Comparison of clinical outcomes between Maastricht-III kidney donors >65 years old and donors after brain death: a single center, matched-pair study

Introduction & Objectives: the inclusion of Maastricht Category-III (MIII) donors after circulatory death (DCD) has increased the donors' pool and, therefore, kidney transplants (KT). However, DCD have higher incidence of delayed graft function (DGF) compared to donors after brain death (DBD), being age one of its risk factors. Available data of using expanded criteria DCD is still controversial and conflicting in the current medical practice. The purpose of this study was to compare aged DCD outcomes to DBD regarding DGF, graft and patient's survival. Materials & Methods: We performed a retrospective observational matched-pair analysis of DCD >65 years old (yo) compared to DBD with minimum 1 year follow-up. Patients were matched according to donors' age (±2 years), receptors' age (±5 years), cold ischemia time (CIT) (±3 hours) and type of storage (cold vs perfusion machine). Stata14 program was used for statistical analysis: Tstudent, χ2 for descriptive analysis, logistic regression for DGF and Kaplan Meier survival curves

Software-defined open architecture for front- and backhaul in 5G mobile networks

New software-defined open network concepts are proposed in this paper to enable an efficient implementation of front- and backhaul solutions for future 5G mobile networks. Main requirements for 5G front- and backhaul are derived and then related to the open network architecture enabling multiple operators to share the same physical infrastructure. The value of software-defined networking (SDN) is particularly outlined therefore. For the use of SDN in the fronthaul, CPRI over Ethernet (CoE) is proposed as a new transport protocol. In the backhaul, distributed security can be implemented using SDN where direct links are confined inside the access domain, as opposed to the current centralized security solution including also the transport domain. In this way, low latency can be realized e.g. for machine-type communications. As the benefits for fixed-mobile convergence are evident, SDN should be enabled increasingly in the access domain. © 2014 IEEE

EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor

ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (Fellowship to E.D.M. and CancerTec grants to X.S.) MICINN (CTQ2009-08850 to X.S.), MINECO (BIO2012-31043 to X.S.; CTQ2014-56361-P to A.R), Marató de TV3 (102030 to X.S. and 102031 to E.E.P) the COFUND programme of the European Commission (C.T.W.P., A. R. and X.S.), the European Research Council (CONCERT, contract number 648201, to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.) the Serra Hunter Programme (E.E.P.) and AGAUR (SGR-2014-56RR14 to E.E.P). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain)Peer reviewedPostprin

Nuevos materiales didácticos para descubrir los aspectos más cotidianos de la Electroquímica

A pesar del amplio abanico de aplicaciones que posee la electroquímica, con importantes repercusiones en muchos aspectos de la vida cotidiana, los egresados de química de las universidades españolas poseen en general un notable desconocimiento de esta materia. Con objeto de hacer más atractivo el aprendizaje de esta parte de la química, al tiempo que se revelan algunas de sus aplicaciones menos conocidas, se han preparado nuevos materiales didácticos. En ellos se describen de manera divulgativa algunas de las aplicaciones más importantes de la electroquímica, como son las baterías, síntesis de aluminio, o su uso en biosensores. Los nuevos materiales se han suministrado al alumnado del primer curso del grado de química de la Universidad de Alicante y se ha pedido su opinión a través de una encuesta. En general la recepción ha sido buena, aunque la respuesta de los estudiantes ha sido algo escasa. Para dar mayor difusión, se está creando una página web con estos mismos contenidos. Esta página web se ha puesto a disposición de los alumnos de la asignatura Electroquímica de 4º curso de la licenciatura (plan a extinguir) de Química y de nuevo se pedirá su opinión a través de un formulario web

Correcting flaws in the assignment of nitrogen chemical environments in N-doped graphene

X-ray Photoelectron Spectroscopy (XPS) applied to N-doped graphene leads to a rather broad N(1s) core level signal that, based on different sources available in the literature, is most often interpreted by fitting the experimental spectra to three peaks. The resulting N(1s) features are assigned to graphitic, pyrrolic, and pyridinic nitrogen, even if these are far from being uniquely defined in the literature. This broadly accepted interpretation has been questioned by recent accurate Hartree-Fock calculations concluding that graphitic and pyrrolic N(1s) core level binding energies are too close to be distinguished. Consideration of models with N in other so far unexplored environments such as N dimers or N at defects show some variations in the calculated core level binding energies. However, these are not large enough to justify a third peak and suggest that the usual three peaks interpretation of the N(1s) XPS in N-doped graphene may be an artefact caused by the fitting procedure. New measurements have been carried out for samples of N-doped graphene and the obtained N(1s) spectra fitted to two or three peaks. It turns out that the spectra can be equally fitted using two or three peaks but only the former is consistent with the results of the unbiased ab initio calculations which calls for a revision of the usual assignment

Diversité Floristique Des Ligneux Et Structure Des Formations À Garcinia Kola Heckel Dans Les Régions Du Centre Et De l’Est, Cameroun

In order to find the strategies to ensure the sustainable management of natural’s resources and especially woody plants in the Congo Basin, a study was carried out on the floristic diversity of woody plants and the structure of Garcinia kola formations in the Centre and East regions of Cameroon. A total of 39 quadrats of 40 m x 40 m were installed in the Garcinia kola formations in these two regions. In each plot, we identified and counted all individuals with a dbh ≥ 10 cm. Seedlings of G. kola (dbh<10 cm) were also counted in all the plots. The height and diameter of each individual were measured. ANOVA was used to compare the density averages of the different plots, and the DUNCAN test at 5% significance level (XLSTAT 2017) was used to separate these mean values. This study confirms that the Clusiaceae (G. kola) forms the floristic background of the stand studied. The surveys revealed a total of 196 species, 156 species (H '= 2.98) and 68 species (H' = 2.13), respectively, identified in the East and Centre among the population of individuals showing dbh ≥ 10 cm. They were distributed into 124 genera and 46 families. The most diversified families in G. kola formations are Euphorbiaceae, Fabaceae, Meliaceae, Sterculiaceae, Moraceae, Anacardiaceae, Apocynaceae, Annonaceae, Rutaceae, Rubiaceae, and Clusiaceae. The average standing density of G. kola varies from 6.51 (East Region) to 40.72 (Centre Region) stems per hectare. The low density observed in the localities of the eastern region can be explained by the pressure exerted on this species in the natural environment linked mostly to methods of exploitation

Esquizofrenia e Neuroinflamação: Uma revisão das pesquisas recentes que exploram as conexões entre a esquizofrenia e processos de neuroinflamação, abrindo caminho para novas estratégias terapêuticas.

This article reviewed recent research exploring the connection between neuroinflammation and schizophrenia, as well as its implications for therapeutic approaches. Increasing evidence suggests that inflammatory processes in the brain, including microglial activation and increased pro-inflammatory cytokines, may play a role in the pathogenesis of schizophrenia. However, the exact causality of this relationship and its relevance to different subtypes of the disease are still being investigated. Clinical studies and experiments in animal models have highlighted the therapeutic potential of modulating neuroinflammation in schizophrenia. Anti-inflammatory agents, such as minocycline, have shown efficacy in improving symptoms in some patients, although the response is variable. Additionally, nutritional approaches such as omega-3 supplementation and modulation of the gut microbiome are being explored as innovative strategies. The heterogeneity of schizophrenia is a crucial aspect to consider, requiring the identification of biomarkers that can differentiate subgroups of patients based on their inflammatory profile. This personalized approach can guide more effective treatments. This article emphasizes the need for a multidisciplinary approach to the treatment of schizophrenia, taking into account both the biological and psychosocial aspects of the disease. As research continues to unravel the mechanisms of neuroinflammation in schizophrenia, we are closer to offering personalized and effective treatments, improving the quality of life for patients.Este artigo revisou as pesquisas recentes que exploram a conexão entre neuroinflamação e esquizofrenia, bem como suas implicações para abordagens terapêuticas. Evidências crescentes sugerem que processos inflamatórios no cérebro, incluindo a ativação da microglia e o aumento de citocinas pró-inflamatórias, podem desempenhar um papel na patogênese da esquizofrenia. No entanto, a causalidade exata dessa relação e sua relevância para diferentes subtipos da doença ainda estão sendo investigadas. Os estudos clínicos e experimentos em modelos animais destacaram o potencial terapêutico da modulação da neuroinflamação na esquizofrenia. Agentes anti-inflamatórios, como a minociclina, mostraram eficácia na melhoria dos sintomas em alguns pacientes, embora a resposta seja variável. Além disso, abordagens nutricionais, como a suplementação de ômega-3, e a modulação do microbioma intestinal estão sendo exploradas como estratégias inovadoras. A heterogeneidade da esquizofrenia é um aspecto fundamental a ser considerado, exigindo a identificação de biomarcadores que possam diferenciar subgrupos de pacientes com base em seu perfil inflamatório. Essa abordagem personalizada pode direcionar tratamentos mais eficazes. Este artigo enfatiza a necessidade de uma abordagem multidisciplinar para o tratamento da esquizofrenia, que leve em consideração tanto os aspectos biológicos quanto os psicossociais da doença. À medida que a pesquisa continua a desvendar os mecanismos da neuroinflamação na esquizofrenia, estamos mais próximos de oferecer tratamentos personalizados e eficazes, melhorando a qualidade de vida dos pacientes

Un nuevo enfoque didáctico para acercar la Electroquímica al alumnado a través de experiencias cotidianas

La electroquímica es una parte importante de la química, incluida en la mayoría de los temarios de diversas ciencias experimentales. Las reacciones químicas con transferencia de electrones aparecen en numerosas situaciones de la vida cotidiana y constituyen un aspecto muy importante en las reacciones biológicas. A pesar de su importancia, la electroquímica suele ser percibida por los estudiantes con dificultad pues incluye conceptos algo abstractos, como el de potencial eléctrico, que combinados con los propios conceptos de química, tienden a desconcertar al alumno. El objetivo del presente trabajo de investigación docente es la elaboración de un portafolio de ejemplos en los que aparece la electroquímica en el ámbito cotidiano. El uso de baterías y acumuladores es ampliamente conocido. Sin embargo, es menos conocido el papel de la electroquímica en síntesis de gran importancia industrial como la del cloro, el aluminio o el nylon. La electroquímica aparece también entre los principios de funcionamiento de diversos biosensores, como los sistemas de control de alcoholemia o glucosa en sangre. Los ejemplos seleccionados servirán para introducir diversos aspectos de la electroquímica, pretendiendo despertar el interés por esta parte de la ciencia

Plantes ornamentals tòxiques

Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Plantes medicinals, etnobotànica i bioprospecció, Curs: 2013-2014, Coordinadors: Carles Benedí i Joan SimonAquesta obra és el resultat de la tasca col·laborativa feta pels estudiants de l’assignatura optativa de l’ensenyament de Farmàcia «Plantes Medicinals, Etnobotànica i Bioprospecció» del curs 2013-2014. El seu contingut se centra en unes monografies didàctiques sobre quinze plantes ornamentals tòxiques, per a les quals es detalla la nomenclatura, l’origen i la distribució geogràfica, la descripció botànica, la toxicitat i la bibliografia utilitzada

MORBIDADE HOSPITALAR POR HIPERTENSÃO ARTERIAL E DIABETES MELLITUS EM IDOSOS RESIDENTES DA REGIÃO NORDESTE

Currently, chronic non-communicable diseases (NCDs) constitute a serious global public health problem and contribute to increased mortality rates, hospitalizations and decreased quality of life. Diabetes mellitus (DM) and systemic arterial hypertension (SAH) are among the most prevalent NCDs and are the main risk factor for diseases of the circulatory system. Their treatment involves controlling glucose and blood pressure, in addition to changes in habits. food and lifestyle. This study aims to analyze the prevalence of hospital admissions caused by arterial hypertension and diabetes mellitus in elderly residents of the northeast region of Brazil. This is an epidemiological, cross-sectional, descriptive, quantitative and retrospective study of hospitalizations of elderly people for high blood pressure and diabetes mellitus in the Northeast region of Brazil, from 2019 to 2022. The information was obtained through the IT Department of the Unified Health System (DATASUS). The variables selected for analysis were: hospitalizations, region, year, sex, cost of hospital services and deaths. For data tabulation and analysis, the Microsoft Office Excel program (Microsoft©, 2013) was used. During the years 2019 to 2022, 368,516 thousand records of patients presenting with hypertension and diabetes were recorded in Brazil, with the Northeast having the highest number of hospitalizations for DM and SAH, 35% (n=132,527), followed by the Southeast region with 33% (n=33%) and South with 13%. The age group from 60 to 69 years old has a higher prevalence of cases for both morbidities, with SAH presenting 39.8% and DM 47%. The prevalence of hospitalizations for essential hypertension was higher in the states of Maranhão and Bahia, with 42.9% and 28.8%, respectively. Regarding diabetes, Bahia has a higher prevalence of hospitalizations, with 27.2%, while Maranhão has 24.1%. Females had the highest number of hospitalization records for both diseases, corresponding to 52.4% for a diagnosis of diabetes mellitus and 59.2% for essential hypertension. 6,877 deaths were recorded, with Bahia having the highest number of deaths for both diseases. The results obtained from this study are capable of assisting in the planning of health actions, aimed at promoting health and preventing diseases, aimed at the elderly, in the Northeast region and in the state of Bahia, who have been shown to be more prone to the development of NCDs.  Atualmente, as doenças crônicas não transmissíveis (DCNT) se constituem um grave problema de saúde pública mundial e favorecem para a elevação das taxas de mortalidade, hospitalizações e diminuição da qualidade de vida. O diabetes mellitus (DM) e a hipertensão arterial sistêmica (HAS) estão entre as DCNT mais prevalentes e são o principal fator de risco para as doenças do aparelho circulatório, seu tratamento envolvem o controle da glicose e pressão arterial, além de modificações nos hábitos alimentares e estilo de vida. Este estudo tem como objetivo analisar a prevalência das internações hospitalares tendo como causa a hipertensão arterial e o diabetes mellitus em idosos residentes da região nordeste do Brasil. Trata-se de um estudo epidemiológico, do tipo transversal, descritivo, quantitativo e retrospectivo das internações de idosos por hipertensão arterial e diabetes mellitus na região Nordeste do Brasil, no período de 2019 a 2022. As informações foram obtidas por meio do Departamento de Informática do Sistema Único de Saúde (DATASUS). As variáveis selecionadas para análise foram: internações, região, ano, sexo, valor dos serviços hospitalares e óbitos. Para tabulação e análise dos dados utilizou-se o programa Microsoft Office Excel (Microsoft©, 2013). Durante os anos de 2019 a 2022 foram registrados 368.516 mil registros de pacientes apresentando quadro de hipertensão e diabetes, no Brasil, sendo que o Nordeste possui maior número de internações por DM e HAS, 35% (n=132.527), seguido da região Sudeste com 33% (n=33%) e Sul com 13%. A faixa etária de 60 a 69 anos possui maior prevalência de casos para as duas morbidades, sendo que HAS apresenta 39,8% e DM 47%. Prevalência de internações por hipertensão essencial foi maior nos estados do Maranhão e Bahia, com 42,9% e 28,8%, respectivamente. Com relação ao diabetes, a Bahia possui maior prevalência de internações, com 27,2%, enquanto que o Maranhão apresenta 24,1%. O sexo feminino apresentou o maior número de registros de hospitalizações por ambas as doenças, correspondendo a 52,4% para diagnostico de diabetes mellitus e 59,2% para hipertensão essencial. Foram registradas 6.877 mortes, sendo que a Bahia apresenta maior número registro para ambas as doenças. Os resultados obtidos com este estudo são capazes de auxiliar no planejamento de ações em saúde, visando à promoção da saúde e a prevenção de agravos, direcionadas aos idosos, na região Nordeste e no estado da Bahia, que demonstraram serem mais propensos ao desenvolvimento de DCNT