RP-HPLC method development and validation for the estimation of antifungal drug terbinafine HCL in bulk and pharmaceutical dosage form

In the present work RP-HPLC method has been developed for the quantitative estimation of Terbinafine hydrochloride in bulk drug and pharmaceutical formulations. A rapid and sensitive RP-HPLC Method with PDA detection (220 nm) for routine analysis of in Bulk drug and Pharmaceutical formulation was developed. Chromatography was performed with mobile phase containing a mixture of Potassium dihydrogen phosphate and Acetonitrile (65:35 v/v) with flow rate 1.5 ml/min. The linearity was found to be in the range of 50-150 µg/ml with (r2=0.999). The proposed method was validated by determining sensitivity, accuracy, precision, LOD, LOQ and system suitability parameters according to ICH guidrelines

Effect of tapered roller bearing supports on the dynamic behaviour of hypoid gear pair differentials

Noise and vibration refinement and energy efficiency are the key drivers in powertrain development. The final drive (the differential) is a source of vibration concern and also contributes to the powertrain inefficiency. To optimise differential characteristics for the key objectives of refinement and efficiency, detailed models of the gear interactions as well as the support bearing dynamics are required. This study reports the integrated lubricated bearing and gear contacts with an eight-degree-of-freedom dynamic analysis (a tribo-dynamic model). Non-Newtonian shear behaviour of thin lubricant-film conjunctions is taken into account in the integrated tribo-dynamic analysis, which has not hitherto been reported in the literature. The results show that the transmitted vibration spectra from the system onto the differential casing are dominated by the bearing frequencies rather than by those due to the meshing of gears. It is also shown that a sufficiently high bearing preload improves the vibration refinement but can lead to a marginally reduced transmission efficiency

Advanced model for the calculation of meshing forces in spur gear planetary transmissions

This paper presents a planar spur gear planetary transmission model, describing in great detail aspects such as the geometric definition of geometric overlaps and the contact forces calculation, thus facilitating the reproducibility of results by fellow researchers. The planetary model is based on a mesh model already used by the authors in the study of external gear ordinary transmissions. The model has been improved and extended to allow for the internal meshing simulation, taking into consideration three possible contact scenarios: involute–involute contact, and two types of involute-tip rounding arc contact. The 6 degrees of freedom system solved for a single couple of gears has been expanded to 6 + 3n degrees of freedom for a planetary transmission with n planets. Furthermore, the coupling of deformations through the gear bodies’ flexibility has been also implemented and assessed. A step-by-step integration of the planetary is presented, using two typical configurations, demonstrating the model capability for transmission simulation of a planetary with distinct pressure angles on each mesh. The model is also put to the test with the simulation of the transmission error of a real transmission system, including the effect of different levels of external torque. The model is assessed by means of quasi-static analyses, and the meshing stiffness values are compared with those provided by the literature.The authors would like to acknowledge Project DPI2013-44860 funded by the Spanish Ministry of Science and Technology

Nonlinear time-varying dynamic analysis of a spiral bevel geared system

In this paper, a nonlinear time-varying dynamic model of a drivetrain composed of a spiral bevel gear pair, shafts and bearings is developed. Gear shafts are modeled by utilizing Timoshenko beam finite elements, and the mesh model of a spiral bevel gear pair is used to couple them. The dynamic model includes the flexibilities of shaft bearings as well. Gear backlash and time variation of mesh stiffness are incorporated into the dynamic model. Clearance nonlinearity of bearings is assumed to be negligible, which is valid for preloaded rolling element bearings. Furthermore, stiffness fluctuations of bearings are disregarded. Multi-term harmonic balance method (HBM) is applied on the system of nonlinear differential equations in order to obtain a system of nonlinear algebraic equations. Utilizing receptance method, system of nonlinear algebraic equations is grouped in nonlinear and linear sets of algebraic equations where the nonlinear set can be solved alone decreasing the number of equations to be solved significantly. This reduces the computational effort drastically which makes it possible to use finite element models for gear shafts. In the calculation of Fourier coefficients, continuous-time Fourier transform as opposed to the gear dynamics studies that utilize discrete Fourier Transform is used. Thus, convergence problems that arise when the number of nonlinear DOFs is large are avoided. Moreover, analytical integration is employed for the calculation of Fourier coefficients rather than numerical integration in order to further reduce the computational time required. Nonlinear algebraic equations obtained are solved by utilizing Newton's method with arc-length continuation. Direct numerical integration is employed to verify the solutions obtained by HBM. Several case studies are carried out, and the influence of backlash amount, fluctuation of gear mesh stiffness and variation of bearing stiffness are investigated. In addition to these, the response of the coupled gear system model is compared with that of gear torsional model in order to study the influence of the coupling on dynamics of the system

Non-Newtonian mixed elastohydrodynamics of differential hypoid gears at high loads

Prediction of friction and transmission efficiency are design objectives in transmission engineering. Unlike spur and helical involute gears, there is a dearth of numerical analysis in the case of hypoid gear pairs. In particular, it is important to take into account the side leakage of the lubricant from the contact as the result of the lubricant entrainment at an angle to the elliptical contact footprint. In the automobile differential hypoid gears, high loads result in non-Newtonian behaviour of the lubricant, which may exceed its limiting shear stress, a fact which has not been taken into account in the open literature. This results in conditions which deviate from observed experimental tractive behaviour. The paper takes into account these salient practical features of hypoid gear pair analysis under high load. It highlights a non-Newtonian shear model, which limits the lubricant shear behaviour. Prediction of friction and transmission efficiency is in line with those reported in the literature