abakar
- Abid Izza
- Abradelo Manuel
- Acheimastos Vasileios
- Afzal Ameer
- Agarwal Rajendra
- Agnoletti Vanni
- Agresta Ferdinando
- Ahmed Salma
- Aiolfi Alberto
- Akalin Murat
- Akbar Ali
- Akin Emrah
- Aktimur Yunus Emre
- Al-Raimi Ibrahim
- Al-Shami Khayry
- Alawadhi Kamel
- Alconchel Felipe
- Alexandridou Eirini
- Ali Iyad
- Ali Syed Muhammad
- Aljaiuossi Osama
- Alla-Angelina Volovich
- Alshaikh Abdulrahman
- Alshargabi Haneen
- Altinel Yuksel
- Altintoprak Fatih
- Alvarez Fernando Andrés
- Ammendola Michele
- Anania Gabriele
- Andreotti Dario
- Andreuccetti Jacopo
- Anestiadou Elissavet
- Ani Mohd Firdaus Che
- Ansaloni Luca
- Anwaar Muhammad Hassan
- Aonzo Paolo
- Aparicio Antonio Carlos Maya
- Apollos Jeyakumar
- Argenio Giulio
- Arina Tsurbanova
- Armellino Mariano Fortunato
- Assenza Marco
- Atanasov Boyko
- Atici Semra Demirli
- Ausania Fabio
- Awad Ahmed
- Awadi Sajeda
- Azamat Ibrahim Fethi
- Álvarez-Torrado Andrea
- Badran Ali
- Bagaglini Giulia
- Baili Efstratia
- Bains Lovenish
- Balla Andrea
- Barone Mirko
- Bayhan Hüseyin
- Bayo Jose Muros
- Beasley Daniel
- Belev Nikolay
- Bellato Vittoria
- Belloni Elena
- Benuzzi Laura
- Bergamini Carlo
- Beristain-Hernandez Jose-Luis
- Bianchi Valentina
- Bianchini Matteo
- Biffl Walter
- Biloslavo Alan
- Bilyak Andriy
- Bini Roberto
- Bogoni Selene
- Bombardini Cristina
- Bona Davide
- Bond-smith Giles
- Bono Dario
- Bottari Andrea
- Bozkurt Mehmet Abdussamet
- Bracale Umberto
- Brachet Contul Riccardo
- Brachini Gioia
- Bradley Alison
- Butturini Giovanni
- Buwaitel Mohammad Musallam Khalil
- Cabrera Vicente Herrera
- Cabrera Zamiara Solange Leon
- Cal Fernando Bonilla
- Calderan Thiago R. A.
- Calik Bulent
- Calì Matteo
- Calleja-Lozano Rafael
- Calu Valentin
- Campanella Gaetano
- Candio Giulio
- Cannavera Alessandro
- Cantafio Stefano
- Caravaca Iban
- Caronna Roberto
- Casadei Massimiliano
- Catena Fausto
- Ceresoli Marco
- Cerioli Alessandra
- Cervellera Maurizio
- Chan Shannon Melissa
- Charalabopoulos Alexandros
- Chiara Osvaldo
- Chiarugi Massimo
- Chidumije Nnaemeka
- Chirletti Piero
- Chiuyari José Ríos
- Chooklin Serge
- Choudhary Hasham
- Chouillard Elie
- Chouliaras Christos
- Chuklin Serhii
- Ciabatti Giulia
- Cianci Pasquale
- Cicako Atea
- Cicuttin Enrico
- Cillara Nicola
- Cioffi Stefano
- Cioffi Stefano Piero Bernardo
- Ciuró Felipe Parej
- Clarizia Guglielmo
- Coccolini Federico
- Colak Elif
- Condoy Jefferson Nieves
- Conti Lorenzo
- Coretti Guido
- Cossa Alessandra
- Costea Radu Virgil
- Couto Gomes Felipe
- Cozzani Federico
- Cremonini Camilla
- Crespi Michele
- Cristaudi Alessandra
- Currò Giuseppe
- Dakis Konstantinos
- Damaskos Dimitrios
- Danna Riccardo
- Dardanov Dragomir
- Das Koray
- Davies Brooke
- de Araujo Jorann
- De Francisco Mario
- De Manzini Nicolo’
- De Nicola Enrico
- de Santibañes Martin
- de Sá Tiago Correia
- De Simone Belinda
- de Villar José Manuel Perez
- del Alamo Yaiza García
- del Pozo Eduardo Perea
- Delis Spiros
- Delogu Daniele
- Demetrashvili Zaza
- Deserra Antonello
- Devi Jalpa
- Di Bella Annamaria
- Di Carlo Isidoro
- Di Donato Luca
- Di Lascio Pierpaolo
- Di Lorenzo Nicola
- Di Martino Marcello
- Di Menno Stavron Juliana
- Di Nuzzo Maria Michela
- Di Saverio Salomone
- Dinuzzi Vincenza Paola
- Domenico Lacavalla
- Domingo-Gonzalez Marta
- Domínguez Fabiana
- Doria Emanuele
- Doulias Triantafyllos
- Draghici Andreea Diana
- Drigo Davide
- Durán Manuel
- Duval Jean-Luc
- D’Acapito Fabrizio
- D’Ambrosio Giancarlo
- Ebied Husam
- Elbadawy Merihan
- Elbahnasawy Mohamed
- Elfallal Ahmed
- Elfeki Hossam
- Elghadban Hosam
- Elmehrath Ahmed
- Elserafy Amr
- Elshami Mohamedraed
- Emile Sameh
- Ercolani Giorgio
- Estevez Sergio
- Estraviz-Mateos Begoña
- Fabbri Nicolò
- Farazi-Chongouki Christos
- Farguell Jordi
- Farid Ahmed
- Fathil Ida Nadiah Ahmed
- Favi Francesco
- Feijóo Eva Pont
- Feo Carlo Vittorio
- Ferrara Francesco
- Ferrari Luca
- Ferrario Luca
- First Necattin
- Fleres Francesco
- Fontana Tommaso
- Fortuna Laura
- Fox Katherine
- Fraga Gustavo
- Fransvea Pietro
- Fratini Geri
- Frontali Alice
- Gaber Mohannad
- Gachabayov Mahir
- Galleano Raffaele
- Garcia-Meza Alejandro
- García Francisco C. Becerra
- García Haydée Calvo
- García-Moreno-Nisa Francisca
- Garino Mauro
- Garzali Ibrahim-Umar
- Gendrikson George
- Genovese Valerio
- Gerardi Chiara
- Germani Paola
- Gerogiannis Ioannis
- Gessa Emanuela
- Ghazouani Omar
- Gianazza Simone
- Giannarakis Miltiadis
- Gioco Rossella
- Giordano Alessio
- Giraudo Giorgio
- Giuffrida Mario
- Giuliani Antonio
- Gomes Carlos Augusto
- González-Abós Carolina
- Gourgiotis Stavros
- Grande Michele
- Grigorean Valentin Titus
- Grimaldi Sergio
- Guadagni Simone
- Guerci Claudio
- Guerci Claudio
- Guerrieri Mario
- Guida Anna
- Gumbs Andrew
- Gundara Justin
- Gupta Amit
- Hamdan Alaa
- Hamed Emad Fawzi
- Hamid Hytham K. S.
- Hanafy Asmaa
- Hasan Layla
- Hernández Edgard Efren Lozada
- Hirano Elcio S.
- Hudson Victoria
- Huei Jih
- Ielpo Benedetto
- Iiritano Elena
- Ilzarbe Lucas
- Inama Marco
- Ioannidis Argyrios
- Ioannidis Orestis
- Ioia Giovanna
- Ippoliti Massimo
- Isik Arda
- Jayant Kumar
- Jovine Elio
- Julianov Alexander
- Julianov Alexander
- Kadir Bushra
- Kalaitzakis Evangelos
- Kalaitzakis Evangelos
- Kaldarov Ayrat
- Kaldarov Ayrat
- Kamar Jubin
- Kapiris Stylianos
- Kara Yasin
- Karamarkovic Milovan
- Kaur Mandeep
- Kchaou Ali
- Kefili Despoina
- Khalil Usama Ahmed
- Khamees Almu’atasim
- Khan Mansoor
- Khutsishvili Kakhi
- Kocataş Ali
- Kokoropoulos Panagiotis
- Komaei Iman
- Konstantinidis Konstantinis
- Konstantinidou Sofia
- Kotecha Pinky
- Kovacevic Bojan
- Kovachev Nikola
- Kozadinos Alexandros
- Kruger Yoram
- Kunitsyna Maria
- Kurtenkov Mikhail
- Kwiatkowski Andrzej
- Kykalos Stylianos
- Lagouvardou Elpiniki
- Lal Pawan
- Lancellotti Francesco
- Landaluce-Olavarria Aitor
- Lapolla Pierfrancesco
- Lasithiotakis Konstantinos
- Leo Cosimo Alex
- Lepiane Pasquale
- Leppaniemi Ari
- Lesko Dusan
- Lezama Tamara
- Liakakos Theodore
- Liaño Julian Ezequiel
- Licitra Edelweiss
- Litvin Andrey
- Lohse Helmut Segovia
- Lohse Herald Segovia
- Lok Hon-Ting
- Lombardo Francesca
- Lostoridis Eftychios
- Loutzidou Lydia
- Lui Rashid
- Lunghi Elia Giuseppe
- Luppi Davide
- Mabilia Andrea
- Machain Gustavo M
- Machairas Nikolaos
- Magee Conor
- Magnoli Matteo
- Manak Jan
- Manatakis Dimitrios
- Manca Roberto
- Manoochehri Farshad
- Marafante Chiara
- Marchese Tiziana Rita Lucia
- Mariani Nicolò Maria
- Marino Marco Vito
- Maroulis Ioannis
- Marra Ester
- Martellucci Jacopo
- Martines Gennaro
- Martín Belén
- Mastrangelo Laura
- Mastronardi Manuela
- Mathur Pawan
- Matías-García Belén
- Mawlichanów Maciej
- Mazza Oscar
- McCormack Kieran
- Medappil Noushif
- Meead Abdullah
- Meléndez Blas Durán
- Mendoza-Moreno Fernando
- Meric Serhat
- Metaxas Panagiotis
- Michalopoulos Nikolaos
- Miglietta Claudio
- Milentijevic Milica
- Millo Paolo
- Mingoli Andrea
- Moggia Elisabetta
- Mohamad Ikhwan Sani
- Mohamad Ikhwan Sani
- Mohamed Salem
- Mole Damian
- Molina Víctor
- Monti Marco
- Morán Laura Álvarez
- Morelli Luca
- Moretto Gianluigi
- Morino Mario
- Morrison Tamsin
- Mouzakis Odysseas
- Mucilli Felice
- Mulita Francesk
- Muñoz-Cruzado Virginia Duran
- Muratore Andrea
- Murgese Alessandra
- Murgia Raimondo
- Murzi Valentina
- Muthukrishnan Vijayanand
- Muttillo Edoardo Maria
- Muttillo Irnerio Angelo
- Nafea Ahmed
- Naffa’ Mo’taz Fawzat Naief
- Nagliati Carlo
- Nagorni Eleni-Aikaterini
- Navarra Giuseppe
- Nicolás-López Tatiana
- Nicotera Antonella
- Nigri Giuseppe
- Noel Colin
- null null
- Occhionorelli Savino
- Olmi Stefano
- Omarov Nail
- Oms Luis
- Oppici Dario
- Orantia Abigail Cheska C.
- Orantia-Carlos Abigail Cheska C.
- Ordemar Jorge
- Ortenzi Monica
- Ozer Nazmi
- Pacella Daniela
- Pachajoa Diana Alejandra Pantoja
- Palacios Andrea Masiá
- Palepa Anna
- Palmieri Francesco
- Palmisano Silvia
- Panyko Arpád
- Papa Gennaro
- Papa Mario Virgilio
- Papadoliopoulou Maria
- Papadopoulos Aristeidis
- Papagni Vincenzo
- Pata Francesco
- Paul Michaela
- Pellino Gianluca
- Peltrini Roberto
- Penalba-Palmí Rafael
- Perotti Bruno
- Perra Elena Sofia
- Perrone Gennaro
- Perrone Stefano
- Pesce Antonio
- Petra Giorgia
- Petracca Gabriele Luciano
- Petrakis George
- Pérez-Bru Susana
- Picardi Biagio
- Picariello Erika
- Picchetto Andrea
- Picciariello Arcangelo
- Pignata Giusto
- Pilia Tiziana
- Pimentel Samuel
- Pinto Margherita
- Pinzón Camilo Levi Acuña
- Piras Enrico
- Pisanu Adolfo
- Pizarro Sergio Olivares
- Podda Mauro
- Poillucci Gaetano
- Police Andrea
- Ponte Elisa
- Porfidia Raffaele
- Portale Giuseppe
- Prasanti Alekhya Kotta
- Prieto Calvo Mikel
- Prioriello Concetta
- Puccioni Caterina
- Quispe-Cruz Darwin Artidoro
- Quitoy Margie Antionette
- Radonak Jozef
- Radulescu Raluca Bievel
- Ralon Sergio
- Ramírez Pablo
- Rampini Alessia
- Riboni Cristiana
- Ricci Claudio
- Rizzi Andrea
- Robayo Diana
- Roccamatisi Linda
- Rocha Mónica
- Rodríguez Martha
- Roesel Raffaello
- Rojas-Bonet Noel
- Rossi Stefano
- Rossini Matteo
- Rottoli Matteo
- Rubicondo Carolina
- Russo Iris Shari
- Saad Ahmed
- Sadik Mohammad
- Sahani Saaz
- Sahani Saaz
- Salah Alzhraa Abbas
- Salcedo Diego
- Salomone Sara
- Salvetti Francesco
- Samhouri Ahmad
- Sammartano Fabrizio
- Sandhar Pardip
- Santini Andrea
- Saroglu Azize
- Sarro Giuliano
- Sartarelli Lodovico
- Sartelli Massimo
- Sartori Alberto
- Sasia Diego
- Saullo Paolina
- Savino Grazia
- Sawalha Hatem
- Sánchez Lianet
- Sánchez-Cabús Santiago
- Sánchez-Guillén Luis
- Scaravilli Luca
- Schizas Dimitrios
- Scifo Giovanna
- Sederino Mariagrazia
- Seerani Nandlal
- Segalini Edoardo
- Seker Ahmet
- Sensi Bruno
- Sepulveda-Rdriguez Rafael
- Sergi William
- Serventi Alberto
- Seth Shatadru
- Sethi Ananya
- Seto Gaby Susana Yamamoto
- Sganga Gabriele
- Sheikh Zara
- Sherief Ghozy
- Sheth Hemant
- Shetiwy Mohamed
- Shoma Ashraf
- Sica Giuseppe
- Siragusa Leandro
- Soares Carlos
- Soggiu Fiammetta
- Sohail-Asghar Mohammad
- Solaini Leonardo
- Soltes Marek
- Sotiropoulou Maria
- Spolini Alessandro
- Stamopoulos Paraskevas
- Stella Marco
- Stoian Alexandru Rares
- Syllaios Athanasios
- Synekidou Eirini
- Tartaglia Dario
- Tasis Nikolaos
- Tebala Giovanni
- Tefay Joan
- Tejedor-Tejada Javier
- Theodorou Dimitrios
- Tlili Ahmed
- Tomasi Ivan
- Tonello Alice Sabrina
- Tonini Valeria
- Tourountzi Paraskevi
- Triantafyllou Tania
- Trigiante Giuseppe
- Triguero-Cánovas Daniel
- Triviño María Alejandra
- Troian Marina
- Troiano Raffaele
- Tsouknidas Ioannis
- Tur-Martínez Jaume
- Türkoğlu Mehmet Akif
- Tvaladze Anano
- Uccelli Matteo
- Ullah Syed Osama Zohaib
- Uymaz Derya Salim
- Uzunoglu Mustafa Yener
- Vailas Michail
- Valenzuela José Ignacio
- Vega Pilar Suárez
- Veroux Gastone
- Veroux Massimiliano
- Viganò Jacopo
- Villalabeitia Ibabe
- Vincenti Leonardo
- Virdis Francesco
- Visconti Diego
- Walędziak Maciej
- Wilson Michael
- Yusoff Ahmad Ramzi
- Zafar Noman
- Zago Marcello
- Zainab null
- Zarnescu Eugenia Claudia
- Zarnescu Narcis Octavian
- Zarnescu Narcis Octavian
- Zuin Matteo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)
Unidad Hospitalaria de Patología Dual Grave: un año de experiencia
- Author
- Publication venue
- Asociación Española de Estudios en Drogodependencias
- Publication date
- 01/01/2014
- Field of study
This is an observational, descriptive, cross-sectional study on patients admitted for one year to the inpatient unit of a Severe Dual Diagnosis Program (SDDP). Socio- demographic, clinical and pharmacological information was obtained using data collection forms designed for this purpose.
The sample size was of 82 inpatients, whose profile was that of males with a mean age of 36.7 years, referred from the outpatient clinic of the SDDP. Admission was mainly involuntary. The main psychiatric diagnosis was psychotic disorder, especially paranoid schizophrenia, and the most prevalent substances consumed were alcohol (33%), cocaine (26%) and cannabis (20%). Among the psychotherapeutic techniques worthy of mention, there was a Brief Motivational Psycho-educational Therapy-Dual (BMPT-D) with a group format, in which around two thirds of the patients participated.
The most widely-used group of drugs was antipsychotics, specifically quetiapine [60%] and the long-term action injectable risperidone (LAIR, 51%). In the group of patients with alcohol abuse or dependence, the most commonly prescribed antipsychotics were quetiapine and tiapride (both 43%). Antidepressants were used in 37% of cases, especially duloxetine. In the group with cocaine abuse or dependence, schizophrenia was the most prevalent co-morbid disorder (75%) and the most widely-prescribed drugs were antipsychotics, especially LAIR (91%). Opioid and cocaine dependence was the most common association within the multi-dependent patients (56%) and schizophrenia the most frequent co-morbid diagnosis in this group.Se trata de un estudio observacional, descriptivo, transversal en el que se incluyeron los pacientes ingresados en la Unidad de Hospitalización del Programa de Patología Dual Grave (UHPPDG) durante un año. Los datos sociodemográficos, clínicos y farmacológicos se obtuvieron mediante hojas de recogida de datos diseñadas al efecto. El total de pacientes ingresados fue de 82 en cuyo perfil prevalecen los varones con una edad media de 36,7 años, derivados del subprograma ambulatorio del propio Programa de Patología Dual Grave (PPDG) y con ingreso de tipo involuntario. El diagnóstico psiquiátrico más frecuente fue el trastorno psicótico, especialmente la Esquizofrenia Paranoide. Las sustancias tóxicas más consumidas fueron: alcohol (33 %), cocaína (26 %) y el cannabis (20 %). Dentro de las técnicas psicoterápicas destaca la Terapia Psicoeducativa Motivacional Breve-Dual (TPMB-D), de formato grupal, en la que participaron alrededor de 2/3 de los pacientes. El grupo de fármacos más utilizados fueron los antipsicóticos (quetiapina [60%] y la risperidona inyectable de larga duración (RILD). En el grupo de pacientes con Dependencia/Abuso de Alcohol, los antipsicóticos más utilizados fueron la quetiapina y la tiaprida (43%). Los antidepresivos se utilizaron en el 37% de los casos, especialmente la duloxetina. En el grupo con Dependencia/ Abuso de Cocaína, la Esquizofrenia es el trastorno comórbido más prevalente (75%), y los antipsicóticos el grupo farmacológico más prescrito, en especial la RILD (91%). Entre los pacientes multidependientes la asociación más frecuente fue la Dependencia de Opiáceos y Cocaína (56%). El diagnóstico comórbido más frecuente en este grupo fue la Esquizofrenia
Timing of Cholecystectomy After Moderate and Severe Acute Biliary Pancreatitis
- Author
- Ababneh Hazim
- Abbas Kinan
- Abdalah Haidar M
- Abdelsalam Wafaa
- Abdullaev Abakar
- Abid Izza
- Acheimastos Vasileios
- Acuña Pinzón Camilo L
- Afzal Ameer
- Agarwal Rajendra
- Agresta Ferdinando
- Ahmed Salma
- Aiolfi Alberto
- Akalin Murat
- Akbar Ali
- Akin Emrah
- Aktimur Yunus E
- Al-Raimi Ibrahim
- Al-Shami Khayry
- Alawadhi Kamel
- Alconchel Felipe
- Alexandridou Eirini
- Ali Iyad
- Aljaiuossi Osama
- Alla-Angelina Volovich
- Alshaikh Abdulrahman
- Alshargabi Haneen
- Altinel Yuksel
- Altintoprak Fatih
- Alvarez Fernando A
- Ammendola Michele
- Anania Gabriele
- Andreotti Dario
- Andreuccetti Jacopo
- Anestiadou Elissavet
- Ansaloni Luca
- Anwaar Muhammad H
- Aonzo Paolo
- Apollos Jeyakumar
- Argenio Giulio
- Armellino Mariano F
- Assenza Marco
- Atanasov Boyko
- Atici Semra D
- Ausania Fabio
- Awad Ahmed
- Awadi Sajeda
- Azamat Ibrahim F
- Álvarez Morán Laura
- Álvarez-Torrado Andrea
- Badran Ali
- Bagaglini Giulia
- Baili Efstratia
- Bains Lovenish
- Balla Andrea
- Barone Mirko
- Bayhan Hüseyin
- Beasley Daniel
- Becerra García Francisco C
- Belev Nikolay
- Bellato Vittoria
- Belloni Elena
- Benuzzi Laura
- Bergamini Carlo
- Beristain-Hernandez Jose L
- Bianchi Valentina
- Bianchini Matteo
- Biloslavo Alan
- Bilyak Andriy
- Bini Roberto
- Bogoni Selene
- Bombardini Cristina
- Bona Davide
- Bond-Smith Giles
- Bonilla Cal Fernando
- Bono Dario
- Bottari Andrea
- Bozkurt Mehmet A
- Bracale Umberto
- Brachet-Contul Riccardo
- Brachini Gioia
- Bradley Alison
- Butturini Giovanni
- Buwaitel Mohammad MK
- Cabrera Zamiara SL
- Calderan Thiago RA
- Calik Bulent
- Calì Matteo
- Calleja-Lozano Rafael
- Calu Valentin
- Calvo García Haydée
- Campanella Gaetano
- Cannavera Alessandro
- Cantafio Stefano
- Caravaca Iban
- Caronna Roberto
- Casadei Massimiliano
- Catena Fausto
- Ceresoli Marco
- Cerioli Alessandra
- Cervellera Maurizio
- Chan Shannon M
- Charalabopoulos Alexandros
- Che Ani Mohd F
- Chiara Osvaldo
- Chiarugi Massimo
- Chidumije Nnaemeka
- Chirletti Piero
- Chiuyari José R
- Chooklin Serge
- Choudhary Hasham
- Chouillard Elie
- Chouliaras Christos
- Chuklin Serhii
- Ciabatti Giulia
- Cianci Pasquale
- Cicako Atea
- Cicuttin Enrico
- Cillara Nicola
- Cioffi Stefano PB
- Clarizia Guglielmo
- Coccolini Federico
- Colak Elif
- Condoy Jefferson N
- Conti Lorenzo
- Coretti Guido
- Correia de Sá Tiago
- Cossa Alessandra
- Costea Radu V
- Cozzani Federico
- Cremonini Camilla
- Crespi Michele
- Cristaudi Alessandra
- Currò Giuseppe
- D'Acapito Fabrizio
- D'Ambrosio Giancarlo
- Dakis Konstantinos
- Damaskos Dimitrios
- Danna Riccardo
- Dardanov Dragomir
- Das Koray
- Davies Brooke
- de Araujo Jorann
- De Francisco Mario
- De Manzini Nicolò
- De Nicola Enrico
- de Santibañes Martin
- De Simone Belinda
- Delis Spiros
- Delogu Daniele
- Demetrashvili Zaza
- Deserra Antonello
- Devi Jalpa
- Di Bella Annamaria
- Di Candio Giulio
- Di Carlo Isidoro
- Di Donato Luca
- Di Lascio Pierpaolo
- Di Martino Marcello
- Di Menno Stavron Juliana
- Di Nuzzo Maria M
- Di Saverio Salomone
- Dinuzzi Vincenza P
- Domingo-Gonzalez Marta
- Domínguez Fabiana
- Doria Emanuele
- Doulias Triantafyllos
- Draghici Andreea D
- Drigo Davide
- Durán Meléndez Blas
- Durán Manuel
- Duval Jean-Luc
- Ebied Husam
- Elbadawy Merihan
- Elbahnasawy Mohamed
- Elfallal Ahmed
- Elfeki Hossam
- Elghadban Hosam
- Elserafy Amr
- Emile Sameh
- Ercolani Giorgio
- Estevez Sergio
- Estraviz-Mateos Begoña
- Fabbri Nicolò
- Farazi-Chongouki Christos
- Farguell Jordi
- Farid Ahmed
- Fathil Ida NA
- Favi Francesco
- Feo Carlo V
- Ferrara Francesco
- Ferrari Luca
- Ferrario Luca
- First Necattin
- Fleres Francesco
- Fontana Tommaso
- Fortuna Laura
- Fox Katherine
- Fraga Gustavo P
- Fransvea Pietro
- Fratini Geri
- Frontali Alice
- Gaber Mohannad
- Gachabayov Mahir
- Galleano Raffaele
- Garcia-Meza Alejandro
- García del Alamo Yaiza
- García-Moreno-Nisa Francisca
- Garino Mauro
- Garzali Ibrahim U
- Gendrikson George
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- Germani Paola
- Gerogiannis Ioannis
- Gessa Emanuela
- Ghazouani Omar
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- Giuffrida Mario
- Giuliani Antonio
- Gomes Carlos A
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- González-Abós Carolina
- Gourgiotis Stavros
- Grande Michele
- Grigorean Valentin T
- Grimaldi Sergio
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- Gundara Justin
- Gupta Amit
- Hamdan Alaa
- Hamed Emad F
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- Hanafy Asmaa
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- Kamar Jubin
- Kapiris Stylianos
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- Kaur Mandeep
- Kchaou Ali
- Kefili Despoina
- Khalil Usama A
- Khamees Almu'atasim
- Khan Mansoor
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- Kluger Yoram
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- Kokoropoulos Panagiotis
- Komaei Iman
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- null null
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- Olivares Pizarro Sergio
- Olmi Stefano
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- Perez de Villar José M
- Perotti Bruno
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- Perrone Gennaro
- Perrone Stefano
- Pesce Antonio
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- Radonak Jozef
- Radulescu Raluca B
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- Rossi Stefano
- Rossini Matteo
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- Rubicondo Carolina
- Russo Iris S
- Saad Ahmed
- Sadik Mohammad
- Sahani Saaz
- Salah–Abbas Alzhraa
- Salcedo Diego
- Salomone Sara
- Salvetti Francesco
- Samhouri Ahmad
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- Sohail- Asghar Mohammad
- Solaini Leonardo
- Soltes Marek
- Sotiropoulou Maria
- Spolini Alessandro
- Stamopoulos Paraskevas
- Stella Marco
- Stoian Alexandru R
- Suárez Vega Pilar
- Syllaios Athanasios
- Synekidou Eirini
- Tartaglia Dario
- Tasis Nikolaos
- Tebala Giovanni
- Tefay Joan
- Tejedor-Tejada Javier
- Theodorou Dimitrios
- Tlili Ahmed
- Tomasi Ivan
- Tonello Alice S
- Tonini Valeria
- Tourountzi Paraskevi
- Triantafyllou Tania
- Trigiante Giuseppe
- Triguero-Cánovas Daniel
- Triviño Maria A
- Troian Marina
- Troiano Raffaele
- Tsouknidas Ioannis
- Tsurbanova Arina
- Tur-Martínez Jaume
- Türkoğlu Mehmet A
- Tvaladze Anano
- Uccelli Matteo
- Ullah Syed OZ
- Uymaz Derya S
- Uzunoglu Mustafa Y
- Vaccari Samuele
- Vailas Michail
- Valenzuela José I
- Veroux Gastone
- Veroux Massimiliano
- Viganò Jacopo
- Villalabeitia Ibabe
- Vincenti Leonardo
- Virdis Francesco
- Visconti Diego
- Walędziak Maciej
- Wilson Michael
- Ya'acob Mohammad Z
- Yamamoto Seto Gaby S
- Yusoff Ahmad R
- Zafar Noman
- Zago Marcello
- Zakaria Andee D
- Zarnescu Eugenia C
- Zarnescu Narcis O
- Zuin Matteo
- Publication venue
- AMER MEDICAL ASSOC
- Publication date
- 01/01/2023
- Field of study
IMPORTANCE Considering the lack of equipoise regarding the timing of cholecystectomy in patients with moderately severe and severe acute biliary pancreatitis (ABP), it is critical to assess this issue.OBJECTIVE To assess the outcomes of early cholecystectomy (EC) in patients with moderately severe and severe ABP.DESIGN, SETTINGS, AND PARTICIPANTS This cohort study retrospectively analyzed real-life data from the MANCTRA-1 (Compliance With Evidence-Based Clinical Guidelines in the Management of Acute Biliary Pancreatitis) data set, assessing 5304 consecutive patients hospitalized between January 1, 2019, and December 31, 2020, for ABP from 42 countries. A total of 3696 patients who were hospitalized for ABP and underwent cholecystectomy were included in the analysis; of these, 1202 underwent EC, defined as a cholecystectomy performed within 14 days of admission. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality and morbidity. Data analysis was performed from January to February 2023.MAIN OUTCOMES Mortality and morbidity after EC.RESULTS Of the 3696 patients (mean [SD] age, 58.5 [17.8] years; 1907 [51.5%] female) included in the analysis, 1202 (32.5%) underwent EC and 2494 (67.5%) underwent delayed cholecystectomy (DC). Overall, EC presented an increased risk of postoperative mortality (1.4% vs 0.1%, P <.001) and morbidity (7.7% vs 3.7%, P < .001) compared with DC. On the multivariable analysis, moderately severe and severe ABP were associated with increased mortality (odds ratio [OR], 361.46; 95% CI, 2.28-57 212.31; P = .02) and morbidity (OR, 2.64; 95% CI, 1.35-5.19; P = .005). In patients with moderately severe and severe ABP (n = 108), EC was associated with an increased risk of mortality (16 [15.6%] vs 0 [0%], P < .001), morbidity (30 [30.3%] vs 57 [5.5%], P < .001), bile leakage (2 [2.4%] vs 4 [0.4%], P = .02), and infections (12 [14.6%] vs 4 [0.4%], P < .001) compared with patients with mild ABP who underwent EC. In patients with moderately severe and severe ABP (n = 108), EC was associated with higher mortality (16 [15.6%] vs 2 [1.2%], P < .001), morbidity (30 [30.3%] vs 17 [10.3%], P < .001), and infections (12 [14.6%] vs 2 [1.3%], P < .001) compared with patients with moderately severe and severe ABP who underwent DC. On the multivariable analysis, the patient's age (OR, 1.12; 95% CI, 1.02-1.36; P = .03) and American Society of Anesthesiologists score (OR, 5.91; 95% CI, 1.06-32.78; P = .04) were associated with mortality; severe complications of ABP were associated with increased mortality (OR, 50.04; 95% CI, 2.37-1058.01; P = .01) and morbidity (OR, 33.64; 95% CI, 3.19-354.73; P = .003).CONCLUSIONS AND RELEVANCE This cohort study's findings suggest that EC should be considered carefully in patients with moderately severe and severe ABP, as it was associated with increased postoperative mortality and morbidity. However, older and more fragile patients manifesting severe complications related to ABP should most likely not be considered for EC
Implementation of Recommendations on the Use of Corticosteroids in Severe COVID-19
- Author
- Aasiyah Rashan
- Abby Hurd
- Abdou Gai
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Abubacarr Jagne
- Adam Ali
- Adam Hall
- Adam Nowinski
- Adrian Ceccato
- Adrian Streinu-Cercel
- Adrian Tey
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agamemnon Bakakos
- Agnès Meybeck
- Agnès Sommet
- Agnieszka Oldakowska
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ailbhe Cullen
- Ailbhe Hayes
- Aine McCarthy
- Aine McElroy
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Browne
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J Mentzer
- Alexander Zoufaly
- Alexandra Bedossa
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Alexis F Turgeon
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Alina Kalicinska
- Aline-Marie Florence
- Alison M Meynert
- Alistair D Nichol
- Aliya Mohammed Alameen
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Am Udara Lakshan Attanyake
- Amal Abrous
- Amanda Corley
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Ami Stuart
- Amiel A Dror
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Catarino
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Marques
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Benjamin Kildal
- Anders Benteson Nygaard
- Anders Tveita
- Andra-Maris Post
- Andre Real
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell'Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Letizia
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- Andrey Svistunov
- André Cabie
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- Andriy Bal
- Andy Law
- Angel Asensio
- Angel Sanchez-Miralles
- Angela Alberti
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- Anilawati Mat Jelani
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- Ankana Satya
- Anna Beltrame
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- Anna Jung
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- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne Opavsky
- Anne-Hélène Boivin
- Anne-Marie Guerguerian
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B Docherty
- Annmarie O Callaghan
- Ansley Hamer
- Anthony L Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
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- Anton Prinssen
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- Antonio Arcadipane
- Antonio Lalueza
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- Anuraj Shankar
- Aoife Driscoll
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- Arabella Fahy
- Ardiyan Apriyana
- Argin G
- Arianne Joy Corpuz
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- Arjen M Dondorp
- Arnaud Scherpereel
- Arne Søraas
- Arsène Kpangon
- Arthur Garan
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- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asma Moin
- Astarini Hidayah
- Atie Suwarti
- Atif Siddiqui
- Audrey Dubot-Pérès
- Aurelius Bonfasius
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
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- Axelle Braconnier
- Ayodhia Pitaloka
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- Biing Horng Lee
- Birgitte Stiksrud
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- Yaseen Arabi
- Yash Doshi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yvelynne Kelly
- Yves Levy
- Zeno Bisoffi
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Importance: Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines. Objectives: To compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation. Design, setting, and participants: This prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set). Exposure: Corticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Main outcomes and measures: Number and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region. Results: Among 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3). Conclusions and relevance: The results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation
Liver injury in hospitalized patients with COVID-19: An International observational cohort study
- Author
- Abby Hurd
- Abdulrahman Al-Fares
- Abhijit Duggal
- Abigail Beane
- Adam Hall
- Adam Nowinski
- Adhikari Neill K. J.
- Adrian Streinu-Cercel
- Adrien Auvet
- Adrien Lemaignen
- Adrienne Chan
- Agnès Meybeck
- Agnès Sommet
- Agostinho Monteiro
- Ahmad Afiq Ramli
- Ahmad Kashfi Haji Ab Rahman
- Ahmed Farooq
- Aidan Burrell
- Ailbhe Hayes
- Aine McCarthy
- Aisling Gavin
- Aisling Murphy
- Akram Zaaqoq
- Al-Awwab Dabaliz
- Al-Fares Abdulrahman
- Alan Hartman
- Alasdair Nazerali-Maitland
- Albert Groenendijk
- Albert Sotto
- Alberto Uribe
- Alberto Zanella
- Albertus Beishuizen
- Aldo Rafael
- Aldric Manuel
- Alejandro Martín-Quiros
- Aleksander Rygh Holten
- Aleksandr Beljantsev
- Alessandra Notari
- Alex Nagrebetsky
- Alexa Debard
- Alexander Daniel Cornet
- Alexander J. Mentzer
- Alexander King
- Alexandra Bedossa
- Alexandra Coelho
- Alexandra Sperry
- Alexandre Ducancelle
- Alexandre Gaymard
- Alexandre Hoctin
- Alexandros Cavayas
- Ali Ait Hssain
- Ali Hachemi
- Alicia Gonzalez
- Alif Adlan Mohd Thabit
- Aline-Marie Florence
- Alison M. Meynert
- Alistair Nichol
- Allison McGeer
- Alpha Diallo
- Alphonsine Diouf
- Amal Abrous
- Amanda Corley
- Amanda Palacios
- Amanda Rojek
- Amandine Gagneux-Brunon
- Amar Bhatt
- Amélie Valran
- Ami Stuart
- Amina Meziane
- Amirul Asyraf
- Amna Faheem
- Amy Lester-Grant
- Amy Stone
- Ana Chora Sousa
- Ana da Silva Filipe
- Ana Freitas Ribeiro
- Ana Isabel de Pinho Oliveira
- Ana L Rios
- Ana Martins
- Ana Motos
- Ana Raquel Maia
- Anant Kataria
- Anatoliy Gavrylov
- Anca Streinu-Cercel
- Anders Tveita
- Andra-Maris Post
- Andrea Angheben
- Andrea Cortegiani
- Andrea Dell’Amore
- Andrea Kelly
- Andrea Rossanese
- Andrea Villoldo
- Andreas Lind
- Andrew Acker
- Andrew Dagens
- Andrew Hershey
- Andrew Law
- Andrew Udy
- Andrey Svistunov
- André Cabie
- André Roberto
- Andriy Bal
- Angela Alberti
- Anika Atique
- Anilawati Mat Jelani
- Anissa Chair
- Anja Grosse Lordemann
- Anjellica Chen
- Anna Beltrame
- Anna Ciullo
- Anna Greti Everding
- Anna Jung
- Anne Conrad
- Anne Guillaumot
- Anne Margarita Dyrhol-Riise
- Anne McCarthy
- Anne-Hélène Boivin
- Anne-Sophie Boureau
- Anne-Sophie Resseguier
- Annelies Verbon
- Annemarie B. Docherty
- Annmarie O Callaghan
- Annmarie O’Callaghan
- Ansley Hamer
- Anthony L. Loschner
- Anthony Lemeur
- Anthony Nghi
- Antoine Cheret
- Antoine Khalil
- Antoine Kimmoun
- Antoine Merckx
- Anton Prinssen
- Antoni Torres
- Antonia Ho
- Antonio Arcadipane
- Antonio Pesenti
- António Mesquita
- Aquiles Henriquez
- Ardiyan Apriyana
- Arfan Ikram
- Argin G
- Arianne Joy Corpuz
- Arie Zainul Fatoni
- Arnaud Scherpereel
- Arsène Kpangon
- Arthur Garan
- Ary Serpa Neto
- Asad Usman
- Asfia Sultana
- Asgar Rishu
- Asim Rana
- Asma Moin
- Audrey Barrelet
- Aurélie Papadopoulos
- Aurélie Veislinger
- Aurélie Wiedemann
- Aurore Bousquet
- Axelle Braconnier
- Azlan Mat Soom
- Bailey Cassandra
- Bairbre McNicholas
- Bambang Pujo Semedi
- Barbara Wanjiru Citarella
- Baruch Joaquin
- Basri Mat Nor
- Beathe Kiland Granerud
- Beatrice Alex
- Beatriz Amorim Beltrão
- Ben Morton
- Benedict Sim Lim Heng
- Benigno Ferreira
- Benjamin Bach
- Benjamin Lefèvre
- Benjamin Smood
- Benjamine Sarton
- Benoit Visseaux
- Benoît Roze
- Benoît Thill
- Bernard Cholley
- Bernardo Ferreira
- Bernhard Roessler
- Bertrand Dussol
- Bénédicte Lefebvre
- Bénédicte Rossignol
- Bharath Kumar Tirupakuzhi Vijayaraghavan
- Bianca Boxma
- Biing Horng Lee
- Birgitte Stiksrud
- Bishnu Saptarshi
- Blake Mergler
- Blandine Rammaert
- Bouchra Loufti
- Brenda Molloy
- Brenda Reeve
- Brigitte Elharrar
- Bruno Levy
- Bruno Lina
- Bruno Pastene
- Bruno Sarmento Banheiro
- Bryan Whelan
- Budha Charan Singh
- Calvache Jose A.
- Calvin Wong
- Cameron J. Fairfield
- Camile Bouisse
- Camille Couffignal
- Caren Friedrich
- Carine Roy
- Carla Eira
- Carlo Giaquinto
- Carlos Alexandre Antunes de Brito
- Carlos M. Luna
- Carlos Pimentel
- Carola Pierobon
- Carolien van Netten
- Caroline Kosgei
- Caroline Martins Rego
- Caroline Mudara
- Caroline Semaille
- Carolline Araujo
- Carrol Gamble
- Cassidy Codan
- Catarina Espírito Santo
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- Catherine A. Shaw
- Catherine Blier
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- Celina Turchi Martelli
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- Cédric Joseph
- Cédric Laouénan
- Céline Dorival
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- Chan Chee Eng
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- Chih-Hsien Wang
- Chloe Donohue
- Chris Kandel
- Christel Arnold-Day
- Christelle Chantalat Auger
- Christelle Delmas
- Christelle Paul
- Christelle Tual
- Christian Prebensen
- Christian Rabaud
- Christiana Kartsonaki
- Christl A. Donnelly
- Christophe Fraser
- Christophe Rapp
- Christopher A. Green
- Christy Kay
- Citarella Barbara Wanjiru
- Claire Andrejak
- Claire Kelly
- Claire Levy-Marchal
- Clara Flateau
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- Clare Jackson
- Clark D. Russell
- Claudia Bianco
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- Claudia Milena Orozco-Chamorro
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- Cleide Barrigoto
- Clément Le Bihan
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- Conar O’Neil
- Coralie Khan
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- Corinne Daniel
- Cornelius Rau
- Courtney Greene
- Craig French
- Cynthia Braga
- Cyril Cadoz
- Cyril Le Bris
- Dafsah Juzar
- Dag Henrik Reikvam
- Daisuke Kasugai
- Damien Bouhour
- Dan Meyer
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- Darren Dahly
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- Duc Nguyen
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- Etienne De Montmollin
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- Lisa Patterson
- Liv Hesstvedt
- Lorna Murphy
- Louis Gerbaud Morlaes
- Louise Sigfrid
- Lovkesh Arora
- Luca Brazzi
- Lucia Moro
- Lucia Proença
- Lucian Durham III
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- Lucille Blumberg
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- Marco Giani
- Mare Pejkovska
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- Marieke Haalboom
- Marielle Boyer-Besseyre
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- Musharaf Sadat
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- Nadiah Ismail
- Nadiah Kamarudin
- Nadir Hadri
- Nadirah Abdul Wahid
- Nagarajan Ramakrishnan
- Namra Asif
- Nassima Si Mohammed
- Nathalie Allou
- Nathalie DeCastro
- Nathalie Dournon
- Nathalie Gault
- Nathalie M. Delfos
- Nathalie Pansu
- Nathan Peiffer-Smadja
- Naveed Latif
- Navy Lolong
- Nazreen Abu Bakar
- Neerusha Kaisbain
- Nelson Cardoso
- Nestor Luque
- Ng Yong Muh
- Ng Yong Siang
- Niamh Kelly
- Niamh Ni Leathlobhair
- Nicholas Rizer
- Nicholas Sedillot
- Nicholas Yee Liang Hing
- Nicholas Yuri Barbosa
- Nick Daneman
- Nicky Van Der Vekens
- Nicolas Benech
- Nicolas Carlier
- Nicolas Ferriere
- Nicolas Terzi
- Nicole White
- Nidyanara Castanheira
- Nik Nur Eliza Mohamed
- Nikita Nekliudov
- Nilar Lwin
- Nina Buchtele
- Nina Jamieson
- Nobuya Kitamura
- Noémie Mercier
- Noémie Tissot
- Noémie Vanel
- Noor Hidayu Wahab
- Nor Arisah Misnan
- Nor Zaila Binti Zaidan
- Nora Fuentes
- Nuno Germano
- Nuno Martins
- Nur Amira
- Nurul Amani Mohd Noordin
- Nurul Faten Izzati Norharizam
- Nurul Najmee Abdulkadir
- Nurul Zaynah
- Oana Sandulescu
- Obada Yousif
- Odile Launay
- Ohshimo Shinichiro
- Oksana Kruglova
- Olavi Maasikas
- Oleksa Rewa
- Olga Martynenko
- Olivier Bouchaud
- Olivier Epaulard
- Olivier Lairez
- Olivier Lesens
- Olivier Picone
- Olivier Robineau
- Olivier Sanchez
- Olivier Terrier
- Olliaro Piero
- Omar Mehkri
- Ong Yiaw Joe
- Oriane Puéchal
- Oryane Mabiala
- Osama Metwally
- Oscar Hoiting
- Ouifiya Kafif
- Paddy Mallon
- Pamela Combs
- Paola Rodari
- Paolo Cattaneo
- Parthena Savvidou
- Pascal Granier
- Pathik Dhanger
- Patricia Gordon
- Patricia Lizotte
- Patricia Patricio
- Patrick Archambault
- Patrick Biston
- Patrick Imbert
- Patrick Murray
- Patrick Rispal
- Patrick Rossignol
- Paul Campbell
- Paul Dunand
- Paul Henri Wicky
- Paul Klenerman
- Paul Le Turnier
- Paul Loubet
- Paul McNally
- Paul van der Valk
- Paula Custodio
- Pauline Caraux-Paz
- Pavan Kumar Vecham
- Pedro Faria
- Pedro Povoa
- Peter de Vries
- Peter Doran
- Peter Horby
- Peter Kiiza
- Peter Openshaw
- Peter S Timashev
- Peter Van der Voort
- Petr Glybochko
- Petra Bryda
- Phil Gallagher
- Philippine Eloy
- Phoebe Ampaw
- Piero L. Olliaro
- Pierre Delobel
- Pierre Jaquet
- Pierre Tattevin
- Pierre-Adrien Bolze
- Pierre-François Sandrine
- Pierre-Marc Villeneuve
- Pierre-Marie Roger
- Pieter Depuydt
- Piret Sillaots
- Pleun Terpstra
- Polina Bugaeva
- Pompini Agustina Sitompul
- Pooja Varghese
- Pranya Sakiyalak
- Prasan Kumar Panda
- Prasanth Sukumar
- Pratap Karpayah
- Pratima Sharma
- Priscila Diaz
- Prompak Nitayavardhana
- Quentin Le Hingrat
- Quentin Lepiller
- Rachael Parke
- Rachel Cregan
- Rachida Ouissa
- Rafael Freitas de Oliveira França
- Rafael Mahieu
- Rakesh Arora
- Rana Imran Sikander
- Raphaël Borie
- Raphaël Favory
- Rashan Haniffa
- Rasidah Bt Senian
- Raul Neto
- Rebecca Hamidfar
- Rebekha Garcia
- Renata Barbalho
- Renato Reis
- Ricardo Fritz
- Richa Su
- Richard S. Tedder
- Riinu Pius
- Rita Alves
- Ritika Ranjan
- Rob Klont
- Robert A. Fowler
- Roberta Cavalin
- Roberto Roncon-Albuquerque Jr
- Robin Kobbe
- Rodrigo Diaz
- Rogério Silva
- Rolando Claure-Del Granado
- Romain Basmaci
- Romain Decours
- Romain Guery
- Roman Ullrich
- Romans Matulevics
- Rosario Maria Torres Santos-Olmo
- Ross Hendry
- Rostane Gaci
- Roxane Courtois
- Rozanah Abd Rahman
- Rui Caetano Garcês
- Rui Pereira
- Rumaisah Satyawati
- Rupert Higgins
- Ruth Jimbo-Sotomayor
- Ruth Lyons
- Ruth N. Jorge García
- Ryadh Pokeerbux
- Ryan Khoo
- Ryan S. Thwaites
- Ryuzo Abe
- Saad Nseir
- Sabelline Bouchez
- Sabina Kali
- Sabine Cornelis
- Sabine Croonen
- Sadie Kelly
- Saef Umar Barnett
- Saleh Al Ageel
- Sally Shrapnel
- Salma Jaafoura
- Samantha Lissauer
- Samira Laribi
- Samreen Ijaz
- Samuel Hinton
- Samuel Markowicz
- Sandrine Couffin-Cadiergues
- Sanne Wesselius
- Santi Dewayanti
- Sara Clohisey
- Sara Machado
- Sara Taleb
- Sara Ventura
- Sarah E. McDonald
- Sarah Isgett
- Sarah Moore
- Sarah Redl
- Sarah Stabler
- Sarah Syahrin
- Sarah Tubiana
- Saye Khoo
- Scott Pharand
- Seamus Daly
- Sean Donohue
- Seán Keating
- Sebastian Vencken
- Sebastiano Maria Colombo
- Segolène Greffe
- Senthilkumar Alegesan
- Sergio Poli
- Sébastien Preau
- Sérgio Gaião
- Séverine Ansart
- Shahdattul Mawarni Taib
- Shaikh Sharjeel
- Shaminee Veeran
- Sharma Keshav
- Shaun Thompson
- Shaunagh Browne
- Sherry McDermott
- Sheryl Ann Abdukahil
- Shiranee Sriskandan
- Shirin Tabrizi
- Shirley Sarfo-Mensah
- Shoban Raj Vasudayan
- Shona C. Moore
- Sia Loong Tonnii
- Silvia Castañeda
- Silvia Lourenco
- Sim Choon Ean
- Simão Rodeia
- Simon Bessis
- Simon Forsyth
- Simon-Djamel Thiberville
- Sinead Monahan
- Siobhan Casey
- Siri Goepel
- Siti Nurul Atikah Ahmad Ridzuan
- Siti Rohani Binti Mohd Yakop
- Siti Zubaidah Othman
- Sivanesen Anthonidass
- Sílvia Ferreira
- Sofia Cardoso
- Soizic Le Mestre
- Sophie Halpin
- Sophie Letrou
- Sophie Mahy
- Sree Satyapriya
- Srinivas Murthy
- Stanislas Rebaudet
- Steffi Ryckaert
- Stella Huo
- Stella Rousset
- Stephanie Nonas
- Stephanie Roberts
- Stephanie Yerkovich
- Stephanie-Susanne Stecher
- Stephen R Knight
- Steve Webb
- Stéphane Jaureguiberry
- Stéphane Lasry
- Stéphane Sallaberry
- Stéphanie Cousse
- Stéphanie Fry
- Stijn Van de Velde
- Stuart Houltham
- Su Hwan Lee
- Subbarao Elapavaluru
- Sudhir Krishnan
- Sue Smith
- Suhaila Abdul Wahab
- Surain Raaj Thanga Thurai
- Suresh Kumar Chidambaram
- Surya Otto Wijaya
- Susana Fernandes
- Susanne Dudman
- Sushil Khanal
- Suvintheran Thangavelu
- Suzanne Bennett
- Suzette Willems
- Syamin Asyraf Shahidan
- Sybille Bevilcaqua
- Sylvain Diamantis
- Sylvie Behilill
- Sylvie LeGac
- Sylvie Lion-Daolio
- Sylvie Van Der Werf
- Synne Jenum
- Sze Kye Teoh
- Taccone Fabio Silvio
- Tae Song
- Tahira Jamal Mohamed
- Takako Akimoto
- Taku Tanaka
- Tala Al-dabbous
- Tan Pei Wen
- Tarek Elshazly
- Tatiana Fonseca
- Tawnya Ogston
- Tânia Sequeira
- Teck Fung Wong
- Teresa Lawrence
- Terese Hammond
- Tharmini Ravi
- Thavamany Kaleesvran
- Théo Trioux
- Thibault Chiarabini
- Thierry Carmoi
- Thierry Mazzoni
- Thomas Flament
- Thomas Guimard
- Thomas Maitre
- Thomas Perpoint
- Thomas Staudinger
- Thushan de Silva
- Tiago Isidoro
- Tiago Reyes
- Tiffany Trouillon
- Timothy M. Uyeki
- Ting Soo Chow
- Tiphaine Goulenok
- Tirupakuzhi Vijayaraghavan Bharath Kumar
- Tjard Schermer
- Todd C. Lee
- Tom Drake
- Tom Fletcher
- Tom Solomon
- Toni Duculan
- Tony Trapani
- Toshiki Yokoyama
- Triona Downer
- Tristan Gigante
- Trude Steinsvik
- Tze Vee Soh
- Tze Yuan Tee
- Vadim Tieroshyn
- Valentine Campana
- Valentine Piquard
- Valeria Balan
- Valérie Gaborieau
- Valérie Garrait
- Valérie Gissot
- Valla Sahraei
- Vanessa Sancho-Shimizu
- Vanina Meysonnier
- Ventzislava Petrov-Sanchez
- Vera Irawany
- Véronique Lemee
- Vicente Souza-Dantas
- Victor Fomin
- Victoria Manda
- Victoria Shaw
- Vincent Dinot
- Vincent Dubee
- Vincent Enouf
- Vincent Langlois
- Vincent Le Moing
- Vincent Peigne
- Vincent Pestre
- Vincent Thibault
- Vinothini Krishnan
- Virginie Williams
- Vladislav Mihnovit
- Waasila Jassat
- Walter Picard
- Wei Han Hoh
- Wei Shen Lim
- Wendy S. Barclay
- William A. Paxton
- William Dechert
- William Greenhalf
- Wilna Oosthuyzen
- Wim Dieperink
- Xavier Duval
- Xin Ci Wong
- Yael Dishon
- Yan Chyi Tan
- Yaseen Arabi
- Yasmin Gani
- Yazdan Yazdanpanah
- Yen Tsen Saw
- Yew Sing Wong
- Yi Bin Ho
- Yi Lin Lee
- Yih-Sharng Chen
- Ymkje Stienstra
- Yoan Lavie-Badie
- Yoann Donohue
- Younes Ait Tamlihat
- Younes Kerroumi
- Yun Sii Ing
- Yuri Kida
- Yusing Gu
- Yves Levy
- Zhang Duan Tham
- Zul Amali Che Kamaruddin
- Zulfiqar Sandhu
- Publication venue
- PUBLIC LIBRARY SCIENCE
- Publication date
- 01/10/2023
- Field of study
Background: Using a large dataset, we evaluated prevalence and severity of alterations in liver enzymes in COVID-19 and association with patient-centred outcomes.MethodsWe included hospitalized patients with confirmed or suspected SARS-CoV-2 infection from the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) database. Key exposure was baseline liver enzymes (AST, ALT, bilirubin). Patients were assigned Liver Injury Classification score based on 3 components of enzymes at admission: Normal; Stage I) Liver injury: any component between 1-3x upper limit of normal (ULN); Stage II) Severe liver injury: any component & GE;3x ULN. Outcomes were hospital mortality, utilization of selected resources, complications, and durations of hospital and ICU stay. Analyses used logistic regression with associations expressed as adjusted odds ratios (OR) with 95% confidence intervals (CI).ResultsOf 17,531 included patients, 46.2% (8099) and 8.2% (1430) of patients had stage 1 and 2 liver injury respectively. Compared to normal, stages 1 and 2 were associated with higher odds of mortality (OR 1.53 [1.37-1.71]; OR 2.50 [2.10-2.96]), ICU admission (OR 1.63 [1.48-1.79]; OR 1.90 [1.62-2.23]), and invasive mechanical ventilation (OR 1.43 [1.27-1.70]; OR 1.95 (1.55-2.45). Stages 1 and 2 were also associated with higher odds of developing sepsis (OR 1.38 [1.27-1.50]; OR 1.46 [1.25-1.70]), acute kidney injury (OR 1.13 [1.00-1.27]; OR 1.59 [1.32-1.91]), and acute respiratory distress syndrome (OR 1.38 [1.22-1.55]; OR 1.80 [1.49-2.17]).ConclusionsLiver enzyme abnormalities are common among COVID-19 patients and associated with worse outcomes
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
- Author
- Abdukahil Sheryl Ann
- Abdulkadir Nurul Najmee
- Abe Ryuzo
- Abel Laurent
- Abreu Julia Rodriguez
- Abrous Amal
- Absil Lara
- Acker Andrew
- Adachi Shingo
- Adam Elisabeth
- Adriano Enrico
- Adrião Diana
- Ageel Saleh Al
- Ahmed Shakeel
- Aiello Marina
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Akimoto Takako
- Akmal Ernita
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Alalqam Razi
- Alberti Angela
- Alegesan Senthilkumar
- Alegre Cynthia
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alfoudri Huda
- Ali Adam
- Ali Imran
- Alidjnou Kazali Enagnon
- Aliudin Jeffrey
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Alves João
- Alves João Melo
- Alves Rita
- Amaral Maria
- Amira Nur
- Ammerlaan Heidi
- Ampaw Phoebe
- Andini Roberto
- Andréjak Claire
- Angheben Andrea
- Angoulvant François
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Anwar Kazi Rubayet
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Asaki Motohiro
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Assie Jean Baptiste
- Asyraf Amirul
- Atique Anika
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Auger Christelle Chantalat
- Aumaitre Hugues
- Auvet Adrien
- Azemar Laurène
- Azoulay Cecile
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie J. Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Balan Valeria
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrelet Audrey
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Battaglini Denise
- Bauer Jules
- Beane Abigail
- Bedossa Alexandra
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Benech Nicolas
- Benjiman Lionel Eric
- Benkerrou Dehbia
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berge Marcel van den
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Betz Adam
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianco Claudia
- Bidin Farah Nadiah
- Bihan Clément Le
- Bisoffi Zeno
- Bissuel François
- Biston Patrick
- Bitker Laurent
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Blumberg Lucille
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Bonelli Patrizia
- Bonfasius Aurelius
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Bouhmani Dounia
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bounphiengsy Thipsavanh
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Bouziotis Jason
- Boxma Bianca
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O
- Bris Cyril Le
- Browne Alex
- Browne Shaunagh
- Brozzi Nicolas
- Brusse-Keizer Marjolein
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Buonsenso Danilo
- Burhan Erlina
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Cabie André
- Cabral Susana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O
- Callahan Mia
- Calligy Kate
- Calvache Jose Andres
- Caminiti Caterina
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caraux-Paz Pauline
- Cardellino Chiara Simona
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlacci Francesca
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Carvalho Leonor
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Chair Anissa
- Chakveatze Catherine
- Chaleunphon Bounthavy
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chatterjee Allegra
- Chau Nguyen Van Vinh
- Chen Anjellica
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chetta Alfredo Antonio
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Hwa Jin
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chommanam Danoy
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Christy Nathaniel
- Chua Hiu Jian
- Chua Jonathan
- Cidade Jose Pedro
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Emma
- Clarke Jennifer
- Clifton Lei
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coelho Alexandra
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Colombo Sebastiano Maria
- Combs Pamela
- Connor Marie
- Conrad Anne
- Contreras Sofía
- Conway Elaine
- Cooke Graham S.
- Copland Mary
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Costigan Emma
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cregan Rachel
- Cristella Cosimo
- Croonen Sabine
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Ger
- Curlier Elodie
- Curran Colleen
- Curto Elena Gallego
- Custodio Paula
- D'Aragon Frédérick
- D'Orleans Charles Crepy
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dahly Darren
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Daneman Nick
- Daniel Corinne
- Dankwa Emmanuelle A
- Dantas Jorge
- Darshana B. P. Sanka Ruwan Sri
- de Brito Carlos Alexandre Antunes
- de Castro Maisa Guimarães
- de Jong Menno
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Oliveira França Rafael Freitas
- de Piero Maria
- de Pinho Oliveira Ana Isabel
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Velde Stijn Van
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Deconninck Lauren
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Desai Mehul
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhanger Pathik
- Diallo Alpha
- Diamantis Sylvain
- Dias Andrea
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M
- Dong Andy
- Donnelly Christl A.
- Donnelly Maria
- Donohue Chloe
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Douangdala Phouvieng
- Douglas James Joshua
- Douma Renee
- Dournon Nathalie
- Dow Denisse Bazan
- Downer Triona
- Downey Joanne
- Downing Mark
- Drake Tom
- Driscoll Aoife
- Dryden Murray
- Dubee Vincent
- Dubos François
- Dubot-Pérès Audrey
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Duplaix Mathilde
- Durante-Mangoni Emanuele
- Durham Lucian
- Dussol Bertrand
- Duthoit Juliette
- Duval Xavier
- Dyrhol-Riise Anne Margarita
- Ean Sim Choon
- Echeverria-Villalobos Marco
- Economopoulos Giorgio
- Egan Siobhan
- Eira Carla
- Elapavaluru Subbarao
- Elharrar Brigitte
- Ellerbroek Jacobien
- Eloy Philippine
- Elshazly Tarek
- Elyazar Iqbal
- Enderle Isabelle
- Endo Tomoyuki
- Eng Chan Chee
- Engelmann Ilka
- Enouf Vincent
- Epaulard Olivier
- Escher Martina
- Esperatti Mariano
- Esperou Hélène
- Esposito-Farese Marina
- Estevão João
- Etienne Manuel
- Ettalhaoui Nadia
- Everding Anna Greti
- Evers Mirjam
- Fabre Isabelle
- Fabre Marc
- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Falher Georges Le
- Faria Pedro
- Fateena Hanan
- Fatoni Arie Zainul
- Faure Karine
- Favory Raphaël
- Fayed Mohamed
- Feely Niamh
- Feeney Laura
- Feltz Machteld Van der
- Fernandes Jorge
- Fernandes Marília Andreia
- Fernandes Susana
- Ferrand François-Xavier
- Ferrari Carlo
- Ferraz Mário
- Ferrão Joana
- Ferreira Benigno
- Ferreira Bernardo
- Ferreira Isabel
- Ferreira Sílvia
- Ferrer-Roca Ricard
- Ferriere Nicolas
- Fevre Lucie Le
- Ficko Céline
- Figueiredo-Mello Claudia
- Finlayson William
- Fiorda Juan
- Flament Thomas
- Flateau Clara
- Fletcher Tom
- Florence Aline-Marie
- Florio Letizia Lucia
- Flynn Brigid
- Flynn Deirdre
- Fogliazza Federica
- Foley Claire
- Foley Jean
- Fomin Victor
- Fonseca Claudio Duarte
- Fonseca Tatiana
- Fontela Patricia
- Forsyth Simon
- Foster Denise
- Foti Giuseppe
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- Fraser Christophe
- Fraser John F
- Freire Marcela Vieira
- Friedrich Caren
- Fritz Ricardo
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- Greene Courtney
- Greenhalf William
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- Khalil Antoine
- Khan Coralie
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- Kho Michelle E
- Khoo Denisa
- Khoo Ryan
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- Kitamura Nobuya
- Klenerman Paul
- Klont Rob
- Knight Stephen R
- Kobbe Robin
- Kodippily Chamira
- Komatsu Mamoru
- Korten ISARIC Collaborator
- Kosgei Caroline
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- Laffey John G.
- Lafhej Nadhem
- Lagrange Marie
- Laine Fabrice
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- Le Minh
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- Lee Yi Lin
- Leeming Gary
- Lefebvre Bénédicte
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- Lopez-Revilla Jose W.
- Lordemann Anja Grosse
- Loschner Anthony L.
- Loubet Paul
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- Maia Ana Raquel
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- Maillet Mylène
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- Mandei Jose M.
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- Manetta Frank
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- Manning Edmund
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- Martinot Martin
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- McElroy Aine
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- McNally Paul
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- McPartlan Elaine
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- Mercier Emmanuelle
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- Merckx Antoine
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- Merson Laura
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- Mestre Soizic Le
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- Meynert Alison M.
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- Meziane Amina
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- Morlaes Louis Gerbaud
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- Ng Pauline Yeung
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- Nichol Alistair D
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- null null
- null null
- Nunez Jose I
- Nuñez Maria Angelica Rivera
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- Olliaro Piero L.
- Ong David S. Y.
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- Paul Mical
- Paulos Jorge
- Paxton William A.
- Payen Jean-François
- Peake Sandra L
- Peariasamy Kalaiarasu
- Peariasamy Kalaiarasu M.
- Peek Giles J.
- Peelman Florent
- Peiffer-Smadja Nathan
- Peigne Vincent
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- Pelosi Paolo
- Peltan Ithan D.
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- Post Andra-Maris
- Postma Douwe F.
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- Preiser Jean-Charles
- Prinssen Anton
- Pritchard Mark G.
- Priyadarshani Gamage Dona Dilanthi
- Proença Lucia
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- Quinones-Cardona Vilmaris
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- Rajahram Giri Shan
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- Rios Ana L
- Rishu Asgar
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- Roche-Campo Ferran
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- Sarton Benjamine
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- Semple Malcolm G.
- Senian Rasidah Bt
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- Shetty Rajesh Mohan
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- Sweeney Lisa Mc
- Syahrin Sarah
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- Tabrizi Shirin
- Taccone Fabio S.
- Tagherset Lysa
- Taib Shahdattul Mawarni
- Talarek Ewa
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- Taufik M Azhari
- Tawfik Hassan
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- Tee Tze Yuan
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- Thomson Emma C.
- Thurai Surain Raaj Thanga
- Thuy Duong Bich
- Thwaites Ryan S.
- Ticinesi Andrea
- Tierney Paul
- Tieroshyn Vadim
- Timashev Peter S
- Timsit Jean-François
- Tissot Noémie
- Toh Jordan Zhien Yang
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- Turmel Jean-Marie
- Turnier Paul Le
- Turtle Lance C. W.
- Tveita Anders
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- Twillert Gitte Van
- Uchiyama Makoto
- Udayanga PG Ishara
- Udy Andrew
- Ullrich Roman
- Uribe Alberto
- Usman Asad
- Uva Maria Sousa
- Uyeki Timothy M.
- Vajdovics Cristinava
- Val-Flores Luís
- Valentini Piero
- Valk Paul van der
- Valran Amélie
- Valzano Ilaria
- van Someren Greve Frank
- Vanel Noémie
- Vanoverschelde Henk
- Varghese Pooja
- Varrone Michael
- Vasconcelos Malte Kohns
- Vasudayan Shoban Raj
- Vauchy Charline
- Vecham Pavan Kumar
- Veen Ilonka van
- Veeran Shaminee
- Veislinger Aurélie
- Vekens Nicky Van Der
- Vencken Sebastian
- Ventura Sara
- Verbon Annelies
- Vickers James
- Vidal José Ernesto
- Vieira César
- Villanueva Joy Ann
- Villar Judit
- Villeneuve Pierre-Marc
- Villoldo Andrea
- Vishwanathan Gayatri
- Visseaux Benoit
- Visser Hannah
- Vitiello Chiara
- Vongsouvath Manivanh
- Vonkeman Harald
- Voort Peter Van der
- Vuotto Fanny
- Wahab Noor Hidayu
- Wahab Suhaila Abdul
- Wahid Nadirah Abdul
- Wainstein Marina
- Webb Steve
- Wei Jia
- Weil Katharina
- Wen Tan Pei
- Werf Sylvie Van Der
- Wesselius Sanne
- West T. Eoin
- Wham Murray
- Whelan Bryan
- Wicky Paul Henri
- Wiedemann Aurélie
- Wijaya Surya Otto
- Wille Keith
- Willems Sue
- Williams Patricia J
- Williams Virginie
- Willigen Hugo Van
- Wils Evert-Jan
- Wong Calvin
- Wong Teck Fung
- Wong Xin Ci
- Wong Xin Ci
- Wong Yew Sing
- Wright Natalie
- Xian Gan Ee
- Xian Lim Saio
- Xuan Kuan Pei
- Xynogalas Ioannis
- Yacoub Sophie
- Yakop Siti Rohani Binti Mohd
- Yamazaki Masaki
- Yarad Elizabeth
- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yiu Ng Wing
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zaidan Nor Zaila Binti
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zawadka Konrad
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 16/07/2024
- Field of study
By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
- Author
- Abbas Syed Ali
- Abdalasalam Sabriya
- Abdalhadi Alaa Abdalfattah
- Abdalla Fadlalla Asgad Osman
- Abdalla Naana Reyam
- Abdalla Walaa
- Abdalrheem Almthani Hamza
- Abdalsalam Ashraf
- Abdeewi Saedah
- Abdelgaum Esraa Hassan
- Abdelghafar Yomna Ali
- Abdelhalim Mohamed
- Abdelkabir Mohammed
- Abdelrahman Mohammedahmed Manahil Omer
- Abdelrahman Israa
- Abdelrhman Abdallahrs Asia Atif
- Abdukahil Sheryl Ann
- Abdulbaqi Lamees Adil
- Abdulhamid Salaheddin
- Abdulhamid Widyan
- Abdulkadir Nurul Najmee
- Abdullah Duha Milad
- Abdulwahed Eman
- Abdunabi Rawad
- Abe Ryuzo
- Abebrese Franklina Korkor
- Abel Laurent
- Abodina Ahmed Mohammed
- Abrous Amal
- Absil Lara
- Abu Salem Talat Ahmed
- Abusalama Abdurraouf
- Abuzaid Tareg Abdallah
- Acharya Subhash
- Acker Andrew
- Adam Elisabeth
- Adem Safia
- Ademnou Manuella
- Adewhajah Francisca
- Adrião Diana
- Ads Alaa Mohamed
- Adusei Amos Amoako
- Afum-Adjei Awuah Anthony
- Agbogbatey Melvin
- Ahmed Khalil Reham Abdelhamid
- Ahmed Mohamed Abdelaziz Ali Mostafa
- Ahmed Aya Mustafa
- Ahmed Musaab Mohammed
- Ahmed Shakeel
- Ainscough Kate
- Airlangga Eka
- Aisa Tharwat
- Aisha Ali
- Aisha Bugila
- Akimoto Takako
- Akmal Ernita
- Akwani Chika
- Al Ageel Saleh
- Al Qasim Eman
- Al-Aquily Mohammed
- Al-dabbous Tala
- Al-Fares Abdulrahman
- Al-Saba'a Yousef
- Alajeeli Ahmed
- Alali Ahmed
- Alalqam Razi
- Alameen Aliya Mohammed
- Alaraji Zainab Ahmed
- Alaraji Zinah A.
- Albakry Khalid
- Albatni Safa
- Alberti Angela
- Aldabbourosama Osama
- Aldhalia Amer
- Aldoukali Abdulkarim
- Alegesan Senthilkumar
- Alessi Marta
- Alex Beatrice
- Alexandre Kévin
- Alflite Asil
- Alfoudri Huda
- Alhadad Qamrah
- Alhaddad Hoda Salem
- Alhouri Ahmad Nabil
- Alhouri Hasan
- Ali Mohammed Abdelmalek Awad
- Ali Adam
- Ali Imran
- Ali Syed Muneeb
- Alidjnou Kazali Enagnon
- Aljadi Mahmoud
- Aljamal Sarah
- Alkahlout Mohammed
- Alkaseek Akram
- Alkhafajee Qabas
- Allavena Clotilde
- Allou Nathalie
- Almasri Lana
- Almjersah Abdulrahman
- Alqandouz Raja Ahmed
- Alrfaea Walaa
- Alrifaee Moayad
- Alsaadi Rawan
- Alshareea Entisar
- Alshenawy Eslam
- Altaf Aneela
- Alves João
- Alves João Melo
- Alves Rita
- Alyasiri Mohammed Saleh
- Amaral Maria
- Amer Amro Essam
- Amira Nur
- Amuasi John
- Andini Roberto
- Andrejak Claire
- Angheben Andrea
- Angoulvant François
- Ankrah Sophia
- Ansari Muhammad Imran
- Ansart Séverine
- Anthonidass Sivanesen
- Antonelli Massimo
- Antunes de Brito Carlos Alexandre
- Apriyana Ardiyan
- Arabi Yaseen
- Aragao Irene
- Arancibia Francisco
- Araujo Carolline
- Arcadipane Antonio
- Archambault Patrick
- Arenz Lukas
- Argin G.
- Arlet Jean-Benoît
- Arnold-Day Christel
- Arora Lovkesh
- Arora Rakesh
- Artaud-Macari Elise
- Aryal Diptesh
- Ascofare Oumou Maiga
- Asensio Angel
- Ashley Elizabeth A.
- Ashraf Muhammad
- Ashraf Muhammad Sheharyar
- Asiedu-Bekoe Franklin
- Asif Namra
- Asim Mohammad
- Assi Grace
- Assie Jean Baptiste
- Asyraf Amirul
- Atangana Fouda
- Atia Ahmed
- Atif Minahel
- Atikah Ahmad Ridzuan Siti Nurul
- Atique Anika
- Atlowly Moad
- Attanyake AM Udara Lakshan
- Auchabie Johann
- Aumaitre Hugues
- Auvet Adrien
- Axelsen Eyvind W.
- Ayad Ared
- Ayadi Kamaluddin Muhammad Aisar
- Azemar Laurène
- Azizeldin Mohammed
- Azoulay Cecile
- Babatunde Hakeem
- Bach Benjamin
- Bachelet Delphine
- Badr Claudine
- Baig Nadia
- Baillie John Kenneth
- Baird J Kevin
- Bak Erica
- Bakakos Agamemnon
- Bakar Nazreen Abu
- Bakeer Hibah Bileid
- Bakri Ashraf
- Bal Andriy
- Balakrishnan Mohanaprasanth
- Bandoh Irene
- Banheiro Bruno Sarmento
- Bani-Sadr Firouzé
- Barbalho Renata
- Barbosa Nicholas Yuri
- Barclay Wendy S.
- Barnett Saef Umar
- Barnikel Michaela
- Barrasa Helena
- Barrigoto Cleide
- Bartoli Marie
- Baruch Joaquin
- Baruch Joaquín
- Basmaci Romain
- Basri Muhammad Fadhli Hassin
- Bassi Gianluigi Li
- Batool AbdAlkarim
- Battaglini Denise
- Bauer Jules
- Bautista Rincon Diego Fernando
- Beane Abigail
- Bedossa Alexandra
- Bedu-Addo Ama Kwakyewaa
- Bee Ker Hong
- Begum Husna
- Behilill Sylvie
- Beishuizen Albertus
- Bekken Gry Kloumann
- Beljantsev Aleksandr
- Bellemare David
- Beltrame Anna
- Beltrão Beatriz Amorim
- Beluze Marine
- Ben Ashur Abir
- Benech Nicolas
- Benjiman Lionel Eric
- Bennett Suzanne
- Bento Luís
- Berdal Jan-Erik
- Berdeweel Lamis
- Bergeaud Delphine
- Bergin Hazel
- Bertoli Giulia
- Bertolino Lorenzo
- Bessis Simon
- Bevilcaqua Sybille
- Bezulier Karine
- Bhatt Amar
- Bhavsar Krishna
- Bianchi Isabella
- Bianco Claudia
- Bichoka Sandra
- Bidin Farah Nadiah
- Bin Kamarudin Mohd Nazlin
- Binnawara Muhannud
- Binti Mohd Yakop Siti Rohani
- Binti Zaidan Nor Zaila
- Bisoffi Zeno
- Biston Patrick
- Bitker Laurent
- Bittaye Mustapha
- Bitton Jonathan
- Blanco-Schweizer Pablo
- Blier Catherine
- Bloos Frank
- Blot Mathieu
- Boccia Filomena
- Bodenes Laetitia
- Bogaert Debby
- Boivin Anne-Hélène
- Bolanga Ariel
- Bolaños Isabela
- Bolze Pierre-Adrien
- Bompart François
- Bonifasius Aurelius
- Bonney Joe
- Borges Diogo
- Borie Raphaël
- Bosse Hans Martin
- Botelho-Nevers Elisabeth
- Bouadma Lila
- Bouchaud Olivier
- Bouchez Sabelline
- Boudoin Herwin Nanda
- Bouhour Damien
- Bouiller Kévin
- Bouillet Laurence
- Bouisse Camile
- Bountthasavong Latsaniphone
- Boureau Anne-Sophie
- Bourke John
- Bouscambert Maude
- Bousquet Aurore
- Boyer-Besseyre Marielle
- Boylan Maria
- Bozza Fernando Augusto
- Braconnier Axelle
- Braga Cynthia
- Brandenburger Timo
- Brazzi Luca
- Breen Dorothy
- Breen Patrick
- Brewster David
- Brickell Kathy
- Brien Fionnuala O.
- Broadley Tessa
- Brotherton Helen
- Browne Alex
- Brozzi Nicolas
- Brunvoll Sonja Hjellegjerde
- Brusse-Keizer Marjolein
- Bryda Petra
- Buchtele Nina
- Bugaeva Polina
- Buisson Marielle
- Buonsenso Danilo
- Burhan Erlina
- Buri Donald
- Burrell Aidan
- Bustos Ingrid G.
- Butnaru Denis
- Bævre-Jensen Roar
- Cabie André
- Cabral Susana
- Cabrita Joana
- Cabrita Joana Alves
- Caceres Eder
- Cadoz Cyril
- Callaghan Annmarie O.
- Calligy Kate
- Calvache Jose Andres
- Camões João
- Campana Valentine
- Campbell Paul
- Campisi Josie
- Canepa Cecilia
- Cantero Mireia
- Caoili Janice
- Caraux-Paz Pauline
- Cardoso Filipa
- Cardoso Filipe
- Cardoso Nelson
- Cardoso Sofia
- Carelli Simone
- Carlier Nicolas
- Carmoi Thierry
- Carney Gayle
- Carqueja Inês
- Carret Marie-Christine
- Carrier François Martin
- Carroll Ida
- Carson Gail
- Casanova Maire-Laure
- Cascão Mariana
- Casey Siobhan
- Casimiro José
- Cassandra Bailey
- Castanheira Nidyanara
- Castañeda Silvia
- Castor-Alexandre Guylaine
- Castro Ivo
- Catarino Ana
- Catherine François-Xavier
- Cattaneo Paolo
- Cavalin Roberta
- Cavalli Giulio Giovanni
- Cavayas Alexandros
- Cárcel Sheila
- Ceccato Adrian
- Ceesay Masaneh
- Cely Lina Morales
- Cerkovnik Shelby
- Cervantes-Gonzalez Minerva
- Cevik Muge
- Chair Anissa
- Chakveatze Catherine
- Chan Adrienne
- Chand Meera
- Chapplain Jean-Marc
- Charpentier Charlotte
- Chas Julie
- Chaudry Muhammad Mobin
- Chávez Iñiguez Jonathan Samuel
- Che Kamaruddin Zul Amali
- Chen Anjellica
- Chen Yih-Sharng
- Chenard Léo
- Cheng Matthew Pellan
- Cheret Antoine
- Chia Jack Song
- Chiarabini Thibault
- Chica Julian
- Chidambaram Suresh Kumar
- Chirouze Catherine
- Chiumello Davide
- Cho Sung-Min
- Choileain Orna Ni
- Cholley Bernard
- Chommanam Danoy
- Chopin Marie-Charlotte
- Chow Ting Soo
- Chow Yock Ping
- Christy Nathaniel
- Chua Hiu Jian
- Chua Jonathan
- Cidade Jose Pedro
- Cisneros Herreros José Miguel
- Citarella Barbara Wanjiru
- Citarella Barbara Wanjiru
- Ciullo Anna
- Clarke Jennifer
- Claure-Del Granado Rolando
- Clohisey Sara
- Codan Cassidy
- Cody Caitriona
- Coles Jennifer
- Coles Megan
- Colin Gwenhaël
- Collins Michael
- Combs Pamela
- Connolly Jennifer
- Connor Marie
- Conrad Anne
- Conway Elaine
- Cooke Graham S.
- Cordel Hugues
- Corley Amanda
- Cornelis Sabine
- Cornet Alexander Daniel
- Corpuz Arianne Joy
- Cortegiani Andrea
- Corvaisier Grégory
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Courtois Roxane
- Cousse Stéphanie
- Cowan Juthaporn
- Cregan Rachel
- Crowl Gloria
- Crump Jonathan
- Cruz Claudina
- Csete Marc
- Cullen Ailbhe
- Cummings Matthew
- Curley Gerard
- Curlier Elodie
- Curran Colleen
- Custodio Paula
- D'Alessandro Umberto
- D'Aragon Frédérick
- D'Ortenzio Eric
- da Silva Filipe Ana
- Da Silva Fernanda Dias
- Da Silveira Charlene
- Dabaliz Al-Awwab
- Dagens Andrew
- Dagens Andrew
- Dahl John Arne
- Dahly Darren
- Daley Peter
- Dalloul Zaina
- Dalton Heidi
- Dalton Jo
- Daly Seamus
- Damas Juliana
- Dame Joycelyn
- Damien Cammandji
- Daneman Nick
- Dantas Jorge
- de Loughry Gillian
- de Mendoza Diego
- De Montmollin Etienne
- de Piero Maria
- De Rosa Rosanna
- De Rose Cristina
- de Silva Thushan
- de Vries Peter
- Deacon Jillian
- Dean David
- Debard Alexa
- DeBenedictis Bianca
- Debray Marie-Pierre
- DeCastro Nathalie
- Dechert William
- Decours Romain
- Defous Eve
- Delacroix Isabelle
- Delamou Alexandre
- Delaveuve Eric
- Delavigne Karen
- Delfos Nathalie M.
- Deligiannis Ionna
- Dell'Amore Andrea
- Delmas Christelle
- Delobel Pierre
- Delsing Corine
- Demonchy Elisa
- Denis Emmanuelle
- Deplanque Dominique
- Depuydt Pieter
- Descamps Diane
- Desvallées Mathilde
- Devouge Eglantine Ferrand
- Dewayanti Santi
- Dhangar Pathik
- Diallo Alpha
- Diallo Souleymane Taran
- Diamantis Sylvain
- Dias André
- Diaz Juan Jose
- Diaz Priscila
- Diaz Rodrigo
- Dibba Bakary K.
- Didier Kévin
- Diehl Jean-Luc
- Dieperink Wim
- Dilanthi Priyadarshani Gamage Dona
- Dimet Jérôme
- Dinot Vincent
- Diop Fara
- Diouf Alphonsine
- Dishon Yael
- Djadda Cedric
- Djossou Félix
- Docherty Annemarie B.
- Doherty Helen
- Dominguez Carmen Infante
- Dondorp Arjen M.
- Donnelly Christl A.
- Donohue Sean
- Donohue Yoann
- Doran Peter
- Dorival Céline
- Doshi Yash
- Douangdala Phouvieng
- Douglas James Joshua
- Douma Renee
- Dournon Nathalie
- Dow Denisse Bazan
- Downey Joanne
- Downing Mark
- Drake Thomas
- Driscoll Aoife
- Duah Ibrahim Kwaku
- Dubee Vincent
- Dubos François
- Dubot-Pérès Audrey
- Ducancelle Alexandre
- Duculan Toni
- Dudman Susanne
- Duggal Abhijit
- Dunand Paul
- Dunning Jake
- Dunning Jake
- Duplaix Mathilde
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- Ean Sim Choon
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- Ehzaz Khadeja
- Eira Carla
- Ekow Harrison Samuel Bernard
- El Sanharawi Mohammed
- El Sayed Marwan
- Elabid Mohammed
- Elagili Mohamed Bashir
- Elapavaluru Subbarao
- Elbahnasawy Mohammad
- Elboshra Sohail
- Elharrar Brigitte
- Elhefnawy Enan Abdulrahman Ahmed
- Eliza Mohamed Nik Nur
- Ellerbroek Jacobien
- Ellingjord-Dale Merete
- ELMagrahi Hamida
- Elmubark Mohammad Muatasm
- Elotmani Loubna
- Eloundou Lauren
- Eloy Philippine
- Elsayed Soliman Mohamed Osama
- Elshaikhy Basma
- Elshazly Tarek
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- Elyazar Iqbal
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- Embarek Hussein
- Enderle Isabelle
- Endo Tomoyuki
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- Estevão João
- Etienne Manuel
- Everding Anna Greti
- Evers Mirjam
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- Fabre Marc
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- Faheem Amna
- Fahy Arabella
- Fairfield Cameron J.
- Fakar Zul
- Fareed Komal
- Faria Pedro
- Farooq Ahmed
- Fateena Hanan
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- Fatima Salem
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- Fatoni Arie Zainul
- Faure Karine
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- Fayed Mohamed
- Feely Niamh
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- Ferreira Benigno
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- Foster Denise
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- Fotso Berline
- Fourn Erwan
- Fowler Robert A.
- Fraher Marianne
- Franch-Llasat Diego
- França Rafael Freitas de Oliveira
- Fraser Christophe
- Fraser John F.
- Freire Marcela Vieira
- French Craig
- Friedrich Caren
- Fritz Ricardo
- Fry Stéphanie
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- Fukuda Masahiro
- Gaborieau Valérie
- Gaci Rostane
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- Gagneux-Brunon Amandine
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- Gebauer Johannes
- Geraud Eva
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- Giani Marco
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- Girvan Michelle
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- Giwangkancana Gezy
- Glikman Daniel
- Glybochko Petr
- Gnall Eric
- Goco Geraldine
- Goehringer François
- Goepel Siri
- Goffard Jean-Christophe
- Goh Jin Yi
- Golács Brigitta
- Golob Jonathan
- Gomez Kyle
- Gominet Marie
- Gonçalves Bronner P.
- Gonzalez Alicia
- Gordon Patricia
- Gorenne Isabelle
- Goubert Laure
- Goujard Cécile
- Goulenok Tiphaine
- Gómez-Junyent Joan
- Grable Margarite
- Graf Jeronimo
- Grandin Edward Wilson
- Granerud Beathe Kiland
- Granier Pascal
- Grasselli Giacomo
- Grazioli Lorenzo
- Green Christopher A.
- Greene Courtney
- Greenhalf William
- Greffe Segolène
- Grieco Domenico Luca
- Griffee Matthew
- Griffiths Fiona
- Grigoras Ioana
- Groenendijk Albert
- Grovogui Fassou Mathias
- Gruner Heidi
- Gu Yusing
- Guedj Jérémie
- Guego Martin
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- Guerreiro Daniela
- Guery Romain
- Guillaumot Anne
- Guilleminault Laurent
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- Guimard Thomas
- Haalboom Marieke
- Haber Daniel
- Hachemi Ali
- Haddud Abdurrahman
- Hadri Nadir
- Hafez Wael
- Haidri Fakhir Raza
- Haji Ab Rahman Ahmad Kashfi
- Hakak Sheeba
- Hall Adam
- Hall Matthew
- Hall Matthew
- Halpin Sophie
- Hamdan Shaher
- Hamdi Abdelhafeez
- Hameed Jawad
- Hamer Ansley
- Hamers Raph L.
- Hamidfar Rebecca
- Hammarström Bato
- Hammond Naomi
- Hammond Terese
- Han Lim Yuen
- Hanan Matly
- Haniffa Rashan
- Hao Kok Wei
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Hartman Alan
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- Hashmi Junaid
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- Hassan Helmi Ahmed Ayman
- Hassan Amoni
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- Hayat Muhammad
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- Hesstvedt Liv
- Hidayah Astarini
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- Higgins Rupert
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- Hinton Samuel
- Hiraiwa Hiroaki
- Hirkani Haider
- Hitoto Hikombo
- Ho Antonia
- Ho Yi Bin
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- Hoffmann Isabelle
- Hoh Wei Han
- Hoiting Oscar
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- Holten Aleksander Rygh
- Holter Jan Cato
- Horby Peter
- Horby Peter
- Horcajada Juan Pablo
- Houas Ikram
- Houderi Mabrouka
- Hough Catherine L.
- Houltham Stuart
- Hssain Ali Ait
- Hulot Jean-Sébastien
- Humaid Felwa Bin
- Hurd Abby
- Hussain Iqbal
- Hussein Aliae Mohamed
- Hussein Mahmood
- Ibáñez-Prada Elsa D.
- Ibrahim Fatima
- Ibran Bashir
- Ijaz Samreen
- Ikram M. Arfan
- Illana Carlos Cañada
- Imbert Patrick
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- Yazdanpanah Yazdan
- Yelnik Cécile
- Yeoh Chian Hui
- Yerkovich Stephanie
- Yiaye Touxiong
- Yokoyama Toshiki
- Yonis Hodane
- Yousif Obada
- Yuliarto Saptadi
- Zaaqoq Akram
- Zabbe Marion
- Zabert Gustavo E.
- Zacharowski Kai
- Zahid Masliza
- Zahran Maram
- Zambon Maria
- Zambrano Miguel
- Zanella Alberto
- Zaynah Nurul
- Zayyad Hiba
- Zoufaly Alexander
- Zucman David
- Publication venue
- Publication date
- 30/05/2024
- Field of study
Background: COVID-19 is primarily known as a respiratory illness; however, many patients present to hospital without respiratory symptoms. The association between non-respiratory presentations of COVID-19 and outcomes remains unclear. We investigated risk factors and clinical outcomes in patients with no respiratory symptoms (NRS) and respiratory symptoms (RS) at hospital admission. Methods: This study describes clinical features, physiological parameters, and outcomes of hospitalised COVID-19 patients, stratified by the presence or absence of respiratory symptoms at hospital admission. RS patients had one or more of: cough, shortness of breath, sore throat, runny nose or wheezing; while NRS patients did not. Results: Of 178,640 patients in the study, 86.4 % presented with RS, while 13.6 % had NRS. NRS patients were older (median age: NRS: 74 vs RS: 65) and less likely to be admitted to the ICU (NRS: 36.7 % vs RS: 37.5 %). NRS patients had a higher crude in-hospital case-fatality ratio (NRS 41.1 % vs. RS 32.0 %), but a lower risk of death after adjusting for confounders (HR 0.88 [0.83-0.93]). Conclusion: Approximately one in seven COVID-19 patients presented at hospital admission without respiratory symptoms. These patients were older, had lower ICU admission rates, and had a lower risk of in-hospital mortality after adjusting for confounders