Dor cervical e distúrbio do sistema visual: qual a relação?

Continuous use of digital devices without rest periods makes individuals more vulnerable to oculomotor disorders. These dysfunctions can lead to adaptive cervical postural changes. It was proposed here to evaluate the correlation between convergence insufficiency, visual attention and neck pain. Fourteen college students with neck pain and 14 without neck pain were evaluated in terms of convergence insufficiency, visual attention and neck mobility. There was difference between the groups in the Royal Air Force (p=0.03), in the Convergence Insufficiency Symptom Survey (p=0.01) and in the flexion (p=0.016) and right and left neck tilt movements (p= 0 .14) and (p=0.28). There was no difference in time and performance of the bell cancellation test (p=0.17). The group with neck pain showed signs of convergence insufficiency with a point close to convergence above the normal value of 10 centimeters and a high score in the Convergence Insufficiency Symptom Survey. The group without neck pain performed within normal limits. Although the sample was of convenience and the individuals only performed clinical evaluations, the results are promising in demonstrating the presence of convergence insufficiency in the group with neck pain.O uso contínuo de dispositivos digitais sem períodos de descanso torna os indivíduos mais vulneráveis às disfunções oculomotoras. Estas disfunções podem levar a alterações posturais cervicais adaptativas. Propôs se aqui avaliar a correlação entre insuficiência de convergência, atenção visual e cervicalgia. Foram avaliados 14 universitários com cervicalgia e 14 sem dor cervical em relação a insuficiência de convergência, atenção visual e mobilidade cervical. Houve diferença entre os grupos no Royal Air Force (p=0,03), no Convergence Insufficiency Symptom Survey (p=0,01) e nos movimentos de flexão (p=0,016) e de inclinação cervical direita e esquerda (p= 0,14) e (p=0,28). Não houve diferença no tempo e desempenho do teste de cancelamento dos sinos (p=0,17). O grupo com cervicalgia demonstrou sinais de insuficiência de convergência com ponto próximo de convergência acima do valor de normalidade de 10 centímetros e escore alto no Convergence Insufficiency Symptom Survey. O grupo sem cervicalgia apresentou desempenho dentro dos padrões de normalidade. Embora a amostra seja de conveniência e os indivíduos tenham realizado apenas avaliações clínicas, os resultados são promissores ao demonstrarem a presença de insuficiência de convergência no grupo com dor cervical

Physicochemical analysis, consumer profile and sensory analysis of goat Coalho cheeses seasoned with alcoholic beverages / Análise fisico-química, perfil de consumidor e análise sensorial de queijos de coalho de cabra condimentados com bebidas alcoólicas

The present study sought to characterize the physicochemical, bacteriological and sensorial effects that alcoholic beverages exert on goat Coalho cheese. For that, goat Coalho cheeses were seasoned with alcoholic beverages and physicochemical and bacteriological analyses were performed on day 0, as well as sensory analysis. The potential consumers were expected to be slightly familiar with goat dairy products. Among the seasoned cheeses, goat Coalho cheese with beer had the best acceptability and purchase intention, a result that is associated with the typical consumption of such alcoholic beverage by potential consumers. Soft and white characteristics were the most emphasized by taste testers, what is in agreement with the instrumental color and texture. According to the principal component analysis (PCA), acid and alcoholic aromas and taste were the characteristics responsible for acceptability. Therefore, it is concluded that goat cheese with alcoholic beverages can be elaborated and have good acceptability

Effect of the triiodothyronine (T3) and the thyroid receptor beta selective agonist GC-24 upon rat skeletal muscle trophism: expression of proteasome-dependent genes.

O objetivo deste estudo foi investigar os efeitos do T3 e do seu análogo GC-24, agonista TRb seletivo, na proteólise muscular mediada pela via ubiquitina-proteassoma. Avaliamos o efeito do T3 e GC-24 no trofismo radial de fibras musculares, no nível de ubiquitinação e na expressão de genes envolvidos na via ubiquitina-proteassoma. Para tanto foram utilizados, ratos Wistar divididos em 4 grupos (Controle, 12 horas, 1 e 7 dias) e tratados com T3 e GC-24. Determinou-se a área de secção transversa dos cortes histológicos através do programa \"Image Pro-Plus\". O nível de ubiquitinação foi determinado através de Western Blot para proteína ubiquitinada e a expressão gênica por PCR em Tempo real. T3 e GC-24 promoveram redução do diâmetro das fibras musculares e aumentaram o nível de proteínas ubiquitinadas em ambos os músculos. Com relação à expressão gênica, T3 e GC-24 modularam a expressão dos genes analisados de maneira diferenciada, demonstrando que GC-24 é capaz de modular genes pouco ou não responsivos ao T3.Triiodothyronine (T3) is known to play a key role in the function of several tissues/organs via the thyroid hormone receptor isoforms a/pha (TRa) and beta (TRI3). Abnormalities in skeletal muscle function have been associated with increased leveis of T3, which is a major sarcopenia (Ioss of sarcomeres). Although the phenomenon of sarcopenia induced by T3 has been widely reported, little is known about the molecular mechanisms invo/ved in proteolysis induced by T3. In this study we have investigated the effects of T3 and GC-24, a novel synthetic TRI3¬selective compound, on the ubiquitin proteasome pathway. We analyzed the effect of T3 and GC-24 on the radial trophism, ubiquitination leveis and gene expression of the ubiquitin-proteasome pathway, which are important regulators of muscle proteolysis in the skeletal muscle. We have addressed the ubiquitin ligases (Atrogin¬1, MuRF-1 and E3a) and the deubiquitinating enzymes (UBP45, UBP69 and USP28). Wistar male rats (170-200g) were divided in 4 groups (Control, 12, 1 and 7 days). Rats received T3 (30l-\'g/100g) and GC-24 (16 I-\'g/1 OOg). After decapitation, EDL and soleus muscles were removed for histological ana/ysis, protein expression and gene expression. Cross sectional area was determined in histological sections through the software \"Image-Pro Plus. The ubiquitination leveis was determined by Western Blot and gene expression determined by Real Time PCR analysis. T3 and GC-24 reduced the diameter of the muscle fibers vs control group. Both T3 and GC-24 incresed the ubiquitination leveis, in the soleus and EDL. Regarding gene expression analysis, T3 and GC-24 modulate the gene expression in a differential manner. In the soleus, T3 increased Atrogin-1 and E3 alpha gene expression, while did not alter Murf-1 gene expression. On the other hand, in EDL Atrogin-1 gene expression is not altered, while E3 alpha and Murf-1 are elevated by T3. In the soleus and EDL deubiquitinating gene expression is mostly not altered, exception made for UBP 45, which is reduced by T3 in soleus muscle. GC-24, increased gene expression of E3a and MuRF-1 in the soleus, while did not alter Atrogin-1 gene expression. However, in EDL muscle, GC-24 increased Atrogin-1 and E3a mRNA, while did not alter MuRF-1. Finally, GC-24 decreased UBP 45 gene expression in EDL muscle and USP 28 gene expression was robustly elevated by GC-24 in both muscles analyzed. This data shows that GC-24 is able to strongly modulate genes that are less responsive or even unresponsive to T3, pointing that the GC-24-TRb complex might trans-activate differently target genes. However, both T3 and GC-24 are able to modulate the muscle proteolysis

Chronic axillary web syndrome: 83 months post lumpectomy-A Case report

Introduction: Axillary Web Syndrome (AWS) is well described until 3 months postoperative breast cancer surgery.&nbsp;Methods: We report a case of a 47 years old patient that arrived our rehabilitation service with pain and limited shoulder range of movement in the ipsilateral side of a breast cancer surgery.&nbsp;Results: An Axillary Web Syndrome was diagnosed 83 months after the surgery.&nbsp;Conclusion: It is important to mention that AWS might persist for a long time and also affect patients a long time after the surgery.</p

Triagem sorológica e influência do conhecimento sobre a dengue em pacientes do ambulatório de especialidades do SUS Serological screening and the influence of dengue awareness on patients from SUS specialty laboratory

INTRODUÇÃO: A dengue é causa de preocupação em países como o Brasil. OBJETIVO: Verificar a soropositividade dos pacientes do ambulatório de especialidades do Sistema Único de Saúde (SUS) para anticorpos antidengue, relacionando os resultados com os dados sociodemográficos. METODOLOGIA: Foram respondidos 184 questionários de avaliação sociodemográfica e de conhecimento sobre a transmissão da dengue. Foi utilizado o método de imunoensaio enzimático (ELISA) para pesquisar imunoglobulina da classe M (IgM) e da classe G (IgG) contra os vírus. RESULTADOS: Quinze por cento dos pacientes apresentaram IgG contra o vírus, sem a presença de IgM. CONCLUSÃO: Os pacientes demonstraram conhecimento sobre a doença e sua prevenção, independentemente da classe econômica. A infecção assintomática deve ser avaliada, principalmente nos casos de doença febril.<br>INTRODUCTION: Dengue is a public health problem in Brazil and worldwide. OBJECTIVE: To determine dengue seropositivity of patients from SUS specialty laboratory by correlating the results with socio-demographic data. METHODS: One hundred and eighty-four questionnaires on socio-demographic assessment and dengue transmission awareness were filled out. Enzyme linked immunosorbent assay (ELISA) method was performed for the detection of IgM and IgG antibodies against dengue virus. RESULTS: Fifteen percent of patients had IgG against dengue virus without the presence of IgM. CONCLUSION: All patients showed disease and prevention awareness regardless of their socio-economic background. The asymptomatic infection must be evaluated mainly in cases of disease with fever

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data