A Measurement Study on the Advertisements Displayed to Web Users Coming from the Regular Web and from Tor

Online advertising is an effective way for businesses to find new customers and expand their reach to a great variety of audiences. Due to the large number of participants interacting in the process, advertising networks act as brokers between website owners and businesses facilitating the display of advertisements. Unfortunately, this system is abused by cybercriminals to perform illegal activities such as malvertising. In this paper, we perform a measurement of malvertising from the user point of view. Our goal is to collect advertisements from a regular Internet connection and using The Onion Router in an attempt to understand whether using different technologies to access the Web could influence the probability of infection. We compare the data from our experiments to find differences in the malvertising activity observed. We show that the level of maliciousness is similar between the two types of accesses. Nevertheless, there are significant differences related to the malicious landing pages delivered in each type of access. Our results provide the research community with insights into how ad traffic is treated depending on the way users access Web content

Aumento de la fertilidad mediante técnicas de procesamiento avanzado de semen: caso clínico

Current equine reproductive clinic aims to improve subfertile stallions semen quality, (which is furthermore affected by the processing protocol) and maintain this quality during storage. The aim of this paper is to present a case referred to the Hospital Clínico Veterinario Complutense, of a stallion with low sperm quality, and 0% fertility rate in the first batch of mares served. Due to these results it was decided to perform a special semen processing protocol, developed by our laboratory, in order to increase its quality throughout a colloidal centrifugation technique with EquiPure® This system is able to increase semen quality and maintain itduring cooling preservation, obtaining results of around 57,1% of total fertility, which validates this technique as an effective method for subfertile stallions semen processing.La clínica reproductiva equina actual persigue mejorar la calidad seminal de sementales subfértiles, (la cual, además, se ve afectada por el procesamiento del semen) y que ésta se conserve durante el almacenamiento. El objetivo de este trabajo es presentar un caso clínico remitido al Hospital Clínico Veterinario Complutense, sobre un semental que presenta una baja calidad seminal, siendo la fertilidad del primer lote de yeguas del 0%. Ante estos resultados se decide realizar un procesado del semen, desarrollado por nuestro laboratorio, enfocado a aumentar su calidad mediante un protocolo de centrifugación coloidal con EquiPure® (Nidacon International AB). La aplicación de este protocolo consigue aumentar la calidad seminal y mantenerla durante la conservación en refrigeración, obteniéndose unos resultados de fertilidad total del 57,1%, lo que lo valida como método efectivo para el procesado del semen en casos de sementales subfértiles

Adaptação cultural e validação da versão portuguesa do questionário Medical Outcomes Study Social Support Survey (MOS-SSS)

O objectivo deste trabalho é calcular as propriedades psicométricas da versão portuguesa do questionário Medical Outcomes Study Social Support Survey (MOS-SSS). Este questionário foi traduzido e adaptado à cultura portuguesa. A amostra é constituída por 101 doentes com doença crónica, utentes de um centro de saúde rural de Portugal. A idade média é 63,4 anos; 56,4% são mulheres. 29% são analfabetos e 2% possuem estudos superiores. 78% sofrem de hipertensão arterial e 56,4% sofrem de diabetes mellitus tipo 2. A consistência interna foi avaliada com o alpha de Cronbach. Depois, foi realizada uma análise factorial exploratória e confirmatória com o objectivo de confirmar a validade e fiabilidade da escala e as suas características multidimensionais. A confiabilidade teste-reteste realizada às duas semanas foi estimada usando a análise kappa ponderado para as variáveis ordinais e o coeficiente de correlação intraclasse para as variáveis quantitativas. A alpha de Cronbach para as subescalas varia entre 0,873 e 0,967 no teste e 0,862 e 0,972 no reteste. A análise factorial exploratória revelou a existência de quatro factores (apoio emocional, material, afectivo e interacção social positiva) que explicam o 72,71% da variância. A análise factorial confirmatória permite concluir a existência destes quatro factores que permitem a aplicação da escala com os itens do questionário original. Os índices de ajustamento são satisfatórios e verificam a estrutura inicial, apresentando valores de χ2/df =2,01; GFI =0,998; CFI=0,999; AGFI =0,998; TLI =0,999; NFI =0,998; SRMR =0,332; RMSEA =0,76. A confiabilidade teste-reteste às duas semanas da versão portuguesa do MOS-SSS foi estimada pelo coeficiente de correlação intraclasse que variou entre 0,941 e 0,966 para as quatro dimensões do questionário e para o índice de apoio total. Os índices kappa ponderados variaram entre 0,67 e 0,87 para todos os itens. A versão portuguesa do MOS-SSS demonstrou boas características psicométricas e parece ser útil para avaliar as características multidimensionais do apoio social em população portuguesa.The aim of this study was the assesment of psychometric properties of the Portuguese version of the instrument «Medical Outcomes Study – Social Support Survey (MOSSSS) ». This questionnaire has been translated and adapted in a Portuguese sample of 101 patients with chronic illness of a rural health centre in Portugal. The average age of patients was 63.4 years, 56.4% female. 29% were illiterate and 2% had completed high school. 78% had arterial hypertension and the 56.4% had diabetes mellitus type 2. The internal consistency was evaluated using Cronbach’s alpha. Exploratory and Confirmatory factor analysis were performed in order to confirm reliability and validity of the scale and its multidimensional characteristics. The 2-week test-retest reliability was estimated using weighted kappa for the ordinals variables and intraclass coefficient correlation for the quantitative variables. Cronbach’s alphas for the subscales ranged from 0.873 to 0.967 at test, and 0.862 to 0.972 at retest. Exploratory factor analysis revealed the existence of four factors (emotional, tangible, positive interaction and affection support) that explain the 72.71% of the variance. Confirmatory factor analysis supported the existence of four factors that allowed the application of the scale with original items. The goodness-of-fit measures corroborate the initial structure, with χ2/ df=2.01, GFI=0.998, CFI=0.999, AGFI=0.998, TLI=0.999, NFI=0.998, SRMR=0.332, RMSEA=0.76. The 2-weeks test-retest reliability of the Portuguese MOS-SSS as measured by the intraclass correlation coefficient was ranged from 0.941 to 0.966 for the four dimensions and the overall support index. The weighted kappa was ranged from 0.67 to 0.87 for all the items. The MOS-SSS Portuguese version demonstrates good psychometric properties and seems to be useful to measure multidimensional aspects of social support in the Portuguese population.Sociedade Espanhola de Medicina Familiar e Comunitária (SEMFYC

Under and over the surface: a comparison of the use of leaked account credentials in the Dark and Surface Web

The world has seen a dramatic increase in cybercrime, in both the Surface Web, which is the portion of content on the World Wide Web that may be indexed by popular engines, and lately in the Dark Web, a portion that is not indexed by conventional search engines and is accessed through network overlays such as the Tor network. For instance, theft of online service credentials is an emerging problem, especially in the Dark Web, where the average price for someone\u2019s online identity is \ua3820. Previous research studied the modus operandi of criminals that obtain stolen account credentials through Surface Web outlets. As part of an effort to understand how the same crime unfolds in the Surface Web and the Dark Web, this study seeks to compare the modus operandi of criminals acting on both by leaking Gmail honey accounts in Dark Web outlets. The results are compared to a previous similar experiment performed in the Surface Web. Simulating operating activity of criminals, we posted 100 Gmail account credentials on hidden services on the Dark Web and monitored the activity that they attracted using a honeypot infrastructure. More specifically, we analysed the data generated by the two experiments to find differences in the activity observed with the aim of understanding how leaked credentials are used in both Web environments. We observed that different types of malicious activity happen on honey accounts depending on the Web environment they are released on. Our results can provide the research community with insights into how stolen accounts are being manipulated in the wild for different Web environments

Prioritization of Alternative Agricultural Products Based on Market Signals as a Tool for the Development of Innovative Projects

The Decentralized Autonomous Government of the province of Chimborazo promotes the agricultural productive development of the province by promoting entrepreneurship, and improving the capacities of producers, access to production factors, and integration of actors and subjects of agriculture and management on the basis to strategic planning. The construction of the Chimborazo Competitiveness Agenda was a participatory process that identified opportunities to improve the agricultural sector, where agricultural production at the primary level was recognized as a vocation and strength of the province; however, a strategic necessity was to establish possibilities of adding value and diversifying agricultural production. The definition of a set of agricultural products with high potential at the primary level and/or in agroindustrial processes that are not deeply explored required determining market signals to identify new medium- and long-term commercial possibilities for Chimborazo farmers. Additionally, it was recognized that the management of the province of Chimborazo was based on its management of the Millennium Development Goals, the Constitution of the Republic, the National Plan for Development in a Supra-Provincial Framework, as well as the Plan Development of Chimborazo, the Territorial Planning Plan and others that promoted planning with a focus on territorial and solidarity sustainable development. Keywords: Chimborazo, productive development, entrepreneurship, agricultural sector. Resumen El Gobierno Autónomo Descentralizado de la Provincia de Chimborazo impulsa el fomento productivo agrícola de la provincia mediante la promoción del emprendimiento, el mejoramiento de las capacidades de los productores, acceso a factores de producción, integración de los actores y sujetos del agro y gestión en base a una planificación estratégica. Como parte de dicho accionar, la construcción de la Agenda de Competitividad Chimborazo fue un proceso participativo que identificó oportunidades para mejorar el sector agrícola, donde se reconoció la producción agrícola a nivel primario como una vocación y fortaleza de la provincia, no obstante, una necesidad estratégica fue el establecer posibilidades de agregación de valor y de diversificar la producción agrícola. La definición de un conjunto de productos agrícolas con alto potencial a nivel primario y/o en procesos agroindustriales que no están profundamente explorados requirió determinar señales de mercado para identificar posibilidades comerciales nuevas a mediano y largo plazo para los agricultores de Chimborazo. Adicionalmente, se reconoció que la gestión de la provincia de Chimborazo tuvo como base los Objetivos del Milenio, la Constitución de la República, el Plan Nacional de Desarrollo en un marco supra-provincial, así como el Plan de Desarrollo de Chimborazo, el Plan de Ordenamiento Territorial y otros en su conjunto que promovieron una planificación con un enfoque de desarrollo sostenible territorial y solidario. Palabras clave: Chimborazo, fomento productivo, emprendimiento, sector agrícola

Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment

Correction for 'Inclusion of new 5-fluorouracil amphiphilic derivatives in liposome formulation for cancer treatment' by M. Petaccia et al., Med. Chem. Commun., 2015, 6, 1639–1642

Graphene catalyzes the reversible formation of a C–C bond between two molecules

Carbon deposits are well-known inhibitors of transition metal catalysts. In contrast to this undesirable behavior, here we show that epitaxial graphene grown on Ru(0001) promotes the reversible formation of a C–C bond between −CH2CN and 7,7,8,8-tetracyano-p-quinodimethane (TCNQ). The catalytic role of graphene is multifaceted: First, it allows for an efficient charge transfer between the surface and the reactants, thus favoring changes in carbon hybridization; second, it holds the reactants in place and makes them reactive. The reaction is fully reversible by injecting electrons with an STM tip on the empty molecular orbitals of the product. The making and breaking of the C–C bond is accompanied by the switching off and on of a Kondo resonance, so that the system can be viewed as a reversible magnetic switch controlled by a chemical reactionJ.J.N., F.C., R.M., and A.L.V.d.P. acknowledge the Ministerio de Economía y Competitividad (MINECO) project FIS2015-67367-C2-1-P and Comunidad de Madrid projects MAD2D P2013/MIT-3007 and Nanofrontmag S2013/MIT-2850. M.P., C.D., and F.M. acknowledge the MINECO project FIS2016-77889-R and computer time from the CCC-UAM and the Red Española de Supercomputación. C.D. acknowledges a Ramón y Cajal contract from MINECO (Spain). E.M.P., J.V., and B.N.-O. acknowledge the European Research Council project MINT, ERC-StG-2012-307609. IMDEA Nanoscience acknowledges support from the “Severo Ochoa” Programme for Centres of Excellence in R&D (MINECO, grant SEV-2016-0686). IFIMAC acknowledges support from the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0377