Adicion al memorial ajustado... del pleyto que seguian en la camara los beneficiados de catorce parroquias... con el dean y cabildo... sobre la parte de diezmos que habian de percibir los beneficiados de los pueblos llamados Moriscos.

Sign.: [], A, B-I2.Texto por: Gonzalo Joseph de Vilches...[et al.]Copia digital : Diputación de Málaga. Biblioteca Canovas del Castillo, 201

Actin cytoskeletal organization in human osteoblasts grown on different dental titanium implant surfaces

The understanding of the cellular basis of osteoblastic cell-biomaterial interaction is crucial to the analysis of the mechanism of osseointegration. Cell adhesion is a complex process that is dependent on the cell types and on the surface microtopography and chemistry of the substrate. We have studied the role of microtopography in modulating cell adhesion, in vitro, using a human osteoblastic cell line for the assessment of actin cytoskeletal organization. Through application of CLSM combining reflection and fluorescence, 2D or 3D images of cytoskeleton were obtained. On smooth surfaces, Ti CP machined, predominantly planar bone cells with an axial ratio of 1.1 were randomly oriented, with stress fibers running in all directions, and thin filopodia. On T iCP Osseotite ® surfaces the osteoblastic cells conformed to the irregular terrain of the sustrate with focal adhesion sites only established on the relative topographical peaks separated for a longer distance than in the machined surface, and defined wide lamellopodia and long filopodia, with enhanced expression of stress fibers, forming large clear focal contacts with the rough surface. The cytoskeletal organization of cells cultured on rough titanium supports an active role for the biomaterial surface in the events that govern osteoblastic cell adhesion. The results enforce the role of the rough sustrate surface in affecting osteoblastic cell adhesion and provide valuable information for the design of material surfaces that are required for the development of an appropriate osteogenic surface for osteoblastic anchorage, compared to machined surface, in dental implants

Mitochondrial bioenergetics and distribution in living human osteoblasts grown on implant surfaces

Osseointegration of implants is crucial for the long-term success of oral implants. The periimplant bone formation by osteoblasts is strongly dependent on the local mechanical environment in the interface zone. Robust demands for energy are placed on osteoblasts during the adhesion process to solid surfaces, and mitochondria are capital organelles in the production of most of the ATP needed for the process. We have assessed the relationship between osteoblast differentiation and mitochondrial bioenergetics in living cells grown on two different titanium surfaces, in order to provide valuable information for the design of material surfaces required for the development of the most appropriate osteogenic surface for osteoblastic anchorage. Combined backscattered and fluorescence confocal microscopy showed that in flat cells grown on a machined surface, highly energized mitochondria were distributed along the cell body. In contrast, cells grown on the rough surface emitted long protrusions in search of surface roughness, with actin stress fibers clearly polarized and highly energized mitochondria clustered at focal adhesion sites. This report using normal human osteoblastic cells indicates that these cells are especially sensitive to surface cues through energy production that enhances the necessary adhesion required for a successful osseointegration

Structural aspects of the non-uniformly continuous functions and the unbounded functions within C(X)

We prove in this paper that if a metric space supports a real continuous function which is not uniformly continuous then, under appropriate mild assumptions, there exists in fact a plethora of such functions, in both topological and algebraical senses. Corresponding results are also obtained concerning unbounded continuous functions on a non-compact metrizable space.Plan Andaluz de Investigación (Junta de Andalucía)Ministerio de Economía y Competitividad (MINECO). Españ

Editorial: En el ecuador de la década de la educación por un futuro sostenible: ¿qué estamos haciendo y qué nos proponemos hacer?

EDITORIALEN EL ECUADOR DE LA DÉCADA DE LA EDUCACIÓN POR UNFUTURO SOSTENIBLE: ¿QUÉ ESTAMOS HACIENDO Y QUÉ NOSPROPONEMOS HACER