Particle Creation in a universe filled by radiation and dust-like matter

In this article the particle creation process of scalar and spin 1/2 particles in a spatially open cosmological model associated with a universe filled by radiation and dustlike matter. The Klein-Gordon and Dirac equations are solved via separation of variables. After comparing the{\it \ in }and% {\it \ out} vacua, we obtain that the number of created particles corresponds to Planckian and Fermi-Dirac distributions for the scalar and Dirac casesComment: 16pp. IVIC-CFLE-93/0

Bound states of scalar particles in the presence of a short range potential

We analyze the behavior of the energy spectrum of the Klein-Gordon equation in the presence of a truncated hyperbolic tangent potential. From our analysis we obtain that, for some values of the potential there is embedding of the bound states into the negative energy continuum, showing that, in opposition to the general belief, relativistic scalar particles in one-dimensional short range potentials can exhibit resonant behavior and not only the Schiff-Snyder effect.Comment: To appear in Modern Physics Letters

Vacuum effects in an asymptotically uniformly accelerated frame with a constant magnetic field

In the present article we solve the Dirac-Pauli and Klein Gordon equations in an asymptotically uniformly accelerated frame when a constant magnetic field is present. We compute, via the Bogoliubov coefficients, the density of scalar and spin 1/2 particles created. We discuss the role played by the magnetic field and the thermal character of the spectrum.Comment: 17 pages. RevTe

Epigenetic alterations leading to TMPRSS4 promoter hypomethylation and protein overexpression predict poor prognosis in squamous lung cancer patients

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, which highlights the need of innovative therapeutic options. Although targeted therapies can be successfully used in a subset of patients with lung adenocarcinomas (ADC), they are not appropriate for patients with squamous cell carcinomas (SCC). In addition, there is an unmet need for the identification of prognostic biomarkers that can select patients at risk of relapse in early stages. Here, we have used several cohorts of NSCLC patients to analyze the prognostic value of both protein expression and DNA promoter methylation status of the prometastatic serine protease TMPRSS4. Moreover, expression and promoter methylation was evaluated in a panel of 46 lung cancer cell lines. We have demonstrated that a high TMPRSS4 expression is an independent prognostic factor in SCC. Similarly, aberrant hypomethylation in tumors, which correlates with high TMPRSS4 expression, is an independent prognostic predictor in SCC. The inverse correlation between expression and methylation status was also observed in cell lines. In vitro studies showed that treatment of cells lacking TMPRSS4 expression with a demethylating agent significantly increased TMPRSS4 levels. In conclusion, TMPRSS4 is a novel independent prognostic biomarker regulated by epigenetic changes in SCC and a potential therapeutic target in this tumor type, where targeted therapy is still underdeveloped

Search for Higgs boson production in dilepton and missing energy final states with 5.4 fb-1 of p-pbar collisions at sqrt(s) =1.96 TeV

A search for the standard model Higgs boson is presented using events with two charged leptons and large missing transverse energy selected from 5.4 fb-1 of integrated luminosity in p-pbar collisions at sqrt(s)=1.96 TeV collected with the D0 detector at the Fermilab Tevatron Collider. No significant excess of events above background predictions is found, and observed (expected) upper limits at 95% confidence level on the rate of Higgs boson production are derived that are a factor of 1.55 (1.36) above the predicted standard model cross section at Higgs boson mass of 165 GeV.Comment: 7 pages with 2 figure and 2 table; updated to reflect published versio