518 research outputs found
Análisis de los factores de riesgo de efectos adversos oncológicos en la cirugía del cáncer de recto
Este estudio analiza una serie de variables demográficas, preoperatorias,
quirúrgicas y anatomopatológicas en pacientes diagnosticados de
cáncer de recto intervenidos con intención curativa, con el objetivo
principal de conocer su influencia en la recurrencia locorregional y a
distancia y en la supervivencia global y libre de enfermedad.
Como segundo objetivo hemos planteado valorar la capacidad
pronóstica de la estadificación ganglionar del sistema TNM
comparandola con otros sistemas como el Cociente Ganglionar
Linfático (CGL) y el Logaritmo de Ganglios Linfáticos Positivos
(LODDS).
Diversas variables resultaron ser factores pronósticos independientes de
una evolución oncológica desfavorable. El LODDS proporciona un
valor predictivo más preciso en los pacientes con ganglios negativos que
los sistemas TNM y CGL
Evolution of Surgical Management of Hemorrhoidal Disease: An Historical Overview
Enfermedad hemorroidal; Terapias quirúrgicasMalaltia hemorroidal; Teràpies quirúrgiquesHemorrhoidal disease; Surgical therapiesHemorrhoidal disease (HD) is the symptomatic enlargement and/or distal displacement of the normal hemorrhoidal cushions and is one of the most frequent diseases in colorectal surgery. Several surgical or office-based therapies are currently available, with the aim of being a more tailored approach. This article aimed to elucidate the historical evolution of surgical therapy for HD from ancient times, highlighting the crucial steps, controversies, and pioneers in the field. In contrast with the previous literature on the topic that is often updated to the 1990s, with the introduction of stapled hemorrhoidopexy and transanal hemorrhoidal dearterialization, this article describes all new surgical and office-based treatments introduced in the first 20 years of the 2000s
The characterization of Thermotoga maritima Arginine Binding Protein variants demonstrates that minimal local strains have an important impact on protein stability
The Ramachandran plot is a versatile and valuable tool that provides fundamental information for protein structure determination, prediction, and validation. The structural/thermodynamic effects produced by forcing a residue to adopt a conformation predicted to be forbidden were here explored using Thermotoga maritima Arginine Binding Protein (TmArgBP) as model. Specifically, we mutated TmArgBP Gly52 that assumes a conformation believed to be strictly disallowed for non-Gly residues. Surprisingly, the crystallographic characterization of Gly52Ala TmArgBP indicates that the structural context forces the residue to adopt a non-canonical conformation never observed in any of the high-medium resolution PDB structures. Interestingly, the inspection of this high resolution structure demonstrates that only minor alterations occur. Nevertheless, experiments indicate that Gly52 replacements in TmArgBP produce destabilizations comparable to those observed upon protein truncation or dissection in domains. Notably, we show that force-fields commonly used in computational biology do not reproduce this non-canonical state. Using TmArgBP as model system we here demonstrate that the structural context may force residues to adopt conformations believed to be strictly forbidden and that barely detectable alterations produce major destabilizations. Present findings highlight the role of subtle strains in governing protein stability. A full understanding of these phenomena is essential for an exhaustive comprehension of the factors regulating protein structures
9-Fluorenon-4-carboxamides: Synthesis, conformational analysis, anti-HSV-2, and immunomodulatory evaluation. Note II
n/
Evolution of Surgical Management of Hemorrhoidal Disease: An Historical Overview
Hemorrhoidal disease (HD) is the symptomatic enlargement and/or distal displacement of the normal hemorrhoidal cushions and is one of the most frequent diseases in colorectal surgery. Several surgical or office-based therapies are currently available, with the aim of being a more tailored approach. This article aimed to elucidate the historical evolution of surgical therapy for HD from ancient times, highlighting the crucial steps, controversies, and pioneers in the field. In contrast with the previous literature on the topic that is often updated to the 1990s, with the introduction of stapled hemorrhoidopexy and transanal hemorrhoidal dearterialization, this article describes all new surgical and office-based treatments introduced in the first 20 years of the 2000s
Methyl (Z)-2-[(2,4-dioxothiazolidin-3-yl)methyl]-3-(2-methylphenyl)prop-2-enoate
The C=C bond in the title compound, C15H15NO4S, has a Z configuration. The thiazolidine ring is essentially planar [maximum deviation = 0.008 (1) Å for the N atom] and is oriented at a dihedral angle of 59.1 (1)° with respect to the benzene ring. In the crystal, pairs of C—H⋯O hydrogen bonds link centrosymmetrically related molecules into dimers, generating R
2
2(18) ring motifs. The crystal packing is further stabilized by C—H⋯π and C—O⋯π [O⋯centroid = 3.412 (2) Å and C—O⋯centroid = 115.0 (1)°] interactions
Osteoid osteoma of the femoral head treated by radiofrequency ablation: a case report
<p>Abstract</p> <p>Introduction</p> <p>We present a case report highlighting the unusual location and atypical imaging characteristics of an osteoid osteoma in the juxta-articular region of the femoral head, and treatment of the condition with radiofrequency ablation. This treatment option is low in both risk and morbidity and is therefore the best option in lesions that are difficult to access surgically because of the risks involved.</p> <p>Case presentation</p> <p>A 40-year-old Indian man from West Bengal presented to our facility with a history of progressively severe left hip pain of insidious onset, requiring analgesics. Imaging with plain radiographs, computed tomography and magnetic resonance imaging confirmed findings of osteoid osteoma in a subarticular location in the femoral head, although imaging features were atypical due to the intra-articular subchondral location.</p> <p>Conclusion</p> <p>Radiofrequency ablation is a newer treatment modality for osteoid osteoma that, being minimally invasive, offers comparable results to surgery with a significantly lower morbidity. To the best of our knowledge, treatment of osteoid osteoma in the foveal region of the femoral head with radiofrequency ablation has not been reported to date. We wish to highlight the successful outcome in our index case using this technique.</p
Methyl (2E)-2-[(2,4-dioxo-1,3-thiazolidin-3-yl)methyl]-3-phenylprop-2-enoate
In the title compound, C14H13NO4S, the thiazolidine ring is essentially planar [maximum deviation = 0.010 (2) Å for the carbonyl C atom between the N and S atoms] and is oriented at a dihedral angle of 60.1 (1)° with respect to the benzene ring. In the crystal, molecules are linked into zigzag chains running along the c axis by C—H⋯O hydrogen bonds. The crystal packing is further stabilized by C—H⋯π interactions involving the benzene ring
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