Caso del software de gestión FeBePOS: ¿Cómo transformar digitalmente un comercio informal y lograr incrementar ventas?

Informal trade is on the rise in Colombia (South America), driven by economic slowdown, increased unemployment, government incentives to activate commerce, and the acceleration of digital delivery platforms like Rappi. This growth requires businesses to adjust their processes to the current dynamics and understand the necessary capabilities to ensure sales growth and customer satisfaction. In response to this need for digital transformation in commerce, FeBePOS has been developed, a software for business management that helps take control of the business and increase sales. This case study is based on qualitative exploration and presents the results of identifying the digital capabilities needed for the software's development, as well as for the digitization and increased sales of a business. Furthermore, the functionalities of the developed software are described in relation to the management modules of the most relevant processes, such as customer management, segmentation under RFM (recency, frequency, and monetary), labeling, the personalized text messaging (SMS) system, and operation and logistics management, among others.El comercio informal viene en auge en Colombia (Suramérica), impulsado por la desaceleracióneconómica, el aumento en el desempleo, los incentivos del gobierno en activar el comercio, y la aceleración de plataformas digitales de domicilios como Rappi. Este crecimiento implica para los comercios ajustar sus procesos a las realidades de la dinámica actual y conocer las capacidades necesarias para poder garantizar un crecimiento en ventas y la satisfacción de los clientes. En respuesta a esta necesidad de transformación digital en el comercio, se ha desarrollado FeBePOS, un software para la gestión de emprendimientos que ayuda a tener el control del negocio y a aumentar las ventas. Este caso de estudio se basa en una exploración cualitativa y presentan los resultados de la identificación de las capacidades digitales necesarias para el desarrollo del software, así como para la digitalización y el aumento en las ventas de un comercio. Además, se describen las funcionalidades del software desarrollado con relación a los módulos de gestión de los procesos más relevantes, como lo son la gestión de clientes, la segmentación bajo RFM (recencia, frecuencia y monto) y etiquetados, el sistema de envío de mensajería de texto personalizado (SMS) y la gestión de la operación y logística, entre otros

Estado de salud y barreras en la atención de niños con defectos congénitos nacidos entre el 2011 y el 2017 en dos instituciones de salud de Cali

Introduction: Birth defects affect 2-3% of births contributing an important load to the causes of infant morbidity and mortality during the first five years of life. In Colombia, they are the second cause of infant mortality according to reports from the Departamento Administrativo Nacional de Estadística (DANE) 2011.Objective: To describe the state of health and barriers in the health care of children with congenital defects born between 2011 and 2017 in two institutions of Cali.Materials and methods: We conducted a descriptive cross-sectional observational study. We included babies born between January, 2011, and December, 2017, with at least one congenital defect who were followed up by telephone.Results: Out of 54,193 births during the period, 1,389 (2.56%) newborns had at least one congenital defect. All cases were classified according to the prognostic scale and 881 were included in the follow-up. The most frequent congenital defect was congenital cardiac malformation with 88 cases (9.99%), followed by malformation/defect of the kidney with 73 cases (8.29%), Down syndrome with 72 cases (8.17%), and testicular abnormalities with 56 cases (6.36%). Out of the 454 cases with effective follow-up, 161 (35.46%) of the caregivers stated that they had experienced at least one type of barrier during health care.Conclusion: Follow-up programs should be implemented for patients with birth defects to contribute to reducing morbidity and mortality.Introducción. Los defectos congénitos afectan entre el 2 y el 3 % de los recién nacidos, y son una carga importante entre las causas de morbilidad y mortalidad infantil en los primeros cinco años de vida. En Colombia, fueron la segunda causa de mortalidad infantil según los reportes del Departamento Administrativo Nacional de Estadística (DANE) para el 2011.Objetivo. Describir el estado de salud y las barreras en la atención de niños con defectos congénitos nacidos entre el 2011 y el 2017 en dos instituciones de salud de Cali.Materiales y métodos. Se hizo un estudio observacional descriptivo de corte transversal. Se incluyeron los nacidos entre enero de 2011 y diciembre de 2017 con, al menos, un defecto congénito, a quienes se les hizo seguimiento telefónico.Resultados. De 54.193 nacidos en el período analizado, 1.389 (2,56 %) tenían, por lo menos, un defecto congénito. Todos los casos se clasificaron según la escala de pronóstico y se incluyeron 881 en el seguimiento. El defecto congénito más frecuente fue la malformación congénita cardíaca, con 88 (9,99 %) casos; en segundo lugar, las malformaciones o defectos del riñón, con 73 (8,29 %) casos; en tercer lugar, el síndrome de Down, con 72 (8,17 %) casos, y en cuarto lugar, las anormalidades testiculares, con 56 (6,36 %). Ciento sesenta y uno (35,46 %) de los cuidadores de los 454 casos con seguimiento efectivo, manifestaron haber encontrado, por lo menos, un tipo de barrera en la atención.Conclusión. Se deben implementar programas de seguimiento de los pacientes con defectos congénitos, que contribuyan a disminuir la morbimortalidad

Oxidación alílica de monoterpenos con metaloftalocianinas

Se presentan los resultados de la oxidación alílica de los monoterpenos limoneno y a-pineno usando metaloftalocianinas inmovilizadas en sílica como catalizadores biomiméticos. Se evaluó el efecto del metal en la producción de carvona y verbenona, observándose el siguiente orden de reactividad: Fe > Co> Cr > Mn > Cu. Los mayores rendimientos hacia verbenona, 15 por ciento, se obtuvieron con los catalizadores FePcS-S y CoPcS-

Oxidación alílica de monoterpenos con metaloftalocianinas

Se presentan los resultados de la oxidación alílica de los monoterpenos limoneno y a-pineno usando metaloftalocianinas inmovilizadas en sílica como catalizadores biomiméticos. Se evaluó el efecto del metal en la producción de carvona y verbenona, observándose el siguiente orden de reactividad: Fe > Co> Cr > Mn > Cu. Los mayores rendimientos hacia verbenona, 15 por ciento, se obtuvieron con los catalizadores FePcS-S y CoPcS-

Resistance to antibiotics in Pseudomonas aeruginosa in Colombian hospitals

Q4Artículo original605-610Pseudomonas aeruginosa infections cause high morbidity and mortality. We performed a descriptive analysis of the rates of antibiotic resistance in isolates of P. aeruginosa in 33 hospitals enrolled in a surveillance network in Colombia. The study was conducted between January 2005 and December 2009 .9905 isolates of P. aeruginosa were identified,(4.9 % of all strains). In intensive care units (ICU) P. aeruginosa showed an overall resistance to aztreonam, cefepime , ceftazidime, imipenem, meropenem , and piperacillin / tazobactam of 31.8% , 23.9% , 24.8%, 22.5%, 20.3% and 22.3%, respectively. Resistance rates increased for piperacillin/tazobactam, cefepime, and imipenem; remained unchanged for meropenem; and decreased for aminoglycosides, quinolones and ceftazidime. Resistance to one, two and three or more families of antibiotics was found in 17%, 12.5%, and 32.1%, respectively. In samples collected from the wards, the resistance rate was lower but usually over 10%. Antibiotic resistance in P. aeruginosa isolates in hospitalized patients and particularly in those admitted to ICUs in Colombia is high

MYT1 role in the microtia-craniofacial microsomia spectrum

Q2Background: Craniofacial microsomia (CFM), also known as the oculo-auriculovertebral spectrum, comprises a variable phenotype with the most common features including microtia and mandibular hypoplasia on one or both sides, in addition to lateral oral clefts, epibulbar dermoids, cardiac, vertebral, and renal abnormalities. The etiology of CFM is largely unknown. The MYT1 gene has been reported as a candidate based in mutations found in three unrelated individuals. Additional patients with mutations in this gene are required to establish its causality. We present two individuals with CFM that have rare variants in MYT1 contributing to better understand the genotype and phenotype associated with mutations in this gene. Methods/Results: We conducted genetic analysis using whole-exome and -genome sequencing in 128 trios with CFM. Two novel MYT1 mutations were identified in two participants. Sanger sequencing was used to confirm these mutations. Conclusion: We identified two additional individuals with CFM who carry rare variants in MYT1, further supporting the presumptive role of this gene in the CFM spectrum.N/

Identificación espacial de los sistemas de humedales continentalesde Colombia

Wetlands are considered strategic ecosystems in Colombia. They play an essential role in water regulation, especially in extreme rainfall events or drought as El Nino and La Nina. Despite that, Colombia did not have a national wetland map. The Humboldt Institute, with the Adaptation Fund support and in partnership with Ideam, built the Identification Wetlands Map of Colombia Inland Territory using official information available at 1:100.000 of soils, geomorphology and associated wetland vegetation coverage. Additionally, a flood frequency map obtained from radar satellite images was integrated; it provided information of the spatial and temporal ecosystem dynamics. We identified 30.781.149 hectares of wetlands (26.99% of the national inland area) distributed in the following categories: open or under canopy permanent wetlands, temporary wetlands, and medium and low potential wetlands. The largest category is temporary wetlands with 17.861.536 ha. The thematic map accuracy was performed through 19 windows and 3176 points with a score of 75.79% total accuracy. To deal such magnitude of national wetlands area, it is necessary to develop policies and actions that enable differentiated management and recognize the identity of each wetland category.Los humedales son considerados ecosistemas estratégicos en Colombia y cumplen un papel esencial en la regulación hídrica especialmente en periodos de extrema lluvia o sequía como El Niño y La Niña. Dado que no existía una cartografía nacional de humedales, el Instituto Humboldt con el apoyo del Fondo Adaptación y en asocio con el Ideam, construyó el Mapa de Identificación de Humedales Continentales de Colombia a partir de la información oficial disponible de suelos, geomorfología y coberturas de la tierra asociadas a humedal a escala 1:100.000. Adicionalmente, se integró el mapa de frecuencias de inundación generado con imágenes satelitales de radar para incorporar la dinámica espacial y temporal del ecosistema. En total se identificaron 30.781.149 hectáreas de humedal (26,99 % del área continental nacional) distribuidas en las categorías: a) permanentes abierto o bajo dosel; b) temporales y c) potenciales medio y bajo. Los humedales temporales fueron la categoría con mayor área (17.861.536 ha). La evaluación temática del mapa contó con 3176 puntos en 19 ventanas y arrojó una exactitud total de 75,79 %. Frente a un área nacional de tal magnitud, se hace evidente la necesidad de generar políticas y acciones de manejo diferenciadas que permitan gestionar cada categoría de forma adecuada

Myxoma Virus-Loaded Mesenchymal Stem Cells in Experimental Oncolytic Therapy of Murine Pulmonary Melanoma

Oncolytic viruses can target neoplasms, triggering oncolytic and immune effects. Their delivery to melanoma lesions remains challenging. Bone-marrow-derived mesenchymal stem cells (MSCs) were shown to be permissive for oncolytic myxoma virus (MYXV), allowing its transfer to melanoma cells, leading to their killing. Involvement of progeny virus was demonstrated in the transfer from MSCs to co-cultured melanoma cells. The inhibitory effect of virus on melanoma foci formation in murine lungs was revealed using melanoma cells previously co-cultured with MYXV-infected MSCs. Virus accumulation and persistence in lungs of lesion-bearing mice were shown following intravenous administration of MSC-shielded MYXV construct encoding luciferase. Therapy of experimentally induced lung melanoma in mice with interleukin (IL)-15-carrying MYXV construct delivered by MSCs led to marked regression of lesions and could increase survival. Elevated natural killer (NK) cell percentages in blood indicated robust innate responses against unshielded virus only. Lung infiltration by NK cells was followed by inflow of CD8+ T lymphocytes into melanoma lesions. Elevated expression of genes involved in adaptive immune response following oncolytic treatment was confirmed using RT-qPCR. No adverse pathological effects related to MSC-mediated oncolytic therapy with MYXV were observed. MSCs allow for safe and efficient ferrying of therapeutic MYXV to pulmonary melanoma foci triggering immune effects

Un enfoque ecosistémico para el análisis de una serie densa detiempo de imágenes de radar Alos PALSAR, para el mapeo dezonas inundadas en el territorio continental colombiano

This article describes a methodology for the interpretation and the processing of wide beam Alos PALSAR Images (WB) of HH polarization, for the detection of flooding areas at 100m resolution. Speckle has to be filter as well as other typical radar geometrical distortions need to be corrected before any classification procedures. The physical interactions between the L band radar waves and the land surface allows the detection of open sky flooding and floods under the canopy. The analysis of a time series of 29 radar (WB) mosaics, covering all the continental Colombian territory, allowed the classification of 29 flooding maps, along an observation window of 5 years from 2007 to 2011, comprising years of extreme climatic variations and consecutive El Niño la Niña events, making of this time a good baseline for flooding studies. The interpretation and the processing of the WB radar images is done following and ecosystemic approach that includes the use of a forest structural map for the correction of the flooding detections. The resultant flooding maps are compile in a single flood frequency map, in which every pixel indicates the number of times that the pixel was detected as flooded within the 29 flooding maps. This flood frequency map was used as an input for the evaluation of the wetland map at national level, and for the delineation of wetland ecosystems. The vegetation structural map used for the flooding analysis was also created with radar images but of the fine beam, Alos PALSAR-FB, polarizations (HV) and (HH). The LCCS (Land Cover Classification system) of the FAO was used to describe the structural vegetation types. A validation procedure was applied to both maps following a random stratification method over 19 windows distributed along the National territory.Se describe una metodología para la interpretación y procesamiento de imágenes de radar Alos PALSAR- de banda ancha (WB) y de polarización (HH), para la detección de inundaciones a 100 m de resolución. Los efectos de "sal y pimienta" o speckle pueden ser disminuidos con filtros y las pendientes y otras distorsiones geométricas típicas del radar deben ser corregidas apropiadamente antes de cualquier análisis o clasificación. Las interacciones físicas de las ondas de radar, de banda L, con la superficie terrestre, permiten detectar y clasificar inundaciones a cielo abierto y bajo dosel con gran precisión. El análisis de una serie de tiempo de 29 mosaicos de imágenes de radar (WB) sobre el territorio colombiano, comprendidas entre 2007 y 2011, permitió generar 29 mapas de inundación con observaciones de inundación máxima y mínima, ya que se incluye años climáticos extremos en los que se registraron los fenómenos de El Niño y La Niña, haciendo de esta ventana temporal una muestra representativa o línea base. La interpretación y el procesamiento de las imágenes se hacen utilizando una aproximación ecosistémica que implica el uso de un mapa de estructura de vegetación para la corrección de las detecciones de inundación de radar. Estos se compilan en un mapa único de frecuencias de inundación, en el que cada pixel indica el número de veces que fue detectado como inundado durante el tiempo de observación. Este mapa constituye un insumo para la delineación de humedales y los tipos de humedales. El mapa de estructuras de vegetación utilizado se realizó también usando imágenes de radar Alos PALSAR pero de tipo fino (FB). Se utilizó una leyenda LCCS (Land Cover Classification System) de FAO para la descripción de los tipos estructurales de vegetación. Se realizó una validación para los mapas finales utilizando una aproximación estratificada al azar, en 19 ventanas de estudio repartidas en todo el territorio nacional

Time series analysis of the Alos PALSAR radar data using an ecosystem approach for the detection and mapping of flooded areas in Continental Colombia

This article describes a methodology for the interpretation and the processing of wide beam Alos PALSAR Images (WB) of HH polarization, for the detection of flooding areas at 100m resolution. Speckle has to be filter as well as other typical radar geometrical distortions need to be corrected before any classification procedures. The physical interactions between the L band radar waves and the land surface allows the detection of open sky flooding and floods under the canopy. The analysis of a time series of 29 radar (WB) mosaics, covering all the continental Colombian territory, allowed the classification of 29 flooding maps, along an observation window of 5 years from 2007 to 2011, comprising years of extreme climatic variations and consecutive El Niño la Niña events, making of this time a good baseline for flooding studies. The interpretation and the processing of the WB radar images is done following and ecosystemic approach that includes the use of a forest structural map for the correction of the flooding detections. The resultant flooding maps are compile in a single flood frequency map, in which every pixel indicates the number of times that the pixel was detected as flooded within the 29 flooding maps. This flood frequency map was used as an input for the evaluation of the wetland map at national level, and for the delineation of wetland ecosystems. The vegetation structural map used for the flooding analysis was also created with radar images but of the fine beam, Alos PALSAR-FB, polarizations (HV) and (HH). The LCCS (Land Cover Classification system) of the FAO was used to describe the structural vegetation types. A validation procedure was applied to both maps following a random stratification method over 19 windows distributed along the National territory