Milán 1838: 'La aurora en Copacabana' traducida por Pietro Monti

En Italia, a comienzos del siglo XIX, tenemos una idea del teatro de Calderón que, en el plano teórico, contrasta con el modelo todavía dominante de clasicismo. Sin embargo con la afirmación del romanticismo apreciamos una valoración nueva de la libertad expresiva y de los contactos entre las literaturas nacionales, por lo cual surge también un interés por el gran dramaturgo español. Así se registran las traducciones de Biagio Gamboa, Giacinto Battaglia, pero, sobre todo de Pietro Monti, una figura de cura de rural, en un pueblecito cerca de Como, que entre 1838 y 1855 publica las versiones de catorce dramas calderonianos. Examinaremos una, 'La aurora en Copacabana', para dar una idea del tipo de interpretación del texto de Calderón por parte de este estudioso y de los problemas que emergen en el contexto del ambiente cultural milanés en el cual el traductor se encuadra. At the beginning of the nineteenth century, in Italy, the received view of Calderón’s theatrical works saw them in contrast with the prevailing classicism at the theoretical level. However, with the growing establishment of romanticism, there was an exploitation of the freedom of expression and exchange among national literatures. As a consequence, there was a new interest in the great Spanish playwright. We find the translations by Biagio Gamboa, Giacinto Battaglia, and particularly Pietro Monti: a remarkable and well- read parish priest from a small village nearby Como, who published the Italian translations of 14 dramas by Calderón between 1838 and 1855.We consider one of them, 'La aurora en Copacabana', to give an idea of the approach of this translator to Calderón’s text and of the influence of the Milanese milieu in which Monti lived

A parametric approach for evaluating the stability of agricultural tractors using implements during side-slope activities

A methodological approach for evaluating a priori the stability of agricultural vehicles equipped with different mounted implements and operating on sloping hillsides is shown here. It uses a Matlab simulator in its first phase and, subsequently, the Response Surface Modelling (RSM) to evaluate the coefficients of a set of regression equations able to account for the Type-I and Type-II stability of the whole vehicle (tractor + implement with known dimensions and mass). The regression equations can give reliable punctual numeric estimations of the minimum value of the Roll Stability Index (RSI) and can verify the existence of a Type-I equilibrium without the need of using the simulator or knowing any detail about the model implemented in it. The same equations can also be used to generate many intuitive graphs (\u201cequilibrium maps\u201d) useful to verify quickly the possible overturning of the vehicle. A case-study concerning a 4-wheel drive articulated tractor is then presented to show the potential of the approach and how using its tools. The tractor has been studied in three scenarios, differing on where the implement has to be connected to the tractor (1: frontally; 2: frontally-laterally; 3: in the back). After performing a series of simulations, a set of polynomial models (with 6 independent variables) has been created and verified. Then, these models were used, together with the related equilibrium maps, to predict the stability of 8 implements for scenario 1, 7 implements for scenario 2, and 3 implements for scenario 3, evidencing in particular the danger of using a lateral shredder with a mass greater than 245 kg. The proposed approach and its main outcomes (i.e., the regression equations and the equilibrium maps) can give an effective contribution to the preventive safety of the tractor driver, so it could be useful to integrate it in the homologation procedures for every agricultural vehicle and to include the resulting documentation within the tractor logbook

RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases

Mitochondrial translation defects can be due to mutations affecting mitochondrial-or nuclear-encoded components. The number of known nuclear genes involved in mitochondrial translation has significantly increased in the past years. RCC1L (WBSCR16), a putative GDP/GTP exchange factor, has recently been described to interact with the mitochondrial large ribosomal subunit. In humans, three different RCC1L isoforms have been identified that originate from alternative splicing but share the same N-Terminus, RCC1LV1, RCC1LV2 and RCC1LV3. All three isoforms were exclusively localized to mitochondria, interacted with its inner membrane and could associate with homopolymeric oligos to different extent. Mitochondrial immunoprecipitation experiments showed that RCC1LV1 and RCC1LV3 associated with the mitochondrial large and small ribosomal subunit, respectively, while no significant association was observed for RCC1LV2. Overexpression and silencing of RCC1LV1 or RCC1LV3 led to mitoribosome biogenesis defects that resulted in decreased translation. Indeed, significant changes in steady-state levels and distribution on isokinetic sucrose gradients were detected not only for mitoribosome proteins but also for GTPases, (GTPBP10, ERAL1 and C4orf14), and pseudouridylation proteins, (TRUB2, RPUSD3 and RPUSD4). All in all, our data suggest that RCC1L is essential for mitochondrial function and that the coordination of at least two isoforms is essential for proper ribosomal assembly

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

The mitochondrial ADP/ATP carrier (AAC) is a major transport protein of the inner mitochondrial membrane. It exchanges mitochondrial ATP for cytosolic ADP and controls cellular production of ATP. In addition, it has been proposed that AAC mediates mitochondrial uncoupling, but it has proven difficult to demonstrate this function or to elucidate its mechanisms. Here we record AAC currents directly from inner mitochondrial membranes from various mouse tissues and identify two distinct transport modes: ADP/ATP exchange and H+ transport. The AAC-mediated H+ current requires free fatty acids and resembles the H+ leak via the thermogenic uncoupling protein 1 found in brown fat. The ADP/ATP exchange via AAC negatively regulates the H+ leak, but does not completely inhibit it. This suggests that the H+ leak and mitochondrial uncoupling could be dynamically controlled by cellular ATP demand and the rate of ADP/ATP exchange. By mediating two distinct transport modes, ADP/ATP exchange and H+ leak, AAC connects coupled (ATP production) and uncoupled (thermogenesis) energy conversion in mitochondria

Blended professional development in physical education: merging long-distance with face-to-face ongoing support

The study focuses on the use of blended professional development (BPD).That is, merging long-distance and face-to-face professional development (PD) characteristics to introduce a physical education pedagogical model to a primary (i.e., elementary) school physical education teacher. This study sought to: (a) to contextually describe how a BPD in Student-Designed Games (SDG) approach was designed and delivered, and (b) identify how the BPD was aligned with O’Sullivan and Deglau (2006) Principles of PD Design and Delivery. Data collection included lesson plans, observations and interviews. Data analysis was undertaken through the BPD indepth description and a systematic process of deductive analysis using O’Sullivan and Deglau (2006) as the theoretical framework. Three key finding emerged relating to: (1) empowering the teacher, (2) meaningful learning in contextualised environments, and (3) ongoing support. The BPD incorporated 4 stages of delivery: preparation, learning game categories, adjustment to students’ background and supporting students to refine games. Through these stages the BPD was able to provide: (i) a balance between the teacher’s background knowledge and PD vision; (ii) meaningful learning in contextualised environments; . However, it should be recognised that the nature of this PD project was challenging to implement because of the high level of time commitment required

Measuring Physical Activity in Older Adults with and without Early Stage Alzheimer’s Disease

This is the author's accepted manuscript. The original is available at http://www.tandfonline.com/doi/abs/10.1080/07317115.2013.788116#.VvMAj_krK70We compared subjective reports of physical activity with objective measures of physical fitness including cardiorespiratory capacity, body composition, and physical performance in 146 older adults with and without early stage Alzheimer’s disease (ESAD). Respondents reported primarily unstructured and low-intensity activities, including walking and housework. Individuals with ESAD participated in fewer and lower intensity physical activities than those without ESAD. In those without ESAD, housework was related to lower body mass index, leisure walking was related to faster speed on a timed walking test, and participation in sports was related to higher peak oxygen intake. In individuals with ESAD, reported physical activities did not predict any of the physical fitness, body composition, or physical performance measures. We conclude that measures of physical activity require expansion of unstructured and low intensity activities to improve sensitivity in sedentary populations, especially in older adults with ESAD

Low Arousal Threshold Estimation Predicts Failure of Mandibular Advancement Devices in Obstructive Sleep Apnea Syndrome

Introduction: The treatment of choice for obstructive sleep apnea syndrome (OSAS) is continuous positive airway pressure (CPAP). However, CPAP is usually poorly tolerated and mandibular advancement devices (MADs) are an alternative innovative therapeutic approach. Uncertainty still remains as to the most suitable candidates for MAD. Herein, it is hypothesized that the presence of low arousal threshold (low ArTH) could be predictive of MAD treatment failure. Methods: A total of 32 consecutive patients, with OSAS of any severity, who preferred an alternate therapy to CPAP, were treated with a tailored MAD aimed at obtaining 50% of their maximal mandibular advancement. Treatment response after 6 months of therapy was defined as AHI 58.3%. Results: There were 25 (78.1%) responders (p-value < 0.01) at 6 months. Thirteen patients (40.6%) in the non-severe group reached AHI lower than 5 events per hour. MAD treatment significantly reduced the median AHI in all patients from a median value of 22.5 to 6.5 (74.7% of reduction, p-value < 0.001). The mandibular advancement device reduced AHI, whatever the disease severity. A significant higher reduction of Delta AHI, after 6 months of treatment, was found for patients without low ArTH. Conclusions: Low ArTH at baseline was associated with a poorer response to MAD treatment and a lower AHI reduction at 6 months. A non-invasive assessment of Low ArTH can be performed through the Edwards' score, which could help to identify an endotype with a lower predicted response to oral appliances in a clinical setting

A Tracked Mobile Robotic Lab for Monitoring the Plants Volume and Health

9noPrecision agriculture has been increasingly recognized for its potential ability to improve agricultural productivity, reduce production cost, and minimize damage to the environment. In this work, the current stage of our research in developing a mobile platform equipped with different sensors for orchard monitoring and sensing is presented. In particular, the mobile platform is conceived to monitor and assess both the geometric and volumetric conditions as well as the health state of the canopy. To do so, different sensors have been integrated and efficient data-processing algorithms implemented for a reliable crop monitoring. Experimental tests have been performed allowing to obtain both a precise volume reconstruction of several plants and an NDVI mapping suitable for vegetation state evaluations.openopenopenBietresato, M; Carabin, G; D’Auria, D; Gallo, R; Gasparetto, A.; Ristorto, G; Mazzetto, F; Vidoni, R; Scalera, L.Bietresato, M; Carabin, G; D’Auria, D; Gallo, R; Gasparetto, Alessandro; Ristorto, G; Mazzetto, F; Vidoni, R; Scalera, Lorenz

A Combined Measure of Vascular Risk for White Matter Lesions

This is the author's accepted manuscript.Background Though hypertension is a commonly studied risk factor for white matter lesions (WMLs), measures of blood pressure may fluctuate depending on external conditions resulting in measurement error. Indicators of arterial stiffening and reduced elasticity may be more sensitive indicators of risk for WMLs in aging; however the interdependent nature of vascular indicators creates statistical complications. Objective The purpose of the study was to determine whether a factor score comprised of multiple vascular indicators would be a stronger predictor of WMLs than traditional measures of blood pressure. Methods In a sample of well-characterized nondemented older adults, we used a factor analytic approach to account for variance common across multiple vascular measures while reducing measurement error. The result was a single factor score reflecting arterial stiffness and reduced elasticity. We used this factor score to predict white matter lesion volumes acquired via fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging. Results The combined vascular factor score was a stronger predictor of deep WML (β = 0.42, p < 0.001) and periventricular WML volumes (β = 0.49, p < 0.001). After accounting for the vascular factor, systolic and diastolic blood pressure measurements were not significant predictors. Conclusions This suggests that a combined measure of arterial elasticity and stiffening may be a stronger predictor of WMLs than systolic and diastolic blood pressure accounting for the multicollinearity associated with a variety of interrelated vascular measures