Lumbar Malignant Peripheral Nerve Sheath Tumor in a Young Dog

Background: The most common location of malignant tumors of the peripheral nerve sheath in the spinal cord is the intradural-extramedullary region, and is rare in the spinal nerve roots in the lumbar region. They mainly affect large female dogs over six years of age. Imaging tests assist in the presumptive diagnosis, but confirmation requires histopathological and immunohistochemical examination. The prognosis is guarded. Diagnostic imaging, anatomopathological and immunohistochemical findings of a malignant tumor of the intradural-extramedullary peripheral nerve sheath with medullary infiltration in the lumbar region in a young dog are reported.Case: A body of a 6-year-old Poodle dog was donated for necropsy and diagnostic clarification. In the history, there was a suspicion of lumbar intramedullary neoplasia, detected by computed tomography (CT), with a 4 years progressive chronic evolution. Additionally, the dog had hidden spina bifida (L7 to S3), as detected by radiography and CT. On post mortem radiographic examination (X-ray), there was an enlargement of the vertebral canal (T10 to S2), intense osteolysis (L1 to S2), spinous processes (L5 to L7), and ankylosis (L3 to L7). Necropsy revealed ankylosis (L3 to L7) and intradural-extramedullary mass (9.5 × 2.6 × 2.3 cm) (L2 to L6). No metastases were identified. On microscopy, there was neoplastic proliferation of cells with intense pleomorphism, arranged in bundles interlaced in palisades and sometimes solid mantles. The mitotic index was high, ranging from 10 to 12 mitoses per field. There was also necrosis, hemorrhage, edema, and focal axonal demyelination of the adjacent white matter in the spinal cord. Masson Trichrome staining highlighted an intense diffuse conjunctive stroma. There was a suspicion of a malignant tumor of the peripheral nerve sheath and an immunohistochemical panel was performed for confirmation. There was strong and diffuse positivity for vimentin and S-100 and partial positivity for neuron-specific enolase (NSE), negative for anti-factor VIII, glial fibrillary acidic protein (GFAP), α-actin for smooth muscle, cytokeratin, neurofilament, and desmin. Thus, the diagnosis of malignant neoplasm of the peripheral nerve sheath was confirmed.Discussion: Peripheral nerve sheath tumors are classified as benign or malignant. In dogs, they are frequent in elderly, females, and large breeds. In this case report, the animal was young, female, and small breed. The location of the spinal nerve roots is uncommon, and is more commonly found in the brachial plexus. In the animal reported, the tumor was observed as lumbar swelling. Clinical signs vary with the affected region, however, neurogenic claudication and muscle atrophy are more frequent, as observed in this report. Imaging examinations such as X-rays and CT assist in the presumptive diagnosis. In this case report, spina bifida was identified on radiography, and CT suggested the presence of intramedullary neoplasia and allowed to monitor tumor growth. Post mortem X-ray imaging revealed intense osteolysis and ankylosis, which were confirmed at necropsy, which also elucidated its intradural-extramedullary location with infiltration into the spinal cord. The confirmation of the neoplasm was made by histopathological and immunohistochemical examination; the latter should be made a panel, not restricted to the use of antibodies S-100 and vimentin only. The prognosis of malignant peripheral nerve sheath tumors (MPNST) of the spinal cord is poor, and although there are palliative methods, there is no curative treatment, as complications can interfere with the quality of life of the animal. MPNST should be included in the differential diagnosis of spinal disorders, even in young dogs and small breeds. CT helps in early diagnosis to make decisions aimed at the animal's well-being

Consensus for the diagnosis, prognosis and treatment of feline mammary tumors

Mammary neoplasms are described as the third most common type of feline tumor, after haematopoietic and skin tumors, and present a challenge for clinicians because the prognosis for feline mammary tumors ranges from guarded to poor. Thus, it is necessary to define new therapeutic approaches and establish more in-depth knowledge about this disease in felines. The main aspects of the diagnosis, prognosis and treatment of feline mammary neoplasia were discussed, aiming to standardize the criteria and to serve as a guide for pathologists and veterinary clinicians.As neoplasias mamárias são descritas como o terceiro tipo mais frequente de tumor em felinos (após as neoplasias hematopoiéticas e cutâneas) e apresentam um desafio para os clínicos devido ao prognóstico, que varia de reservado a ruim. Assim, é necessário conhecer melhor essa doença em felinos e definir novas abordagens terapêuticas. Discutiu-se os principais aspectos de diagnóstico, prognóstico e tratamento da neoplasia mamária felina, com o objetivo de padronizar os critérios e servir de guia para patologistas e clínicos veterinários

Cistoadenocarcinoma biliar em felino - Relato de caso

Neoplasias hepatobiliares primárias são consideradas raras em felinos, representando apenas 3,0% do total de neoplasias nesta espécie. O cistoadenocarcinoma biliar é uma neoplasia epitelial maligna, descrita em humanos, sendo considerado um tumor incomum. O presente estudo objetivou relatar um caso de cistoadenocarcinoma biliar em felino, racialmente indefinido, macho, com nove anos de idade, com histórico clínico de apatia, anorexia, emese e icterícia. Na necropsia, foram observados múltiplos nódulos brancacentos e de aspecto umbilicado em lobos hepáticos, distribuídos multifocalmente, associados a lesões semelhantes nos pulmões, linfonodos mesentéricos, omento e peritônio. O exame histopatológico dos nódulos hepáticos e das lesões nos demais órgãos relatados evidenciou proliferação neoplásica de crescimento infiltrativo, formada por ductos biliares dilatados com projeções papilares intraluminais, revestidas por células epiteliais pleomórficas. Com base nos achados macro e microscópicos foi firmado o diagnóstico de cistoadenocarcinoma biliar com metástases para linfonodo, pulmão, omento e peritônio

Quimioterapia convencional e metronômica no tratamento de cadela com carcinoma em tumor misto em estadio avançado - Relato de caso

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-06-08T14:01:57Z No. of bitstreams: 1 Santos KC Quimioterapia convencional....pdf: 3128467 bytes, checksum: 6f18aa744c9f6325f1279a5f6acdc882 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-06-08T14:16:34Z (GMT) No. of bitstreams: 1 Santos KC Quimioterapia convencional....pdf: 3128467 bytes, checksum: 6f18aa744c9f6325f1279a5f6acdc882 (MD5)Made available in DSpace on 2018-06-08T14:16:34Z (GMT). No. of bitstreams: 1 Santos KC Quimioterapia convencional....pdf: 3128467 bytes, checksum: 6f18aa744c9f6325f1279a5f6acdc882 (MD5) Previous issue date: 2016Universidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Pós-Graduação Ciência Animal nos Trópicos. Salvador, BA, BrasilHospital Veterinário SEMEVE. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Medicina Veterinária. Aracaju, SE, BrasilUniversidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Pós-Graduação Ciência Animal nos Trópicos. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Pós-Graduação Ciência Animal nos Trópicos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Departamento de Anatomia, Patologia e Clínicas Veterinárias. Salvador, BA, BrasilUniversidade Federal da Bahia. Escola de Medicina Veterinária e Zootecnia. Pós-Graduação Ciência Animal nos Trópicos. Salvador, BA, BrasilCanine mammary tumors are frequent in veterinary medical routine, leading to death due to high malignancy rate. Different chemotherapy modalities show large potential on treatment of mammary tumors, mainly improving quality of life. The objective of this report was present and discuss a conventional and metronomic chemotherapy in treatment of advanced stage of canine carcinoma in mixed tumor in femele dog with nine in canine female, nine years old, SRD, attended at the Veterinary Medicine Hospital of the Universidade Federal da Bahia. For this, were described in detail the data of clinical, anatomical and histological, Immune-histochemical and therapeutic therapeutic reports. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. So, metronomic chemotherapy has been shown excellent results, probably due to control of angiogenesis. Necroscopic and tomography findings were similars. This work also highlights the importance of a long time clinical monitoring of oncologic patients after surgery, in order to detect distant metastasis earlier

GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors

Introduction: The transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer. Canine mammary tumours, proposed as comparative and translational study models, have epidemiological, clinical, biological, and genetic characteristics similar to those of human breast cancers. Methods: Here, we evaluated the frequency of GATA-3 expression in mammary tumors of dogs and its relationship with prognostic factors and survival. Tumor samples were obtained from 40 female dogs and grouped according to histological type into benign tumors (n = 10), carcinoma in mixed tumors (CMTs) (n = 20), and aggressive tumors (n = 10). CMTs were further separated according to histological grade, and data on clinical staging and diagnosis, histopathological grading, and survival rate were collected. Results: GATA-3 and estrogen receptor (ER) expression were higher in benign and well-differentiated carcinomas than in aggressive tumors, which showed greater Ki-67 expression. The expression rate of ER in the studied groups was equivalent to that of GATA-3. We identified a strong positive correlation between GATA-3 and ER expression frequencies and a negative correlation between those of GATA-3 and Ki-67. There were associations between GATA-3 (p = 79.4% of cells had significantly higher survival rates (p = 79.4% of cells effectively predicted survival or death in dogs with mammary tumors. Collectively, these results suggest that GATA-3 can be a relevant marker in the study of mammary tumor progression and has potential as a prognosis marker for predicting outcomes in canine mammary tumors.Peer reviewe

Consenso para o diagnóstico, prognóstico e tratamento de tumores mamários em felinos

Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2018-10-23T17:29:03Z No. of bitstreams: 1 Cassali D Consensus for the diagn...2018.pdf: 2217674 bytes, checksum: 6d83d03e193fac360ceab673080a29a7 (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2018-10-23T18:20:46Z (GMT) No. of bitstreams: 1 Cassali D Consensus for the diagn...2018.pdf: 2217674 bytes, checksum: 6d83d03e193fac360ceab673080a29a7 (MD5)Made available in DSpace on 2018-10-23T18:20:46Z (GMT). No. of bitstreams: 1 Cassali D Consensus for the diagn...2018.pdf: 2217674 bytes, checksum: 6d83d03e193fac360ceab673080a29a7 (MD5) Previous issue date: 2018Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Mayo Clinic. Division of Hematology and Oncology. Scottsdale, AZ, USA.Instituto de Pesquisas Veterinárias Desidério Finamor. Secretaria da Agricultura, Pecuária e Irrigação. Departamento de Diagnóstico e Pesquisa Agropecuária. Eldorado do Sul, RS, Brasil.Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Patologia e Clínica. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Escola de Veterinária. Hospital Veterinário. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Estadual Paulista. Faculdade de Ciências Agrárias e Veterinárias. Departamento de Clínica e Cirurgia. Jaboticabal, SP, Brasil.Universidade de São Paulo. Faculdade de Medicina Veterinária e Zootecnia. Departamento de Patologia. São Paulo, SP, Brasil.Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária. Departamento de Medicina Animal. Porto Alegre, RS, Brasil.Onco Cane Clínica Veterinária. São Paulo, SP, Brasil.Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil.Universidade Federal de Pelotas. Faculdade de Veterinária. Departamento de Patologia Animal. Laboratório Regional de Diagnóstico. Pelotas, RS, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Universidade Federal do Espírito Santo. Centro Biomédico. Vitória, ES, Brasil.Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Patologia e Clínica. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Patologia e Clínica. Salvador, BA, Brasil.Universidade Federal da Bahia. Escola de Medicina Veterinária. Departamento de Patologia e Clínica. Salvador, BA, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil / Instituto de Pesquisas Veterinárias Desidério Finamor. Secretaria da Agricultura, Pecuária e Irrigação. Departamento de Diagnóstico e Pesquisa Agropecuária. Eldorado do Sul, RS, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Laboratório de Patologia Comparada. Belo Horizonte, MG, Brasil.As neoplasias mamárias são descritas como o terceiro tipo mais frequente de tumor em felinos (após as neoplasias hematopoiéticas e cutâneas) e apresentam um desafio para os clínicos devido ao prognóstico, que varia de reservado a ruim. Assim, é necessário conhecer melhor essa doença em felinos e definir novas abordagens terapêuticas. Discutiuse os principais aspectos de diagnóstico, prognóstico e tratamento da neoplasia mamária felina, com o objetivo de padronizar os critérios e servir de guia para patologistas e clínicos veterinários.Mammary neoplasms are described as the third most common type of feline tumor, after haematopoietic and skin tumors, and present a challenge for clinicians because the prognosis for feline mammary tumors ranges from guarded to poor. Thus, it is necessary to define new therapeutic approaches and establish more in-depth knowledge about this disease in felines. The main aspects of the diagnosis, prognosis and treatment of feline mammary neoplasia were discussed, aiming to standardize the criteria and to serve as a guide for pathologists and veterinary clinicians

Resumos concluídos - Medicina

Resumos concluídos - Medicin